Serotonergic regulation of neuronal excitability in the prefrontal cortex

Andrade, Rodrigo

doi:10.1016/j.neuropharm.2011.01.015

Cited by 167Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Serotonergic regulation of neuronal excitability in the prefrontal cortex

Open access

Andrade, Rodrigo·2011·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.01.015PMC PMC3110517

Open this paper in CoChat — free account

Abstract

The cerebral cortex receives a dense serotonergic innervation originating predominantly from the dorsal raphe nucleus. This innervation regulates cortical functioning by activating multiple serotonin receptors that are differentially expressed by pyramidal cells and interneurons. Electrophysiological studies in the prefrontal cortex indicate that receptors of the 5-HT(1A) and 5-HT(2A) subtypes are the main serotonin receptors regulating membrane excitability in pyramidal cells. Most pyramidal cells in layer V coexpress 5-HT(1A) and 5-HT(2A) receptors that together regulate how these neurons encode excitatory input into neuronal firing. In contrast, a subset of large pyramidal cells of deep layer V appears to express exclusively 5-HT(2A) receptors that depolarize and excite these cells. Serotonin also depolarizes and excites at least two classes of GABAergic interneurons by acting on 5-HT(3) and 5-HT(2A) receptors. The differential expression of serotonin receptors in different pyramidal cells and interneurons is consistent with a growing appreciation of the anatomical, molecular and functional heterogeneity of pyramidal cells and interneurons of the cerebral cortex. These findings begin to lay the ground for a cellular-level understanding of the serotonergic regulation of the prefrontal cortex.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2011.01.015

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Psychedelics primarily act on 5-HT2ARs expressed on glutamatergic pyramidal cells in cortical and deep cortical layers (V and VI).
“Psychedelics primarily act on 5-HT2ARs expressed on glutamatergic pyramidal cells in cortical and deep cortical layers (V and VI) (86, 87).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [87]
Section 4.1 reports 5-HT2A receptors on layer V pyramidal cells, and section 4.2 describes a 5-HT2A-expressing population in deep layer V associated with increased glutamate release. The paper discusses serotonin rather than establishing where psychedelics primarily act, and section 4.2 says little is known about serotonin’s effects in layer VI. No page numbers are available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works
Structure and function of the brain serotonin system
Jacobs, B. L., & Azmitia, E. C. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.1.165 · Cited by 2,574 · see citing works
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Klausberger, T., & Somogyi, P. (2008) · Science · doi:10.1126/science.1149381 · Cited by 2,050 · see citing works
Neuronal subtype specification in the cerebral cortex
Molyneaux, B. J., Arlotta, P., Menezes, J. R. L., & Macklis, J. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2151 · Cited by 1,632 · see citing works
Evidence for the existence of monoamine neurons in the central nervous system
Fuxé, K. (1965) · Cell and Tissue Research · doi:10.1007/bf00337069 · Cited by 1,567 · see citing works
EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.
Fuxé, K. (1965) · PubMed · Cited by 1,544 · see citing works
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,518 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works
A G Protein Couples Serotonin and GABA B Receptors to the Same Channels in Hippocampus
Andrade, R., Malenka, R. C., & Nicoll, R. A. (1986) · Science · doi:10.1126/science.2430334 · Cited by 869 · see citing works
Self-citation
Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding
Pompeiano, M., Palacios, J., & Mengod, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00440.1992 · Cited by 699 · see citing works
5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Self-citation
The temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.034 · Cited by 587 · see citing works
Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain
Wright, D. E., Seroogy, K. B., Lundgren, K. H., Davis, B. M., & Jennes, L. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903510304 · Cited by 548 · see citing works
Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells
Aghajanian, G. K., & Marek, G. J. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00051-8 · Cited by 516 · see citing works
The serotonin innervation of the cerebral cortex in the rat—an immunohistochemical analysis
Lidov, H. G. W., Grzanna, R., & Molliver, M. E. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90099-8 · Cited by 417 · see citing works
The determination of projection neuron identity in the developing cerebral cortex
