Serum levels of chemokines in adolescents with major depression treated with fluoxetine.
Open accessAbstract
BACKGROUND: Major depressive disorder (MDD) is a global health issue that affects 350 million people of all ages. Although between 2% and 5.6% of affected individuals are adolescents, research on young patients is limited. The inflammatory response contributes to the onset of depression, and in adult MDD patients, symptom severity has been linked to chemokine levels. AIM: To determine the differences in circulatory levels of chemokines in healthy volunteers (HVs) and adolescents with MDD, and assess the changes induced by fluoxetine consume. METHODS: The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale (HDRS). The serum levels of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β, interleukin (IL)-8, interferon gamma-induced protein (IP)-10, and eotaxin were measured in patients and HVs. RESULTS: < 0.0001) compared with 0 wk. CONCLUSION: Despite the consumption of fluoxetine, patients had significantly higher chemokine levels, even after considering the improvement in HDRS score. The high levels of eotaxin, IP-10, and IL-8 partially explain certain aspects that are affected in MDD such as cognition, memory, and learning.
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The major purpose of chemokines is to control leukocyte migration (homing) to their proper regions during inflammation and homeostasis; some control immune cell chemotaxis during immune surveillance, while others attract neutrophils to the site of infection or tissue injury for anti-infection, acting as a directing role in innate and adaptive immune systems; chemokines have an important role inthe
“the major purpose of chemokines is to control leukocyte migration (homing) to their proper regions during inflammation and homeostasis. Some control immune cell chemotaxis during the immune surveillance process, while others attract neutrophils to the site of infection or tissue injury for anti-infection, which acts as a directing role in the innate and adaptive immune systems. Furthermore, chemo”
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- Authors
- Peña, F. R. D. L., Cruz-Fuentes, C., Palacios, L., Girón-Pérez, M. I., Medina-Rivero, E., Ponce-Regalado, M. D., Alvarez-Herrera, S., Pérez-Sánchez, G., Becerril-Villanueva, E., Maldonado-García, J. L., Jiménez-Martínez, M. C., & Pavón, L.
- Affiliations
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Venue
- World Journal of Psychiatry
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2020-08-19
- Volume
- 10
- Issue
- 8
- Pages
- 175-186
- ISSN
- 2220-3206 (ISSN-L)
- PMC
- PMC7439300
- OpenAlex
- W3048628644
- Cited by
- 24
- References
- 46
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Psychiatry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, adolescents, fluoxetine, chemokines, serum biomarkers, inflammation, MCP-1, MIP-1α, MIP-1β, interleukin-8, CXCL10, eotaxin, antidepressant response, cognitive impairment
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