The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus
Open accessAbstract
Increasing evidence suggests that neurogenesis occurs in the postnatal and adult mammalian hypothalamus. However, the identity and location of the putative progenitor cells is under much debate, and little is known about the dynamics of neurogenesis in unchallenged brain. Previously, we postulated that Fibroblast growth factor 10-expressing (Fgf10+) tanycytes constitute a population of progenitor cells in the mouse hypothalamus. Here, we show that Fgf10+tanycytes express markers of neural stem/progenitor cells, divide late into postnatal life, and can generate both neurons and astrocytes in vivo. Stage-specific lineage-tracing of Fgf10+tanycytes using Fgf10-creERT2 mice, reveals robust neurogenesis at postnatal day 28 (P28), lasting as late as P60. Furthermore, we present evidence for amplification of Fgf10-lineage traced neural cells within the hypothalamic parenchyma itself. The neuronal descendants of Fgf10+tanycytes predominantly populate the arcuate nucleus, a subset of which express the orexigenic neuronal marker, Neuropeptide-Y, and respond to fasting and leptin-induced signaling. These studies provide direct evidence in support of hypothalamic neurogenesis during late postnatal and adult life, and identify Fgf10+tanycytes as a source of parenchymal neurons with putative roles in appetite and energy balance.
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Cites
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3079 · Cited by 502
Hypothalamic tanycytes: a key component of brain-endocrine interaction
RODRIGUEZ, E., BLAZQUEZ, J., PASTOR, F., PELAEZ, B., PENA, P., PERUZZO, B., & AMAT, P. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)47003-5 · Cited by 475 · cited 10×
“Fgf10-expressing ( ) tanycytes are not a major source of putative Sox2-expressing parenchymal progenitor cells (Li et al., 2012), however, since very few parenchymally located gal cells in Fgf10 nLacZ brains express Sox2 (Fig.”
BackgroundInfluentialMori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398 · cited 1×
“…cells, should resolve whether these orientations correspond to a particular mode of division and/or whether one mode predominates over another with progressive age, as is the case during early phases of cortical neurogenesis (Noctor et al., 2008) (for review, see Lancaster and Knoblich, 2012).”
BackgroundCircumventricular organs: A novel site of neural stem cells in the adult brain
Bennett, L., Yang, M., Enikolopov, G., & Iacovitti, L. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.007 · Cited by 186
Cited by
Robins, S. C., Stewart, I., McNay, D. E., Taylor, V., Giachino, C., Goetz, M., Ninkovic, J., Briancon, N., Maratos-Flier, E., Flier, J. S., et al. (2013) · Nature Communications · doi:10.1038/ncomms3049 · Cited by 306
Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain
Dimou, L., & Götz, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2013 · Cited by 264
Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control
Haddad-Tóvolli, R., Dragano, N. R. V., Ramalho, A. F. S., & Velloso, L. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00224 · Cited by 226
Brain regulation of energy balance and body weight
Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168
Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes
Fuente-Martín, E., García-Cáceres, C., Argente-Arizón, P., Díaz, F., Granado, M., Freire-Regatillo, A., Castro-González, D., Ceballos, M. L., Frago, L. M., Dickson, S. L., et al. (2016) · Scientific Reports · doi:10.1038/srep23673 · Cited by 91
Metadata
- Authors
- Haan, N., Goodman, T., Najdi-Samiei, A., Stratford, C. M., Rice, R., El Agha, E., Bellusci, S., & Hajihosseini, M. K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-04-03
- Volume
- 33
- Issue
- 14
- Pages
- 6170-6180
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2162867596
- Cited by
- 239
- References
- 7
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus. https://app.cochat.ai/papers/10.1523/jneurosci.2437-12.2013
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- Haan, N., Goodman, T., Najdi-Samiei, A., Stratford, C. M., Rice, R., El Agha, E., Bellusci, S., & Hajihosseini, M. K. (2013). Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2437-12.2013
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