The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Itch-Producing Agents Histamine and Cowhage Activate Separate Populations of Primate Spinothalamic Tract Neurons
Open accessAbstract
Itch is an everyday sensation, but when associated with disease or infection it can be chronic and debilitating. Several forms of itch can be blocked using antihistamines, but others cannot and these constitute an important clinical problem. Little information is available on the mechanisms underlying itch that is produced by nonhistaminergic mechanisms. We examined the responses of spinothalamic tract neurons to histaminergic and, for the first time, nonhistaminergic forms of itch stimuli. Fifty-seven primate spinothalamic tract (STT) neurons were identified using antidromic activation techniques and examined for their responses to histamine and cowhage, the nonhistaminergic itch-producing spicules covering the pod of the legume Mucuna pruriens . Each examined neuron had a receptive field on the hairy skin of the hindlimb and responded to noxious mechanical stimulation. STT neurons were tested with both pruritogens applied in a random order and we found 12 that responded to histamine and seven to cowhage. Each pruritogen-responsive STT neuron was activated by the chemical algogen capsaicin and two-thirds responded to noxious heat stimuli, demonstrating that these neurons convey chemical, thermal, and mechanical nociceptive information as well. Histamine or cowhage responsive STT neurons were found in both the marginal zone and the deep dorsal horn and were classified as high threshold and wide dynamic range. Unexpectedly, histamine and cowhage never activated the same cell. Our results demonstrate that the spinothalamic tract contains mutually exclusive populations of neurons responsive to histamine or the nonhistaminergic itch-producing agent cowhage.
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Cites
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Specific C-Receptors for Itch in Human Skin
Schmelz, M., Schmidt, R., Bickel, A., Handwerker, H. O., & Torebjörk, H. E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-20-08003.1997 · Cited by 913
Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P. S., Luger, T. A., & Schmelz, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06176.2003 · Cited by 653
Antidromic activation of neurones as an analytic tool in the study of the central nervous system
Lipski, J. (1981) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(81)90015-7 · Cited by 593
Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
Andrew, D., & Craig, A. D. (2001) · Nature Neuroscience · doi:10.1038/82924 · Cited by 568
TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase
Shim, W.-S., Tak, M.-H., Lee, M.-H., Kim, M., Kim, M., Koo, J.-Y., Lee, C.-H., Kim, M., & Oh, U. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-06.2007 · Cited by 465
Chemical Response Pattern of Different Classes of C-Nociceptors to Pruritogens and Algogens
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Klein, P. A., & Clark, R. A. F. (1999) · Archives of Dermatology · doi:10.1001/archderm.135.12.1522 · Cited by 369
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Cited by
TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2789 · Cited by 599
Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus
Kremer, A. E., Martens, J. J. W. W., Kulik, W., Ruëff, F., Kuiper, E. M. M., van Buuren, H. R., van Erpecum, K. J., Kondrackiene, J., Prieto, J., Rust, C., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.009 · Cited by 410
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Mollanazar, N. K., Smith, P. K., & Yosipovitch, G. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8488-5 · Cited by 353
Separate Peripheral Pathways for Pruritus in Man
Namer, B., Carr, R., Johanek, L. M., Schmelz, M., Handwerker, H. O., & Ringkamp, M. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90482.2008 · Cited by 274
Akiyama, T., & Carstens, E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.035 · Cited by 272
Metadata
- Authors
- Davidson, S., Zhang, X., Yoon, C. H., Khasabov, S. G., Simone, D. A., & Giesler, G. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-12
- Volume
- 27
- Issue
- 37
- Pages
- 10007-10014
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2076606084
- Cited by
- 254
- References
- 35
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Davidson, S., Zhang, X., Yoon, C. H., Khasabov, S. G., Simone, D. A., & Giesler, G. J. (2007). The Itch-Producing Agents Histamine and Cowhage Activate Separate Populations of Primate Spinothalamic Tract Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2862-07.2007
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