Default Network Connectivity in Medial Temporal Lobe Amnesia
Open accessAbstract
There is substantial overlap between the brain regions supporting episodic memory and the default network. However, in humans, the impact of bilateral medial temporal lobe (MTL) damage on a large-scale neural network such as the default mode network is unknown. To examine this issue, resting fMRI was performed with amnesic patients and control participants. Seed-based functional connectivity analyses revealed robust default network connectivity in amnesia in cortical default network regions such as medial prefrontal cortex, posterior medial cortex, and lateral parietal cortex, as well as evidence of connectivity to residual MTL tissue. Relative to control participants, decreased posterior cingulate cortex connectivity to MTL and increased connectivity to cortical default network regions including lateral parietal and medial prefrontal cortex were observed in amnesic patients. In contrast, somatomotor network connectivity was intact in amnesic patients, indicating that bilateral MTL lesions may selectively impact the default network. Changes in default network connectivity in amnesia were largely restricted to the MTL subsystem, providing preliminary support from MTL amnesic patients that the default network can be fractionated into functionally and structurally distinct components. To our knowledge, this is the first examination of the default network in amnesia.
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Disorders affecting the structural or functional integrity of the default network will produce marked impairments in the quality of self-generated thought and may compromise its production mechanism altogether.
“In summary, disorders that affect the integrity of the default network’s structural or functional neuroanatomy (e.g., aging, neurodegenerative disease, focal lesions,105 or disorders of consciousness205) will produce marked impairments in the quality of self-generated thought and may compromise the production mechanism altogether.”
From The default network and self-generated thought: component processes, dynamic control, and clinical relevance (2014) · cites this paper as [105]
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- Authors
- Hayes, S. M., Salat, D. H., & Verfaellie, M.
- Affiliations
- Boston University (US)
- VA Boston Healthcare System (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-10-17
- Volume
- 32
- Issue
- 42
- Pages
- 14622-14629a
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3573849
- OpenAlex
- W2027149658
- Cited by
- 46
- References
- 47
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 1 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- Rehabilitation Research and Development Service
- Clinical Science Research and Development
- National Institute on Aging (P50AG005134, P30AG062421)
- National Institute of Mental Health (R01MH093431)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- default mode network, medial temporal lobe amnesia, episodic memory, posterior cingulate cortex, functional connectivity, sensorimotor network, medial prefrontal cortex, posterior medial cortex, lateral parietal cortex, resting-state fMRI
- MeSH terms
- Adult, Amnesia, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Temporal Lobe, Memory, Episodic
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