Cited by 509Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

Open access

Pliakas, Andrea M., Carlson, Richard R., Neve, Rachael L., Konradi, Christine, Nestler, Eric J., Carlezon, William A.·2001·The Journal of Neuroscience

DOI 10.1523/jneurosci.21-18-07397.2001PMC PMC4205577

Open this paper in CoChat — free account Open PDF

Abstract

Drugs of abuse regulate the transcription factor cAMP response element-binding protein (CREB) in striatal regions, including the nucleus accumbens (NAc). To explore how regulation of CREB in the NAc affects behavior, we used herpes simplex virus (HSV) vectors to elevate CREB expression in this region or to overexpress a dominant-negative mutant CREB (mCREB) that blocks CREB function. Rats treated with HSV-mCREB in place conditioning studies spent more time in environments associated with cocaine, indicating increased cocaine reward. Conversely, rats treated with HSV-CREB spent less time in cocaine-associated environments, indicating increased cocaine aversion. Studies in which drug-environment pairings were varied to coincide with either the early or late effects of cocaine suggest that CREB-associated place aversions reflect increased cocaine withdrawal. Because cocaine withdrawal can be accompanied by symptoms of depression, we examined how altered CREB function in the NAc affects behavior in the forced swim test (FST). Elevated CREB expression increased immobility in the FST, an effect that is opposite to that caused by standard antidepressants and is consistent with a link between CREB and dysphoria. Conversely, overexpression of mCREB decreased immobility, an effect similar to that caused by antidepressants. Moreover, the kappa opioid receptor antagonist nor-Binaltorphimine decreased immobility in HSV-CREB- and HSV-mCREB-treated rats, suggesting that CREB-mediated induction of dynorphin (an endogenous kappa receptor ligand) contributes to immobility behavior in the FST. Exposure to the FST itself dramatically increased CREB function in the NAc. These findings raise the possibility that CREB-mediated transcription within the NAc regulates dysphoric states.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.21-18-07397.2001

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,133
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
Self-citation
An opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704
Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,466

Show all 42 references

Research works printed but not linked: 1

Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: The neuropharmacological basis of reward (Liebman JM, Cooper SJ, eds), pp 264 -319. Oxford: Clarendon.

