The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Double Dissociation of Stimulus-Value and Action-Value Learning in Humans with Orbitofrontal or Anterior Cingulate Cortex Damage
Open accessAbstract
Adaptive decision making involves selecting the most valuable option, typically by taking an action. Such choices require value comparisons, but there is debate about whether these comparisons occur at the level of stimuli (goods-based) value, action-based value, or both. One view is that value processes occur in series, with stimulus value informing action value. However, lesion work in nonhuman primates suggests that these two kinds of choice are dissociable. Here, we examined action-value and stimulus-value learning in humans with focal frontal lobe damage. Orbitofrontal damage disrupted the ability to sustain the correct choice of stimulus, but not of action, after positive feedback, while damage centered on dorsal anterior cingulate cortex led to the opposite deficit. These findings argue that there are distinct, domain-specific mechanisms by which outcome value is applied to guide subsequent decisions, depending on whether the choice is between stimuli or between actions.
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“In line with this, comparative studies of ACC and OFC highlight their dissociative roles in encoding outcome value; the OFC encodes outcome-related information during Pavlovian (cue-outcome) learning rather than during the instrumental (action-outcome) learning, while the opposite contribution is found in the ACC47,48.”
From Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior (2026) · cites this paper as [47]
Experimental — accuracy not yet measuredIn the citing paper
“We note also that human lesion data has led to the suggestion that orbital prefrontal cortex implements encoding of stimulus value with dorsal cingulate cortex implementing encoding of action value (Camille et al., 2011).”
From Goals and Habits in the Brain (2013) · cites this paper as Camille et al., 2011
In the citing paper
“However, the anterior cingulate cortex appears to be involved in learning actions to obtain rewards (action–outcome learning), where the outcome refers to the reward or punisher for which an action is being learned (Rudebeck et al., 2008; Camille et al., 2011; Rushworth et al., 2011, 2012; Rolls, 2019b,c).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Camille et al., 2011
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Citations
Cites
A framework for studying the neurobiology of value-based decision making
Rangel, A., Camerer, C., & Montague, P. R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2357 · Cited by 2,184
Functional role of the supplementary and pre-supplementary motor areas
Nachev, P., Kennard, C., & Husain, M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2478 · Cited by 1,928
The neural correlates of subjective value during intertemporal choice
Kable, J. W., & Glimcher, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn2007 · Cited by 1,916
The Medial Frontal Cortex and the Rapid Processing of Monetary Gains and Losses
Gehring, W. J., & Willoughby, A. R. (2002) · Science · doi:10.1126/science.1066893 · Cited by 1,884
Optimal decision making and the anterior cingulate cortex
Kennerley, S. W., Walton, M. E., Behrens, T. E. J., Buckley, M. J., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1724 · Cited by 948
Neurobiology of economic choice: a good-based model
Padoa-Schioppa, C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113648 · Cited by 600
Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex
Mansouri, F. A., Tanaka, K., & Buckley, M. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2538 · Cited by 559
Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour
Rushworth, M. F. S., Behrens, T. E. J., Rudebeck, P. H., & Walton, M. E. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.01.004 · Cited by 507
Value Representations in the Primate Striatum during Matching Behavior
Lau, B., & Glimcher, P. W. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.021 · Cited by 419
Neural representations of subjective reward value
Peters, J., & Büchel, C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.031 · Cited by 405
Walton, M. E., Behrens, T. E. J., Buckley, M. J., Rudebeck, P. H., & Rushworth, M. F. S. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.027 · Cited by 397
Gläscher, J., Hampton, A. N., & O'Doherty, J. P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn098 · Cited by 387
Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning
Ostlund, S. B., & Balleine, B. W. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5443-06.2007 · Cited by 379 · cited 2×
“, Lau and Glimcher, 2008), and by lesion studies showing that stimulus-value and action-value learning can be dissociated in rats and nonhuman primates (Kennerley et al., 2006; Ostlund and Balleine, 2007; Rudebeck et al., 2008).”
