Clinical immunologic approaches for the treatment of Alzheimer's disease

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Alzheimer's Disease: Genes, Proteins, and Therapy

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Alzheimer's Disease Is a Synaptic Failure

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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The molecular pathology of Alzheimer's disease

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

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Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

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Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

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Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

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Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

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Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

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Some morphometric aspects of the brain in senile dementia of the alzheimer type

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Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

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Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

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Alzheimer's Disease: A Central Role for Amyloid

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Roles of Fc receptors in autoimmunity

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Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

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Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease

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Disaggregation of Alzheimer β-amyloid by site-directed mAb

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Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage.

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Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367 · see citing works

Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD

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Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

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Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

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Immunology and immunotherapy of Alzheimer's disease

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Intravenous immunoglobulins containing antibodies against -amyloid for the treatment of Alzheimer's disease

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Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.

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Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

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Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

Cribbs, D. H. (2003) · International Immunology · doi:10.1093/intimm/dxg049 · Cited by 280 · see citing works

Aβ Species Removal After Aβ ₄₂ Immunization

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Alzheimer disease: progress or profit?

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Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

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Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice

Sigurdsson, E. M., Scholtzova, H., Mehta, P. D., Frangione, B., & Wısnıewskı, T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61715-4 · Cited by 258 · see citing works

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases

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Cell Mediators of Inflammation in the Alzheimer Disease Brain

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Amyloid-β Peptide Remnants in AN-1792-Immunized Alzheimer's Disease Patients

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Filamentous phage as vector-mediated antibody delivery to the brain

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Mechanisms of action of IVIg and therapeutic considerations in the treatment of acute and chronic demyelinating neuropathies

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Human antibodies against amyloid β peptide: A potential treatment for Alzheimer's disease

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Transgenic mouse models of Alzheimer's disease: phenotype and application.

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Single Chain Variable Fragments against β-Amyloid (Aβ) Can Inhibit Aβ Aggregation and Prevent Aβ-Induced Neurotoxicity

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Insights into the mechanisms of action of anti‐Aβ antibodies in Alzheimer's disease mouse models

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N-terminal EFRH sequence of Alzheimer's β-amyloid peptide represents the epitope of its anti-aggregating antibodies

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Reduction of β-amyloid plaques in brain of transgenic mouse model of Alzheimer’s disease by EFRH-phage immunization

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Modulation of Alzheimer’s β-amyloid neurotoxicity by site-directed single-chain antibody

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Hormonal Regulation of Growth Plate Cartilage

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Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-β peptide

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High affinity binding of monoclonal antibodies to the sequential epitope EFRH of β-amyloid peptide is essential for modulation of fibrillar aggregation

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EFRH–Phage Immunization of Alzheimer's Disease Animal Model Improves Behavioral Performance in Morris Water Maze Trials

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Aβ Immunotherapy: Lessons Learned for Potential Treatment of Alzheimer’s Disease

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Brain Amyloid — A Physicochemical Perspective

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Antibody Assisted Protein Refolding

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Chaperone‐like effect of monoclonal antibodies on refolding of heat‐denatured carboxypeptidase A

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Risk Factors Associated With β-Amyloid(1-42) Immunotherapy in Preimmunization Gene Expression Patterns of Blood Cells

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Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related Aβ peptide

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Open peer commentary regarding Aβ immunization and CNS inflammation by Pasinetti et al.

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Preventing and treating Alzheimer’s disease: strategies and prospects

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Inhibitory effect of monoclonal antibodies on Alzheimer's β-amyloid peptide aggregation

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Concern over the amyloid vaccine: amyloid heterogeneity and Fc receptor signaling

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Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

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Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

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Molecular and cellular aspects of protein misfolding and disease

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The Impact of Surgery and Anesthesia on Post-Operative Cognitive Decline and Alzheimer's Disease Development: Biomarkers and Preventive Strategies

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IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders

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Biomarkers for early diagnosis of Alzheimer disease: ‘ALZheimer ASsociated gene’– a new blood biomarker?

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Protein aggregation, misfolding and consequential human neurodegenerative diseases

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Is passive immunization for Alzheimer's disease ‘alive and well’ or ‘dead and buried’?

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Angiotensin I-Converting Enzyme Gln1069Arg Mutation Impairs Trafficking to the Cell Surface Resulting in Selective Denaturation of the C-Domain

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Advances in vaccine technology and their impact on managed care.

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Chaperone-like Antibodies Targeting Misfolded Tau Protein: New Vistas in the Immunotherapy of Neurodegenerative Foldopathies

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Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs

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Therapy of Alzheimer's disease: an update.

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Inherent Anti-amyloidogenic Activity of Human Immunoglobulin γ Heavy Chains

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The Black Book of Psychotropic Dosing and Monitoring

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Chaperone-Like Antibodies in Neurodegenerative Tauopathies: Implication for Immunotherapy

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Immunotherapy for Alzheimer's disease: attacking amyloid-β from the inside

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Immunization as Treatment for Parkinson’s Disease

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The potential value of early screening for neurological deficits in participants in certain sports

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Current and Future Therapies for Alzheimer Disease

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Innovative Therapie der Alzheimer-Demenz

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La prise en charge des démences

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Immunotherapy for Alzheimer's disease: will vaccination work?

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Immunotherapy as treatment for Alzheimer’s disease

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Alzheimer’s disease vaccines: promises and pitfalls

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Immunotherapy Against Amyloid-β in Alzheimer’s Disease: An Overview

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Vaccine Development for Alzheimers Disease

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