MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280

Pericytes are required for blood–brain barrier integrity during embryogenesis

Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128

A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes

Baldi, P., & Long, A. D. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.6.509 · Cited by 1,615

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H.-W., Chang, T.-C., Vivekanandan, P., Torbenson, M., Clark, K. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.021 · Cited by 1,452

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325

A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors

Voorhoeve, P. M., le Sage, C., Schrier, M., Gillis, A., Stoop, H., Nagel, R., Liu, Y. P., van Duijse, J., Drost, J., Griekspoor, A., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.037 · Cited by 1,266

Involvement of noncoding RNA in blood-brain barrier integrity in central nervous system disease

Liu, X., Shen, L., Han, B., & Yao, H. (2021) · Non-coding RNA Research · doi:10.1016/j.ncrna.2021.06.003 · Cited by 13

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Greenwood, J., Hammarlund‐Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbroucke, R. E., Romero, I. A., Campbell, M., Fricker, G., Brodin, B., Manninga, H., et al. (2017) · Fluids and Barriers of the CNS · doi:10.1186/s12987-017-0079-9 · Cited by 12

Urine microRNA Profiling Displays miR-125a Dysregulation in Children with Fragile X Syndrome

Putkonen, N., Laiho, A., Ethell, D. W., Pursiheimo, J., Anttonen, A., Pitkonen, J., Gentile, A., de Diego‐Otero, Y., & Castrén, M. L. (2020) · Cells · doi:10.3390/cells9020289 · Cited by 12

Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation

Geranmayeh, M. H., Nourazarian, A., Avcı, Ç. B., Rahbarghazi‬, R., & Farhoudi, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0286-4 · Cited by 12

The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Xu, L., Li, L., Chen, Q., Huang, Y., Chen, X., & Qiao, D. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01323-x · Cited by 9

Differentially expressed micro RNA in multiple sclerosis: A window into pathogenesis?

Martin, N. A., & Illés, Z. (2014) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12131 · Cited by 8

Hypoxia preconditioned MSC exosomes attenuate high-altitude cerebral edema via the miR-125a-5p/RTEF-1 axis to protect vascular endothelial cells

Zuo, J., Liang, J., Hu, N., Yao, B., Zhang, Q. Q., Zeng, X., Zhang, L.-J., Zhang, X. D., Chang, Z., Chen, C., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.06.018 · Cited by 7

miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats

Orzeł-Gajowik, K., Milewski, K., & Zielińska, M. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00484-7 · Cited by 6

Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment

Tahmasebi, F., Asl, E. R., Vahidinia, Z., & Barati, S. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01478-1 · Cited by 6

Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?

Yerlikaya, F. H., Onmaz, D. E., Altunhan, H., & İlhan, M. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13472 · Cited by 5

Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis

Franzoi, A. E. D. A., Machado, F. S. D. M., de Medeiros, W. L. G., Bandeira, I. P., Brandão, W. N., & Gonçalves, M. V. M. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07263 · Cited by 5

Crosstalk between breast cancer-derived microRNAs and brain microenvironmental cells in breast cancer brain metastasis

Khan, M. S., Wong, G. L., Zhuang, C., Najjar, M. K., & Lo, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1436942 · Cited by 5

Downregulation of miR-125a-5p and miR-218-5p in Peripheral Blood Mononuclear Cells of Patients with Relapsing-Remitting Multiple Sclerosis

Mosarrezaii, A., Rezaei, S., Nalivan, F. Z., Babaie, F., Nikpour, M. R. A., & Torkamandi, S. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1909616 · Cited by 5

Epigenetics and the role of nutraceuticals in health and disease

El-Sayed, A., Aleya, L., & Kamel, M. S. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-25236-w · Cited by 6

Human‐BasedIn VitroBrain Endothelial Cell Models

Wilson, H. K., & Shusta, E. V. (2015) · Wiley eBooks · doi:10.1002/9781118788523.ch11 · Cited by 5

Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava

SUN, G.-X., Su, Y., Li, Y., ZHANG, Y.-F., Xu, L., Zu, M., Huang, S., ZHANG, J.-P., & LU, Z.-J. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.2981 · Cited by 4

Molecule of the month: miRNA and Multiple Sclerosis

Shapshak, P. (2013) · Bioinformation · doi:10.6026/97320630009847 · Cited by 4

Epigenetic Mechanisms of the Pathogenesis of Multiple Sclerosis

Вахитов, В. А., Kuzmina, U. S., Bakhtiyarova, K. Z., Зайнуллина, Л. Ф., Maksimova, M. A., Zileeva, Z. R., & Vakhitova, Y. V. (2020) · Human Physiology · doi:10.1134/s0362119720010144 · Cited by 4

The significance of miRNA-191-5P and miRNA-24-3P as novel biomarkers for multiple sclerosis: a case–control study

Shaheen, N., Sherif, M., Hassan, A., Toukhy, M. M. E., Ahmed, S. R. M. S., Samy, L. A., & Tamim, H. H. (2024) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-023-00467-1 · Cited by 3

Anatomy and Physiology of the Blood-Brain Barriers*

Abbott, N. J. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_1 · Cited by 4

Les microARN

Jagot, F., & Davoust, N. (2017) · médecine/sciences · doi:10.1051/medsci/20173306019 · Cited by 4

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Eyileten, C., Wicik, Z., Shahzadi, A., Ahmadova, S., Czajka, P., Domitrz, I., Wierzchowska‐Ciok, A., Mirowska-Guzel, D. M., Członkowska, A., & Postula, M. A. (2026) · Scientific Reports · doi:10.1038/s41598-026-36494-2 · Cited by 2