Leone, D. P., Srinivasan, K., Chen, B., Alcamo, E., & McConnell, S. K. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.006 · Cited by 382 · see citing works
Co-expression and In Vivo Interaction of Serotonin1A and Serotonin2A Receptors in Pyramidal Neurons of Prefrontal Cortex
Amargos-Bosch, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg128 · Cited by 370 · see citing works
Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex
O’Leary, D. D. M., & Koester, S. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90049-w · Cited by 361 · see citing works
Localization of 5-HT1B, 5-HT1Dα, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain
Bruinvels, A. T., Landwehrmeyer, G. B., Gustafson, E. L., Durkin, M. M., Mengod, G., Branchek, T. A., Hoyer, D., & Palacios, J. M. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90067-1 · Cited by 350 · see citing works
Decision by division: making cortical maps
RAKIC, P. T., Ayoub, A. E., Breunig, J. J., & Dominguez, M. H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.007 · Cited by 272 · see citing works
Organization of raphe-cortical projections in rat: A quantitative retrograde study
O’Hearn, E., & Molliver, M. E. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90232-6 · Cited by 247 · see citing works
Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites
Mengod, G., Pompeiano, M., ́nez-Mir, M. I. M., & Palacios, J. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90502-3 · Cited by 240 · see citing works
Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex
Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.2989 · Cited by 238 · see citing works
GABAergic Interneuron Lineages Selectively Sort into Specific Cortical Layers during Early Postnatal Development
Miyoshi, G., & Fishell, G. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq155 · Cited by 230 · see citing works
Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex
Béïque, J.-C., Imad, M., Mladenovic, L., Gingrich, J. A., & Andrade, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700436104 · Cited by 229 · see citing works
Self-citation
Genetic regulation of arealization of the neocortex
O’Leary, D. D. M., & Sahara, S. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.011 · Cited by 219 · see citing works
5-HT<sub>3</sub>Receptors Mediate Serotonergic Fast Synaptic Excitation of Neocortical Vasoactive Intestinal Peptide/Cholecystokinin Interneurons
Férézou, I., Cauli, B., Hill, E. L., Rossier, J., Hamel, E., & Lambolez, B. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07389.2002 · Cited by 215 · see citing works
Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice
Weber (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00036 · Cited by 205 · see citing works
Serotonin Modulates Fast-Spiking Interneuron and Synchronous Activity in the Rat Prefrontal Cortex through 5-HT1Aand 5-HT2AReceptors
Puig, M. V., Watakabe, A., Ushimaru, M., Yamamori, T., & Kawaguchi, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3335-09.2010 · Cited by 200 · see citing works
Muscarinic Activation of a Voltage-Dependent Cation Nonselective Current in Rat Association Cortex
Haj‐Dahmane, S., & Andrade, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03848.1996 · Cited by 187 · see citing works
Self-citation
Serotonergic Regulation of Membrane Potential in Developing Rat Prefrontal Cortex: Coordinated Expression of 5-Hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7Receptors
Béïque, J.-C., Campbell, B., Perring, P., Hamblin, M. W., Walker, P. D., Mladenovic-Lucas, L., & Andrade, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5113-03.2004 · Cited by 184 · see citing works
Self-citation
The organization of serotonergic projections to cerebral cortex in primates: Regional distribution of axon terminals
Wilson, M. A., & Molliver, M. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90076-z · Cited by 152 · see citing works
A Century of Progress in Corticoneurogenesis: From Silver Impregnation to Genetic Engineering
RAKIC, P. T. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk036 · Cited by 142 · see citing works
The organization of serotonergic projections to cerebral cortex in primates: Retrograde transport studies
Wilson, M. A., & Molliver, M. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90077-2 · Cited by 133 · see citing works
Diversity of Gain Modulation by Noise in Neocortical Neurons: Regulation by the Slow Afterhyperpolarization Conductance
Higgs, M. H., Slee, S. J., & Spain, W. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1792-06.2006 · Cited by 124 · see citing works
The Role of Kv1.2-Containing Potassium Channels in Serotonin-Induced Glutamate Release from Thalamocortical Terminals in Rat Frontal Cortex
Lambe, E. K., & Aghajanian, G. K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09955.2001 · Cited by 112 · see citing works
Chapter 12 The age of plasticity: Developmental regulation of synaptic plasticity in neocortical microcircuits
Maffei, A., & Turrigiano, G. G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00012-x · Cited by 100 · see citing works
The Serotonin Receptors
Sanders‐Bush, E. (1989) · Cited by 100 · see citing works
Layer II/III of the Prefrontal Cortex: Inhibition by the Serotonin 5-HT 1A Receptor in Development and Stress
Goodfellow, N. M., Benekareddy, M., Vaidya, V. A., & Lambe, E. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1960-09.2009 · Cited by 90 · see citing works
5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by μ-opiate receptor activation
Marek, G. J., & Aghajanian, G. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00043-8 · Cited by 89 · see citing works
Serotonin Induces EPSCs Preferentially in Layer V Pyramidal Neurons of the Frontal Cortex in the Rat
Lambe, E. K. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.974 · Cited by 86 · see citing works
Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex
Zhang, Z., & Arsenault, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086066 · Cited by 82 · see citing works
Serotonin Induces Tonic Firing in Layer V Pyramidal Neurons of Rat Prefrontal Cortex during Postnatal Development
Zhang, Z. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03373.2003 · Cited by 81 · see citing works
Psychopharmacology: The Fourth Generation of Progress
Stein, D. J. (1998) · CNS Spectrums · doi:10.1017/s1092852900006702 · Cited by 70 · see citing works
Serotonergic regulation of calcium‐activated potassium currents in rodent prefrontal cortex
Villalobos, C. A., Béïque, J.-C., Gingrich, J. A., & Andrade, R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04307.x · Cited by 61 · see citing works
Self-citation
5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion
Bonaventure, P., Voorn, P., Luyten, W. H. M. L., & Leysen, J. E. (1998) · Neuroreport · doi:10.1097/00001756-199803090-00015 · Cited by 40 · see citing works
Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain
Mengod, G., Vilaró, M. T., Cortés, R., López-Giménez, J. F., Raurich, A., & Palacios, J. M. (2006) · The Receptors · doi:10.1007/978-1-59745-080-5_10 · Cited by 33 · see citing works

Flagged first, then by citations

Sorted by citations

The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs.
Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00020 · Cited by 1,252 · see citing works
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172 · see citing works
Serotonin and brain function: a tale of two receptors
Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739 · see citing works
Increased global functional connectivity correlates with LSD-induced ego dissolution
Tagliazucchi, E., Roseman, L., Kaelen, M., Orban, C., Muthukumaraswamy, S. D., Murphy, K., Laufs, H., Leech, R., McGonigle, J., Crossley, N., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.02.010 · Cited by 503 · see citing works
Broadband Cortical Desynchronization Underlies the Human Psychedelic State
Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R., Brookes, M. J., Williams, T. M., Errtizoe, D., Sessa, B., Papadopoulos, A., Bolstridge, M., Singh, K. D., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2063-13.2013 · Cited by 465 · see citing works
The role of serotonin receptors in the action of atypical antipsychotic drugs
Meltzer, H., & Massey, B. W. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.02.007 · Cited by 381 · see citing works
Effects of Schedule I drug laws on neuroscience research and treatment innovation
Nutt, D., King, L. A., & Nichols, D. E. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3530 · Cited by 338 · see citing works
Psychedelic Psychiatry’s Brave New World
Nutt, D., Erritzøe, D., & Carhart-Harris, R. L. (2020) · Cell · doi:10.1016/j.cell.2020.03.020 · Cited by 322 · see citing works
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.
de Vos, C. M. H., Mason, N. L., & Kuypers, K. P. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.724606 · Cited by 269 · see citing works
Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin
Mason, N. L., Kuypers, K. P. C., Müller, F., Reckweg, J., Tse, D. H. Y., Toennes, S. W., Hutten, N. R. P. W., Jansen, J. F. A., Stiers, P., Feilding, A., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0718-8 · Cited by 258 · see citing works
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression
Roseman, L., Demetriou, L., Wall, M. B., Nutt, D. J., & Carhart-Harris, R. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.041 · Cited by 230 · see citing works
Synaptic plasticity and mental health: methods, challenges and opportunities
Appelbaum, L. G., Shenasa, M. A., Stolz, L., & Daskalakis, Z. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01370-w · Cited by 240 · see citing works
Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin
Lord, L.-D., Expert, P., Atasoy, S., Roseman, L., Rapuano, K. M., Lambiotte, R., Nutt, D., Deco, G., Carhart-Harris, R. L., Kringelbach, M. L., et al. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.060 · Cited by 210 · see citing works
Unifying Theories of Psychedelic Drug Effects
Swanson, L. R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00172 · Cited by 181 · see citing works
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity
Carhart-Harris, R. L., Murphy, K., Leech, R., Erritzøe, D., Wall, M. B., Ferguson, B., Williams, L. T. J., Roseman, L., Brugger, S. P., Meer, I. D., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.015 · Cited by 178 · see citing works
Serotonin neurons modulate learning rate through uncertainty
Grossman, C. D., Bari, B. A., & Cohen, J. Y. (2022) · Current Biology · doi:10.1016/j.cub.2021.12.006 · Cited by 164 · see citing works
Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience
Fogaça, M. V., Reis, F. M. C. V., Campos, A. C., & Guimarães, F. S. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.012 · Cited by 153 · see citing works
Pivotal mental states
Brouwer, A., & Carhart-Harris, R. L. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959637 · Cited by 159 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety
Asan, E., Steinke, M. R., & Lesch, K. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1081-1 · Cited by 137 · see citing works
LSD modulates music-induced imagery via changes in parahippocampal connectivity
Kaelen, M., Roseman, L., Kahan, J., Santos-Ribeiro, A., Orbán, C., Lorenz, R., Barrett, F. S., Bolstridge, M., Williams, T., Williams, L., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.018 · Cited by 131 · see citing works
Control of Intermale Aggression by Medial Prefrontal Cortex Activation in the Mouse
Takahashi, A., Nagayasu, K., Nishitani, N., Kaneko, S., & Koide, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094657 · Cited by 123 · see citing works
Withdrawal symptoms and rebound syndromes associated with switching and discontinuing atypical antipsychotics: theoretical background and practical recommendations
Cerovecki, A., Musil, R., Klimke, A., Seemüller, F., Haen, E., Schennach, R., Kühn, K.-U., Volz, H.-P., & Riedel, M. (2013) · CNS Drugs · doi:10.1007/s40263-013-0079-5 · Cited by 112 · see citing works
Serotonergic Mechanisms as Targets for Existing and Novel Antipsychotics
Meltzer, H. Y. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25761-2_4 · Cited by 96 · see citing works
Serotonergic psychedelics LSD & psilocybin increase the fractal dimension of cortical brain activity in spatial and temporal domains
Varley, T. F., Carhart-Harris, R. L., Roseman, L., Menon, D. K., & Stamatakis, E. A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117049 · Cited by 88 · see citing works
Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine
Pehrson, A. L., Leiser, S. C., Gulinello, M. E., Dale, E., Li, Y., Waller, J. A., & Sánchez, C. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.044 · Cited by 94 · see citing works
Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids
Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522754113 · Cited by 90 · see citing works
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 89 · see citing works
Psychedelic perceptions: mental health service user attitudes to psilocybin therapy
Corrigan, K., Haran, M., McCandliss, C., McManus, R., Cleary, S., Trant, R., Kelly, Y., Ledden, K., Rush, G., O’Keane, V., et al. (2022) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-021-02668-2 · Cited by 84 · see citing works
Modulation of Synaptic Plasticity in the Cortex Needs to Understand All the Players
Meunier, C. N. J., Chameau, P. J. P., & Fossier, P. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00002 · Cited by 82 · see citing works
Role of medial prefrontal cortex serotonin 2A receptors in the control of retrieval of recognition memory in rats
Bekinschtein, P., Renner, M. C., Gonzalez, M. C., & Weisstaub, N. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2087-13.2013 · Cited by 69 · see citing works
Psychedelic therapy's transdiagnostic effects: A research domain criteria (RDoC) perspective
Kelly, J. R., Gillan, C. M., Prenderville, J., Kelly, C., Harkin, A., Clarke, G., & O'Keane, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.800072 · Cited by 69 · see citing works
Elucidating the Mechanism of Action of Pregabalin
Micó, J. A., & Prieto, R. (2012) · CNS Drugs · doi:10.2165/11634510-000000000-00000 · Cited by 66 · see citing works
Fluoxetine (Prozac) and Serotonin Act on Excitatory Synaptic Transmission to Suppress Single Layer 2/3 Pyramidal Neuron-Triggered Cell Assemblies in the Human Prefrontal Cortex
Komlósi, G., Molnár, G., Rózsa, M., Oláh, S., Barzó, P., & Tamás, G. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2618-12.2012 · Cited by 57 · see citing works
Psychological mechanisms and functions of 5-HT and SSRIs in potential therapeutic change: Lessons from the serotonergic modulation of action selection, learning, affect, and social cognition
Roberts, C., Sahakian, B. J., & Robbins, T. W. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.001 · Cited by 61 · see citing works
Neural mechanisms underlying psilocybin’s therapeutic potential – the need for preclinical in vivo electrophysiology
Smausz, R., Neill, J. C., & Gigg, J. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221092508 · Cited by 60 · see citing works
Common neural signatures of psychedelics: Frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition
Atasoy, S., Vohryzek, J., Deco, G., Carhart-Harris, R. L., & Kringelbach, M. L. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.08.009 · Cited by 57 · see citing works
Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats
Li, Y., Raaby, K. F., Sánchez, C., & Gulinello, M. E. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.002 · Cited by 60 · see citing works
Serotonin Differentially Regulates L5 Pyramidal Cell Classes of the Medial Prefrontal Cortex in Rats and Mice
Elliott, M. C., Tanaka, P. M., Schwark, R., & Andrade, R. (2018) · eNeuro · doi:10.1523/eneuro.0305-17.2018 · Cited by 57 · see citing works
Self-citation
More than meets the eye: The role of sensory dimensions in psychedelic brain dynamics, experience, and therapeutics
Aqil, M., & Roseman, L. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109300 · Cited by 58 · see citing works
Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD
Burt, J. B., Preller, K. H., Demirtaş, M., Ji, J. L., Krystal, J. H., Vollenweider, F. X., Anticevic, A., & Murray, J. D. (2021) · eLife · doi:10.7554/elife.69320 · Cited by 48 · see citing works
Effects of pregabalin on sleep in generalized anxiety disorder
Holsboer‐Trachsler, E., & Prieto, R. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000922 · Cited by 53 · see citing works
Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions
Perrenoud, Q., Rossier, J., Férézou, I., Geoffroy, H., Gallopin, T., Vitalis, T., & Rancillac, A. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00050 · Cited by 51 · see citing works
Could psychedelic drugs have a role in the treatment of schizophrenia? Rationale and strategy for safe implementation
Wolf, G., Singh, S., Blakolmer, K., Lerer, L. A., Lifschytz, T., Heresco-Levy, U., Lotan, A., & Lerer, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01832-z · Cited by 33 · see citing works
Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster
Sizemore, T. R., & Dacks, A. M. (2016) · Scientific Reports · doi:10.1038/srep37119 · Cited by 48 · see citing works
5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux
Huang, M., Horiguchi, M., Felix, A. R., & Meltzer, H. Y. (2012) · Neuroreport · doi:10.1097/wnr.0b013e328352de40 · Cited by 45 · see citing works
Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release – Species differences
Ferreira, S. G., Teixeira, F. M., Garção, P., Agostinho, P. M., Ledent, C. A., Cortes, L., Mackie, K., & Köfalvi, A. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.05.009 · Cited by 43 · see citing works
An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7and 5-HT1AReceptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models
Canal, C. E., Felsing, D. E., Liu, Y., Zhu, W., Wood, J. T., Perry, C. K., Vemula, R., & Booth, R. G. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00099 · Cited by 43 · see citing works
Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress
Mikail, H. G., Dalla, C., Kokras, N., Kafetzopoulos, V., & Papadopoulou‐Daifoti, Z. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.06.016 · Cited by 42 · see citing works
Are psychedelics the answer to chronic pain: A review of current literature
Kooijman, N. I., Willegers, T., Reuser, A. M., Mulleners, W. M., Kramers, C., Vissers, K. C. P., & van der Wal, S. E. I. (2023) · Pain Practice · doi:10.1111/papr.13203 · Cited by 43 · see citing works
Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats
Rask‐Andersen, M., Jacobsson, J. A., Moschonis, G., Chavan, R. A., Sikder, M. A. N., Allzén, E., Alsiö, J., Chrousos, G. P., Μanios, Y., Fredriksson, R., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.176 · Cited by 37 · see citing works
Neurovascular and neuroimaging effects of the hallucinogenic serotonin receptor agonist psilocin in the rat brain
Spain, A., Howarth, C., Khrapitchev, A. A., Sharp, T., Sibson, N. R., & Martin, C. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.018 · Cited by 37 · see citing works
5-HT1A receptors direct the orientation of plasticity in layer 5 pyramidal neurons of the mouse prefrontal cortex
Meunier, C. N. J., Amar, M., Lanfumey, L., Hamon, M., & Fossier, P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.003 · Cited by 34 · see citing works
How do serotonergic psychedelics treat depression: The potential role of neuroplasticity
Artin, H., Zisook, S., & Ramanathan, D. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i6.201 · Cited by 33 · see citing works
Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex
West, A. M., Best, J. A., Abdalla, A., Nijhout, H. F., Reed, M. C., & Hashemi, P. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.004 · Cited by 33 · see citing works
Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction
Isbell, E., Stevens, C., Pakulak, E., Wray, A. H., Bell, T. A., & Neville, H. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707241114 · Cited by 33 · see citing works
Serotonergic neuromodulation of synaptic plasticity
Higa, G. S. V., Viana, F. J. C., Francis-Oliveira, J., Cruvinel, E., Franchin, T. S., Marcourakis, T., Ulrich, H., & De Pasquale, R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110036 · Cited by 29 · see citing works
Acute restraint differently alters defensive responses and fos immunoreactivity in the rat brain
de Andrade, J. S., Abrão, R. O., Céspedes, I. C., Garcia, M. C., Nascimento, J. O. G., Spadari-Bratfisch, R. C., Melo, L. L., da Silva, R. C. B., & Viana, M. D. B. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.034 · Cited by 29 · see citing works
The Sigma-1 Receptor: When Adaptive Regulation of Cell Electrical Activity Contributes to Stimulant Addiction and Cancer
Soriani, O., & Kourrich, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01186 · Cited by 29 · see citing works
Combined serotonin (5-HT)1A agonism, 5-HT2A and dopamine D2 receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats
Oyamada, Y., Horiguchi, M., Rajagopal, L., Miyauchi, M., & Meltzer, H. Y. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.040 · Cited by 29 · see citing works
A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex
Luppi, A. I., Girn, M., Rosas, F. E., Timmermann, C., Roseman, L., Erritzøe, D., Nutt, D., Stamatakis, E. A., Spreng, R. N., Xing, L., et al. (2023) · Brain · doi:10.1093/brain/awad311 · Cited by 30 · see citing works
Neonatal fluoxetine exposure affects the action potential properties and dendritic development in cortical subplate neurons of rats
Liao, C., & Lee, L. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.09.028 · Cited by 28 · see citing works
(S)-5-(2′-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder
Armstrong, J. L., Casey, A. B., Saraf, T. S., Mukherjee, M., Booth, R. G., & Canal, C. E. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00101 · Cited by 26 · see citing works
Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT2A and 5‐HT1A receptors
Werle, I., Nascimento, L. M. M., dos Santos, A. L. A., Soares, L. A., SANTOS, R. G. D., Hallak, J. E. C., & Bertoglio, L. J. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16315 · Cited by 28 · see citing works
ΔFosB Decreases Excitability of Dorsal Hippocampal CA1 Neurons
Eagle, A. L., WILLIAMS, E. S., Beatty, J. A., Cox, C. L., & Robison, A. J. (2018) · eNeuro · doi:10.1523/eneuro.0104-18.2018 · Cited by 26 · see citing works
CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains
Eickelbeck, D., Karapinar, R., Jäck, A., Süß, S. T., Barzan, R., Azimi, Z., Surdin, T., Grömmke, M., Mark, M. D., Gerwert, K. B., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0292-y · Cited by 26 · see citing works
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
Hammo, A., Wisser, S., & Cichon, J. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02068-0 · Cited by 25 · see citing works
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Padawer-Curry, J. A., Krentzman, O. J., Kuo, C., Wang, X., Bice, A. R., Nicol, G. E., Snyder, A. Z., Siegel, J. S., McCall, J. G., & Bauer, A. Q. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02069-z · Cited by 28 · see citing works
Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens
Delint‐Ramírez, I., García‐Oscos, F., Segev, A., & Kourrich, S. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0092-7 · Cited by 23 · see citing works
Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development
Olusakin, J., Moutkine, I., Dumas, S., Ponimaskin, E. G., Païzanis, E., Soiza‐Reilly, M., & Gaspar, P. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0775-z · Cited by 24 · see citing works
Comodulation of dopamine and serotonin on prefrontal cortical rhythms: a theoretical study
Wang, D., & Wong‐Lin, K. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00054 · Cited by 24 · see citing works
5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction
Nakao, K., Singh, M., Sapkota, K., Fitzgerald, A., Hablitz, J. J., & Nakazawa, K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01930-0 · Cited by 23 · see citing works
A Characterization of the Manduca sexta Serotonin Receptors in the Context of Olfactory Neuromodulation
Dacks, A. M., Reale, V., Pi, Y.-L., Zhang, W., Dacks, J., Nighorn, A., & Evans, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069422 · Cited by 20 · see citing works
Temporal derivative computation in the dorsal raphe network revealed by an experimentally driven augmented integrate-and-fire modeling framework
Harkin, E. F., Lynn, M. B., Payeur, A., Boucher, J.-F., Caya-Bissonnette, L., Cyr, D., Stewart, C. A., Longtin, A., Naud, R., & Béïque, J.-C. (2023) · eLife · doi:10.7554/elife.72951 · Cited by 21 · see citing works
Dual role of serotonin in the acquisition and extinction of reward-driven learning: Involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors
Frick, L. R., Bernardez-Vidal, M., Höcht, C., Zanutto, B. S., & Rapanelli, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.025 · Cited by 21 · see citing works
Role of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and psychedelics in the treatment of major depressive disorder: A perspective on mechanistic insight and current status
Singh, N., Hazari, P. P., Mittal, P., Yadav, S. K., Kumar, N., Mishra, G., Dahiya, S., & Mishra, A. K. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177737 · Cited by 19 · see citing works
Serotonergic Regulation in Alzheimer’s Disease
Долгачева, Л. П., Зинченко, В. П., Nadeev, A. D., & Goncharov, N. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115218 · Cited by 21 · see citing works
Neural Plasticity Is Involved in Physiological Sleep, Depressive Sleep Disturbances, and Antidepressant Treatments
Zhang, M., Li, R., Wang, Y., & Huang, Z. (2017) · Neural Plasticity · doi:10.1155/2017/5870735 · Cited by 19 · see citing works
Spatial Correspondence of LSD-Induced Variations on Brain Functioning at Rest With Serotonin Receptor Expression
Pizzi, S. D., Chiacchiaretta, P., Sestieri, C., Ferretti, A., ONOFRJ, M. C., Penna, S. D., Roseman, L., Timmermann, C., Nutt, D. J., Carhart-Harris, R. L., et al. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.03.009 · Cited by 19 · see citing works
Neural Geometrodynamics, Complexity, and Plasticity: A Psychedelics Perspective
Ruffini, G., Lopez-Sola, E., Vohryzek, J., & Sanchez-Todo, R. (2024) · Entropy · doi:10.3390/e26010090 · Cited by 17 · see citing works
Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing
Alexander, G. M., Graef, J. D., Hammarback, J. A., Nordskog, B. K., Burnett, E. J., Daunais, J. B., Bennett, A. J., Friedman, D. P., Suomi, S. J., & Godwin, D. W. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.027 · Cited by 18 · see citing works
Comparison of noradrenaline, dopamine and serotonin in mediating the tachycardic and thermogenic effects of methamphetamine in the ventral medial prefrontal cortex
Hassan, S. F., Zumut, S., Burke, P. G. R., McMullan, S., Cornish, J. L., & Goodchild, A. K. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.028 · Cited by 17 · see citing works
Elevated serotonergic signaling amplifies synaptic noise and facilitates the emergence of epileptiform network oscillations
Puzerey, P. A., Decker, M. J., & Galán, R. F. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00031.2014 · Cited by 16 · see citing works
Effects of LSD on music-evoked brain activityPreprint
Kaelen, M., Lorenz, R., Barrett, F. S., Roseman, L., Orbán, C., Santos-Ribeiro, A., Wall, M. B., Feilding, A., Nutt, D. J., Muthukumaraswamy, S. D., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/153031 · Cited by 18 · see citing works
Psilocybin as a novel treatment for chronic pain
Askey, T., Lasrado, R., Maiarù, M., & Stephens, G. J. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17420 · Cited by 17 · see citing works
Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine
Ionescu, T. M., Amend, M., Watabe, T., Hatazawa, J., Maurer, A., Reischl, G., Pichler, B. J., Wehrl, H. F., & Herfert, K. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264391 · Cited by 16 · see citing works
Bridging the gap between single receptor type activity and whole‐brain dynamics
Jancke, D., Herlitze, S., Kringelbach, M. L., & Deco, G. (2021) · FEBS Journal · doi:10.1111/febs.15855 · Cited by 15 · see citing works
Antidepressants share the ability to increase catecholamine output in the bed nucleus of stria terminalis: a possible role in antidepressant therapy?
Cadeddu, R., Ibba, M., Sadile, A. G., & Carboni, E. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3335-y · Cited by 16 · see citing works
Unveiling serotonergic dysfunction of obsessive-compulsive disorder on prefrontal network dynamics: a computational perspective
Yin, L., Yu, Y., Han, F., & Wang, Q. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae258 · Cited by 16 · see citing works
The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder
Ruffini, G., Castaldo, F., Lopez-Sola, E., Sanchez-Todo, R., & Vohryzek, J. (2024) · Entropy · doi:10.3390/e26110953 · Cited by 18 · see citing works
5-HT2A Receptors and BDNF Regulation: Implications for Psychopathology
Jaggar, M., & Vaidya, V. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-70474-6_17 · Cited by 15 · see citing works
Psilocybin for Depression: From Credibility to Feasibility, What’s Missing?
Munafò, A., Arillotta, D., Mannaioni, G., Schifano, F., Bernardini, R., & Cantarella, G. (2022) · Pharmaceuticals · doi:10.3390/ph16010068 · Cited by 15 · see citing works
Repeated toluene exposure increases the excitability of layer 5 pyramidal neurons in the prefrontal cortex of adolescent rats
Armenta-Reséndiz, M., Cruz, S. L., & Galván, E. J. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.04.006 · Cited by 15 · see citing works
Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex
Carlos-Lima, E., Higa, G. S. V., Viana, F. J. C., Tamais, A. M., Cruvinel, E., Borges, F. S., de Oliveira, J. F., Ulrich, H., & Pasquale, R. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010519 · Cited by 12 · see citing works
Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms
Eriksson, O., Wall, A. E., Olsson, U., Marteinsdóttir, Í., Holstad, M., Ågren, H., Hartvig, P., Långström, B., & Naessén, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159538 · Cited by 13 · see citing works
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives
Czopek, A., Jończyk, J., Fryc, M., Kluzik, D., & Zagórska, A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00152 · Cited by 12 · see citing works
Involvement of serotonergic receptors in depressive processes and their modulation by β-arrestins: A review
Tejeda-Martínez, A. R., Ramos-Molina, A. R., Rubalcava, P. A. B., & Flores-Soto, M. E. (2024) · Medicine · doi:10.1097/md.0000000000038943 · Cited by 12 · see citing works
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders
Antonijevic, M., Dallemagne, P., & Rochais, C. (2024) · Medicinal Research Reviews · doi:10.1002/med.22075 · Cited by 12 · see citing works
Dorsal prefrontal cortical serotonin 2A receptor binding indices are differentially related to individual scores on harm avoidance
Baeken, C., Bossuyt, A. M., & Raedt, R. D. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.12.005 · Cited by 11 · see citing works
Upregulated 5-HT1A receptor-mediated currents in the prefrontal cortex layer 5 neurons in the 15q11–13 duplication mouse model of autism
Saitow, F., Takumi, T., & Suzuki, H. (2020) · Molecular Brain · doi:10.1186/s13041-020-00655-9 · Cited by 11 · see citing works

Serotonergic Regulation of Membrane Potential in Developing Rat Prefrontal Cortex: Coordinated Expression of 5-Hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7Receptors
Béïque, J.-C., Campbell, B., Perring, P., Hamblin, M. W., Walker, P. D., Mladenovic-Lucas, L., & Andrade, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5113-03.2004 · Cited by 184 · see citing works
Self-citation
Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits
Rama, R., Qi, G., Radnikow, G., Yang, D., & Feldmeyer, D. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70573 · Cited by 1 · see citing works
Reviewed by:
Celada, P., Puig, M. V., Artigas, F., Romcy-Pereira, R. N., Gruber, A., Neurochemistry, & De, I. B. (2013)
Serotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462 · see citing works
Serotonin Differentially Regulates L5 Pyramidal Cell Classes of the Medial Prefrontal Cortex in Rats and Mice
Elliott, M. C., Tanaka, P. M., Schwark, R., & Andrade, R. (2018) · eNeuro · doi:10.1523/eneuro.0305-17.2018 · Cited by 57 · see citing works
Self-citation

Authors: Andrade, R.
Affiliations: Wayne State University (US)
Corresponding author: Andrade, Rodrigo
ORCID: Andrade, Rodrigo
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2011-09
Volume: 61
Issue: 3
Pages: 382-386
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.01.015
PMC: PMC3110517
OpenAlex: W1990926259
Cited by: 167
References: 48
Citations by year: 2026: 9 · 2025: 18 · 2024: 17 · 2023: 9 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 12
FWCI: 1.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Intellectum (Universidad de La Sabana) (submittedVersion, other-oa)
Funders: NIH grant (MH43987)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: serotonin, prefrontal cortex, neuronal excitability, dorsal raphe nucleus, 5-HT1A receptor, 5-HT2A receptor, 5-HT3 receptor, pyramidal neurons, GABAergic interneurons, cortical layer V, receptor heterogeneity, cortical excitability
MeSH terms: Animals, gamma-Aminobutyric Acid, Humans, Interneurons, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Receptors, Serotonin, Serotonin, Prefrontal Cortex, Pyramidal Cells, Glutamic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Serotonergic regulation of neuronal excitability in the prefrontal cortex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks