The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
Open accessAbstract
Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recent findings of a long-range crosstalk between periphery and CNS via miRNA-containing exosomes position the BBB in the center of this communication (685) under physiological (635, 660) and pathophysiological (378, 493, 498, 587) conditions.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [493]
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Pericytes are required for blood–brain barrier integrity during embryogenesis
Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128
Baldi, P., & Long, A. D. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.6.509 · Cited by 1,615
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H.-W., Chang, T.-C., Vivekanandan, P., Torbenson, M., Clark, K. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.021 · Cited by 1,452
Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line
Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325
Self-citationA Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors
Voorhoeve, P. M., le Sage, C., Schrier, M., Gillis, A., Stoop, H., Nagel, R., Liu, Y. P., van Duijse, J., Drost, J., Griekspoor, A., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.037 · Cited by 1,266
Cited by
Sorted by citations
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Bai, Y., Zhang, Y., Han, B., Yang, L., Chen, X., Huang, R., Wu, F., Chao, J., Liu, P., Hu, G., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1348-17.2017 · Cited by 379
Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier
Dyken, P. C. V., & Lacoste, B. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00930 · Cited by 377
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338
Factors controlling permeability of the blood–brain barrier
Almutairi, M. M., Chen, G., Xu, Y. G., Chang, Y., & Shi, H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2050-8 · Cited by 321
Factors influencing the blood-brain barrier permeability
Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147937 · Cited by 291
Tiedt, S., Prestel, M., Malik, R., Schieferdecker, N., Duering, M., Kautzky, V., Stoycheva, I., Böck, J., Northoff, B. H., Klein, M., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.311572 · Cited by 279
Michinaga, S., & Koyama, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030571 · Cited by 263
MicroRNA‐155 negatively affects blood–brain barrier function during neuroinflammation
Lopez‐Ramirez, M. A., Wu, D., Pryce, G., Simpson, J. E., Reijerkerk, A., King‐Robson, J., Kay, O., de Vries, H. E., Hirst, M. C., Sharrack, B., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-248880 · Cited by 233
Self-citationTight junction modulation of the blood brain barrier: CNS delivery of small molecules
Greene, C., & Campbell, M. (2016) · Tissue Barriers · doi:10.1080/21688370.2015.1138017 · Cited by 254
Alzheimer's disease and the microbiome
Bhattacharjee, S., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00153 · Cited by 253
Expression, Regulation and Function of MicroRNAs in Multiple Sclerosis
Ma, X., Zhou, J., Yin, Z., Jiang, L., Mu, P., Li, Y., Singh, N. P., Nagarkatti, M., & Nagarkatti, P. S. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8647 · Cited by 207
Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. C. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 202
Brown, T. D., Habibi, N., Wu, D., Lahann, J., & Mitragotri, S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00743 · Cited by 182
MiR-146 and miR-125 in the regulation of innate immunity and inflammation
Lee, H., Kim, T. S., & Jo, E. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.6.056 · Cited by 183
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 151
miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions
Rom, S., Dykstra, H., Zuluaga-Ramirez, V., Reichenbach, N. L., & Persidsky, Y. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.154 · Cited by 118
Disturbed function of the blood–cerebrospinal fluid barrier aggravates neuro-inflammation
Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S. M. A., Hof, B. V. H., Gollasch, M., Drexhage, J., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1227-1 · Cited by 113
