Cited by 386Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Age-Related Decline in Circadian Output

Open access

Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., Block, G. D.·2011·Journal of Neuroscience

DOI 10.1523/jneurosci.0451-11.2011PMC PMC3155746

Open this paper in CoChat — free account Open PDF

Abstract

Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and fragmentation of the sleep episodes, are commonly associated with aging in humans and other mammals. While there are undoubtedly many factors contributing to these changes, a body of literature is emerging, suggesting that an age-related decline in the central circadian clock in the suprachiasmatic nucleus (SCN) may be a key element responsible. To explore age-related changes in the SCN, we have performed in vivo multiunit neural activity (MUA) recordings from the SCN of freely moving young (3-5 months) and middle-aged (13-18 months) mice. Importantly, the amplitude of day-night difference in MUA was significantly reduced in the older mice. We also found that the neural activity rhythms are clearly degraded in the subparaventricular zone, one of the main neural outputs of the SCN. Surprisingly, parallel studies indicate that the molecular clockwork in the SCN as measured by PER2 exhibited only minor deficits at this same age. Thus, the circadian output measured at the level of neural activity rhythms in the SCN is degraded by aging, and this decline occurs before the disruption of key components of the molecular clockwork.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.0451-11.2011

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citation
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Persistence of circadian rhythmicity in a mammalian hypothalamic “island” containing the suprachiasmatic nucleus
Inouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985
Sleep in Normal Aging and Dementia
Bliwise, D. L. (1993) · SLEEP · doi:10.1093/sleep/16.1.40 · Cited by 854
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681
Self-citation
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
Dijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467
Sleep states alter activity of suprachiasmatic nucleus neurons
Deboer, T., Vansteensel, M. J., Détári, L., & Meijer, J. H. (2003) · Nature Neuroscience · doi:10.1038/nn1122 · Cited by 328
Effects of aging on central and peripheral mammalian clocks
Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152318499 · Cited by 317
Self-citation

Flagged first, then by citations

Show all 35 references

Sorted by citations

Items 201–300 of 385

Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity
Ohara, T., Nakamura, T. J., Nakamura, W., & Tokuda, I. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-73669-x · Cited by 18
Self-citation
Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges
Banerjee, S., & Ray, S. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102387 · Cited by 18
The Dorsal Medial Habenula Minimally Impacts Circadian Regulation of Locomotor Activity and Sleep
Hsu, Y. A., Gile, J. J., Perez, J. G., Morton, G., Ben‐Hamo, M., Turner, E. E., & de la Iglesia, H. O. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417730169 · Cited by 18
Resetting the Aging Clock: Implications for Managing Age-Related Diseases
Nobrega, A. K. D., Luz, K. V., & Lyons, L. C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_9 · Cited by 20
Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1
Yin, Y., Tang, Q., Yang, J., Gui, S., Zhang, Y., Shen, Y., Zhou, X., Yu, S., Chen, G., Sun, J., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176660 · Cited by 17
Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
Shuboni‐Mulligan, D. D., Young, D., Minyety, J. D. L. C., Vera, E. M., Munasinghe, J., Gall, A. J., Gilbert, M. R., Armstrong, T. S., & Smart, D. D. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00063-w · Cited by 16
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
Sato, S., Hishida, T., Kinouchi, K., Hatanaka, F., Li, Y., Nguyen, Q., Chen, Y., Wang, P. H., Kessenbrock, K., Li, W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112590 · Cited by 22
The Circadian Clock GenePeriod1Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus
Kudo, T., Block, G. D., & Colwell, C. S. (2015) · ASN NEURO · doi:10.1177/1759091415610761 · Cited by 17
Self-citation
Seasonal Variations of Locomotor Activity Rhythms in Melatonin-Proficient and -Deficient Mice under Seminatural Outdoor Conditions
Metzger, J., Wicht, H., Korf, H., & Pfeffer, M. (2019) · Journal of Biological Rhythms · doi:10.1177/0748730419881922 · Cited by 17
Aging effects on the diurnal patterns of gut microbial composition in male and female mice
Kim, H.-J., Moon, C. M., Kang, J., & Park, E. (2021) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2021.25.6.575 · Cited by 16
Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease
Bains, R. S., Forrest, H., Sillito, R. R., Armstrong, J. D., Stewart, M. E., Nolan, P. M., & Wells, S. E. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1148172 · Cited by 16
Circadian Biology and the Neurovascular Unit
Li, W., Tiedt, S., Lawrence, J. H., Harrington, M. E., Musiek, E. S., & Lo, E. H. (2024) · Circulation Research · doi:10.1161/circresaha.124.323514 · Cited by 17
How does healthy aging impact on the circadian clock?
Popa‐Wagner, A., Buga, A.-M., Dumitraşcu, D. I., Uzoni, A., Thome, J., & Coogan, A. N. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1424-2 · Cited by 17
The Suprachiasmatic Nucleus and the Circadian Timekeeping System of the Body
Evans, J. A., & Silver, R. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_66-3 · Cited by 15
Molecular and Cellular Networks in The Suprachiasmatic Nuclei
Hussein, L. E. C., Mollard, P., & Bonnefont, X. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20082052 · Cited by 19
Hypothalamic Control of Sleep in Aging
Rolls, A. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8175-0 · Cited by 17
CircadiOmic medicine and aging
TABIBZADEH, S. S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101424 · Cited by 17
Aging affects GABAergic function and calcium homeostasis in the mammalian central clock
Engberink, A. H. O. O., Gutiérrez, P. D. T., Chiosso, A., Das, A., Meijer, J. H., & Michel, S. H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1178457 · Cited by 15
Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
Gendron, C. M., Chakraborty, T. S., Chung, B. Y., Harvanek, Z. M., Holme, K. J., Johnson, J. C., Lyu, Y., Munneke, A. S., & Pletcher, S. D. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034440 · Cited by 17
Age-Related Unstructured Spike Patterns and Molecular Localization in Drosophila Circadian Neurons
Nguyen, D. L., Hutson, A. N., Zhang, Y., Daniels, S. D., Peard, A. R., & Tabuchi, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.845236 · Cited by 18
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging
Wong, H., Buck, J. M., Borski, C., Pafford, J., Keller, B. N., Milstead, R. A., Hanson, J. L., Stitzel, J. A., & Hoeffer, C. A. (2022) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-022-09444-y · Cited by 15
Suprachiasmatic nucleus-dependent and independent outputs driving rhythmic activity in hypothalamic and thalamic neurons
Harding, C., Bechtold, D. A., & Brown, T. M. (2020) · BMC Biology · doi:10.1186/s12915-020-00871-8 · Cited by 15
Circadian system and aging: where both times interact
Cobarro, C., Soares, L. I., Kutsenko, Y., & Tomás‐Loba, A. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1646794 · Cited by 15
The intersection between menopause and depression: overview of research using animal models
Herrera-Pérez, J., Hernández-Hernández, O. T., Flores-Ramos, M., Cueto-Escobedo, J., Rodríguez-Landa, J., & Martínez-Mota, L. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1408878 · Cited by 16
Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice
Ramírez-Rodríguez, G. B., Gómez‐Sánchez, A., & Ortíz‐López, L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.014 · Cited by 14
Circadian Dysfunction in Response to in Vivo Treatment with the Mitochondrial Toxin 3-Nitropropionic Acid
Kudo, T., Loh, D. H., Tahara, Y., Truong, D. A., Hernández, E., & Colwell, C. S. (2013) · ASN NEURO · doi:10.1042/an20130042 · Cited by 15
Self-citation
Gene expression profiling of the SCN in young and old rhesus macaques
Eghlidi, D. H., Luna, S. L., Brown, D. I., Garyfallou, V. T., Kohama, S. G., & Urbanski, H. F. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0062 · Cited by 14
Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA)
Erickson, M. L., BLACKWELL, T. L., Mau, T., Cawthon, P. M., Glynn, N. W., Qiao, Y., Cummings, S. R., Coen, P. M., Lane, N. E., Kritchevsky, S. B., et al. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae049 · Cited by 13
Spatiotemporal Control Over Circadian Rhythms With Light
Kolarski, D., Szymański, W., & Feringa, B. L. (2025) · Medicinal Research Reviews · doi:10.1002/med.22099 · Cited by 14
Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Body Mass Index in Older Men: A Novel Analysis Using Harmonic Hidden Markov Models
Heckler, B., Lee, M., Stone, K. L., Bauer, C., & Xiao, Q. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221134163 · Cited by 13
Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery
Weger, M., Weger, B. D., & Gachon, F. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2224554 · Cited by 15
Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson’s disease model in male Wistar rat and its modulation by melatonin
Jagota, A., & Mattam, U. (2017) · Biogerontology · doi:10.1007/s10522-017-9711-y · Cited by 13
Changes in the suprachiasmatic nucleus during aging: Implications for biological rhythms.
Engelberth, R. C. G. J., de Pontes, A. L. B., Fiuza, F. P., Silva, K. D. D. A., Resende, N. D. S., de Azevedo, C. V. M., Costa, M. S. M. O., Cavalcante, J. C., do Nascimento, E. S., Gavioli, E. C., et al. (2013) · Psychology & Neuroscience · doi:10.3922/j.psns.2013.3.07 · Cited by 13
Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria
Xu, W. Q., & Li, X. (2023) · Molecules · doi:10.3390/molecules28114432 · Cited by 11
Rest-activity rhythm fragmentation and synchronization are linked with reduced cortical thickness in older adults “at risk” for dementia
Espinosa, N., Hoyos, C. M., McKinnon, A. C., Almgren, H., Duffy, S. L., & Naismith, S. L. (2025) · SLEEP · doi:10.1093/sleep/zsaf017 · Cited by 15
Cryptochrome-dependent circadian periods in the arcuate nucleus
Uchida, H., Nakamura, T. J., Takasu, N. N., Todo, T., Sakai, T., & Nakamura, W. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.071 · Cited by 12
Self-citation
Resilience in the suprachiasmatic nucleus: Implications for aging and Alzheimer's disease
Fernandez, F., Kaladchibachi, S., & Negelspach, D. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111258 · Cited by 12
Zebrafish Behavioral Models of Ageing
Brock, A. J., Sudwarts, A., Parker, M. O., & Brennan, C. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-33774-6_11 · Cited by 12
Circadian Rhythms and Disease
Zhang, S., & Sehgal, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812536-6.00011-0 · Cited by 12
Effects of testosterone on circadian rhythmicity in old mice
Hashimoto, A., Fujiki, S., Nakamura, W., & Nakamura, T. J. (2019) · The Journal of Physiological Sciences · doi:10.1007/s12576-019-00695-4 · Cited by 14
Self-citation
Gender and age influence in daytime and nighttime seizure occurrence in epilepsy associated with mesial temporal sclerosis
Passarelli, V., & Castro, L. H. M. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.05.028 · Cited by 12
Analysis of circadian rhythm components in EEG/EMG data of aged mice
Masuda, K., Katsuda, Y., Niwa, Y., Sakurai, T., & Hirano, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1173537 · Cited by 11
Diurnal variation of brain activity in the human suprachiasmatic nucleus
Oka, S., Ogawa, A., Osada, T., Tanaka, M., Nakajima, K., Kamagata, K., Aoki, S., Oshima, Y., Tanaka, S., Kirino, E., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1730-23.2024 · Cited by 11
Self-citation
Circadian Rhythms, Sleep, and Aging
Garbarino, S., Lanteri, P., Prada, V., Falkenstein, M., & Sannita, W. G. (2020) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000267 · Cited by 11
Aging clocks: disrupted circadian rhythms
Steponenaite, A., Biello, S. M., & Lall, G. S. (2018) · Aging · doi:10.18632/aging.101642 · Cited by 11
Suprachiasmatic Nucleus
Krishna, H., Motwani, R., Kumar, A., & Priya, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-08956-5_141-1 · Cited by 11
Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases
Reglero-Real, N., Rolas, L., & Nourshargh, S. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20242154 · Cited by 11
Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration
Kaluski-Kopatch, S., Stein, D., García-Venzor, A., Campos, A. M. F., Planque, M., Goldstein, B., Allende-Becerra, E. D., Smirnov, D., Zaretsky, A., Eremenko, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67021-y · Cited by 12
The circadian clock regulates metabolic responses to physical exercise
Cheng, Q., Lü, C., & Qian, R. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2050384 · Cited by 10
Circadian Control of Glial Cell Homeodynamics
Rojo, D., Badner, A., & Gibson, E. M. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221120966 · Cited by 11
Photoperiod Modulates Fast Delayed Rectifier Potassium Currents in the Mammalian Circadian Clock
Farajnia, S., Meijer, J. H., & Michel, S. H. (2016) · ASN NEURO · doi:10.1177/1759091416670778 · Cited by 10
Factors influencing sleep quality among Jordanian intensive care patients
Younis, M. B., Hayajneh, F. A., & Rubbai, Y. (2020) · British Journal of Nursing · doi:10.12968/bjon.2020.29.5.298 · Cited by 16
Retina and melanopsin neurons
Morgia, C. L., Carelli, V., & Sadun, A. A. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00020-0 · Cited by 10
Multifaceted dynamics of circadian timing system influence aging and longevity
Jagota, A., Khan, Z. A., Sharma, S. A., & Priyanka (2025) · Biogerontology · doi:10.1007/s10522-025-10324-w · Cited by 9
In Vivo Monitoring of Multi-Unit Neural Activity in the Suprachiasmatic Nucleus Reveals Robust Circadian Rhythms in Period1−/− Mice
Takasu, N. N., Pendergast, J. S., Olivas, C. S., Yamazaki, S., & Nakamura, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064333 · Cited by 9
Self-citation
Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice
Haraguchi, A., Du, Y., Shiraishi, R., Takahashi, Y., Nakamura, T. J., & Shibata, S. (2022) · Sleep and Biological Rhythms · doi:10.1007/s41105-021-00365-2 · Cited by 9
Self-citation
Circadian arrhythmia dysregulates emotional behaviors in aged Siberian hamsters
Prendergast, B. J., Onishi, K. G., Patel, P. N., & Stevenson, T. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.010 · Cited by 9
Lifestyle Factors and Successful Cognitive Aging in Older Adults
O’Connor, M. K., & Kraft, M. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6605-5_7 · Cited by 10
Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus
Miyazaki, S., Tahara, Y., Colwell, C. S., Block, G. D., Nakamura, W., & Nakamura, T. J. (2021) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2021.100070 · Cited by 9
Self-citation
Deterioration of temporal order and circadian disruption with age 2: Systemic mechanisms of aging-related circadian disruption and approaches to its correction
Gubin, D. G., & Weinert, D. (2016) · Advances in Gerontology · doi:10.1134/s2079057016010057 · Cited by 9
Importance of mechanical cues in regulating musculoskeletal circadian clock rhythmicity: Implications for articular cartilage
Dintwa, L., Hughes, C., & Blain, E. J. (2023) · Physiological Reports · doi:10.14814/phy2.15780 · Cited by 8
Circadian clocks and their role in kidney and eye diseases across organ systems
Chen, X., Zhang, W., Gu, Y., & Huang, S. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1583502 · Cited by 9
Reduced Plasticity in Coupling Strength in the Aging SCN Clock as Revealed by Kuramoto Modeling
van Beurden, A. W., Meylahn, J. M., Achterhof, S., Buijink, M. R., Engberink, A. H. O. O., Michel, S. H., Meijer, J. H., & Rohling, J. H. T. (2023) · Journal of Biological Rhythms · doi:10.1177/07487304231175191 · Cited by 8
Inter-individual variations in circadian misalignment-induced NAFLD pathophysiology in mice
Koike, N., Umemura, Y. M., Inokawa, H., Tokuda, I. T., Tsuchiya, Y., Sasawaki, Y., Umemura, A., Masuzawa, N., Yabumoto, K., Seya, T., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108934 · Cited by 8
Loss of temporal coherence in the circadian metabolome across multiple tissues during ageing in mice
Buijink, M. R., van Weeghel, M., Harms, A. C., Murli, D. S., Meijer, J. H., Hankemeier, T., Michel, S. H., & Kervezee, L. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16428 · Cited by 9
Clock Regulation of Skin Regeneration in Stem Cell Aging
Welz, P.-S. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.10.009 · Cited by 8
Transgenic rats expressing dominant negative BMAL1 showed circadian clock amplitude reduction and rapid recovery from jet lag
Minami, Y., Yoshikawa, T., Nagano, M., Koinuma, S., Morimoto, T., Fujioka, A., Furukawa, K., Ikegami, K., Tatemizo, A., 江川, 賢., et al. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15085 · Cited by 8
Circadian clock and its effect on aging and lifespan
Verma, A. K., Singh, S., & Rizvi, S. I. (2025) · Biogerontology · doi:10.1007/s10522-025-10281-4 · Cited by 8
The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease
Shirkouhi, S. G., Karimi, A., Khatami, S. S., Gashtrodkhani, A. A., Kamari, F., Blaabjerg, M., & Andalib, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070547 · Cited by 7
Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice
Zhao, H., Liao, M., Huo, R., He, T., Tian, H., Li, Z., Chen, C., Yu, Z., Chai, J., Song, X., et al. (2026) · Cell · doi:10.1016/j.cell.2026.01.016 · Cited by 8
A Journey in the Brain’s Clock: In Vivo Veritas?
Davidson, A., Beckner, D., & Bonnefont, X. (2023) · Biology · doi:10.3390/biology12081136 · Cited by 7
Molecular connections between circadian clock and health/ageing
Nakahata, Y., & Fukada, Y. (2022) · The Journal of Biochemistry · doi:10.1093/jb/mvac028 · Cited by 7
Temporal order deterioration and circadian disruption with age 1. Central and peripheral mechanisms
Gubin, D. G., & Weinert, D. (2015) · Advances in Gerontology · doi:10.1134/s2079057015040086 · Cited by 7
The Circadian System and Aging of Drosophila
Giebultowicz, J. M. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-64543-8_6 · Cited by 5
Endogenous glucocorticoids during skeletal ageing
Macfarlane, E., Zhou, H., & Seibel, M. J. (2024) · Exploration of Endocrine and Metabolic Diseases · doi:10.37349/eemd.2024.00016 · Cited by 9
A minimal model of peripheral clocks reveals differential circadian re-entrainment in aging
Huang, Y., Zhang, Y., & Braun, R. (2023) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/5.0157524 · Cited by 6
Normalisation against Circadian and Age-Related Disturbances Enables Robust Detection of Gene Expression Changes in Liver of Aged Mice
Costa, S. S., Wegmann, D., & Ripperger, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169615 · Cited by 5
The interface of aging and the circadian clock
Britz, J., & Tischkau, S. A. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.02.004 · Cited by 6
A standardized method to assess the endogenous activity and the light-response of the retinal clock in mammals.
Calligaro, H., Kinane, C., Bennis, M., Coutanson, C., & Dkhissi‐Benyahya, O. (2020) · PubMed Central · Cited by 5
Reuniting the Body “Neck Up and Neck Down” to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience
Hernandez, A. R., Hoffman, J. M., Hernandez, C. M., Cortés, C. J., Jumbo-Lucioni, P., Baxter, M. G., Esser, K. A., Liu, A. C., McMahon, L. L., Bizon, J. L., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab215 · Cited by 9
Circadian disruption of hippocampus in an early senescence male mouse model
Davis, J. A., Paul, J. R., Mokashi, M. V., Yates, S. D., Mount, D. J., Munir, H. A., Goode, L. K., Young, M. E., Allison, D. B., & Gamble, K. L. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173388 · Cited by 6
The Suprachiasmatic Nucleus and the Circadian Timekeeping System of the Body
Evans, J. A., & Silver, R. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_66 · Cited by 6
Effects of Age and MPTP-Induced Parkinson’s Disease on the Expression of Genes Associated with the Regulation of the Sleep–Wake Cycle in Mice
Семенова, Е. И., Rudenok, M. M., Rybolovlev, I. N., Shulskaya, M. V., Lukashevich, M. V., Partevian, S. A., Budko, A. I., Nesterov, M. S., Абаимов, Д. А., Slominsky, P. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147721 · Cited by 5
Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer’s model
Khabirova, E., Chen, K., O'Neill, J. S., & Crowther, D. C. (2016) · Scientific Reports · doi:10.1038/srep33759 · Cited by 5
LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes
Lv, P., Yang, X., & Du, J. (2024) · Nature Communications · doi:10.1038/s41467-024-47740-4 · Cited by 5
Reduction of translation rate stabilizes circadian rhythm and reduces the magnitude of phase shift
Nakajima, M., Koinuma, S., & Shigeyoshi, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.158 · Cited by 5
Aging: rewiring the circadian clock
Ohkubo, R., & Chen, D. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3461 · Cited by 5
Molluskan Ocular Pacemakers: Lessons Learned
Block, G. D., & Colwell, C. S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9613-7_11 · Cited by 5
Self-citation
Editorial: Development of Circadian Clock Functions
Myung, J., Nakamura, T. J., Jones, J. R., Silver, R., & Ono, D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.735007 · Cited by 5
Self-citation
Time after time – circadian clocks through the lens of oscillator theory
del Olmo, M., Ector, C., & Herzel, H. (2026) · FEBS Letters · doi:10.1002/1873-3468.70257 · Cited by 5
Differential effects of sex and age on daily and infradian rhythms of mice
Chang, P., Hitrec, T., Muir, C., Sofyana, M., Truong, V., Lacey, S., Chrobok, Ł., Myung, J., & Piggins, H. D. (2026) · The Journal of Physiology · doi:10.1113/jp289676 · Cited by 4
Metabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study
Zhang, L., Yeung, C. H. C., Lee, K. A. V., Shadyab, A. H., LaCroix, A. Z., Stone, K. L., Yaffe, K. S., Hayden, K. M., Casanova, R., Rapp, S. R., et al. (2025) · SLEEP · doi:10.1093/sleep/zsaf320 · Cited by 4
Strain and Age Dependent Entrainable Range of Circadian Behavior in C57BL/6 and BALB/c Mice
Ma, C., Ren, B., Chen, L., & Yang, G. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113917 · Cited by 4
High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models
Sun, Y. X., Zhong, M., Xu, N., Zhang, X., Sun, H., Wang, Y., Lü, Y., Nie, Y., Li, Q., Sun, Q., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109381 · Cited by 4
Circadian biology of cardiac aging
Bettadapura, S. S., Todd, W. D., McGinnis, G. R., & Bruns, D. R. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.12.001 · Cited by 4
Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence
Xu, W., Li, L., Cao, Z., Ye, J., & Gu, X. (2025) · Aging and Disease · doi:10.14336/ad.2024.1188 · Cited by 5
A review of symptom, pathogenesis and treatment characteristics of the elderly with chronic insomnia
Xia, L., Liu, H., & Ren, J. (2025) · Medicine · doi:10.1097/md.0000000000041346 · Cited by 6
Clinical daily rhythms of seizure in different subtypes of temporal lobe epilepsy
Gong, S., Long, Z., Ji, D., Guo, Q., Zhang, T., Li, S., Yang, X., & Sui, L. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1599236 · Cited by 4
Are circadian rest–activity rhythms sex‐specific markers of frailty risk in older adults? A narrative review
Kim, J., Kirkman, D. L., Lü, J., Sargent, L. J., & Kim, Y. (2025) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.70110 · Cited by 4
The Development and Decay of the Circadian Clock in Drosophila melanogaster
Zhao, J., Warman, G. R., & Cheeseman, J. F. (2019) · Clocks & Sleep · doi:10.3390/clockssleep1040037 · Cited by 4

Authors: Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D.
Affiliations: University of California, Los Angeles (US)
The University of Osaka (JP)
Vanderbilt University (US)
Corresponding author: Colwell, C. S.
ORCID: Nakamura, T. J.
Nakamura, W.
Yamazaki, S.
Kudo, T.
Colwell, C. S.
Block, G. D.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-07-13
Volume: 31
Issue: 28
Pages: 10201-10205
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0451-11.2011
PMC: PMC3155746
OpenAlex: W2094874423
Cited by: 386
References: 35
Citations by year: 2026: 17 · 2025: 27 · 2024: 27 · 2023: 33 · 2022: 25 · 2021: 34 · 2020: 36 · 2019: 31 · 2018: 19 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 14 · 2013: 23 · 2012: 26
FWCI: 9.46
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: CHDI Foundation
National Institutes of Health (AG028748)
Japan Society for the Promotion of Science (23659871)
National Institute on Aging (P30AG028748)
National Institute of Mental Health (R01MH062517)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: suprachiasmatic nucleus, sleep-wake cycle, Per2, sleep fragmentation, mice
MeSH terms: Aging, Animals, Biological Clocks, Circadian Rhythm, Electrodes, Implanted, Electrophysiology, Male, Motor Activity, Suprachiasmatic Nucleus, Mice, Period Circadian Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-Related Decline in Circadian Output

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks