Control of a specific motor program by a small brain area in zebrafish
Open accessAbstract
Complex motor behaviors are thought to be coordinated by networks of brain nuclei that may control different elementary motor programs. Transparent zebrafish larvae offer the opportunity to analyze the functional organization of motor control networks by optical manipulations of neuronal activity during behavior. We examined motor behavior in transgenic larvae expressing channelrhodopsin-2 throughout many neurons in the brain. Wide-field optical stimulation triggered backward and rotating movements caused by the repeated execution of J-turns, a specific motor program that normally occurs during prey capture. Although optically-evoked activity was widespread, behavioral responses were highly coordinated and lateralized. 3-D mapping of behavioral responses to local optical stimuli revealed that J-turns can be triggered specifically in the anterior-ventral optic tectum (avOT) and/or the adjacent pretectum. These results suggest that the execution of J-turns is controlled by a small group of neurons in the midbrain that may act as a command center. The identification of a brain area controlling a defined motor program involved in prey capture is a step toward a comprehensive analysis of neuronal circuits mediating sensorimotor behaviors of zebrafish.
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The optic tectum of teleosts receives sensory information mainly from multiple sensory modalities to form real-time representations of the animal surrounding, to identify significant stimuli, like preys or predators, and to trigger sensory guided responses.
“The optic tectum of teleosts receives sensory information mainly from multiple sensory modalities to form real-time representations of the animal surrounding, to identify significant stimuli, like preys, or potentially dangerous objects, as predators, and to trigger sensory guided responses.”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [129]
The Introduction (page unavailable) describes visual input to the zebrafish optic tectum and its role in prey capture; the Discussion reports that stimulating a tectal subregion can trigger prey-orienting turns. The paper does not establish that the teleost tectum integrates multiple sensory modalities or forms real-time representations of its surroundings. Its predator example concerns toads and assigns predator-signaling visual stimuli to the pretectum, not the optic tectum. (LLM, conf=0.88)
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Tsai, T. I., Dlugaiczyk, J., Bardins, S., Huppert, D., Brandt, T., & Wuehr, M. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00199.2021 · Cited by 6 · see citing works
Confidence in predicted position error explains saccadic decisions during pursuit
Coutinho, J., Lefèvre, P., & Blohm, G. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00492.2019 · Cited by 6 · see citing works
On analogies in vertebrate and insect visual systems
Tanaka, R., & Portugues, R. (2025) · Nature Reviews Neuroscience · doi:10.1038/s41583-025-00932-3 · Cited by 5 · see citing works
Recording Channelrhodopsin-Evoked Field Potentials and Startle Responses from Larval Zebrafish
Ozdemir, Y. I., Hansen, C. A., Ramy, M. A., Troconis, E. L., McNeil, L. D., & Trapani, J. G. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0830-2_13 · Cited by 4 · see citing works
Dynamic real-time subtraction of stray-light and background for multiphoton imaging
Fernández, A., Straw, A. D., Distel, M., Leitgeb, R. A., Baltuška, A., & Verhoef, A. J. (2020) · Biomedical Optics Express · doi:10.1364/boe.403255 · Cited by 4 · see citing works
Patterned Two-Photon Illumination for High-Speed Functional Imaging of Brain Networks In Vivo
Bovetti, S., Moretti, C., & Fellin, T. (2018) · Progress in optical science and photonics · doi:10.1007/978-981-10-9020-2_7 · Cited by 1 · see citing works
Bayesian inference of neuronal ensemblesPreprint
Diana, G., Sainsbury, T. T. J., & Meyer, M. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/452557 · Cited by 1 · see citing works
Functional investigation of neural circuits in larval zebrafish
Thompson, A. W. (2016) · The University of Queensland · doi:10.14264/uql.2016.47
Meyer, M. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-39581-4_16
Predatory orienting is jointly controlled by optic tectum and pretectumPreprint
Antinucci, P., Colinas-Fischer, S., & Bianco, I. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.10.687578
Octopamine and tyramine modulate fictive motor program competition in Drosophila larvae
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- Authors
- Fajardo, O., Zhu, P., & Friedrich, R. W.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Fajardo, Otto
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 67-67
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC3640207
- OpenAlex
- W2117425657
- Cited by
- 47
- References
- 66
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 3
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- motor programs, prey capture, zebrafish larvae, optic tectum, pretectum, channelrhodopsin-2, optogenetic stimulation, laterality, sensorimotor behavior
- MeSH terms
- Animals, Mesencephalon, Motor Activity, Neural Pathways, Photic Stimulation, Psychomotor Performance, Superior Colliculi, Zebrafish, Animals, Genetically Modified
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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