Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
Abstract
Cannabinoid drugs such as Delta9-THC are euphoric and rewarding, and also stimulate food intake in humans and animals. Little is known about how naturally occurring endogenous brain cannabinoids mediate pleasure from food or other natural sensory rewards. The taste reactivity paradigm measures effects of brain manipulations on affective orofacial reactions to intraorally administered pleasant and unpleasant tastes. Here we tested if anandamide microinjection into medial nucleus accumbens shell enhances these affective reactions to sweet and bitter tastes in rats. Anandamide doubled the number of positive 'liking' reactions elicited by intraoral sucrose, without altering negative 'disliking' reactions to bitter quinine. Anandamide microinjections produced Fos plumes of approximately 0.02-1 mm3 volume. Plume-based maps, integrated with behavioral data, identified the medial shell of accumbens as the anatomical hotspot responsible for hedonic amplification. Anandamide produced especially intense hedonic enhancement in a roughly 1.6 mm3 'hedonic hotspot' in dorsal medial shell, where anandamide also stimulated eating behavior. These results demonstrate that endocannabinoid signals within medial accumbens shell specifically amplify the positive hedonic impact of a natural reward (though identification of the receptor specificity of this effect will require future studies). Identification of an endocannabinoid hotspot for sensory pleasure gives insight into brain mechanisms of natural reward, and may be relevant to understanding the neural effects of cannabinoid drugs of abuse and therapeutic agents.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reward responsiveness also involves the nucleus accumbens, but opioids and endocannabinoids are the major neurochemical mediators of this component.
“Responsiveness to reward also involves the nucleus accumbens (in addition to other regions, such as the ventral pallidum), but opioids and endocannabinoids are the major neurochemical mediators of reward responsiveness (Mahler et al., 2007; Peciña and Berridge, 2005).”
From The effects of early life stress on reward processing (2018) · cites this paper as Mahler et al., 2007
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Hsu, S. M., Raine, L., & Fanger, H. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.4.6166661 · Cited by 14,248 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
Isaacson, P. G., Doǧan, A., Price, S. K., & Spencer, J. (1989) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198912000-00004 · Cited by 1,913 · see citing works
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869 · see citing works
Leptin-regulated endocannabinoids are involved in maintaining food intake
Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559 · see citing works
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
Müller, R., Bravo, R., Burckhardt, J., & Curran, T. (1984) · Nature · doi:10.1038/312716a0 · Cited by 1,369 · see citing works
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90568-1 · Cited by 1,203 · see citing works
Tanda, G., Pontieri, F. E., & Chiara, G. D. (1997) · Science · doi:10.1126/science.276.5321.2048 · Cited by 1,079 · see citing works
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
Pagotto, U., Marsicano, G., Cota, D., Lutz, B., & Pasquali, R. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0009 · Cited by 856 · see citing works
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
Gong, J.-P., Onaivi, E. S., Ishiguro, H., Liu, Q.-R., Tagliaferro, P. A., Brusco, A., & Uhl, G. R. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.035 · Cited by 820 · see citing works
Kirkham, T. C., Williams, C. M., Fezza, F., & Marzo, V. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704767 · Cited by 788 · see citing works
Endocannabinoid control of food intake and energy balance
Marzo, V. D., & Matias, I. (2005) · Nature Neuroscience · doi:10.1038/nn1457 · Cited by 746 · see citing works
Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works
Self-citationPeciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Pharmacological Actions of Cannabinoids
Pertwee, R. G. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_1 · Cited by 600 · see citing works
Erratum to: “Parsing reward” [Trends Neurosci. 26 (2003) 507–513]
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.001 · Cited by 559 · see citing works
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
Herkenham, M. A., Lynn, A. B., de Costa, B. R., & Richfield, E. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90970-7 · Cited by 515 · see citing works
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors
Williams, C. M., & Kirkham, F. J. (1999) · Psychopharmacology · doi:10.1007/s002130050953 · Cited by 508 · see citing works
Peciña, S., & Berridge, K. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02102-8 · Cited by 405 · see citing works
Self-citationReynolds, S. M., & Berridge, K. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07308.2002 · Cited by 403 · see citing works
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Endocannabinoid signaling system and brain reward: emphasis on dopamine
GARDNER, E. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.032 · Cited by 387 · see citing works
Brain microdialysis of GABA and glutamate: What does it signify?
Timmerman, W., & Westerink, B. H. C. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199711)27:3 · Cited by 387 · see citing works
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05344.2001 · Cited by 378 · see citing works
Rodriguez, J. J., Mackie, K., & Pickel, V. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00823.2001 · Cited by 363 · see citing works
Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats
Cheer, J. F., Wassum, K. M., Heien, M. L. A. V., Phillips, P. E. M., & Wightman, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0529-04.2004 · Cited by 343 · see citing works
Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study☆
Moldrich, G., & Wenger, T. (2000) · Peptides · doi:10.1016/s0196-9781(00)00324-7 · Cited by 335 · see citing works
Cannabinoids, opioids and eating behavior: The molecular face of hedonism?
Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.10.004 · Cited by 330 · see citing works
Zhang, M., & Kelley, A. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00198-6 · Cited by 260 · see citing works
Hyperphagia in pre-fed rats following oral δ9-THC
Williams, C. M., Rogers, P. J., & Kirkham, T. C. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00170-x · Cited by 258 · see citing works
Sodium depletion enhances salt palatability in rats
Berridge, K. C., Flynn, F. W., Schulkin, J., & Grill, H. J. (1984) · Behavioral Neuroscience · doi:10.1037/0735-7044.98.4.652 · Cited by 257 · cited 3× · see citing works
“…response patterns were later scored off-line in slow motion (frame by frame to 1/10th actual speed) by a trained observer who was blind to experimental condition, using time bin scoring procedures developed to assess hedonic vs aversive taste valuations (Berridge et al, 1984; Berridge, 2000).”
BackgroundMethodFoltin, R. W., Fischman, M. W., & Byrne, M. F. (1988) · Appetite · doi:10.1016/s0195-6663(88)80017-5 · Cited by 256 · see citing works
Pickel, V. M., Chan, J., Kash, T. L., Rodrı́guez, J.-J., & Mackie, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.015 · Cited by 243 · see citing works
Marzo, V. D., PETROCELLIS, L. D., Fezza, F., Ligresti, A., & Bisogno, T. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0349 · Cited by 238 · see citing works
Endocannabinoids in the regulation of appetite and body weight
Kirkham, T. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00004 · Cited by 220 · see citing works
Cannabinoid CB1 receptors control conditioned drug seeking
Vries, T. J. D., & Schoffelmeer, A. N. M. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.06.002 · Cited by 219 · see citing works
Observational analysis of feeding induced by Δ9-THC and anandamide
Williams, C. M., & Kirkham, T. C. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00725-4 · Cited by 194 · see citing works
Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia
Mátyás, F., Yanovsky, Y., Mackie, K., Kelsch, W., Misgeld, U., & Freund, T. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.005 · Cited by 191 · see citing works
Solinas, M., & Goldberg, S. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300720 · Cited by 174 · see citing works
Two brain sites for cannabinoid reward
Zangen, A., Solinas, M., Ikemoto, S., Goldberg, S. R., & Wise, R. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3554-05.2006 · Cited by 174 · see citing works
Plant, Synthetic, and Endogenous Cannabinoids in Medicine
Marzo, V. D., & PETROCELLIS, L. D. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.57.011205.135648 · Cited by 170 · see citing works
Molecular and cellular basis of cannabinoid and opioid interactions
Viganò, D., Rubino, T., & Parolaro, D. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.021 · Cited by 167 · see citing works
Reynolds, S. M., & Berridge, K. C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02642.x · Cited by 163 · see citing works
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
Williams, C. M., & Kirkham, T. C. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00694-3 · Cited by 158 · see citing works
Synergistic efects of opioid and cannabinoid antagonists on food intake
Kirkham, T. C., & Williams, C. M. (2001) · Psychopharmacology · doi:10.1007/s002130000596 · Cited by 156 · see citing works
Higgs, S., Williams, C. M., & Kirkham, T. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1263-3 · Cited by 154 · see citing works
Rowland, N. E., Mukherjee, M., & Robertson, K. (2001) · Psychopharmacology · doi:10.1007/s002130100910 · Cited by 139 · see citing works
Mapping of chemical trigger zones for reward
Ikemoto, S., & Wise, R. A. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.012 · Cited by 137 · see citing works
Harrold, J. A., Elliott, J. C., King, P., Widdowson, P. S., & Williams, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03245-6 · Cited by 130 · see citing works
Schoffelmeer, A. N. M., Hogenboom, F., WARDEH, G., & Vries, T. J. D. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.05.019 · Cited by 124 · see citing works
Cannabinoid Modulation of Opiate Reinforcement through the Ventral Striatopallidal Pathway
Caillé, S., & Parsons, L. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300848 · Cited by 118 · see citing works
Striatal regulation of morphine-induced hyperphagia: an anatomical mapping study
Bakshi, V. P., & Kelley, A. E. (1993) · Psychopharmacology · doi:10.1007/bf02245525 · Cited by 92 · see citing works
Thornton-Jones, Z. D., Vickers, S. P., & Clifton, P. G. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2047-8 · Cited by 84 · see citing works
Immunolocalization of CB 1 receptor in rat striatal neurons: A confocal microscopy study
Fusco, F. R., Martorana, A., Giampà, C., March, Z. D., Farini, D., D’Angelo, V., Sancesario, G., & Bernardi, G. (2004) · Synapse · doi:10.1002/syn.20047 · Cited by 83 · see citing works
Effect of Δ9-tetrahydrocannabinol on sucrose palatability as measured by the taste reactivity test
Jarrett, M. M., Limebeer, C. L., & PARKER, L. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.033 · Cited by 81 · see citing works
Cooper, S. J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.009 · Cited by 78 · see citing works
Koch, J. E., & Matthews, S. M. (2001) · Nutritional Neuroscience · doi:10.1080/1028415x.2001.11747361 · Cited by 57 · see citing works
Mallet, P. E., Verty, A. N. A., Singh, M. E., & McGregor, I. S. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1451-9 · Cited by 43 · see citing works
Ongali, B., Ase, A. R., H�bert, C., Amdiss, F., & Reader, T. A. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200007)37:1 · Cited by 21 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Paxinos G, Watson C (2005). The Rat Brain in Stereotaxic Coordinates. Elsevier: Amsterdam.
