Prat, Alexandre

The blood-brain barrier

Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 3,437

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 1,759

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine

Tryptophan and brain disordersinterferon and immune responses

Cited by 1,559

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., et al. (2011) · Science

Barrier Structure and Function StudiesHedgehog Signaling Pathway Studies

Cited by 845

An updated histological classification system for multiple sclerosis lesions

Kuhlmann, T., Ludwin, S., Prat, A., Antel, J., Brück, W., & Lassmann, H. (2017) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 692

Preferential recruitment of interferon‐γ–expressing T H 17 cells in multiple sclerosis

Kebir, H., Ifergan, I., Alvarez, J. I., Bernard, M., Poirier, J., Arbour, N., Duquette, P., & Prat, A. (2009) · Annals of Neurology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 551

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Takenaka, M. C., Gabriely, G., Rothhammer, V., Mascanfroni, I. D., Wheeler, M. A., Chao, C.-C., Gutiérrez-Vázquez, C., Kenison, J., Tjon, E. C., Barroso, A., et al. (2019) · Nature Neuroscience

Immune cells in cancerGlioma Diagnosis and Treatment

Cited by 517

MAFG-driven astrocytes promote CNS inflammation

Wheeler, M. A., Clark, I. C., Tjon, E. C., Li, Z., Zandee, S. E. J., Couturier, C. P., Watson, B. R., Scalisi, G., Alkwai, S., Rothhammer, V., et al. (2020) · Nature

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 501

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

Cayrol, R., Wosik, K., Berard, J. L., Dodelet-Devillers, A., Ifergan, I., Kebir, H., Haqqani, A. S., Kreymborg, K., Krug, S., Moumdjian, R., et al. (2008) · Nature Immunology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 444

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

Larochelle, C., Alvarez, J. I., & Prat, A. (2011) · FEBS Letters

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 405

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

Rojas, O. L., Pröbstel, A.-K., Porfilio, E. A., Wang, A. A., Charabati, M., Sun, T., Lee, D. S. W., Galicia, G., Ramaglia, V., Ward, L. A., et al. (2019) · Cell

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 382

Glial cell influence on the human blood‐brain barrier

Prat, A., Biernacki, K., Wosik, K., & Antel, J. P. (2001) · Glia

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 334

Disruption of central nervous system barriers in multiple sclerosis

Alvarez, J. I., Cayrol, R., & Prat, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 334

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

Sanmarco, L. M., Wheeler, M. A., Gutiérrez-Vázquez, C., Polonio, C. M., Linnerbauer, M., Pinho-Ribeiro, F. A., Li, Z., Giovannoni, F., Batterman, K. V., Scalisi, G., et al. (2021) · Nature

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 331

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Clark, I. C., Gutiérrez-Vázquez, C., Wheeler, M. A., Li, Z., Rothhammer, V., Linnerbauer, M., Sanmarco, L. M., Guo, L., Blain, M., Zandee, S. E. J., et al. (2021) · Science

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 285

Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

Greenwood, J., Heasman, S. J., Alvarez, J. I., Prat, A., Lyck, R., & Engelhardt, B. (2011) · Neuropathology and Applied Neurobiology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 240

Integration of Th17- and lymphotoxin-derived signals initiates meningeal-resident stromal cell remodeling to propagate neuroinflammation.

Pikor, N. B., Astarita, J. L., Summers-Deluca, L., Galicia, G., Qu, J., Ward, L. A., Armstrong, S., Dominguez, C. X., Malhotra, D., Heiden, B., et al. (2015) · Immunity

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 229

Retinoic Acid Induces Blood–Brain Barrier Development

Mizee, M. R., Wooldrik, D., Lakeman, K. A. M., van het Hof, B., Drexhage, J. A. R., Geerts, D., Bugiani, M., Aronica, E., Mebius, R. E., Prat, A., et al. (2013) · The Journal of Neuroscience

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 203

Determinants of Human B Cell Migration Across Brain Endothelial Cells

Alter, A., Duddy, M., Hebert, S., Biernacki, K., Prat, A., Antel, J. P., Yong, V. W., Nuttall, R. K., Pennington, C. J., Edwards, D. R., et al. (2003) · The Journal of Immunology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 195

Netrin 1 regulates blood–brain barrier function and neuroinflammation

Podjaski, C., Alvarez, J. I., Bourbonniere, L., Larouche, S., Terouz, S., Bin, J. M., Lécuyer, M.-A., Saint-Laurent, O., Larochelle, C., Darlington, P. J., et al. (2015) · Brain

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 185

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

Dong, Y., D’Mello, C., Pinsky, W., Lozinski, B. M., Kaushik, D. K., Ghorbani, S., Moezzi, D., Brown, D., Melo, F. C., Zandee, S., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 181

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

Alvarez, J. I., Saint-Laurent, O., Godschalk, A., Terouz, S., Briels, C., Larouche, S., Bourbonnière, L., Larochelle, C., & Prat, A. (2015) · Neurobiology of Disease

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 150

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

Larochelle, C., Cayrol, R., Kebir, H., Alvarez, J. I., Lécuyer, M.-A., Ifergan, I., Viel, É., Bourbonnière, L., Beauseigle, D., Terouz, S., et al. (2012) · Brain

Multiple Sclerosis Research StudiesCell Adhesion Molecules Research

Cited by 145

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., et al. (2013) · The Journal of Neuroscience

Barrier Structure and Function StudiesMicroRNA in disease regulation

Cited by 138