Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol
Open accessAbstract
AIM: To determine the effect of maternal cigarette smoking on cord blood concentrations of E3, hPL, beta-hCG, FSH, LH, and cortisol. METHODS: Hormone concentrations were measured in term neonates of 100 smoking and 100 non-smoking mothers. RESULTS: The median E3, hPL, beta-hCG, FSH, LH and cortisol cord blood concentrations in the non-smoking mothers' offspring were 212 ng/mL, 2.00 microg/mL, 57.5 mIU/mL, 0.10 mIU/mL, 0.20 mIU/mL, and 14.3 microg/mL, respectively; in the smoking they were 163, 1.39, 45.4, 0.10, 0.20, and 25.1, respectively (P=0.008, 0.004, 0.037, 0.498, 0.286, 0.004, respectively). There was a significant but poor negative correlation between number of cigarettes/day and E3 (r=-0.163, P=0.021), hPL (r=-0.191, P=0.007), and beta-hCG (r=-0.143, P=0.044), whereas the correlation with cortisol was positive (r=0.259, P<0.0001). Multiple linear regression analyses showed that maternal smoking is a determinant of cord blood E3, hPL, beta-hCG, FSH, and cortisol concentrations. CONCLUSIONS: Tobacco smoking is associated with a reduction in cord blood E3, hPL, and beta-hCG concentrations, whereas it is associated with increased cortisol concentrations. The disturbed endocrine equilibrium of the fetus induced by tobacco smoking could have adverse consequences on the fetus and child since fetal brain is a target organ for hormonal actions.
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Cortisol is higher in cord blood of newborns whose mothers smoked.
“the stress hormone, cortisol, was increased in the cord blood of newborns of smoking mothers”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [132]
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- Authors
- Varvarigou, A. A., Liatsis, S. G., Vassilakos, P., Decavalas, G., & Beratis, N. G.
- Affiliations
- University of Patras (GR)
- Venue
- Journal of Perinatal Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2009-01-01
- Volume
- 37
- Issue
- 4
- Pages
- 364-9
- ISSN
- 0300-5577 (ISSN-L)
- 1619-3997
- OpenAlex
- W2113642166
- Cited by
- 41
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
- edoc.hu-berlin.de
- Locations
- Journal of Perinatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- edoc Publication server (Humboldt University of Berlin) (submittedVersion)
- edoc Publication server (Humboldt University of Berlin)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal smoking, umbilical cord blood, estriol, placental lactogen, beta-hCG, follicle-stimulating hormone, luteinizing hormone, cortisol, fetal endocrine system, tobacco smoke exposure, fetal brain, term infants
- MeSH terms
- Adult, Estriol, Female, Fetal Blood, Gonadotropins, Humans, Hydrocortisone, Infant, Newborn, Male, Placental Lactogen, Pregnancy, Prenatal Exposure Delayed Effects, Smoking, Young Adult
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