Cited by
Sorted by citations
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942 · see citing works
“Thus, comparing the effects of mu opioid activity in or outside the hotspot in NAc medial shell indicates that opioid sites responsible for ‘liking’ are anatomically dissociable from those that influence ‘wanting’ [14 ,16].”
BackgroundInfluentialSelf-citationBerridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730 · see citing works
“Beyond opioid signals , endocannabinoid stimulation by microinjections of anandamide similarly enhances ''liking'' reactions in an overlapping subregion of the NAc medial shell (Mahler et al., 2007).”
BackgroundInfluentialLiking, wanting, and the incentive-sensitization theory of addiction
Berridge, K. C., & Robinson, T. E. (2016) · American Psychologist · doi:10.1037/amp0000059 · Cited by 1,440 · see citing works
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254 · see citing works
“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
“exist in medial shell for anandamide, which likely acts by stimulating the CB1 type of cannabinoid receptor [55,77].”
BackgroundThe tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873 · see citing works
Ventral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548 · see citing works
Self-citationNeuroscience of affect: brain mechanisms of pleasure and displeasure
Berridge, K. C., & Kringelbach, M. L. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.017 · Cited by 532 · see citing works
“One surprising finding has been that neural generators of intense pleasure are much more restricted neurochemically than was previously envisioned [48 ,49,50,51].”
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Hillard, C. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.130 · Cited by 449 · see citing works
Dopamine modulates the reward experiences elicited by music
Ferreri, L., Herrero, E. M., Zatorre, R. J., Ripollés, P., Gómez-Andrés, A., Alicart, H., Olivé, G., Marco‐Pallarés, J., Antonijoan, R. M., Valle, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811878116 · Cited by 440 · see citing works
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387 · see citing works
“The consumption of reward appears to be related to opioid and endocannabinoid pathways.[87] Neural regions most strongly linked with liking of reward include the ventral striatum (representing overlap with the anticipation of reward) and orbitofrontal cortex.”
Background“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346 · see citing works
“sibly also extend to caudodorsal shell) [90,91].”
Instant transformation of learned repulsion into motivational “wanting”
Robinson, M. J. F., & Berridge, K. C. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.016 · Cited by 320 · see citing works
Alexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 329 · see citing works
“Animal research has significantly contributed to advancing the identification of localized ‘hedonic hotspots ’ in neural reward structures that generate ‘liking ’ responses (Mahler et al., 2007; Pecina and Ber-ridge, 2005; Smith and Berridge, 2005; Steiner et al., 2001).”
Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward
DiFeliceantonio, A. G., Coppin, G., Rigoux, L., Thanarajah, S. E., Dagher, A., Tittgemeyer, M., & Small, D. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.018 · Cited by 302 · see citing works
Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma
Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288 · see citing works
Raichlen, D. A., Foster, A. D., Gerdeman, G. L., Seillier, A., & Giuffrida, A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.063677 · Cited by 269 · see citing works
“Through this and perhaps other mechanisms intrinsic to the NAc, eCBs are thought to act as a ‘hedonic’ signal (Mahler et al., 2007), triggering neurobiological rewards that are similar to those described by runners (Dietrich and McDaniel, 2004), and which likely contribute to the development of habitual reward-directe…”
BackgroundNucleus Accumbens μ-Opioid Receptors Mediate Social Reward
Trezza, V., Damsteegt, R., Achterberg, E. J. M., & Vanderschuren, L. J. M. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5492-10.2011 · Cited by 263 · see citing works
“Histological confirmation of injection sites Injection sites were verified according to the procedure described by Mahler et al. (2007) and Simmons and Self (2009).”
MethodHill, M. N., Carrier, E. J., McLaughlin, R. J., Morrish, A. C., Meier, S. E., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05567.x · Cited by 246 · see citing works
Evaluating the rewarding nature of social interactions in laboratory animals
Trezza, V., Campolongo, P., & Vanderschuren, L. J. M. J. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.007 · Cited by 258 · see citing works
“Interest-ingly, among the rodents species for which sexual behavior induces CPP, both male and female mice (Agustin-Pavon et al., 2007; Martinez-Ricos et al., 2007; Pankevich et al., 2006; Pierman et al., 2006) and male Syrian hamsters (Bell et al., 2010) are known to show CPP for chemosensory…”
The endocannabinoid system in brain reward processes
Solinas, M., Goldberg, S. R., & Piomelli, D. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.130 · Cited by 243 · see citing works
“food palatability, as measured by hedonic reactions to food, appear to be mediated by the more dorsal part of the shell of the NAcc (Mahler et al., 2007).”
