Mitophagy: mechanisms, pathophysiological roles, and analysis

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Autophagy: process and functionPreprint

Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 4,104

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

Autophagy regulates lipid metabolism

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Functions of Lysosomes

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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835

Eaten alive: a history of macroautophagy

Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,155

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.035 · Cited by 2,124

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · cited 1×

ER Tubules Mark Sites of Mitochondrial Division

Friedman, J. R., Lackner, L. L., West, M., DiBenedetto, J. R., Nunnari, J., & Voeltz, G. K. (2011) · Science · doi:10.1126/science.1207385 · Cited by 2,072

Mitochondrial fusion and fission in cell life and death

Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002 · cited 3×

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., García-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,789

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788

Dynamics and diversity in autophagy mechanisms: lessons from yeast

Nakatogawa, H., Suzuki, K., Kamada, Y., & Ohsumi, Y. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2708 · Cited by 1,761

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2422 · Cited by 1,738

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705

Selective degradation of mitochondria by mitophagy

Kim, I., Rodriguez-Enriquez, S., & Lemasters, J. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.034 · Cited by 1,558

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-09 · Cited by 1,501

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008084 · Cited by 1,375

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007013 · Cited by 1,369

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

Lemasters, J. J. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.3 · Cited by 1,342

Autophagy-deficient mice develop multiple liver tumors

Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., & Mizushima, N. (2011) · Genes & Development · doi:10.1101/gad.2016211 · Cited by 1,342

Nix is a selective autophagy receptor for mitochondrial clearance

Novak, I., Kirkin, V., McEwan, D. G., Zhang, J., Wild, P., Rozenknop, A., Rogov, V., Löhr, F., Popovic, D., Occhipinti, A., et al. (2010) · The EMBO Reports · doi:10.1038/embor.2009.256 · Cited by 1,309

A Unified Nomenclature for Yeast Autophagy-Related Genes

Klionsky, D. J., Cregg, J. M., Dunn, W. A., Emr, S. D., Sakai, Y., Sandoval, I. V., Sibirny, A. А., Subramani, S. E., Thumm, M., Marten Veenhuis, A., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00296-x · Cited by 1,305

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

Yang, L., Li, P., Fu, S., Calay, E. S., & Hotamisligil, G. S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.005 · Cited by 1,274

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270

A Role for Ubiquitin in Selective Autophagy

Kirkin, V., McEwan, D. G., Novak, I., & Đikić, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.026 · Cited by 1,268

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

Cully, M., You, H., Levine, A. J., & Mak, T. W. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1819 · Cited by 1,267

Regulation of autophagy by ROS: physiology and pathology

Scherz-Shouval, R., & Elazar, Z. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.007 · Cited by 1,263

Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

Rambold, A. S., Kostelecky, B., Elia, N., & Lippincott‐Schwartz, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107402108 · Cited by 1,188

Essential role for Nix in autophagic maturation of erythroid cells

Sandoval, H., Thiagarajan, P., Dasgupta, S. K., Schumacher, A., Prchal, J. T., Chen, M., & Wang, J. (2008) · Nature · doi:10.1038/nature07006 · Cited by 1,185

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., & Mihara, K. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007152 · Cited by 1,110 · cited 1×

Ambra1 regulates autophagy and development of the nervous system

Fimia, G. M., Stoykova, A., Romagnoli, A., Giunta, L., Bartolomeo, S. D., Nardacci, R., Corazzari, M., Fuoco, C., Uçar, A., Schwartz, P. J., et al. (2007) · Nature · doi:10.1038/nature05925 · Cited by 1,082

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

Chan, N. C., Salazar, A. M., Pham, A. H., Sweredoski, M. J., Kolawa, N. J., Graham, R. L. J., Hess, S., & Chan, D. C. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr048 · Cited by 993

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708818104 · Cited by 979

Endogenous HMGB1 regulates autophagy

Tang, D., Kang, R., Livesey, K. M., Cheh, C.-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M. E., Tracey, K. J., Zeh, H. J., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911078 · Cited by 951

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Gegg, M. E., Cooper, J. M., Chau, K.-Y., Rojo, M., Schapira, A. H. V., & Taanman, J.-W. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq419 · Cited by 910

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

Ishihara, N., Fujita, Y., Oka, T., & Mihara, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601184 · Cited by 899

