Cited by 174Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Two Brain Sites for Cannabinoid Reward

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Zangen, Abraham, Solinas, Marcello, Ikemoto, Satoshi, Goldberg, Steven R., Wise, Roy A.·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.3554-05.2006PMC PMC6674153

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Abstract

The recent findings that Delta9tetrahydrocannabinol (Delta9THC), the active agent in marijuana and hashish, (1) is self-administered intravenously, (2) potentiates the rewarding effects of electrical brain stimulation, and (3) can establish conditioned place preferences in laboratory animals, suggest that these drugs activate biologically primitive brain reward mechanisms. Here, we identify two chemical trigger zones for stimulant and rewarding actions of Delta9THC. Microinjections of Delta9THC into the posterior ventral tegmental area (VTA) or into the shell of the nucleus accumbens (NAS) increased locomotion, and rats learned to lever-press for injections of Delta9THC into each of these regions. Substitution of vehicle for drug or treatment with a cannabinoid CB1 receptor antagonist caused response cessation. Microinjections of Delta9THC into the posterior VTA and into the posterior shell of NAS established conditioned place preferences. Injections into the core of the NAS, the anterior VTA, or dorsal to the VTA were ineffective. These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action.

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Authors: Zangen, A., Solinas, M., Ikemoto, S., Goldberg, S. R., & Wise, R. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Wise, Roy A.
ORCID: Zangen, Abraham
Solinas, Marcello
Ikemoto, Satoshi
Wise, Roy A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-05-03
Volume: 26
Issue: 18
Pages: 4901-4907
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3554-05.2006
PMC: PMC6674153
OpenAlex: W1994818402
Cited by: 174
References: 42
Citations by year: 2026: 2 · 2025: 3 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 5
FWCI: 9.88
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: delta-9-tetrahydrocannabinol, ventral tegmental area, nucleus accumbens shell, conditioned place preference, locomotor activity, self-administration, CB1 receptor antagonist
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Cannabinoids, Conditioning, Operant, Male, Motor Activity, Nucleus Accumbens, Psychotropic Drugs, Reward, Self Stimulation, Dronabinol, Time Factors, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats

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