BackgroundInfluentialBuilding a neuroscience of pleasure and well-being
Berridge, K. C., & Kringelbach, M. L. (2011) · Psychology of Well-Being: Theory, Research and Practice · doi:10.1186/2211-1522-1-3 · Cited by 229 · see citing works
“capable of generating enhancements of ‘liking’ reactions to a sensory pleasure such as sweetness, when opioid, endocannabinoid or other hedonic neurochemical receptor circuits within the hotspot are stimulated (Mahler et al. 2007; Peciña and Berridge 2005; Peciña et al. 2006; Smith and Berridge 2005).”
BackgroundThomsen, K. R., Whybrow, P. C., & Kringelbach, M. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00049 · Cited by 235 · see citing works
“Stimulation with opioids here, or other signals such as endocannabinoid or orexin, can amplify sensory pleasure by doubling or tripling the normal number of “liking” reactions to sucrose taste (Peciña and Berridge, 2005; Smith and Berridge, 2005; Mahler et al., 2007; Ho and Berridge, 2013).”
BackgroundMahler, S. V., & Berridge, K. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3875-08.2009 · Cited by 223 · see citing works
“This procedure follows similar methods to those used in previous studies (Peciña and Berridge, 2005; Mahler et al., 2007; Smith and Berridge, 2007).”
BackgroundMethodInfluentialSelf-citationDillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209 · see citing works
“Critically, depression is associated with dysfunction in this circuitry,[63] which is distinct from opioid and endocannabinoid pathways more reliably linked to the experience of pleasure.[64, 65] Indeed, although “anhedonia” suggests reduced pleasure upon reward consummation, accruing evidence relates anhedonic depres…”
BackgroundOpioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula
Castro, D. C., & Berridge, K. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705753114 · Cited by 202 · see citing works
“Subcortically, DAMGO or orexin microinjection in the OFC hotspot also recruited increases of >50% Fos expression in the medial shell of the NAc and specifically in its rostrodorsal quadrant that has been previously identified as containing a NAc hedonic hotspot (16, 26, 30).”
BackgroundThe effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“Responsiveness to reward also involves the nucleus accumbens (in addition to other regions, such as the ventral pallidum), but opioids and endocannabinoids are the major neurochemical mediators of reward responsiveness (Mahler et al., 2007; Peciña and Berridge, 2005).”
BackgroundEndocannabinoids selectively enhance sweet taste
Yoshida, R., Ohkuri, T., Jyotaki, M., Yasuo, T., Horio, N., Yasumatsu, K., Sanematsu, K., Shigemura, N., Yamamoto, T., Margolskee, R. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912048107 · Cited by 200 · see citing works
“Infusions of AEA into the nucleus accumbens enhance taste reactivity to sucrose, although standard chow intake is also enhanced (7).”
BackgroundThe Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease
Mazier, W., Saucisse, N., Gatta‐Cherifi, B., & Cota, D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.007 · Cited by 202 · see citing works
Randall, P. A., Pardo, M., Nunes, E. J., López‐Cruz, L., Vemuri, K. V., Makriyannis, A., Baqi, Y., Müller, C. E., Correa, M., & Salamone, J. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047934 · Cited by 196 · see citing works
“Moreover, stimulation of CB1 receptors in nucleus accumbens shell increased hedonic taste reactivity for intraoral sucrose [57].”
BackgroundMorgan, C. J., Freeman, T. P., Schafer, G. L., & Curran, H. V. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.58 · Cited by 196 · see citing works
“The endocannabinoid system is known to be involved in mediating ‘liking’ reactions and microinjection of anandamide into the nucleus accumbens doubles the level of ‘liking’ of sucrose taste in rats (Mahler et al., 2007).”
Faure, A., Reynolds, S. M., Richard, J. M., & Berridge, K. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4961-07.2008 · Cited by 193 · see citing works
“Rostrocaudal keyboard organization of glutamate-related generators of appetitive behavior versus defensive behavior is consistent with other evidence suggesting anatomical heterogeneity or localization of affective function within the medial shell (Peciña and Berridge, 2000; Liberzon et al., 2003; Smith and Berridge,…”
ResultEndocannabinoid signal in the gut controls dietary fat intake
DiPatrizio, N. V., Astarita, G., Schwartz, G. J., Li, X., & Piomelli, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104675108 · Cited by 192 · see citing works
“The proposed role of endocannabinoids in the hedonic evaluation (‘liking’) of palatable foods (7, 8) prompted us to ask whether these lipid mediators might be involved in the positive feedback mechanism originating in the mouth, which maintains fat intake once it has begun (9).”
