Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study
Abstract
Background Previous investigations suggest that maltreated children evidence alterations of chemical mediators of stress and adverse brain development. Previous anatomical magnetic resonance imaging (MRI) brain studies have not controlled for socioeconomic status. Methods In this study, 28 psychotropic naïve children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) and 66 sociodemographically similar healthy control subjects underwent comprehensive clinical assessments and anatomical MRI brain scans. Results Compared with control subjects, subjects with PTSD had smaller intracranial, cerebral, and prefrontal cortex, prefrontal cortical white matter, and right temporal lobe volumes and areas of the corpus callosum and its subregions (2, 4, 5, 6, and 7), and larger frontal lobe cerebrospinal fluid (CSF) volumes than control subjects. The total midsagittal area of corpus callosum and middle and posterior regions remained smaller in subjects with PTSD, whereas right, left, and total lateral ventricles and frontal lobe CSF were proportionally larger than in control subjects, after adjustment for cerebral volume. Brain volumes positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse. Significant gender x group effect demonstrated greater lateral ventricular volume increases in maltreated male subjects with PTSD than maltreated female subjects with PTSD. No hippocampal differences were seen. Conclusions The…
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Children with PTSD have smaller whole brain and corpus callosum volume and alterations in structure of the cerebellum and frontal cortex.
“Children with PTSD have smaller whole brain and corpus callosum volume (Carrion and Steiner 2000; De Bellis 2002) and alterations in structure of the cerebellum (Anderson 2002) and frontal cortex. (De Bellis and Thomas 2003b; Carrion 2001).”
From The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology (2006) · cites this paper as De Bellis 2002
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- Authors
- De Bellis, M. D., Keshavan, M. S., Shifflett, H., Iyengar, S., Beers, S. R., Hall, J., & Moritz, G.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 52
- Issue
- 11
- Pages
- 1066-1078
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1988220459
- Cited by
- 632
- References
- 9
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 15 · 2023: 11 · 2022: 9 · 2021: 26 · 2020: 22 · 2019: 27 · 2018: 32 · 2017: 37 · 2016: 56 · 2015: 55 · 2014: 35 · 2013: 37 · 2012: 45
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03mh043687-01)
- National Institute of Mental Health (K08MH001324, MH 01180, 5 K08 MHO1324-02, MH-43687, K02MH001180)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- child abuse, post-traumatic stress disorder, brain structure, corpus callosum, lateral ventricle, cerebrospinal fluid volume, prefrontal cortex, white matter, temporal lobe, socioeconomic status, gender differences, abuse duration
- MeSH terms
- Adolescent, Brain, Child, Child Abuse, Child, Preschool, Female, Humans, Magnetic Resonance Imaging, Male, Sex Factors, Stress Disorders, Post-Traumatic, Case-Control Studies
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