The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
P2X7Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+Signaling
Open accessAbstract
Modulation of synaptic transmission and brain microcirculation are new roles ascribed to astrocytes in CNS function. A mechanism by which astrocytes modify neuronal activity in the healthy brain depends on fluctuations of cytosolic Ca 2+levels, which regulate the release of “gliotransmitters” via an exocytic pathway. Under pathological conditions, however, the participation of other pathways, including connexin hemichannels and the pore-forming P2X 7 R, have been proposed but remain controversial. Through the use of genetically modified 1321N1 human astrocytoma cells and of spinal cord astrocytes derived from neonatal Cx43- and P2X 7 R-null mice, we provide strong evidence that P2X 7 Rs, but not Cx43 hemichannels, are sites of ATP release that promote the amplification of Ca 2+signal transmission within the astrocytic network after exposure to low divalent cation solution. Moreover, our results showing that gap junction channel blockers (heptanol, octanol, carbenoxolone, flufenamic acid, and mefloquine) are antagonists of the P2X 7 R indicate the inadequacy of using these compounds as evidence for the participation of connexin hemichannels as sites of gliotransmitter release.
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Reanalysis of P2X7Receptor Expression in Rodent Brain
Sim, J. A., Young, M. T., Sung, H.-Y., North, R. A., & Surprenant, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-04.2004 · Cited by 264
Carbenoxolone Inhibition of Voltage-Gated Ca Channels and Synaptic Transmission in the Retina
Vessey, J. P., Lalonde, M. R., Mizan, H. A., Welch, N. C., Kelly, M. E. M., & Barnes, S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00148.2004 · Cited by 178
Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
Papp, L., Vizi, E. S., & Sperlágh, B. (2004) · Neuroreport · doi:10.1097/00001756-200410250-00017 · Cited by 102
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P2X7 receptors mediate ischemic damage to oligodendrocytes
Domercq, M., Perez‐Samartin, A., Aparicio, D., Alberdi, E., Pampliega, O., & Matute, C. (2010) · Glia · doi:10.1002/glia.20958 · Cited by 221
Juszczak, G. R., & Swiergiel, A. H. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.014 · Cited by 211
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Glial Connexins and Pannexins in the Healthy and Diseased Brain
Giaume, C., Naus, C. C., Sáez, J. C., & Leybaert, L. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2018 · Cited by 154
Cellular localization of P2X7 receptor mRNA in the rat brain
Yu, Y., Ugawa, S., Ueda, T., Ishida, Y., Inoue, K., Kyaw Nyunt, A., Umemura, A., Mase, M., Yamada, K., & Shimada, S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.11.064 · Cited by 132
P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129
Lrp4 in astrocytes modulates glutamatergic transmission
Sun, X.-D., Li, L., Liu, F., Huang, Z.-H., Bean, J. C., Jiao, H.-F., Barik, A., Kim, S.-M., Wu, H., Shen, C., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4326 · Cited by 102
Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti
Piazza, V., Ciubotaru, C. D., Gale, J. E., & Mammano, F. (2007) · Cell Calcium · doi:10.1016/j.ceca.2006.05.005 · Cited by 105
Marcoli, M., Cervetto, C., Paluzzi, P., Guarnieri, S., Alloisio, S., Thellung, S., Nobile, M., & Maura, G. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05322.x · Cited by 70
Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors
Khakpay, R., Polster, D., Köles, L., Skorinkin, A., Szabo, B., Wirkner, K., & Illes, P. (2010) · Purinergic Signalling · doi:10.1007/s11302-010-9198-3 · Cited by 24
Metadata
- Authors
- Suadicani, S. O., Brosnan, C. F., & Scemes, E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-01
- Volume
- 26
- Issue
- 5
- Pages
- 1378-1385
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2068517470
- Cited by
- 512
- References
- 4
- FWCI
- 21.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