BackgroundEndocannabinoids in Amygdala and Nucleus Accumbens Mediate Social Play Reward in Adolescent Rats
Trezza, V., Damsteegt, R., Manduca, A., Petrosino, S., Van Kerkhof, L. W. M., Pasterkamp, R. J., Zhou, Y., Campolongo, P., Cuomo, V., Di Marzo, V., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0114-12.2012 · Cited by 190 · see citing works
“It is known that endocannabinoid activity in the NAc increases the rewarding properties of food and drugs (Gardner, 2005; Caillé et al., 2007; Mahler et al., 2007; Soria-Gómez et al., 2007; Di Marzo et al., 2009; Orio et al., 2009; Shinohara et al., 2009; Berridge et al., 2010).”
MethodInfluentialCannabinoids and appetite: food craving and food pleasure
Kirkham, T. C. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782810 · Cited by 189 · see citing works
“That accumbens endocannabinoids can enhance the hedonic impact of sweet taste is directly supported by the finding that intra-AcbSh administration of anandamide specifically increases the number of positive ingestive responses to intra-oral infusions of sweet solutions in taste reactivity tests (Mahler et al., 2007).”
BackgroundInfluentialObesity: Current and potential pharmacotherapeutics and targets
Narayanaswami, V., & Dwoskin, L. P. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.015 · Cited by 184 · see citing works
“Anandamide enhanced hedonic 'liking' reactions (orofacial expressions) elicited by sucrose taste (Berridge, 2000; Mahler et al., 2007).”
InfluentialMarzo, V. D., Ligresti, A., & Cristino, L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.67 · Cited by 181 · see citing works
Harrold, J. A., Dovey, T. M., Blundell, J. E., & Halford, J. C. G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.007 · Cited by 177 · see citing works
Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley
Richard, J. M., Castro, D. C., DiFeliceantonio, A. G., Robinson, M. J. F., & Berridge, K. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.008 · Cited by 175 · see citing works
What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex
Mahler, S. V., & Berridge, K. C. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2588-6 · Cited by 170 · see citing works
“Analysis of DAMGO-induced Fos plumes of neuronal activation Our procedure for measuring drug-induced Fos plumes immediately surrounding microinjection sites followed those described previously (Mahler and Berridge 2009; Mahler et al. 2007; Peciña and Berridge 2005; Smith and Berridge 2005).”
Self-citationCognitive processing of food rewards
Higgs, S. (2015) · Appetite · doi:10.1016/j.appet.2015.10.003 · Cited by 166 · see citing works
Patel, S., & Hillard, C. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06266.x · Cited by 162 · see citing works
Impact of dietary fats on brain functions
Chianese, R., Coccurello, R., Viggiano, A., Scafuro, M., Fiore, M., Coppola, G., Operto, F. F., Fasano, S., Laye, S., Pierantoni, R., et al. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171017102547 · Cited by 159 · see citing works
“The best-known and described eCBs, AEA and 2-AG produce robust effects in terms of energy preservation, increasing energy intake and lipid storage, also contributing to the consumption of hedonic food via the increase of DA release in mesolimbic structures [90, 91].”
BackgroundFulton, S. (2010) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2009.10.003 · Cited by 164 · see citing works
“crease affective taste reactivity patterns for a sucrose solution [211].”
BackgroundAdvances in the neurobiological bases for food ‘liking’ versus ‘wanting’
Castro, D. C., & Berridge, K. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.022 · Cited by 160 · see citing works
“Related evidence has demonstrated endocannabinoid stimulation in the NAc hotspot and even GABAergic hyperpolarizations in the same hotspot can also enhance ‘liking’ reactions to sweet tastes [43,69,84,91,92].”
An Orexin Hotspot in Ventral Pallidum Amplifies Hedonic ‘Liking’ for Sweetness
Ho, C., & Berridge, K. C. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.62 · Cited by 159 · see citing works
Current perspectives on incentive salience and applications to clinical disorders
Olney, J. J., Warlow, S. M., Naffziger, E. E., & Berridge, K. C. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.007 · Cited by 157 · see citing works
Eating beyond metabolic need: how environmental cues influence feeding behavior
Johnson, A. W. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.002 · Cited by 155 · see citing works
Wenzel, J. M., & Cheer, J. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.126 · Cited by 154 · see citing works
Obesity and the Neurocognitive Basis of Food Reward and the Control of Intake
Ziauddeen, H., Alonso‐Alonso, M., Hill, J. O., Kelley, M. J., & Khan, N. A. (2015) · Advances in Nutrition · doi:10.3945/an.115.008268 · Cited by 144 · see citing works
“An endocannabinoid hotspot that overlaps this opioid hotspot was also identified (22).”
