Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB

Kreibich, Arati S; Briand, Lisa; Cleck, Jessica N; Ecke, Laurel; Rice, Kenner C; Blendy, Julie A

doi:10.1038/npp.2009.91

Cited by 89Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB

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Kreibich, Arati S, Briand, Lisa, Cleck, Jessica N, Ecke, Laurel, Rice, Kenner C, Blendy, Julie A·2009·Neuropsychopharmacology

DOI 10.1038/npp.2009.91PMC PMC4034179

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Abstract

Both clinical and preclinical research have shown that stress can potentiate drug use; however, the underlying mechanisms of this interaction are unknown. Previously, we have shown that a single exposure to forced swim (FS) reinstates extinguished conditioned place preference (CPP) to cocaine and that cAMP response element binding protein (CREB) is necessary for this response. CREB can be activated by corticotropin releasing factor (CRF) receptor type 1 (CRF(R1)) binding, which mediates neuroendocrine and behavioral responses to stress as well as to drugs of abuse. The present experiments investigate whether changes in cocaine reward elicited by previous exposure to stress are mediated by CREB and/or CRF(R1). Chronic exposure to FS in advance of conditioning enhances cocaine CPP in wild-type mice, but this is blocked in CREB-deficient mice. In addition, pretreatment with the CRF(R1) antagonist, antalarmin, before FS exposure blocks this stress-induced enhancement of cocaine CPP. Furthermore, FS-induced increase in phosphorylated CREB (pCREB), specifically in the lateral septum (LS) and nucleus accumbens (NAc) is also blocked by antalarmin. Taken together, these studies suggest that both CREB and CRF(R1) activation are necessary for stress-induced potentiation of drug reward.

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CRF in the NAC shell can enhance the positive motivational value and salience of incentive cues.
“CRF in the NAC shell can also enhance the positive motivational value and salience of incentive cues (Pecina et al 2006; Kreibich et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Kreibich et al 2009
The NAC shell is activated during stress in rats and mice, and this activation in mice is blocked by a CRF-R1 antagonist.
“The NAC shell is activated during stress in rats and mice, and this same activation in mice is blocked by CRF-R1 antagonist (Pliakas et al 2001; Kreibich et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Kreibich et al 2009

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The role of cAMP response element binding (CREB) protein in mediating stress induced reward and reinstatement
Kreibich, A. S. (2005) · Scholarly Commons (University of Pennsylvania)
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Behavioral/Systems/Cognitive cAMP Response Element-Binding Protein Is Required for Stress But Not Cocaine-Induced Reinstatement
Kreibich, A. S., & Blendy, J. A. (2004)
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cAMP Response Element-Binding Protein Is Required for Stress But Not Cocaine-Induced Reinstatement
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Cellular/Molecular Chronic Cocaine Enhances Corticotropin-Releasing Factor- Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons
Hahn, J., Hopf, F. W., & Bonci, A. (2013)
Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons
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Authors: Kreibich, A. S., Briand, L., Cleck, J. N., Ecke, L., Rice, K. C., & Blendy, J. A.
Affiliations: University of Pennsylvania (US)
National Institute on Drug Abuse (US)
Corresponding author: Blendy, Julie A
ORCID: Briand, Lisa
Rice, Kenner C
Blendy, Julie A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2009-08-12
Volume: 34
Issue: 12
Pages: 2609-2617
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2009.91
PMC: PMC4034179
OpenAlex: W2033746591
Cited by: 89
References: 69
Citations by year: 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 4 · 2012: 7
FWCI: 3.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse (R01DA011649, DA116-49-01A2)
National Institute of General Medical Sciences (T32GM008076)
National Institute of Diabetes and Digestive and Kidney Diseases
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: cocaine reward, stress, conditioned place preference, corticotropin-releasing hormone receptor 1, CREB, antalarmin, forced swim test, lateral septum, nucleus accumbens
MeSH terms: CRF Receptor, Type 1, Animals, Cocaine, Conditioning, Classical, Nucleus Accumbens, Phosphorylation, Pyrimidines, Pyrroles, Reward, Space Perception, Stress, Psychological, Swimming, Time Factors, Cyclic AMP Response Element-Binding Protein, Receptors, Corticotropin-Releasing Hormone, Mice, Knockout, Dopamine Uptake Inhibitors, Septum of Brain, Mice

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Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB

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