BackgroundReward Encoding in the Monkey Anterior Cingulate Cortex
Amiez, C., Joseph, J., & Procyk, E. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj046 · Cited by 377
Neural Systems for Error Monitoring: Recent Findings and Theoretical Perspectives
Taylor, S. F., Stern, E. R., & Gehring, W. J. (2007) · The Neuroscientist · doi:10.1177/1073858406298184 · Cited by 368
Functional organization of the medial frontal cortex
Rushworth, M. F., Buckley, M. J., Behrens, T. E., Walton, M. E., & Bannerman, D. M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.03.001 · Cited by 353
Frontal cortex subregions play distinct roles in choices between actions and stimuli
Rudebeck, P. H., Behrens, T. E., Kennerley, S. W., Baxter, M. G., Buckley, M. J., Walton, M. E., & Rushworth, M. F. S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3541-08.2008 · Cited by 350
Reward prediction error signals associated with a modified time estimation task
Holroyd, C. B., & Krigolson, O. E. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00561.x · Cited by 341
Human anterior cingulate neurons and the integration of monetary reward with motor responses
Williams, Z. M., Bush, G., Rauch, S. L., Cosgrove, G. R., & Eskandar, E. N. (2004) · Nature Neuroscience · doi:10.1038/nn1354 · Cited by 340
Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions
Buckley, M. J., Mansouri, F. A., Hoda, H., Mahboubi, M., Browning, P. G. F., Kwok, S. C., Phillips, A., & Tanaka, K. (2009) · Science · doi:10.1126/science.1172377 · Cited by 319
Neural computations underlying action-based decision making in the human brain
Wunderlich, K., Rangel, A., & O'Doherty, J. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901077106 · Cited by 301
Neurocomputational models of basal ganglia function in learning, memory and choice
Cohen, M. X., & Frank, M. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.029 · Cited by 248
Murray, E. A., O'Doherty, J. P., & Schoenbaum, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1556-07.2007 · Cited by 238
Neurons in anterior cingulate cortex multiplex information about reward and action
Hayden, B. Y., & Platt, M. L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4874-09.2010 · Cited by 236
Tsuchida, A., Doll, B. B., & Fellows, L. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1958-10.2010 · Cited by 188 · cited 4×
“The task is described in more detail by Tsuchida et al. (2010).”
BackgroundInfluentialSelf-citationEconomic choices can be made using only stimulus values
Wunderlich, K., Rangel, A., & O’Doherty, J. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002258107 · Cited by 138
The Role of Orbitofrontal Cortex in Decision Making
Fellows, L. K. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.023 · Cited by 133
Self-citationDorsal Medial Prefrontal Cortex Plays a Necessary Role in Rapid Error Prediction in Humans
Modirrousta, M., & Fellows, L. K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4450-08.2008 · Cited by 132
Self-citationMonkey Orbitofrontal Cortex Encodes Response Choices Near Feedback Time
Tsujimoto, S., Genovesio, A., & Wise, S. P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5777-08.2009 · Cited by 98
van Wingerden, M., Vinck, M. A., Lankelma, J. V., & Pennartz, C. M. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0222-10.2010 · Cited by 87
Gambling for Gatorade: risk-sensitive decision making for fluid rewards in humans
Hayden, B. Y., & Platt, M. L. (2008) · Animal Cognition · doi:10.1007/s10071-008-0186-8 · Cited by 83
Cited by
Sorted by citations
The role of medial prefrontal cortex in memory and decision making
Euston, D. R., Gruber, A. J., & McNaughton, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.12.002 · Cited by 1,541
Neuronal Reward and Decision Signals: From Theories to Data
Schultz, W. (2015) · Physiological Reviews · doi:10.1152/physrev.00023.2014 · Cited by 1,126
Dolan, R. J., & Dayan, P. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.007 · Cited by 977
Haber, S. N. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/shaber · Cited by 922
The cingulate cortex and limbic systems for emotion, action, and memory
Rolls, E. T. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01945-2 · Cited by 859
Metadata
- Authors
- Camille, N., Tsuchida, A., & Fellows, L. K.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Fellows, Lesley K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-10-19
- Volume
- 31
- Issue
- 42
- Pages
- 15048-15052
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6623552
- OpenAlex
- W2102726432
- Cited by
- 195
- References
- 31
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 11 · 2020: 19 · 2019: 12 · 2018: 20 · 2017: 17 · 2016: 22 · 2015: 13 · 2014: 26 · 2013: 13 · 2012: 11
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (97821_1, MOP-77583)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- orbitofrontal cortex, dorsal anterior cingulate cortex, frontal lobe lesions, adaptive decision-making, value-based choice, positive feedback, outcome value
- MeSH terms
- Adult, Aged, Analysis of Variance, Brain Injuries, Brain Mapping, Choice Behavior, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Reward, Case-Control Studies, Problem-Based Learning
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