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B. T., Ding, Z., Larrea, M. D., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1537 · Cited by 886

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

Kanki, T., Wang, K., Cao, Y., Baba, M., & Klionsky, D. J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.014 · Cited by 812

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

Narendra, D. P., Kane, L. A., Hauser, D. N., Fearnley, I. M., & Youle, R. J. (2010) · Autophagy · doi:10.4161/auto.6.8.13426 · Cited by 810

Eating Oneself and Uninvited Guests

Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.01.005 · Cited by 810

Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21

Aita, V. M., Liang, X. H., Murty, V. V. V. S., Pincus, D. L., Yu, W., Cayanis, E., Kalachikov, S. M., Gilliam, T. C., & Levine, B. (1999) · Genomics · doi:10.1006/geno.1999.5851 · Cited by 800

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.-W., Yang, L., Beal, M. F., Vogel, H., & Lu, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602493103 · Cited by 798

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

Okamoto, K., Kondo-Okamoto, N., & Ohsumi, Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.013 · Cited by 797

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

Gandre-Babbe, S., & van der Bliek, A. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1287 · Cited by 769

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

Bruick, R. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9082 · Cited by 767

Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

Cipolat, S., Rudka, T., Hartmann, D., Costa, V., Serneels, L., Craessaerts, K., Metzger, K., Frezza, C., Annaert, W. G., D'adamio, L., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.021 · Cited by 756

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

Kraft, C., Deplazes, A., Sohrmann, M., & Peter, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1723 · Cited by 733

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., & Nukina, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.039 · Cited by 714

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680

Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons

Barsoum, M. J., Yuan, H., Gerencser, A. A., Liot, G., Kushnareva, Y., Gräber, S., Kovács, I., Lee, W. D., Waggoner, J., Cui, J., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601253 · Cited by 677

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.014 · Cited by 670

BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore

Velde, C. V., Cizeau, J., Dubik, D., Alimonti, J. B., Brown, T., Israels, S. J., Hakem, R., & Greenberg, A. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5454-5468.2000 · Cited by 618

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Ando, J., Iwadate, M., Yamamoto, M. P., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201102031 · Cited by 615

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

Yoshii, S. R., Kishi, C., Ishihara, N., & Mizushima, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209338 · Cited by 612

The mitochondrial permeability transition initiates autophagy in rat hepatocytes

Elmore, S. P., Qian, T., Grissom, S. F., & Lemasters, J. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0206fje · Cited by 607

Regulation of OPA1 processing and mitochondrial fusion by m -AAA protease isoenzymes and OMA1

Ehses, S., Lauria, I., Mancuso, G., Bernacchia, A., Geimer, S., Tondera, D., Martinou, J., Westermann, B., Rugarli, E. I., & Langer, T. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200906084 · Cited by 596

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

Kundu, M., Lindsten, T., Yang, C.-Y., Wu, J., Zhao, F., Zhang, J., Selak, M. A., Ney, P. A., & Thompson, C. B. (2008) · Blood · doi:10.1182/blood-2008-02-137398 · Cited by 594

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

Ding, W.-X., Ni, H.-M., Li, M., Liao, Y., Chen, X., Stolz, D. B., Dorn, G. W., & Yin, X.-M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.119537 · Cited by 551

Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration

Grumati, P., Coletto, L., Sabatelli, P., Cescon, M., Angelin, A., Bertaggia, E., Blaauw, B., Urciuolo, A., Tiepolo, T., Merlini, L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2247 · Cited by 540

Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell Death

Jaeschke, H., & Bajt, M. L. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi336 · Cited by 529

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L., & Yin, X. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.041 · Cited by 515

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

Head, B., Griparic, L., Amiri, M., Gandre-Babbe, S., & van der Bliek, A. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200906083 · Cited by 515

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

Sato, M., & Sato, K. (2011) · Science · doi:10.1126/science.1210333 · Cited by 491

Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

Griparić, L., Kanazawa, T., & van der Bliek, A. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704112 · Cited by 486

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

Casley, C. S., Canevari, L., Land, J. M., Clark, J. B., & Sharpe, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00681.x · Cited by 485

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

Boyd, J. M., Malstrom, S. E., Subramanian, T., Venkatesh, L., Schaeper, U., Elangovan, B., D’Sa-Eipper, C., & Chinnadurai, G. (1994) · Cell · doi:10.1016/0092-8674(94)90202-x · Cited by 476