Lateral Amyotrophic Sclerosis and Intestinal Microbiota Transplantation

Tiburcio, Á. Z. (2019) · Gastroenterology Medicine & Research · doi:10.31031/gmr.2019.03.000558 · Cited by 1

Processo epigenéticos envolvidos na fisiopatologia da esclerose múltipla com ênfase na função dos miRNAs

Siqueira, M. K. D., & Pires, L. C. (2017) · Semina Ciências Biológicas e da Saúde · doi:10.5433/1679-0367.2016v37n2p125 · Cited by 1

microRNAs in Brain Endothelium and Inflammation

Roig-Carles, D., Cerutti, C., Lopez‐Ramirez, M. A., Wu, D., Male, D. K., de Vries, H. E., & Romero, I. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-45514-3_7 · Cited by 1

Mechanisms for Extracellular Matrix-Dependent Blood-Brain Barrier Dysfunction

Hoettles, B. A. (2021) · doi:10.18122/td/1903/boisestate · Cited by 1

Extracellular vesicle miRNA signatures in pediatric onset-multiple sclerosis and obesity-driven immune and metabolic dysregulationPreprint

Hade, M. D., Reátegui, E., Brenton, J. N., & Magaña, S. M. (2025) · medRxiv · doi:10.1101/2025.07.16.25331404 · Cited by 2

GENETIC AND EPIGENETIC FACTORS SHAPING THE TRANSCRIPTOME IN MULTIPLE SCLEROSIS AND ITS ANIMAL MODEL

Bergman, P. (2014) · Figshare

Serum microRNA profile and serum neuron specific enolase, S-100, and interleukin-6 level as biomarkers for differentiating acute vertigo between cerebellar or brainstem infarction and peripheral vertigo

Kijpaisalratana, N., Charnnarong, N., Payungporn, S., & Pisitkun, T. (2019) · Chula Digiverse · doi:10.58837/chula.the.2019.371

Role of miR-30e-5p in the Occurrence and Development of Posterior Circulation Ischemic Stroke

Zhu, Y., Long, F., Peng, T., Zhou, B., & Wang, Q. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700163

Additional file 1 of Serum miRNA125a-5p, miR-125b-5p, and miR-433-5p as biomarkers to differentiate between posterior circulation stroke and peripheral vertigo

Kijpaisalratana, N., Nimsamer, P., Khamwut, A., Payungporn, S., Pisitkun, T., Chutinet, A., Utoomprurkporn, N., Kerr, S. J., Vongvasinkul, P., & Suwanwela, N. C. (2020) · Figshare · doi:10.6084/m9.figshare.13077534

Additional file 1 of miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats

Orzeł-Gajowik, K., Milewski, K., & Zielińska, M. (2024) · Figshare · doi:10.6084/m9.figshare.26651445

Design of albumin-based nanotherapeutics for glioblastoma management: Biological barriers, targeting strategies, and translational perspectives

Salunkhe, D. S., Nangare, S., Jadhav, N. R., Tade, R. S., Desai, A., & Vihal, S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151872 · Cited by 1

Multiple sclerosis: The role of miRNAs and their implications in cellular pathways

Ellakwa, D. E., Amer, A., Ibrahim, A., Aboeleneen, R., Wadan, A. S., & Ellakwa, T. E. (2026) · Human Gene · doi:10.1016/j.humgen.2026.201562

How do pro-inflammatory cytokines alter miRNA profiles in brain endothelial cells? Mechanisms, consequences, and therapeutic strategies for blood-brain barrier protection

Metwally, N. G., Mohamad, S., & Bruchhaus, I. (2026) · Frontiers in Malaria · doi:10.3389/fmala.2026.1849845 · Cited by 1

MicroRNA Profiling of the Pathophysiological Mechanisms Underlying Carotid Atherosclerosis Progression

Prus, K., Sanvitti, M., & Bilotta, F. (2026) · Biomolecules · doi:10.3390/biom16071026

Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging

Terribile, G., Pedrinazzi, M., Frigerio, I., Sancini, G., & Combi, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167165

Plasma microRNA dysregulation in treatment-naïve primary progressive multiple sclerosis: an exploratory case-control study

Eker, E. D., Yetişgin, S. O., Altıntaş, Z. M., Ünal, N., Şahin, N. Ö., & Sevim, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12987-1

The Blood-Brain Barrier in Multiple Sclerosis: microRNAs as Key Regulators

Kamphuis, W. W., Troletti, C. D., Reijerkerk, A., Romero, I. A., & de Vries, H. E. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150116125246 · Cited by 65

MicroRNAs in Brain Endothelium and Inflammation

Cerutti, C. (2016) · Bristol Research (University of Bristol)

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation

Lopez‐Ramirez, M. A., Reijerkerk, A., de Vries, H. E., & Romero, I. A. (2016) · The FASEB Journal · doi:10.1096/fj.201600435rr · Cited by 55

Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination

Yu, Z., Xue, F., Liu, W., Sun, R. X., Zhou, J., Pu, Y., Zhao, M., Sun, D., Xiang, Z., Liu, P., et al. (2022) · Advanced Science · doi:10.1002/advs.202105442 · Cited by 71

MicroRNA‐155 negatively affects blood–brain barrier function during neuroinflammation

Lopez‐Ramirez, M. A., Wu, D., Pryce, G., Simpson, J. E., Reijerkerk, A., King‐Robson, J., Kay, O., de Vries, H. E., Hirst, M. C., Sharrack, B., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-248880 · Cited by 233