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Cited by 165Posttraumatic Stress Disorder ResearchChild Abuse and TraumaTraumatic Brain Injury Research

Converging evidence for abnormalities of the prefrontal cortex and evaluation of midsagittal structures in pediatric posttraumatic stress disorder: An MRI study

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Carrion, Victor G., Weems, Carl F., Watson, Christa, Eliez, Stephan, Menon, Vinod, Reiss, Allan L.·2009·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2008.07.008PMC PMC2704559
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Abstract

Volumetric imaging research has shown abnormal brain morphology in posttraumatic stress disorder (PTSD) when compared with control subjects. We present results on a study of brain morphology in the prefrontal cortex (PFC) and midline structures, via indices of gray matter volume and density, in pediatric PTSD. We hypothesized that both methods would demonstrate aberrant morphology in the PFC. Further, we hypothesized aberrant brainstem anatomy and reduced corpus callosum volume in children with PTSD. Twenty-four children (aged 7-14) with history of interpersonal trauma and 24 age- and gender-matched controls underwent structural magnetic resonance imaging (sMRI). Images of the PFC and midline brain structures were first analyzed using volumetric image analysis. The PFC data were then compared with whole brain voxel-based techniques using statistical parametric mapping (SPM). The PTSD group showed significantly increased gray matter volume in the right and left inferior and superior quadrants of the PFC and smaller gray matter volume in the pons and posterior vermis areas by volumetric image analysis. The voxel-by-voxel group comparisons demonstrated increased gray matter density mostly localized to ventral PFC as compared with the control group. Abnormal frontal lobe morphology, as revealed by separate-complementary image analysis methods, and reduced pons and posterior vermis areas are associated with pediatric PTSD. Voxel-based morphometry may help to corroborate and further localize data obtained by volume of interest methods in PTSD.

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  • No differences in average hippocampal volume between PTSD and TD youth were found in three studies.

    “none of these studies found differences in average hippocampal volume between PTSD and TD youth.”

    From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [52]

    The Introduction reports that smaller hippocampal volumes in earlier pediatric cross-sectional studies were not statistically significant after controlling for total brain volume. But this paper’s Methods and Results report analyses of other regions, not a hippocampal-volume comparison; it therefore does not establish that this study found no difference. (LLM, conf=0.84)

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  • One study found increased vmPFC gray matter volume in youth with PTSD symptoms compared to TD youth.

    “Carrion and colleagues found increased vmPFC gray matter volume in youth with PTSD symptoms compared to TD youth [52].”

    From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [52]

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Research works printed but not linked: 1

  1. Rauch SL Shin LM Pitman RK Yehuda R Evaluating the effects of psychological trauma using neuroimaging techniques Review of Psychiatry Series 1998 17 67 96 American Psychiatric Press Washington, DC

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Authors
Carrion, V. G., Weems, C. F., Watson, C., Eliez, S., Menon, V., & Reiss, A. L.
Affiliations
  • LSU New Orleans (US)
  • Stanford Medicine (US)
ORCID
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2009-06
Volume
172
Issue
3
Pages
226-234
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2008.07.008
PMC
PMC2704559
OpenAlex
W2077950225
Cited by
165
References
92
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 16 · 2017: 18 · 2016: 16 · 2015: 14 · 2014: 7 · 2013: 11 · 2012: 19
FWCI
11.29
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • American Foundation for Suicide Prevention
  • National Alliance for Research on Schizophrenia and Depression
  • National Institute of Mental Health (K23MH063893, MH01142, K02MH001142, MH 63893)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
prefrontal cortex, gray matter volume, gray matter density, brainstem, passive optical networks, posterior vermis, corpus callosum, interpersonal trauma, ventral prefrontal cortex, brain structure
MeSH terms
Adolescent, Brain Mapping, Brain Stem, Cerebellum, Child, Corpus Callosum, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Case-Control Studies, Prefrontal Cortex, Agenesis of Corpus Callosum

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