Self-citationNijland, P. G., Michailidou, I., Witte, M. E., Mizee, M. R., van der Pol, S. M. A., Hof, B. V. H., Reijerkerk, A., Pellerin, L., van der Valk, P., de Vries, H. E., et al. (2014) · Glia · doi:10.1002/glia.22667 · Cited by 113
Self-citationNon-coding RNAs in cerebral endothelial pathophysiology: Emerging roles in stroke
Yin, K., Hamblin, M., & Chen, Y. E. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.013 · Cited by 106
MicroRNA based theranostics for brain cancer: basic principles
Petrescu, G. E. D., Sabo, A. A., Torsin, L. I., Călin, G. A., & Dragomir, M. P. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1180-5 · Cited by 110
Yang, L., Han, B., Zhang, Y., Bai, Y., Chao, J., Hu, G., & Yao, H. (2017) · Autophagy · doi:10.1080/15548627.2017.1414755 · Cited by 103
DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression
Wingo, A. P., Almli, L. M., Stevens, J. S., Klengel, T., Uddin, M., Li, Y., Bustamante, A. C., Lori, A., Koen, N., Stein, D. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms10106 · Cited by 98
Troletti, C. D., Fontijn, R. D., Gowing, E., Charabati, M., Hof, B. V. H., Didouh, I., van der Pol, S. M. A., Geerts, D., Prat, A., van Horssen, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1294-2 · Cited by 96
Self-citationEpigenetic control of autoimmune diseases: From bench to bedside
Picascia, A., Grimaldi, V., Pignalosa, O., Pascale, M. R. D., Schiano, C., & Claudio Napoli, A. (2015) · Clinical Immunology · doi:10.1016/j.clim.2014.12.013 · Cited by 93
Wu, D., Cerutti, C., Lopez‐Ramirez, M. A., Pryce, G., King‐Robson, J., Simpson, J. E., van der Pol, S. M. A., Hirst, M. C., de Vries, H. E., Sharrack, B., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.207 · Cited by 90
Self-citationDalvi, P., Sun, B., Tang, N., & Pulliam, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-10449-0 · Cited by 83
Complement and blood–brain barrier integrity
Jacob, A., & Alexander, J. J. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.039 · Cited by 87
Breast Cancer Brain Metastasis—Overview of Disease State, Treatment Options and Future Perspectives
Watase, C., Shiino, S., Shimoi, T., Noguchi, E., Kaneda, T., Yamamoto, Y., Yonemori, K., Takayama, S., & Suto, A. (2021) · Cancers · doi:10.3390/cancers13051078 · Cited by 84
Bai, Y., Zhang, Y., Hua, J., Yang, X., Zhang, X., Duan, M., Zhu, X., Huang, W., Chao, J., Zhou, R., et al. (2016) · Scientific Reports · doi:10.1038/srep35642 · Cited by 78
Lecca, D., Marangon, D., Coppolino, G., Méndez, A. M., Finardi, A., Costa, G. D., Martinelli, V., Furlan, R., & Abbracchio, M. P. (2016) · Scientific Reports · doi:10.1038/srep34503 · Cited by 76
Mirnas as Biomarkers of Neurodegenerative Disorders
Viswambharan, V., Thanseem, I., Vasu, M. M., Poovathinal, S. A., & Anitha, A. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0242 · Cited by 76
Ma, F., Zhang, X., & Yin, K. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113094 · Cited by 72
Danka Mohammed, C. P., Park, J. S., Nam, H. G., & Kim, K. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.01.007 · Cited by 69
microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy
Kanchan, R. K., Siddiqui, J. A., Mahapatra, S., Batra, S. K., & Nasser, M. W. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1140-x · Cited by 70
Freiesleben, S., Hecker, M., Zettl, U. K., Fuellen, G., & Taher, L. (2016) · Scientific Reports · doi:10.1038/srep34512 · Cited by 66
Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis
Wade, S. M., Ohnesorge, N., McLoughlin, H. S., Biniecka, M., Carter, S. P., Trenkmann, M., Cunningham, C. C., McGarry, T., Canavan, M., Kennedy, B. N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.043 · Cited by 66
The Blood-Brain Barrier in Multiple Sclerosis: microRNAs as Key Regulators
Kamphuis, W. W., Troletti, C. D., Reijerkerk, A., Romero, I. A., & de Vries, H. E. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150116125246 · Cited by 65
Self-citationMicroRNAs associated with the pathogenesis of multiple sclerosis
Huang, Q., Xiao, B., Ma, X., Qu, M., Li, Y., Nagarkatti, P. S., Nagarkatti, M., & Zhou, J. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.04.014 · Cited by 65
Sun, P., Hamblin, M. H., & Yin, K. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00317-z · Cited by 67
