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Cited by 421Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Serotonin and Prefrontal Cortex Function: Neurons, Networks, and Circuits

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Puig, M. Victoria, Gulledge, Allan T.·2011·Molecular Neurobiology
DOI 10.1007/s12035-011-8214-0PMC PMC3282112
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Abstract

Higher-order executive tasks such as learning, working memory, and behavioral flexibility depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The prominent innervation by serotonin neurons and the dense expression of serotonergic receptors in the PFC suggest that serotonin is a major modulator of its function. The most abundant serotonin receptors in the PFC, 5-HT1A, 5-HT2A and 5-HT3A receptors, are selectively expressed in distinct populations of pyramidal neurons and inhibitory interneurons, and play a critical role in modulating cortical activity and neural oscillations (brain waves). Serotonergic signaling is altered in many psychiatric disorders such as schizophrenia and depression, where parallel changes in receptor expression and brain waves have been observed. Furthermore, many psychiatric drug treatments target serotonergic receptors in the PFC. Thus, understanding the role of serotonergic neurotransmission in PFC function is of major clinical importance. Here, we review recent findings concerning the powerful influences of serotonin on single neurons, neural networks, and cortical circuits in the PFC of the rat, where the effects of serotonin have been most thoroughly studied.

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Cited by

Sorted by citations

Authors
Puig, M. V., & Gulledge, A. T.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Dartmouth College (US)
Corresponding author
Puig, M. Victoria
ORCID
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2011-11-11
Volume
44
Issue
3
Pages
449-464
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
DOI
10.1007/s12035-011-8214-0
PMC
PMC3282112
OpenAlex
W2014643576
Cited by
421
References
17
Citations by year
2026: 23 · 2025: 31 · 2024: 42 · 2023: 24 · 2022: 28 · 2021: 37 · 2020: 28 · 2019: 20 · 2018: 28 · 2017: 26 · 2016: 20 · 2015: 36 · 2014: 37 · 2013: 27 · 2012: 13
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01 MH-83806, R01MH083806)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
serotonin, prefrontal cortex, serotonergic neurotransmission, 5-HT1A receptor, 5-HT2A receptor, 5-HT3 receptor, pyramidal neurons, inhibitory interneurons, neural oscillations, cortical circuits, artificial neural networks, working memory, schizophrenia, depression, psychiatric medication, rats
MeSH terms
Animals, Interneurons, Nerve Net, Synaptic Transmission, Neurons, Receptors, Serotonin, Serotonin, Prefrontal Cortex, Protein Isoforms

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