Sorted by citations

Items 101–200 of 509

Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety
Wallace, T. L., Stellitano, K. E., Neve, R. L., & Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.010 · Cited by 133
Self-citation
Overexpression of CREB in the Nucleus Accumbens Shell Increases Cocaine Reinforcement in Self-Administering Rats
Larson, E. B., Graham, D. L., Arzaga, R. R., Buzin, N., Webb, J., Green, T. A., Bass, C. E., Neve, R. L., Terwilliger, E. F., Nestler, E. J., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3070-11.2011 · Cited by 127
Self-citation
Opiates as Antidepressants
Berrocoso, E., Sánchez‐Blázquez, P., Garzón, J., & Micó, J. A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168100 · Cited by 131
Molecular and genetic substrates linking stress and addiction
Briand, L. A., & Blendy, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.002 · Cited by 125
Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory
Barco, Á., & Marie, H. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8209-x · Cited by 131
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats
Carr, G. V., Bangasser, D. A., Bethea, T. T., Young, M., Valentino, R. J., & Lucki, I. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.183 · Cited by 124
Peptide Kappa Opioid Receptor Ligands: Potential for Drug Development
Aldrich, J. V., & McLaughlin, J. P. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9105-4 · Cited by 124
Mutant mouse models of depression: Candidate genes and current mouse lines
Urani, A., Chourbaji, S., & Gass, P. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.020 · Cited by 128
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine
Wee, S., Orío, L., Ghirmai, S., Cashman, J. R., & Koob, G. F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1563-y · Cited by 119
Overexpression of 5-HT1B Receptor in Dorsal Raphe Nucleus Using Herpes Simplex Virus Gene Transfer Increases Anxiety Behavior after Inescapable Stress
Clark, M. S., Sexton, T. J., McClain, M. E., Root, D., Kohen, R., & Neumaier, J. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04550.2002 · Cited by 119
Gene Expression Profiling in Postmortem Prefrontal Cortex of Major Depressive Disorder
Kang, H. J., Adams, D. H., Simen, A. A., Simen, B. B., Rajkowska, G., Stockmeier, C. A., Overholser, J. C., Meltzer, H. Y., Jurjus, G., Konick, L. C., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4083-07.2007 · Cited by 119
Vocalizations during withdrawal from opiates and cocaine: possible expressions of affective distress
Covington, H. E., & Miczek, K. A. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01558-9 · Cited by 121
Stress Produces Aversion and Potentiates Cocaine Reward by Releasing Endogenous Dynorphins in the Ventral Striatum to Locally Stimulate Serotonin Reuptake
Schindler, A. G., Messinger, D. I., Smith, J. S., Shankar, H., Gustin, R. M., Schattauer, S. S., Lemos, J. C., Chavkin, N. W., Hagan, C. E., Neumaier, J. F., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3220-12.2012 · Cited by 122
Wnt2 Expression and Signaling Is Increased by Different Classes of Antidepressant Treatments
Okamoto, H., Voleti, B., Banasr, M., Sarhan, M., Đurić, V., Girgenti, M. J., Dileone, R., Newton, S. S., & Duman, R. S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.023 · Cited by 116
The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction
Xu, L., Nan, J., & Lan, Y. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00037 · Cited by 123
The locus coeruleus: A key nucleus where stress and opioids intersect to mediate vulnerability to opiate abuse
Bockstaele, E. J. V., Reyes, B. A. S., & Valentino, R. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.036 · Cited by 115
Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD‐1 mice
Hebb, A. L. O., Zacharko, R. M., Gauthier, M. S., Trudel, F., Laforest, S., & Drolet, G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03704.x · Cited by 113
Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders
Tejeda, H. A., & Bonci, A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.023 · Cited by 117
Elevated Expression of 5-HT1BReceptors in Nucleus Accumbens Efferents Sensitizes Animals to Cocaine
Neumaier, J. F., Vincow, E. S., Arvanitogiannis, A., Wise, R. A., & Carlezon, W. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10856.2002 · Cited by 114
Self-citation
Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules
Carlezon, W. A., & Konradi, C. L. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.021 · Cited by 108
Self-citation
The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction
Pandey, S. C. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.002 · Cited by 109
Role of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108
Self-citation
Psychobiological Mechanisms of Resilience and Vulnerability
Charney, D. S. (2004) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.2.3.368 · Cited by 127
