The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Separate Peripheral Pathways for Pruritus in Man
Open accessAbstract
Recent findings suggest that itch produced by intradermal insertion of cowhage spicules in human is histamine independent. Neuronal mechanisms underlying nonhistaminergic itch are poorly understood. To investigate which nerve fibers mediate cowhage induced itch in man, action potentials were recorded from cutaneous C-fibers of the peroneal nerve in healthy volunteers using microneurography. Mechano-responsive and -insensitive C-nociceptors were tested for their responsiveness to cowhage spicules, histamine, and capsaicin. Cowhage spicules induced itching and activated all tested mechano-responsive C-units (24/24, but no mechano-insensitive C-fibers (0/17). Histamine also induced itch, but in contrast to cowhage, it caused lasting activation only in mechano-insensitive units (8/12). In mechano-responsive C-units, histamine caused no or only short and weak responses unrelated to the time course of itching. Capsaicin injections activated four of six mechano-responsive fibers and three of four mechano-insensitive C-fibers. Cowhage and histamine activate distinctly different nonoverlapping populations of C-fibers while inducing similar sensations of itch. We hypothesize that cowhage activates a pathway for itch that originates peripherally from superficial mechano-responsive (polymodal) C-fibers and perhaps other afferent units. It is distinct from the pathway for histamine-mediated pruritus and does not involve the histamine-sensitive mechano-insensitive fibers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specific C-Receptors for Itch in Human Skin
Schmelz, M., Schmidt, R., Bickel, A., Handwerker, H. O., & Torebjörk, H. E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-20-08003.1997 · Cited by 913
Self-citationSystematic review of treatments for atopic eczema.
Hoare, Po, L. W., & Williams (2000) · Health Technology Assessment · doi:10.3310/hta4370 · Cited by 794
Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P. S., Luger, T. A., & Schmelz, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06176.2003 · Cited by 653
Self-citationSpinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
Andrew, D., & Craig, A. D. (2001) · Nature Neuroscience · doi:10.1038/82924 · Cited by 568
Activity from skin mechanoreceptors recorded percutaneously in awake human subjects
Vallbo, Å. B., & Hagbarth, K.-E. (1968) · Experimental Neurology · doi:10.1016/0014-4886(68)90041-1 · Cited by 530
Novel classes of responsive and unresponsive C nociceptors in human skin
Schmidt, R., Schmelz, M., Forster, C., Ringkamp, M., Torebjork, E., & Handwerker, H. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00333.1995 · Cited by 504
Self-citationThe Thermal Grill Illusion: Unmasking the Burn of Cold Pain
Craig, A. D., & Bushnell, M. C. (1994) · Science · doi:10.1126/science.8023144 · Cited by 497
LaMotte, R. H., & Campbell, J. N. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.509 · Cited by 456
Itch: scratching more than the surface
Twycross, R. (2003) · QJM · doi:10.1093/qjmed/hcg002 · Cited by 407
Chemical Response Pattern of Different Classes of C-Nociceptors to Pruritogens and Algogens
Schmelz, M., Schmidt, R., Weidner, C., Hilliges, M., Torebjörk, H. E., & Handwerker, H. O. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01139.2002 · Cited by 399
Self-citation
Cited by
TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2789 · Cited by 599
The Cells and Circuitry for Itch Responses in Mice
Mishra, S. K., & Hoon, M. A. (2013) · Science · doi:10.1126/science.1233765 · Cited by 507
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Tavares-Ferreira, D., Shiers, S., Ray, P. R., Wangzhou, A., Jeevakumar, V., Sankaranarayanan, I., Cervantes, A. M., Reese, J. C., Chamessian, A., Copits, B. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj8186 · Cited by 451
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Mollanazar, N. K., Smith, P. K., & Yosipovitch, G. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8488-5 · Cited by 353
Physiology and Pathophysiology of Itch
Cevikbas, F., & Lerner, E. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 282
Metadata
- Authors
- Namer, B., Carr, R., Johanek, L. M., Schmelz, M., Handwerker, H. O., & Ringkamp, M.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2008-10
- Volume
- 100
- Issue
- 4
- Pages
- 2062-2069
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1988408110
- Cited by
- 274
- References
- 42
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Separate Peripheral Pathways for Pruritus in Man. https://app.cochat.ai/papers/10.1152/jn.90482.2008
- The paper
- Namer, B., Carr, R., Johanek, L. M., Schmelz, M., Handwerker, H. O., & Ringkamp, M. (2008). Separate Peripheral Pathways for Pruritus in Man. Journal of Neurophysiology. https://doi.org/10.1152/jn.90482.2008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
