To be specific: The role of orbitofrontal cortex in signaling reward identity.
Open accessAbstract
The orbitofrontal cortex (OFC) plays a prominent role in signaling reward expectations. Two important features of rewards are their value (how good they are) and their specific identity (what they are). Whereas research on OFC has traditionally focused on reward value, recent findings point toward a pivotal role of reward identity in understanding OFC signaling and its contribution to behavior. Here, we review work in rodents, nonhuman primates, and humans on how the OFC represents expectations about the identity of rewards, and how these signals contribute to outcome-guided behavior. Moreover, we summarize recent findings suggesting that specific reward expectations in OFC are learned and updated by means of identity errors in the dopaminergic midbrain. We conclude by discussing how OFC encoding of specific rewards complements recent proposals that this region represents a cognitive map of relevant task states, which forms the basis for model-based behavior. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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Positively and negatively valenced functions take place within the prefrontal cortex.
“There is excellent evidence that these positively and negatively valenced functions take place within the PFC [168][169][170].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [169]
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- Authors
- Howard, J. D., & Kahnt, T.
- Affiliations
- Northwestern University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2021-04
- Volume
- 135
- Issue
- 2
- Pages
- 210-217
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC8224467
- OpenAlex
- W3139067400
- Cited by
- 57
- References
- 87
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 4
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Behavioral Neuroscience (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC015426)
- National Institute on Drug Abuse (R03DA040668)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- orbitofrontal cortex, reward anticipation, reward value, dopaminergic midbrain, cognitive maps, task state
- MeSH terms
- Animals, Dopamine, Learning, Reward, Signal Transduction, Prefrontal Cortex
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