Cited by 342Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesSpinal Cord Injury Research

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Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

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Balasingam, V, Tejada-Berges, T, Wright, E, Bouckova, R, Yong, VW·1994·The Journal of Neuroscience

DOI 10.1523/jneurosci.14-02-00846.1994PMC PMC6576825

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Abstract

Reactive astrogliosis is a characteristic response of astrocytes to inflammation and trauma of the adult CNS. To assess the hypothesis that cytokines from inflammatory mononuclear cells that accumulate around lesion sites have a role in modulating astrogliosis, this study sought to take advantage of the neonatal system in which astrogliosis is reported to be minimal following injury and in which the immune system is relatively immature compared to adult animals. A nitrocellulose membrane implant into the cortex of postnatal day 3 mice resulted in a tremendous astrogliotic response 4 d later, as measured by glial fibrillary acidic protein (GFAP) immunoreactivity and GFAP content. In contrast, a neonatal stab wound produced limited astroglial response when compared to the adult stab wound. Utilizing the neonatal stab wound model, cytokines were microinjected into the wound site at the time of injury. All cytokines tested (gamma-IFN, IL-1, IL-2, IL-6, TNF- alpha, and M-CSF) resulted in a significantly increased astrogliosis. The specificity of the cytokine response was demonstrated by the inability of human gamma-IFN, but not mouse gamma-IFN, in enhancing neonatal mouse astrogliosis, in accordance with reports that the interaction of gamma-IFN with its receptor occurs in a species-specific manner. We conclude that neonatal astrocytes can become reactive if an adequate injury stimulus is presented, and that the release of immunoregulatory cytokines by cells around lesion sites may be a mechanism that contributes to the production of gliosis.

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McKeon, R., Schreiber, R., Rudge, J., & Silver, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03398.1991 · Cited by 1,188
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847
Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes
Eng, L. F. (1985) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(85)80063-1 · Cited by 737
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
Giulian, D., Woodward, J., Young, D., Krebs, J., & Lachman, L. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02485.1988 · Cited by 583
Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production
Woodroofe, M. N., Sarna, G. S., Wadhwa, M., Hayes, G. M., Loughlin, J., Tinker, A., & Cuzner, M. L. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90110-s · Cited by 580
Quantitative aspects of reactive gliosis: A review
Norton, W. T., Aquino, D. A., Hozumi, I., Chiu, F., & Brosnan, C. F. (1992) · Neurochemical Research · doi:10.1007/bf00993263 · Cited by 549
Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.
Selmaj, K. W., Farooq, M., Norton, W. T., Raine, C. S., & Brosnan, C. F. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.129 · Cited by 544
Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion
Taupin, V., Toulmond, S., Serrano, A., Bénavidès, J., & Zavala, F. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90008-m · Cited by 512
The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain
Giulian, D., Chen, J., Ingeman, J., George, J., & Noponen, M. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-12-04416.1989 · Cited by 498
Astrocyte‐specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein
Bignami, A., & Dahl, D. R. (1974) · The Journal of Comparative Neurology · doi:10.1002/cne.901530104 · Cited by 491

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Authors: Balasingam, V, Tejada-Berges, T., Wright, E., Bouckova, R., & Yong, V.
Affiliations: McGill University (CA)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1994-02-01
Volume: 14
Issue: 2
Pages: 846-856
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.14-02-00846.1994
PMC: PMC6576825
OpenAlex: W2158406932
Cited by: 342
References: 63
Citations by year: 2026: 1 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 14 · 2012: 7
FWCI: 13.60
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Government of Canada
Medical Research Council Canada
Medical Research Council
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: reactive astrogliosis, neonatal brain, cytokines, astrocytes, stab wounds, glial fibrillary acidic protein, interferon-gamma, neuroinflammation, neonatal mice
MeSH terms: Animals, Animals, Newborn, Astrocytes, Brain, Brain Injuries, Cell Division, DNA, Female, Glial Fibrillary Acidic Protein, Humans, Inflammation, Interferon-gamma, Interleukin-1, Interleukin-2, Male, Mice, Inbred Strains, Microinjections, Recombinant Proteins, Thymidine, Time Factors, Tumor Necrosis Factor-alpha, Wounds, Stab, Biomarkers, Interleukin-6, Macrophage Colony-Stimulating Factor, Cytokines, Mice

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Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

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