BackgroundNeural Mechanisms of Reward in Insects
Perry, C. J., & Barron, A. B. (2013) · Annual Review of Entomology · doi:10.1146/annurev-ento-120811-153631 · Cited by 135 · see citing works
Marco, E. M. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00063 · Cited by 136 · see citing works
“…throughout the brain; they are found at highest concentrations in the hippocampus, neocortex, basal ganglia, and cerebellum; while a moderate presence is observed in the basolateral amygdala, hypothalamus, and midbrain (Herkenham et al., 1991; Mailleux and Vanderhaeghen, 1992; Glass et al., 1997).”
BackgroundCastro, D. C., Terry, R. A., & Berridge, K. C. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.10 · Cited by 130 · see citing works
Opioid reward ‘liking’ and ‘wanting’ in the nucleus accumbens
Peciña, S. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.006 · Cited by 132 · see citing works
“By relating the behavioral ‘liking’ enhancements caused by drug microinjections we can objectively and precisely map plots of hedonic hotspots in the brain [2,16–19].”
BackgroundHedonic Eating and the “Delicious Circle”: From Lipid-Derived Mediators to Brain Dopamine and Back
Coccurello, R., & Maccarrone, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00271 · Cited by 133 · see citing works
“Notably, activation of CB1 receptor underlid “liking” and increased intake of a sucrose rewarding solution after direct AEA infusion into the NAc shell (Mahler et al., 2007).”
BackgroundCocaine Cues Drive Opposing Context-Dependent Shifts in Reward Processing and Emotional State
Wheeler, R. A., Aragona, B. J., Fuhrmann, K. A., Jones, J. L., Day, J. J., Cacciapaglia, F., Wightman, R. M., & Carelli, R. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.014 · Cited by 127 · see citing works
The thrifty lipids: endocannabinoids and the neural control of energy conservation
DiPatrizio, N. V., & Piomelli, D. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.04.006 · Cited by 128 · see citing works
“Microinfusions of anandamide into select “hot spots” of the NAc shell was shown to increase “liking” responses to a sucrose solution in rats, and this effect was prevented by CB1R blockade [42].”
BackgroundResultInfluentialMalézieux, M., Klein, A. S., & Gogolla, N. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-103314 · Cited by 131 · see citing works
Endocannabinoid signaling and food addiction
D’Addario, C., Bonaventura, M. V. M. D., Pucci, M., Romano, A., Gaetani, S., Ciccocioppo, R., Cifani, C., & Maccarrone, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.008 · Cited by 123 · see citing works
The endocannabinoid system and appetite: relevance for food reward
Jager, G., & Witkamp, R. F. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000080 · Cited by 119 · see citing works
“There are other reports, however, where amplification of the positive hedonic impact of endocanna-binoids such as AEA to intra-oral sucrose is confirmed, but no changes in ‘disliking’ reactions to bitter quinine were found (126) .”
Hedonic Hotspots: Generating Sensory Pleasure in the Brain
Smith, K. S., Mahler, S. V., Peciña, S., & Berridge, K. C. (2009) · Oxford University Press eBooks · doi:10.1093/oso/9780195331028.003.0003 · Cited by 117 · see citing works
The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
Bermúdez‐Silva, F. J., Cardinal, P., & Cota, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408458 · Cited by 117 · see citing works
Faure, A., Richard, J. M., & Berridge, K. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011223 · Cited by 114 · see citing works
Self-citationHo, C., & Berridge, K. C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12720 · Cited by 115 · see citing works
“…rostrodorsal quadrant of the medial shell is not a site for disgust induction, despite containing another hotspot for hedonic enhancement by opioid or endocannabinoid stimulation (Peci~na & Berridge, 2005; Mahler et al., 2007; Smith & Berridge, 2007; Smith et al., 2011; Castro & Berridge, 2014).”
BackgroundPlasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance
Birnie, M. T., Kooiker, C. L., Short, A. K., Bolton, J. L., Chen, Y., & Baram, T. Z. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.018 · Cited by 115 · see citing works
“endocannabinoids act as major neurochemical mediators of reward responsiveness (46,47).”
BackgroundRossi, S., Chiara, V. D., Musella, A., Kusayanagi, H., Mataluni, G., Bernardi, G., Usiello, A., & Centonze, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5346-07.2008 · Cited by 112 · see citing works
“Of note, the recovery of stress-induced synaptic defects were accelerated when the mice were given access to a running wheel or to sucrose consumption, which function as potent natural rewarding stimuli (Werme et al., 2000, 2002; Mahler et al., 2007; Rademacher and Hillard, 2007).”
