The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Early-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone
Open accessAbstract
Increased sensory input from maternal care attenuates neuroendocrine and behavioral responses to stress long term and results in a lifelong phenotype of resilience to depression and improved cognitive function. Whereas the mechanisms of this clinically important effect remain unclear, the early, persistent suppression of the expression of the stress neurohormone corticotropin-releasing hormone (CRH) in hypothalamic neurons has been implicated as a key aspect of this experience-induced neuroplasticity. Here, we tested whether the innervation of hypothalamic CRH neurons of rat pups that received augmented maternal care was altered in a manner that might promote the suppression of CRH expression and studied the cellular mechanisms underlying this suppression. We found that the number of excitatory synapses and the frequency of miniature excitatory synaptic currents onto CRH neurons were reduced in “care-augmented” rats compared with controls, as were the levels of the glutamate vesicular transporter vGlut2. In contrast, analogous parameters of inhibitory synapses were unchanged. Levels of the transcriptional repressor neuron-restrictive silencer factor (NRSF), which negatively regulates Crh gene transcription, were markedly elevated in care-augmented rats, and chromatin immunoprecipitation demonstrated that this repressor was bound to a cognate element (neuron-restrictive silencing element) on the Crh gene. Whereas the reduced excitatory innervation of CRH-expressing neurons dissipated by adulthood, increased NRSF levels and repression of CRH expression persisted, suggesting that augmented early-life experience reprograms Crh gene expression via mechanisms involving transcriptional repression by NRSF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · cited 5×
“…reprograms expression of stress-related molecules The consequences of early-life experience (i.e., a phenotype of reduced stress responsiveness) (Plotsky and Meaney, 1993; Avishai-Eliner et al., 2001a) and improved learning and memory (Liu et al., 2000; Fenoglio et al., 2005) is associated with…”
BackgroundInfluentialJoëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Self-citationMaternal care, hippocampal synaptogenesis and cognitive development in rats
Liu, D., Diorio, J., Day, J. C., Francis, D. D., & Meaney, M. J. (2000) · Nature Neuroscience · doi:10.1038/77702 · Cited by 1,195
Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905
Weaver, I. C. G., Meaney, M. J., & Szyf, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507526103 · Cited by 771
Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522
Role of GABA and Glutamate Circuitry in Hypothalamo‐Pituitary‐Adrenocortical Stress Integration
HERMAN, J. P., MUELLER, N. K., & FIGUEIREDO, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.004 · Cited by 282
Miklós, I. H., & Kovács, K. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00147-1 · Cited by 182
Avishai‐Eliner, S., Gilles, E. E., Eghbal‐Ahmadi, M., Bar‐El, Y., & Baram, T. Z. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00698.x · Cited by 139
Self-citation
Research works printed but not linked: 37
- 10.1210/en.142.1.89 · DOI
- 10.1111/j.1460-9568.2004.03167.x · DOI
- 10.1016/S0306-4522(97)00577-0 · DOI · Paper page
- Boudaba, 1996, Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus, J Neurosci, 16, 7151, 10.1523/JNEUROSCI.16-22-07151.1996 · DOI · Paper page
- Boudaba, 1997, Physiological evidence for local excitatory synaptic circuits in the rat hypothalamus, J Neurophysiol, 77, 3396, 10.1152/jn.1997.77.6.3396 · DOI · Paper page
- 10.1016/j.nbd.2004.12.015 · DOI
- 10.1002/dev.420100311 · DOI
- Cole, 2002, Neurotransmitter regulation of cellular activation and neuropeptide gene expression in the paraventricular nucleus of the hypothalamus, J Neurosci, 22, 959, 10.1523/JNEUROSCI.22-03-00959.2002 · DOI · Paper page
- 10.1002/(SICI)1096-9861(20000410)419:3<344::AID-CNE6>3.0.CO;2-Z · DOI
- 10.1002/(SICI)1096-9861(19960422)368:1<88::AID-CNE6>3.0.CO;2-G · DOI · Paper page
- Di, 2003, Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism, J Neurosci, 23, 4850, 10.1523/JNEUROSCI.23-12-04850.2003 · DOI · Paper page
- 10.1210/en.2004-1285 · DOI · Paper page
- 10.1523/JNEUROSCI.4080-05.2006 · DOI · Paper page
- 10.1016/j.brainres.2007.05.064 · DOI
- 10.1126/science.1097468 · DOI · Paper page
- 10.1111/j.1469-7793.2001.0237b.x · DOI · Paper page
- Herzog E Bellenchi GC Gras C Bernard V Ravassard P Bedet C Gasnier B Giros B El Mestikawy S (2001) The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci 21:RC181(1–6). · DOI · Paper page
- 10.1038/nn1453 · DOI · Paper page
- Kiss, 1996, Distribution of metabotropic glutamate receptor 1a in the rat hypothalamus: an immunocytochemical study using monoclonal and polyclonal antibody, Acta Biol Hung, 47, 221
- 10.1126/science.156.3772.258 · DOI · Paper page
- 10.1038/39908 · DOI · Paper page
- 10.1016/0960-0760(91)90072-D · DOI
- 10.1016/0896-6273(92)90219-4 · DOI · Paper page
- 10.1038/nprot.2006.27 · DOI · Paper page
- 10.1016/0006-8993(73)90290-4 · DOI · Paper page
- Palm, 1998, Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene, J Neurosci, 18, 1280, 10.1523/JNEUROSCI.18-04-01280.1998 · DOI · Paper page
- 10.1002/cne.903320109 · DOI · Paper page
- 10.1002/cne.902180202 · DOI · Paper page
- Sawchenko, 1985, Localization, colocalization, and plasticity of corticotropin-releasing factor immunoreactivity in rat brain, Fed Proc, 44, 221
- 10.1074/jbc.M007745200 · DOI
- 10.1111/j.1528-1157.1999.tb00847.x · DOI
- 10.1016/0306-4522(81)90190-1 · DOI · Paper page
- 10.1111/j.1460-9568.2004.03568.x · DOI · Paper page
- 10.1523/JNEUROSCI.4164-06.2007 · DOI · Paper page
- 10.1016/j.brainres.2005.01.090 · DOI
- 10.1186/gb-2009-10-1-r9 · DOI
- 10.1002/cne.20445 · DOI
Cited by
Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785
Early Life Programming and Neurodevelopmental Disorders
Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961
Self-citationTurecki, G., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.022 · Cited by 796
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751
Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.008 · Cited by 579
Metadata
- Authors
- Korosi, A., Shanabrough, M., McClelland, S., Liu, Z.-W., Borok, E., Gao, X.-B., Horvath, T. L., & Baram, T. Z.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-01-13
- Volume
- 30
- Issue
- 2
- Pages
- 703-713
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2077798470
- Cited by
- 171
- References
- 11
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Early-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone. https://app.cochat.ai/papers/10.1523/jneurosci.4214-09.2010
- The paper
- Korosi, A., Shanabrough, M., McClelland, S., Liu, Z.-W., Borok, E., Gao, X.-B., Horvath, T. L., & Baram, T. Z. (2010). Early-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4214-09.2010
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