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475

Image-based genome-wide siRNA screen identifies selective autophagy factors

Orvedahl, A., Sumpter, R., Xiao, G., Ng, A., Zou, Z., Tang, Y., Narimatsu, M., Gilpin, C., Sun, Q., Roth, M., et al. (2011) · Nature · doi:10.1038/nature10546 · Cited by 474

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

Al Rawi, S., Louvet-Vallée, S., Djeddi, A., Sachse, M., Culetto, E., Hajjar, C., Boyd, L., Legouis, R., & Galy, V. (2011) · Science · doi:10.1126/science.1211878 · Cited by 461

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

Silvestri, L., Caputo, V., Bellacchio, E., Atorino, L., Dallapiccola, B., Valente, E. M., & Casari, G. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi377 · Cited by 449

Regulation of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 Chaperone Network

Kang, B. H., Plescia, J., Dohi, T., Rosa, J., Doxsey, S., & Altieri, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.08.028 · Cited by 448

Control of autophagy by oncogenes and tumor suppressor genes

Maiuri, M. C., Tasdemir, E., Criollo, A., Morselli, E., Vicencio, J. M., Carnuccio, R., & Kroemer, G. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.131 · Cited by 447

Can autophagy promote longevity?

Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 440

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

Bhatia‐Kiššová, I., Deffieu, M. S., Manon, S., & Camougrand, N. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406960200 · Cited by 431

Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity

Ni, H., Bockus, A. B., Boggess, N., Jaeschke, H., & Ding, W. (2011) · Hepatology · doi:10.1002/hep.24690 · Cited by 429

Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution

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Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells

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p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

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PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

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Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

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Mitochondria removal by autophagy

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Role of Mitochondrial Inner Membrane Permeabilization in Necrotic Cell Death, Apoptosis, and Autophagy

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

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Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

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Hypoxia induces the expression of the pro-apoptotic gene BNIP3

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BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

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Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

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The E1B 19K/Bcl-2–binding Protein Nip3 is a Dimeric Mitochondrial Protein that Activates Apoptosis

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Tracker Dyes to Probe Mitochondrial Autophagy (Mitophagy) in Rat Hepatocytes

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Foxo3 is required for the regulation of oxidative stress in erythropoiesis

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Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes

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The kinase domain of mitochondrial PINK1 faces the cytoplasm

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Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

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The multiple roles of autophagy in cancer

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Nix and Nip3 Form a Subfamily of Pro-apoptotic Mitochondrial Proteins

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Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

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High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

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Parkin Interacts with Ambra1 to Induce Mitophagy

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Viruses and autophagy

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Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

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Atg11 Links Cargo to the Vesicle-forming Machinery in the Cytoplasm to Vacuole Targeting Pathway

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Dissection of the multiple mechanisms of TNF‐α‐induced apoptosis in liver injury

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Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival

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The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria

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High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

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LKB1; linking cell structure and tumor suppression

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A Short Mitochondrial Form of p19ARF Induces Autophagy and Caspase-Independent Cell Death

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Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation

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Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy

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Phosphorylation of Serine 114 on Atg32 mediates mitophagy

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Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

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Adenovirus E1B-19K/BCL-2 Interacting Protein BNIP3 Contains a BH3 Domain and a Mitochondrial Targeting Sequence

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Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy

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Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

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Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae

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Ubiquitination of Prohibitin in Mammalian Sperm Mitochondria: Possible Roles in the Regulation of Mitochondrial Inheritance and Sperm Quality Control1

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OPA1 Processing Reconstituted in Yeast Depends on the Subunit Composition of them-AAA Protease in Mitochondria

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Autophagy protects renal tubular cells against cyclosporine toxicity

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p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

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TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy

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Hsp90 Inhibition Decreases Mitochondrial Protein Turnover

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Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice

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Distinct Pathways Regulate Proapoptotic Nix and BNip3 in Cardiac Stress

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Glutathione Participates in the Regulation of Mitophagy in Yeast

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Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted reproductive technologies and mtDNA inheritance

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The emerging role of autophagy in alcoholic liver disease

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Metabolic dysfunction and depletion of mitochondria in hearts of septic rats

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Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes

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Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

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Endogenous HMGB1 regulates autophagy

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Glutathione participates in the regulation of mitophagy in yeast

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Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

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Pathophysiology of type 2 diabetes mellitus

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Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

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