BackgroundAnti-obesity drugs and neural circuits of feeding
Adan, R. A. H., Vanderschuren, L. J. M. J., & ELAFLEUR, S. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.01.008 · Cited by 112 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Cognitive and autonomic determinants of energy homeostasis in obesity
Richard, D. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.103 · Cited by 108 · see citing works
Hindocha, C., Freeman, T. P., Grabski, M., Stroud, J., Crudgington, H., Davies, A. C., Das, R., Lawn, W., Morgan, C. J. A., & Curran, H. V. (2018) · Addiction · doi:10.1111/add.14243 · Cited by 107 · see citing works
“In humans, users of high, in comparison to low CBD : THC ratio cannabis showed lower self-reported pleasantness of cannabis stimuli, which follows the same pattern as the present study [29] andmay be related to endocannabinoid involvement in hedonic experiences [58].”
ResultA peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome
Bowles, N. P., Karatsoreos, I. N., Li, X., Vemuri, K. V., Wood, J.-A., Li, Z., Tamashiro, K. L., Schwartz, G. J., Makriyannis, A., Kunos, G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421420112 · Cited by 105 · see citing works
Hedonic and motivational roles of opioids in food reward: Implications for overeating disorders
Peciña, S., & Smith, K. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.016 · Cited by 104 · see citing works
“…pallidum to include, at least, endocannabinoid and GABAergic transmission, especially in the accumbens (Jarrett et al., 2005, 2007; Kirkham, 2009; Mahler et al., 2007; Reynolds and Berridge, 2002), benzodiazepine activity, especially in the brainstem parabrachial nucleus (Higgs and Cooper,…”
The neuropsychology of consumer behavior and marketing
Shaw, S. D., & Bagozzi, R. P. (2017) · Consumer Psychology Review · doi:10.1002/arcp.1006 · Cited by 112 · see citing works
The neurobiology of stress management.
Esch, T., & Stefano, G. B. (2010) · PubMed · Cited by 103 · see citing works
HPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 130 · see citing works
Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits
Lau, B. K., Cota, D., Cristino, L., & Borgland, S. L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.05.033 · Cited by 102 · see citing works
“Indeed, direct administration of endocannabinoids in the NAc induces a hedonic taste reactivity response (Mahler et al., 2007).”
BackgroundAdolescent neurodevelopment and substance use: receptor expression and behavioral consequences
Thorpe, H. H. A., Hamidullah, S., Jenkins, B. W., & Khokhar, J. Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107431 · Cited by 97 · see citing works
Higgs, S., Spetter, M. S., Thomas, J. M., Rotshtein, P., Lee, M. D., Hallschmid, M., & Dourish, C. T. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117736917 · Cited by 103 · see citing works
Dissecting the cannabinergic control of behavior: The where matters
Busquets-García, A., Desprez, T., Metna‐Laurent, M., Bellocchio, L., Marsicano, G., & Gómez, E. S. (2015) · BioEssays · doi:10.1002/bies.201500046 · Cited by 99 · see citing works
New insights on the role of the endocannabinoid system in the regulation of energy balance
Gatta‐Cherifi, B., & Cota, D. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.179 · Cited by 100 · see citing works
Resendez, S. L., Dome, M., Gormley, G., Franco, D., Nevárez, N., Hamid, A. A., & Aragona, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4123-12.2013 · Cited by 93 · see citing works
“For example, the rostral dorsomedial NAc shell modulates positive hedonics, whereas the ventral NAc shell does not (Pecina and Berridge, 2005; Mahler et al., 2007; Faure et al., 2010; Smith et al., 2010).”
BackgroundIntestinal lipid–derived signals that sense dietary fat
DiPatrizio, N. V., & Piomelli, D. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76302 · Cited by 97 · see citing works
The endocannabinoid system as a target for the treatment of cannabis dependence
Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.018 · Cited by 92 · see citing works
“Injections of anandamide into the shell of the nucleus accumbens have been shown to increase positive ‘liking’ reactions to intraoral sucrose in rats (Mahler et al., 2007).”
BackgroundCannabinoid facilitation of behavioral and biochemical hedonic taste responses
Luca, M. A. D., Solinas, M., Bimpisidis, Z., Goldberg, S. R., & Chiara, G. D. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.10.018 · Cited by 91 · see citing works
“Finally, Mahler et al. (2007) found that intra-shell injections of the endogenous cannabinoid anandamide also increased hedonic reactions to sucrose.”
BackgroundSuardi, A., Sotgiu, I., Costa, T., Cauda, F., & Rusconi, M. (2016) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-016-0414-7 · Cited by 80 · see citing works
The adolescent brain: Insights from functional neuroimaging research
Ernst, M., & Mueller, S. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20615 · Cited by 85 · see citing works
“Within neuroscience, they have been probed within three major disciplines: addiction (Pecina et al., 2006; Mahler et al., 2007), learning (Martin-Soelch et al., 2007), and decision-making (Ernst and Paulus, 2005).”
BackgroundFAAH deficiency promotes energy storage and enhances the motivation for food
Touriño, C., Oveisi, F., Lockney, J., Piomelli, D., & Maldonado, R. J. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.262 · Cited by 87 · see citing works
“AEA stimulates appetite when administered systemically (12) and locally in the hypothalamus (5), and enhances the incentive value of food when administered into the nucleus accumbens (13).”
