Cited by 138Barrier Structure and Function StudiesMicroRNA in disease regulationMultiple Sclerosis Research Studies

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MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

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Reijerkerk, Arie, Lopez-Ramirez, M. Alejandro, van het Hof, Bert, Drexhage, Joost A.R., Kamphuis, Wouter W., Kooij, Gijs, Vos, Joost B., van der Pouw Kraan, Tineke C.T.M., van Zonneveld, Anton J., Horrevoets, Anton J., Prat, Alexandre, Romero, Ignacio A., de Vries, Helga E.·2013·The Journal of Neuroscience

DOI 10.1523/jneurosci.3965-12.2013PMC PMC6618888

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Abstract

Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.

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Authors: Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., Prat, A., Romero, I. A., & de Vries, H. E.
Affiliations: Amsterdam Neuroscience (NL)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Leiden University Medical Center (NL)
Hôpital Notre-Dame (CA)
The Open University (GB)
ORCID: Kooij, Gijs
Vos, Joost B.
van Zonneveld, Anton J.
Prat, Alexandre
Romero, Ignacio A.
de Vries, Helga E.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2013-04-17
Volume: 33
Issue: 16
Pages: 6857-6863
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3965-12.2013
PMC: PMC6618888
OpenAlex: W2084419599
Cited by: 138
References: 42
Citations by year: 2026: 7 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 5
FWCI: 8.98
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Open Research Online (The Open University) (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Funders: Multiple Sclerosis Society
ZonMw
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: microRNA, blood-brain barrier, brain endothelial cells, multiple sclerosis, miR-125a-5p, tight junctions, BBB dysfunction, inflammation, BBB repair
MeSH terms: Blood-Brain Barrier, Brain, Cell Line, Transformed, Gene Expression Regulation, Genetic Vectors, Humans, Inflammation, Multiple Sclerosis, Transfection, Cytokines, RNA, Small Interfering, MicroRNAs, Endothelial Cells, Transendothelial and Transepithelial Migration

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MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

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