Properties of Synaptically Evoked Astrocyte Calcium Signal Reveal Synaptic Information Processing by Astrocytes
Open accessAbstract
The synaptic control of the astrocytic intracellular Ca 2+is crucial in the reciprocal astrocyte-neuron communication. Using electrophysiological and Ca 2+imaging techniques in rat hippocampal slices, we investigated the astrocytic Ca 2+signal modulation induced by synaptic terminals that use glutamate and acetylcholine. Ca 2+elevations were evoked by glutamate released from Schaffer collaterals and by acetylcholine, but not glutamate, released by alveus stimulation, indicating that astrocytes discriminate the activity of different synapses belonging to different axon pathways. The Ca 2+signal was modulated bidirectionally by simultaneous activation of both pathways, being depressed at high stimulation frequencies and enhanced at low frequencies. The Ca 2+modulation was attributable to astrocytic intrinsic properties, occurred at discrete regions of the processes, and controlled the intracellular expansion of the Ca 2+signal. In turn, astrocyte Ca 2+signal elicited NMDA receptor-mediated currents in pyramidal neurons. Therefore, because astrocytes discriminate and integrate synaptic information, we propose that they can be considered as cellular elements involved in the information processing by the nervous system.
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Acetylcholine released during vigilance activates astrocyte networks and promotes astrocyte-mediated neuronal modulation.
“Acetylcholine, which is released during vigilance state by long-range cholinergic fibers (modulating attention and learning), also activates astrocyte networks and promotes astrocyte-mediated neuronal modulation 32, 52, 53, 55, 65 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [65]
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- Authors
- Perea, G., & Araque, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Araque, Alfonso
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-03-02
- Volume
- 25
- Issue
- 9
- Pages
- 2192-2203
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6726085
- OpenAlex
- W2070408678
- Cited by
- 488
- References
- 53
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 19 · 2023: 27 · 2022: 18 · 2021: 28 · 2020: 16 · 2019: 24 · 2018: 30 · 2017: 14 · 2016: 22 · 2015: 28 · 2014: 22 · 2013: 23 · 2012: 39
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- astrocytes, astrocyte calcium signaling, synaptic modulation, glutamate, acetylcholine, Schaffer collaterals, alveus, hippocampus, synaptic integration, NMDA receptor currents, pyramidal neurons, astrocyte-neuron communication
- MeSH terms
- Acetylcholine, Aniline Compounds, Animals, Animals, Newborn, Astrocytes, Atropine, Calcium, Cell Communication, Diagnostic Imaging, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, Glial Fibrillary Acidic Protein, Glycine, Hippocampus, Immunohistochemistry, Synaptic Transmission, Neurons, Synapses, Tetrodotoxin, Xanthenes, 4-Aminopyridine, Rats, Wistar, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Glutamic Acid, Muscarinic Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Excitatory Postsynaptic Potentials, Calcium Signaling, Potassium Channel Blockers, Rats, In Vitro Techniques
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