Pathomechanisms of Blood-Brain Barrier Disruption in ALS
Kakaroubas, N., Brennan, S. E., Keon, M., & Saksena, N. (2019) · Neuroscience Journal · doi:10.1155/2019/2537698 · Cited by 63
Ghadiri, N., Emamnia, N., Ganjalıkhani-Hakemi, M., Ghaedi, K., Etemadifar, M., Salehi, M., Shirzad, H., & Nasr‐Esfahani, M. H. (2018) · Gene · doi:10.1016/j.gene.2018.03.035 · Cited by 56
Pinheiro, M. A. L., Kamermans, A., García-Vallejo, J. J., Hof, B. V. H., Wierts, L., O’Toole, T. G., Boeve, D., Verstege, M. I., van der Pol, S. M. A., van Kooyk, Y., et al. (2016) · eLife · doi:10.7554/elife.13149 · Cited by 59
Muñoz‐Culla, M., Irizar, H., Castillo‐Triviño, T., Sáenz-Cuesta, M., Sepúlveda, L., Lopetegi, I., de Munaín, A. L., Olascoaga, J., Baranzini, S. E., & Otaegui, D. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514534513 · Cited by 56
Lopez‐Ramirez, M. A., Male, D. K., Wang, C., Sharrack, B., Wu, D., & Romero, I. A. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-27 · Cited by 60
Self-citationRegulation of brain endothelial barrier function by microRNAs in health and neuroinflammation
Lopez‐Ramirez, M. A., Reijerkerk, A., de Vries, H. E., & Romero, I. A. (2016) · The FASEB Journal · doi:10.1096/fj.201600435rr · Cited by 55
Self-citationTargeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice
Li, J., Zhao, Y., Choi, J. P., Ting, K. K., Coleman, P. R., Chen, J., Cogger, V. C., Wan, L., Shi, Z., Møller, T., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000734 · Cited by 52
P-glycoprotein regulates trafficking of CD8+ T cells to the brain parenchyma
Kooij, G., Kroon, J., Paul, D., Reijerkerk, A., Geerts, D., van der Pol, S. M. A., Hof, B. V. H., Drexhage, J., van Vliet, S. J., Hekking, L. H. P., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1244-8 · Cited by 53
Self-citationAmoruso, A., Blonda, M., Gironi, M., Grasso, R., Di Francescantonio, V., Scaroni, F., Furlan, R., Verderio, C., & Avolio, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-63282-3 · Cited by 46
Small and Long Regulatory RNAs in the Immune System and Immune Diseases
Stachurska, A., Zorro, M. M., van der Sijde, M. R., & Withoff, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00513 · Cited by 48
Is It worth Considering Circulating microRNAs in Multiple Sclerosis?
Jagot, F., & Davoust, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00129 · Cited by 45
Nuzziello, N., Vilardo, L., Pelucchi, P., Consiglio, A., Liuni, S., Trojano, M., & Liguori, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113652 · Cited by 46
de Bruin, R. G., van der Veer, E. P., Prins, J., Lee, D. H., Dane, M. J. C., Zhang, H., Roeten, M. K., Bijkerk, R., de Boer, H. C., Rabelink, T. J., et al. (2016) · Scientific Reports · doi:10.1038/srep21643 · Cited by 46
Epigenetics in blood–brain barrier disruption
Ihezie, S. A., Mathew, I. E., McBride, D. W., Dienel, A., Blackburn, S., & Pandit, P. K. T. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00250-7 · Cited by 48
Harati, R., Hammad, S., Tlili, A., Mahfood, M., Mabondzo, A. M., & Hamoudi, R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262152 · Cited by 50
MicroRNA-150: A potential regulator in pathogens infection and autoimmune diseases
Huang, X., Zhang, L., Li, J., Wang, Y., Duan, Y., & Wang, J. (2015) · Autoimmunity · doi:10.3109/08916934.2015.1072518 · Cited by 44
Wang, P., Pan, R., Weaver, J. M. R., Jia, M., Yang, X. P., Yang, T., Liang, J., & Liu, K. J. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20926787 · Cited by 44
Non-coding RNAs: the extensive and interactive regulators of the blood-brain barrier permeability
Yang, R., Xu, B., Yang, B., Fu, J., Chen, H., & Wang, X. (2021) · RNA Biology · doi:10.1080/15476286.2021.1950465 · Cited by 45
Impact of extracellular RNA on endothelial barrier function
Fischer, S., Cabrera-Fuentes, H. A., Noll, T., & Preissner, K. T. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1850-8 · Cited by 43
The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
Duffy, C. P., & McCoy, C. E. (2020) · Cells · doi:10.3390/cells9071711 · Cited by 42
Tarantini, S., Giles, C. B., Wren, J. D., Ashpole, N. M., Valcarcel‐Ares, M. N., Wei, J. Y., Sonntag, W. E., Ungvari, Z. I., & Csiszár, A. (2016) · AGE · doi:10.1007/s11357-016-9943-9 · Cited by 41
Using Extracellular Circulating microRNAs to Classify the Etiological Subtypes of Ischemic Stroke
Gui, Y., Xu, Z., Jin, T., Zhang, L., Chen, L., Hong, B., Xie, F., Lv, W., & Hu, X. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0659-2 · Cited by 40
MicroRNA (miRNA): Sequence and stability, viroid-like properties, and disease association in the CNS
Pogue, A. I., Hill, J. M., & Lukiw, W. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.042 · Cited by 39
Dissecting gene expression at the blood-brain barrier
Huntley, M. A., Bien‐Ly, N., Daneman, R., & Watts, R. J. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00355 · Cited by 41
Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation
Roig-Carles, D., Willms, E., Fontijn, R. D., Pacheco, S., Mäger, I., de Vries, H. E., Hirst, M. C., Sharrack, B., Male, D. K., Hawkes, C. A., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091525 · Cited by 38
Self-citationDicer and microRNA expression in multiple sclerosis and response to interferon therapy
Magner, W. J., Weinstock‐Guttman, B., Rho, M., Hojnacki, D. W., Ghazi, R., Ramanathan, M. K., & Tomasi, T. B. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.01.009 · Cited by 37
Recent insights into endothelial control of leukocyte extravasation
Hordijk, P. L. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2136-y · Cited by 38
Environmental Influencers, MicroRNA, and Multiple Sclerosis
Mohammed, E. M. A. (2020) · Journal of Central Nervous System Disease · doi:10.1177/1179573519894955 · Cited by 39
Targeting microRNAs to Regulate the Integrity of the Blood–Brain Barrier
Wang, J., Xu, F., Zhu, X., Li, X., Li, Y., & Li, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.673415 · Cited by 37
Venkatesha, S. H., Dudics, S., Song, Y., Mahurkar, A., & Moudgil, K. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123990 · Cited by 35
The MALAT1-H19/miR-19b-3p axis can be a fingerprint for diabetic neuropathy
Rajabinejad, M., Asadi, G., Ranjbar, S., Varmaziar, F. R., Karimi, M., Salari, F., Karaji, A. G., Rezaiemanesh, A., & Hezarkhani, L. A. (2022) · Immunology Letters · doi:10.1016/j.imlet.2022.03.004 · Cited by 37
Gut microbiota, epigenetic modification and colorectal cancer.
Rezasoltani, S., Asadzadeh‐Aghdaei, H., Mojarad, E. N., Dabiri, H., Ghanbari, R., & Zali, M. R. (2017) · PubMed Central · Cited by 34
Therapeutic perspective on vascular cognitive impairment
Toyama, K., Spin, J. M., Mogi, M., & Tsao, P. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104266 · Cited by 31
Dong, Y., Fan, X., Wang, Z., Zhang, L., & Guo, S. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147114 · Cited by 31
Wang, Z., Xie, J., Wu, C., & Xiao, G.-R. (2019) · Medical Science Monitor · doi:10.12659/msm.912863 · Cited by 33
Jin, Y., Wu, R., Li, L., Shen, L., Gu, Y., & Sun, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03179-6 · Cited by 30
Li, J., Qiu, D., Chen, Z., Du, W., Liu, J., & Mo, X. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.02.005 · Cited by 28
Anatomy and Physiology of the Blood–Brain Barriers
Abbott, N. J. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_1 · Cited by 26
Extracellular vesicles as contributors in the pathogenesis of multiple sclerosis
Zamboni, S., D’Ambrosio, A., & Margutti, P. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104554 · Cited by 25
Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model
Spampinato, S. F., Merlo, S., Fagone, E., Fruciano, M., Barbagallo, C., Kanda, T., Sano, Y., Purrello, M., Vancheri, C., Ragusa, M., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00337 · Cited by 25
Epigenetics in Multiple Sclerosis
Chan, V. S. F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_12 · Cited by 27
Nejad, A. E., Zadeh, S. M. M., Nickho, H., Abbasian, A. S., Forouzan, A., Ahmadlou, M., Nedaeinia, R., Shaverdi, S., & Manian, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1281567 · Cited by 27
Giuliani, A., Lattanzi, S., Ramini, D., Graciotti, L., Danni, M. C., Procopio, A. D., Silvestrini, M., Olivieri, F., & Sabbatinelli, J. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103126 · Cited by 23
Epigenetics of T lymphocytes in health and disease
Leoni, C., Vincenzetti, L., Emming, S., & Monticelli, S. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14191 · Cited by 23
Hill, W. J. L. J. M. (2014) · Journal of Aging Science · doi:10.4172/2329-8847.1000119 · Cited by 23
Su, P., Zhao, F., Cao, Z., Zhang, J., Aschner, M., & Luo, W. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.05.002 · Cited by 21
Teymoori‐Rad, M., Mozhgani, S., Ghobadi, M. Z., Sahraian, M. A., Nejati, A., Amiri, M. M., Shokri, F., & Marashi, S. M. (2018) · Gene · doi:10.1016/j.gene.2018.12.004 · Cited by 21
Reinhold, A., Yang, S., Chen, J. T.-C., Hu, L., Sauer, R., Krug, S. M., Mambretti, E. M., Fromm, M., Brack, A., & Rittner, H. L. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.008 · Cited by 21
MiRNA-125a-5p attenuates blood–spinal cord barrier permeability under hypoxia in vitro
Wang, J., Zhikui, N., Zhao, H., Gao, K., & Cao, Y. (2019) · Biotechnology Letters · doi:10.1007/s10529-019-02753-8 · Cited by 20
Kijpaisalratana, N., Nimsamer, P., Khamwut, A., Payungporn, S., Pisitkun, T., Chutinet, A., Utoomprurkporn, N., Kerr, S. J., Vongvasinkul, P., & Suwanwela, N. C. (2020) · BMC Neurology · doi:10.1186/s12883-020-01946-3 · Cited by 20
Ma, X., Liao, X., Liu, J., Wang, Y., Wang, X., Chen, Y., Yin, X., & Pan, Q. (2022) · Stroke and Vascular Neurology · doi:10.1136/svn-2021-001476 · Cited by 18
Shen, X., Shao-hong, Z., Li, H., Xi-di, C., Jiang, L., Huang, Q., & Xu, S. (2018) · Medical Science Monitor · doi:10.12659/msm.908555 · Cited by 18
Scavenging the hidden impacts of non-coding RNAs in multiple sclerosis
Elkhodiry, A. A., & Tayebi, H. M. E. (2021) · Non-coding RNA Research · doi:10.1016/j.ncrna.2021.12.002 · Cited by 18
The gut microflora assay in patients with colorectal cancer: in feces or tissue samples?
Rezasoltani, S., Dabiri, H., Asadzadeh‐Aghdaei, H., Sepahi, A. A., Modarressi, M. H., & Mojarad, E. N. (2019) · Iranian Journal of Microbiology · doi:10.18502/ijm.v11i1.696 · Cited by 17
Song, J., Yoon, S. R., & Kim, O. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6051874 · Cited by 16
Guerau‐de‐Arellano, M., & Liu, Y. (2015) · Journal of Autoimmune Disorders · doi:10.21767/2471-8153.100006 · Cited by 16
Regulation of P-glycoprotein by miR-27a-3p at the Brain Endothelial Barrier
Hammad, S., Mabondzo, A. M., Hamoudi, R., & Harati, R. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.10.021 · Cited by 15
MicroRNAs in the biology and hallmarks of neurodegenerative diseases
Dhuppar, S., Poller, W. C., & Murugaiyan, G. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.03.006 · Cited by 16
Fawaz, C. N., Makki, I., Kazan, J. M., Gebara, N. Y., Andary, F. S., Itani, M. M., El-Sayyed, M., Zeidan, A., Quartarone, A., Darwish, H., et al. (2015) · Expert Review of Proteomics · doi:10.1586/14789450.2015.1099435 · Cited by 13
The role of microRNAs in multiple sclerosis
Rostami-Mansoor, S., Ghasemi‐Kasman, M., & Yavarpour‐Bali, H. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1826474 · Cited by 13
Metadata
- Authors
- Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., Prat, A., Romero, I. A., & de Vries, H. E.
- Affiliations
- Amsterdam Neuroscience (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Leiden University Medical Center (NL)
- Hôpital Notre-Dame (CA)
- The Open University (GB)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-04-17
- Volume
- 33
- Issue
- 16
- Pages
- 6857-6863
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618888
- OpenAlex
- W2084419599
- Cited by
- 138
- References
- 42
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 5
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Open Research Online (The Open University) (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Multiple Sclerosis Society
- ZonMw
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- microRNA, blood-brain barrier, brain endothelial cells, multiple sclerosis, miR-125a-5p, tight junctions, BBB dysfunction, inflammation, BBB repair
- MeSH terms
- Blood-Brain Barrier, Brain, Cell Line, Transformed, Gene Expression Regulation, Genetic Vectors, Humans, Inflammation, Multiple Sclerosis, Transfection, Cytokines, RNA, Small Interfering, MicroRNAs, Endothelial Cells, Transendothelial and Transepithelial Migration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review