Neuropharmacology of the Naturally Occurring κ-Opioid Hallucinogen Salvinorin A
Cunningham, C. W., Rothman, R. B., & Prisinzano, T. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003244 · Cited by 112
Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism
Wells, A. M., Ridener, E., Bourbonais, C. A., Kim, W., Pantazopoulos, H., Carroll, F. I., Kim, K., Cohen, B. M., & Carlezon, W. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0885-17.2017 · Cited by 110
Self-citation
Does the kappa opioid receptor system contribute to pain aversion?
Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., MorÃ³n, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105
Psychostimulant withdrawal as an inducing condition in animal models of depression
Barr, A. M., & Markou, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.012 · Cited by 112
Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence
Walker, B. M., Valdez, G. R., McLaughlin, J. P., & Bakalkin, G. Y. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.10.006 · Cited by 107
Molecular profiling of midbrain dopamine regions in cocaine overdose victims
Tang, W., Fasulo, W. H., Mash, D. C., & Hemby, S. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01740.x · Cited by 106
Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression
Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., & Ohmori, T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.014 · Cited by 105
Activation of CREB in the Nucleus Accumbens Shell Produces Anhedonia and Resistance to Extinction of Fear in Rats
Muschamp, J. W., Veer, A. V., Parsegian, A., Gallo, M. S., Chen, M., Neve, R. L., Meloni, E. G., & Carlezon, W. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5973-10.2011 · Cited by 106
Self-citation
Presynaptic Inhibition of Diverse Afferents to the Locus Ceruleus by -Opiate Receptors: A Novel Mechanism for Regulating the Central Norepinephrine System
Kreibich, A., Reyes, B. A. S., Curtis, A. L., Ecke, L. E., Chavkin, C., Bockstaele, E. J. V., & Valentino, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0390-08.2008 · Cited by 104
Extracellular Signal-Regulated Kinase-2 within the Ventral Tegmental Area Regulates Responses to Stress
Iñiguez, S. D., Vialou, V., Warren, B. L., Cao, J.-L., Alcantara, L. F., Davis, L. C., Manojlovic, Z., Neve, R. L., Russo, S. J., Han, M.-H., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0951-10.2010 · Cited by 103
Self-citation
Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats
Russell, S. E., Rachlin, A. B., Smith, K. L., Muschamp, J. W., Berry, L., Zhao, Z., & Chartoff, E. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.042 · Cited by 103
Kappa opioid antagonists: Past successes and future prospects
Metcalf, M. D., & Coop, A. (2005) · The AAPS Journal · doi:10.1208/aapsj070371 · Cited by 103
A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
Abildgaard, A. M., Solskov, L., Volke, V., Harvey, B. H., Lund, S. A., & Wegener, G. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.004 · Cited by 104
Faster, better, stronger: Towards new antidepressant therapeutic strategies
O’Leary, O. F., Dinan, T. G., & Cryan, J. F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.046 · Cited by 104
The opioid system in depression
Jelen, L. A., Stone, J. M., Young, A. H., & Mehta, M. A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104800 · Cited by 108
cAMP Response Element-Binding Protein Deficiency Allows for Increased Neurogenesis and a Rapid Onset of Antidepressant Response
Gur, T., Conti, A. C., Holden, J., Bechtholt, A. J., Hill, T. E., Lucki, I., Malberg, J. E., & Blendy, J. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2051-07.2007 · Cited by 101
Altered Sensitivity to Rewarding and Aversive Drugs in Mice with Inducible Disruption of cAMP Response Element-Binding Protein Function within the Nucleus Accumbens
DiNieri, J. A., Nemeth, C. L., Parsegian, A., Carle, T. L., Gurevich, V. V., Gurevich, E. V., Neve, R. L., Nestler, E. J., & Carlezon, W. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5104-08.2009 · Cited by 98
Self-citation
Targeting opioid dysregulation in depression for the development of novel therapeutics
Browne, C. A., & Lucki, I. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.009 · Cited by 100
Active behaviours produced by antidepressants and opioids in the mouse tail suspension test
Berrocoso, E., Ikeda, K., Sora, I., Uhl, G. R., Sánchez‐Blázquez, P., & Micó, J. A. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001842 · Cited by 95
Epigenetic Regulation in Substance Use Disorders
McQuown, S. C., & Wood, M. A. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0099-5 · Cited by 95
The roles of calcium/calmodulin‐dependent and Ras/mitogen‐activated protein kinases in the development of psychostimulant‐induced behavioral sensitization
Licata, S. C., & Pierce, R. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01662.x · Cited by 93
Regulation of CRE‐mediated transcription in mouse brain by amphetamine
Shaw‐Lutchman, T. Z., Impey, S., Storm, D. R., & Nestler, E. J. (2003) · Synapse · doi:10.1002/syn.10172 · Cited by 92
Self-citation
Endogenous κ Opioid Activation Mediates Stress-Induced Deficits in Learning and Memory
Carey, A. N., Lyons, A. M., Shay, C. F., Dunton, O., & McLaughlin, J. P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6146-08.2009 · Cited by 91
Neural plasticity: consequences of stress and actions of antidepressant treatment
Duman, R. S. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/rduman · Cited by 95
Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication
Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Castro, E., Dos-Anjos, S., Pascual-Brazo, J., Linge, R., Vargas, V. I., Blanco, H., Martínez‐Villayandre, B., et al. (2013) · Neural Plasticity · doi:10.1155/2013/537265 · Cited by 90
Repeated Exposure to the κ-Opioid Receptor Agonist Salvinorin A Modulates Extracellular Signal-Regulated Kinase and Reward Sensitivity
Potter, D. N., Damez-Werno, D. M., Carlezon, W. A., Cohen, B. M., & Chartoff, E. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.021 · Cited by 88
Self-citation
The Kappa-Opioid Agonist U69,593 Blocks Cocaine-Induced Enhancement of Brain Stimulation Reward
Tomasiewicz, H. C., Todtenkopf, M. S., Chartoff, E. H., Cohen, B. M., & Carlezon, W. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.029 · Cited by 90
Self-citation
Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB
Kreibich, A. S., Briand, L., Cleck, J. N., Ecke, L., Rice, K. C., & Blendy, J. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.91 · Cited by 89
Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior
Green, T. A., Alibhai, I. N., Unterberg, S., Neve, R. L., Ghose, S., Tamminga, C. A., & Nestler, E. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5273-07.2008 · Cited by 89
Self-citation
Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds
Resendez, S. L., Keyes, P. C., Day, J. J., Hambro, C., Austin, C. J., Maina, F. K., Eidson, L. N., Porter-Stransky, K. A., Nevárez, N., McLean, J. W., et al. (2016) · eLife · doi:10.7554/elife.15325 · Cited by 88
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids
Leitl, M. D., Onvani, S., Bowers, M. S., Cheng, K., Rice, K. C., Carlezon, W. A., Banks, M. L., & Negus, S. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.236 · Cited by 87
Self-citation
Yohimbine Increases Impulsivity Through Activation of cAMP Response Element Binding in the Orbitofrontal Cortex
Sun, H., Green, T. A., Theobald, D. E. H., Birnbaum, S. G., Graham, D. L., Zeeb, F. D., Nestler, E. J., & Winstanley, C. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.030 · Cited by 87
Self-citation
Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/κ-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms
Schindler, A. G., Li, S., & Chavkin, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.67 · Cited by 85
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys
Negus, S. S. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1878-7 · Cited by 83
Central κ-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies
Zhang, H., Shi, Y., Woods, J. H., Watson, S. J., & Ko, M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.045 · Cited by 85
Behavioral and Molecular Effects of Dopamine D1 Receptor Stimulation during Naloxone-Precipitated Morphine Withdrawal
Chartoff, E. H., Mague, S. D., Barhight, M. F., Smith, A. M., & Carlezon, W. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0491-06.2006 · Cited by 85
Self-citation
Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats
Mague, S. D., Andersen, S. L., & Carlezon, W. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.037 · Cited by 84
Self-citation
Animal models and treatments for addiction and depression co-morbidity
Paterson, N. E., & Markou, A. (2007) · Neurotoxicity Research · doi:10.1007/bf03033479 · Cited by 85
Alterations in ionotropic glutamate receptor subunits during binge cocaine self‐administration and withdrawal in rats
Tang, W., Wesley, M. J., Freeman, W. M., Liang, B., & Hemby, S. E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02392.x · Cited by 84
Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine‐induced locomotor activity, reward and CREB phosphorylation
Karasinska, J. M., George, S. R., Cheng, R., & O’Dowd, B. F. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04353.x · Cited by 83
Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex
Levine, J. B., Youngs, R. M., MacDonald, M. L., Chu, M. S., Leeder, A., Francois Berthiaume, B., & Konradi, C. L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.063 · Cited by 81
Self-citation
Sex-related differential response to clomipramine treatment in a rat model of depression
Kokras, N., Antoniou, K., Dalla, C., Bekris, S., Xagoraris, M., Ovestreet, D., & Papadopoulou‐Daifoti, Z. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108095914 · Cited by 80
The role of signaling molecules in reward-related incentive learning
Beninger, R. J., & Gerdjikov, T. V. (2004) · Neurotoxicity Research · doi:10.1007/bf03033301 · Cited by 79
Desipramine Reduces Stress-Activated Dynorphin Expression and CREB Phosphorylation in NAc Tissue
Chartoff, E. H., Papadopoulou, M., MacDonald, M. L., Parsegian, A., Potter, D. N., Konradi, C. L., & Carlezon, W. A. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051417 · Cited by 80
Self-citation
A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress
Razzoli, M., Domenici, E., Carboni, L., Rantamäki, T., Lindholm, J., Ċastrén, E., & Arban, R. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00681.x · Cited by 80
Use patterns and self-reported effects of Salvia divinorum: An internet-based survey
Baggott, M. J., Erowid, E., Erowid, F., Galloway, G. P., & Mendelson, J. E. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.05.003 · Cited by 77
Corticotropin-releasing factor in the nucleus accumbens shell induces swim depression, anxiety, and anhedonia along with changes in local dopamine/acetylcholine balance
Chen, Y.-W., Rada, P. V., Bützler, B. P., LEIBOWITZ, S. F., & Hoebel, B. G. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.009 · Cited by 78
κ opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake
Whitfield, T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1978-13.2015 · Cited by 75
The role of kappa opioid receptors in stress‐induced reinstatement of alcohol seeking in rats
Funk, D. R., Coen, K. M., & Lê, A. D. (2014) · Brain and Behavior · doi:10.1002/brb3.222 · Cited by 77
Antidepressant-like effects of cytidine in the forced swim test in rats
Carlezon, W. A., Pliakas, A. M., Parow, A. M., Detke, M. J., Cohen, B. M., & Renshaw, P. F. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01344-0 · Cited by 77
Self-citation
Antidepressant Treatment Can Normalize Adult Behavioral Deficits Induced by Early-Life Exposure to Methylphenidate
Bolaños, C. A., Wiley, M. D., Maffeo, M. L., Powers, K. D., Kinka, D. W., Grausam, K. B., & Henderson, R. P. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.024 · Cited by 75
Inducible cAMP Early Repressor (ICER) and Brain Functions
Borlikova, G. G., & Endo, S. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8072-1 · Cited by 72
Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H
Logrip, M. L., Janak, P. H., & Dorit Ron, A. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.05.001 · Cited by 72
Withdrawal from Chronic Phencyclidine Treatment Induces Long-Lasting Depression in Brain Reward Function
Spielewoy, C., & Markou, A. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300124 · Cited by 73
Salvinorin A Analogs and Other Kappa-Opioid Receptor Compounds as Treatments for Cocaine Abuse
Kivell, B. M., Ewald, A. W. M., & Prisinzano, T. E. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00012-3 · Cited by 71
Roles of Nucleus Accumbens CREB and Dynorphin in Dysregulation of MotivationPreprint
Muschamp, J. W., & Carlezon, W. A. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012005 · Cited by 74
Self-citation
Kappa Opioid Receptor Antagonists as Potential Therapeutics for Stress-Related Disorders
Jacobson, M. L., Browne, C. A., & Lucki, I. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023317 · Cited by 70
Effect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREB-BDNF pathway in rat model of depression through chronic unpredictable stress
Wang, C., Guo, J., & Guo, R. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1543-9 · Cited by 73
DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats
Guo, L., Zhou, H., Wang, R., Xu, J., Zhou, W., Zhang, F., Tang, S., Liu, H., & Jiang, J. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.09.012 · Cited by 68
Running has Differential Effects on NPY, Opiates, and Cell Proliferation in an Animal Model of Depression and Controls
Bjørnebekk, A., Mathé, A. A., & Brené, S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300820 · Cited by 69
CREB Binding and Activity in Brain: Regional Specificity and Induction by Electroconvulsive Seizure
Tanis, K. Q., Duman, R. S., & Newton, S. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.003 · Cited by 70
Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats
Der‐Avakian, A., D’Souza, M. S., Potter, D. N., Chartoff, E. H., Carlezon, W. A., Pizzagalli, D. A., & Markou, A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4584-y · Cited by 69
Self-citation
Transient Overexpression of α-Ca2+/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell Enhances Behavioral Responding to Amphetamine
Loweth, J. A., Singer, B. F., Baker, L. K., Wilke, G. A., Inamine, H., Bubula, N., Alexander, J. K., Carlezon, W. A., Neve, R. L., & Vezina, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4383-09.2010 · Cited by 66