BackgroundThe endocannabinoid system and nondrug rewarding behaviours
Fattore, L., Melis, M., Fadda, P., Pistis, M., & Fratta, W. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.020 · Cited by 88 · see citing works
Keeney, B. K., Raichlen, D. A., Meek, T. H., Wijeratne, R. S., Middleton, K. M., Gerdeman, G. L., & Garland, T. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32831c3b6b · Cited by 86 · see citing works
Arpana Agrawal, A., Nelson, E. C., Littlefield, A. K., Bucholz, K. K., Degenhardt, L. J., Henders, A. K., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Pergadia, M. L., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2273 · Cited by 83 · see citing works
“Both eCBS and chronic stress are independently associated with hedonic capacity.(4,17) However, the link between chronic stress, anhedonia, and the endocannabinoid system is highly complex.”
BackgroundAyres, C., Agranonik, M., Portella, A. K., Filion, F., Johnston, C. C., & Silveira, P. P. (2012) · International Journal of Pediatrics · doi:10.1155/2012/657379 · Cited by 81 · see citing works
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats
DiPatrizio, N. V., Joslin, A., Jung, K., & Piomelli, D. (2013) · The FASEB Journal · doi:10.1096/fj.13-227587 · Cited by 81 · see citing works
Roitman, M. F., Wheeler, R. A., Tiesinga, P. H. E., Roitman, J. D., & Carelli, R. M. (2010) · Learning & Memory · doi:10.17615/f90b-8s20 · Cited by 81 · see citing works
Chiara, V. D., Errico, F., Musella, A., Rossi, S., Mataluni, G., Sacchetti, L., Siracusano, A., Castelli, M., Cavasinni, F., Bernardi, G., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.141 · Cited by 78 · see citing works
The Functional and Neurobiological Properties of Bad Taste
Schier, L. A., & Spector, A. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2017 · Cited by 75 · see citing works
The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer’s disease
Karl, T., Garner, B., & Cheng, D. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000247 · Cited by 78 · see citing works
Dissecting motivational circuitry to understand substance abuse
Wheeler, R. A., & Carelli, R. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.028 · Cited by 77 · see citing works
“Opioid, GABA, and cannabanoid agonist microinfusions into the NAc shell increase appetitive behavior and hedonic responses for gustatory stimuli (Kelley et al., 2002; Kelley and Swanson, 1997; Mahler et al., 2007; Pecina and Berridge, 2000, 2005; Reynolds and Berridge, 2002).”
BackgroundRoles of nucleus accumbens and basolateral amygdala in autoshaped lever pressing
Chang, S. E., Wheeler, D. S., & Holland, P. C. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.03.008 · Cited by 68 · see citing works
Behavioural activation system sensitivity is associated with cerebral μ-opioid receptor availability
Karjalainen, T., Tuominen, L. J., Manninen, S., Kalliokoski, K. K., Nuutila, P., Jääskeläinen, I. P., Hari, R., Sams, M. E., & Nummenmaa, L. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw044 · Cited by 74 · see citing works
“contribute to motivational and reward functions (Mahler et al., 2007; Fields and Margolis, 2015).”
“Wanting,” “liking,” and their relation to consciousness.
Anselme, P., & Robinson, M. J. F. (2015) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000090 · Cited by 73 · see citing works
- Authors
- Mahler, S. V., Smith, K. S., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- Venue
- Neuropsychopharmacology
- Published
- 2007-04-04
- Volume
- 32
- Issue
- 11
- Pages
- 2267-2278
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2096012985
- Semantic Scholar
- c3722206c8cdf7589109f0c15c2ec82f8c398a76
- Cited by
- 377
- References
- 60
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 9 · 2023: 16 · 2022: 27 · 2021: 19 · 2020: 16 · 2019: 18 · 2018: 22 · 2017: 22 · 2016: 21 · 2015: 24 · 2014: 19 · 2013: 24 · 2012: 33
- FWCI
- 15.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DC00011)
- National Institute of Mental Health (MH063649, R01MH063649)
- National Institute on Drug Abuse (DC00011, DA021481, DA015188, R01DA015188, F31DA021481)
- National Institute on Deafness and Other Communication Disorders (DC-00011)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- anandamide, endocannabinoids, nucleus accumbens shell, sensory pleasure, taste reactivity, sucrose, quinine, Fos expression, natural reward, dietary habits
- MeSH terms
- Analysis of Variance, Animals, Arachidonic Acids, Behavior, Animal, Dose-Response Relationship, Drug, Feeding Behavior, Food Preferences, Gene Expression Regulation, Male, Microinjections, Nucleus Accumbens, Reaction Time, Reward, Sucrose, Sweetening Agents, Taste, Oncogene Proteins v-fos, Rats, Sprague-Dawley, Rats, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
