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An Unbiased cDNA Library Prepared from Isolated Aplysia Sensory Neuron Processes Is Enriched for Cytoskeletal and Translational mRNAs
Open accessAbstract
Local protein synthesis is required for long-lasting synapse-specific plasticity in cultured Aplysia sensorimotor synapses. To identify synaptically localized mRNAs, we prepared a cDNA library from isolated sensory neurites. By sequence analysis, we estimate that the library contains 263 distinct mRNAs, with 98 of these mRNAs constituting 70% of all clones. The localized transcripts are enriched for mRNAs encoding cytoskeletal elements and components of the translational machinery.In situ hybridization confirms that the mRNAs for at least eight of these transcripts are present in distal neurites. Immunocytochemistry reveals that serotonin regulates the translation of one of the localized mRNAs, that encoding α1-tubulin. Our identification of mRNAs encoding cytoskeletal elements suggests that local protein synthesis is required for the growth of new synaptic connections associated with persistent synaptic strengthening. Our finding of mRNAs encoding components of the translational machinery suggests that local protein synthesis serves to increase the translational capacity of synapses.
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Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944
Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity
Kelleher, R. J., Govindarajan, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.013 · Cited by 592
Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs
Zivraj, K. H., Tung, Y. C. L., Piper, M., Gumy, L., Fawcett, J. W., Yeo, G. S. H., & Holt, C. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1800-10.2010 · Cited by 315
Synaptic regulation of translation of dendritic mRNAs
Schuman, E. M., Dynes, J. L., & Steward, O. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1796-06.2006 · Cited by 230
Piper, M., & Holt, C. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.111746 · Cited by 196
Metadata
- Authors
- Moccia, R., Chen, D., Lyles, V., Kapuya, E., E, Y., Kalachikov, S., Spahn, C. M. T., Frank, J., Kandel, E. R., Barad, M., & Martin, K. C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-10-15
- Volume
- 23
- Issue
- 28
- Pages
- 9409-9417
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2169284406
- Cited by
- 172
- References
- 6
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moccia, R., Chen, D., Lyles, V., Kapuya, E., E, Y., Kalachikov, S., Spahn, C. M. T., Frank, J., Kandel, E. R., Barad, M., & Martin, K. C. (2003). An Unbiased cDNA Library Prepared from Isolated Aplysia Sensory Neuron Processes Is Enriched for Cytoskeletal and Translational mRNAs. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-28-09409.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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