Self-citation
The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders
Xiao, X., Zhang, C., Grigoroiu‐Serbânescu, M., Wang, L., Li, L., Zhou, D., Yuan, T.-F., Wang, C., Chang, H., Wu, Y. F., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.243 · Cited by 65
Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system
Donahue, R. J., Landino, S. M., Golden, S. A., Carroll, F. I., Russo, S. J., & Carlezon, W. A. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000155 · Cited by 67
Self-citation
Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell
Crofton, E. J., Nenov, M. N., Zhang, Y., Scala, F., Page, S. A., McCue, D. L., Li, D., Hommel, J. D., Laezza, F., & Green, T. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.020 · Cited by 64
Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system
SIROHI, S. K., Bakalkin, G. Y., & Walker, B. M. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00095 · Cited by 68
Induction of Inducible cAMP Early Repressor Expression in Nucleus Accumbens by Stress or Amphetamine Increases Behavioral Responses to Emotional Stimuli
Green, T. A., Alibhai, I. N., Hommel, J. D., Dileone, R., Kumar, A., Theobald, D. E. H., Neve, R. L., & Nestler, E. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0880-06.2006 · Cited by 63
Self-citation
Intracellular signaling pathways pave roads to recovery for mood disorders
Tanis, K. Q., & Duman, R. S. (2007) · Annals of Medicine · doi:10.1080/07853890701483270 · Cited by 64
Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors
Bolaños, C. A., Perrotti, L. I., Edwards, S., Eisch, A. J., Barrot, M., Olson, V. G., Russell, D. S., Neve, R. L., & Nestler, E. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07569.2003 · Cited by 62
Cocaine‐induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non‐human primates
Hemby, S. E., Tang, W., Muly, E. C., Kuhar, M. J., Howell, L. L., & Mash, D. C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03517.x · Cited by 67
Strategies for Developing κ Opioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects
Paton, K. F., Atigari, D. V., Kaska, S., Prisinzano, T. E., & Kivell, B. M. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000134 · Cited by 61
The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-α induced alterations to monoamine turnover in prefrontal cortex and hippocampus
Garza, R. D. L., & Asnis, G. M. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02757-4 · Cited by 64
Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety
Anderson, E. M., Larson, E. B., Guzman, D. D., Wissman, A. M., Neve, R. L., Nestler, E. J., & Self, D. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1657-17.2017 · Cited by 59
Self-citation
5‐HT1B receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine
Barot, S. K., Ferguson, S. M., & Neumaier, J. F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05568.x · Cited by 59
Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression
Romeas, T., Morissette, M.-C., Mnie‐Filali, O., Piñeyro, G., & Boye, S. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1539-y · Cited by 59
Altered Gene Expression and Spine Density in Nucleus Accumbens of Adolescent and Adult Male Mice Exposed to Emotional and Physical Stress
Warren, B. L., Sial, O. K., Parise, L. F., Greenwood, M. A., Brewer, J. S., Rozofsky, J. P., Parise, E. M., & Bolaños‐Guzmán, C. A. (2014) · Developmental Neuroscience · doi:10.1159/000362875 · Cited by 64

Authors: Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A.
Affiliations: Harvard University (US)
The University of Texas Southwestern Medical Center (US)
ORCID: Neve, Rachael L.
Konradi, Christine
Nestler, Eric J.
Carlezon, William A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2001-09-15
Volume: 21
Issue: 18
Pages: 7397-7403
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.21-18-07397.2001
PMC: PMC4205577
OpenAlex: W1928329059
Cited by: 509
References: 42
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 20 · 2016: 21 · 2015: 22 · 2014: 23 · 2013: 28 · 2012: 33
FWCI: 7.88
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health
National Institute on Drug Abuse (R01DA007134)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: CREB, nucleus accumbens, cocaine reward, cocaine withdrawal, depression-like behavior, kappa opioid receptor, nor-binaltorphimine, dynorphin, dominant-negative CREB, place conditioning
MeSH terms: Animals, Cocaine, Conditioning, Psychological, Dynorphins, Genes, Dominant, Genetic Vectors, Male, Microinjections, Motor Activity, Narcotic Antagonists, Nucleus Accumbens, Reaction Time, Swimming, Gene Expression, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Receptors, Opioid, kappa, Gene Transfer Techniques, Simplexvirus, Hypokinesia, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks