Cited by 386Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

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Age-Related Decline in Circadian Output

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Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., Block, G. D.·2011·Journal of Neuroscience

DOI 10.1523/jneurosci.0451-11.2011PMC PMC3155746

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Abstract

Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and fragmentation of the sleep episodes, are commonly associated with aging in humans and other mammals. While there are undoubtedly many factors contributing to these changes, a body of literature is emerging, suggesting that an age-related decline in the central circadian clock in the suprachiasmatic nucleus (SCN) may be a key element responsible. To explore age-related changes in the SCN, we have performed in vivo multiunit neural activity (MUA) recordings from the SCN of freely moving young (3-5 months) and middle-aged (13-18 months) mice. Importantly, the amplitude of day-night difference in MUA was significantly reduced in the older mice. We also found that the neural activity rhythms are clearly degraded in the subparaventricular zone, one of the main neural outputs of the SCN. Surprisingly, parallel studies indicate that the molecular clockwork in the SCN as measured by PER2 exhibited only minor deficits at this same age. Thus, the circadian output measured at the level of neural activity rhythms in the SCN is degraded by aging, and this decline occurs before the disruption of key components of the molecular clockwork.

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Authors: Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D.
Affiliations: University of California, Los Angeles (US)
The University of Osaka (JP)
Vanderbilt University (US)
Corresponding author: Colwell, C. S.
ORCID: Nakamura, T. J.
Nakamura, W.
Yamazaki, S.
Kudo, T.
Colwell, C. S.
Block, G. D.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-07-13
Volume: 31
Issue: 28
Pages: 10201-10205
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0451-11.2011
PMC: PMC3155746
OpenAlex: W2094874423
Cited by: 386
References: 35
Citations by year: 2026: 17 · 2025: 27 · 2024: 27 · 2023: 33 · 2022: 25 · 2021: 34 · 2020: 36 · 2019: 31 · 2018: 19 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 14 · 2013: 23 · 2012: 26
FWCI: 9.46
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: CHDI Foundation
National Institutes of Health (AG028748)
Japan Society for the Promotion of Science (23659871)
National Institute on Aging (P30AG028748)
National Institute of Mental Health (R01MH062517)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: suprachiasmatic nucleus, sleep-wake cycle, Per2, sleep fragmentation, mice
MeSH terms: Aging, Animals, Biological Clocks, Circadian Rhythm, Electrodes, Implanted, Electrophysiology, Male, Motor Activity, Suprachiasmatic Nucleus, Mice, Period Circadian Proteins

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Age-Related Decline in Circadian Output

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