The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation
Open accessAbstract
For >20 years, noninvasive transcranial stimulation techniques like repetitive transcranial magnetic stimulation (rTMS) and direct current stimulation (tDCS) have been used to induce neuroplastic-like effects in the human cortex, leading to the activity-dependent modification of synaptic transmission. Here, we introduce a novel method of electrical stimulation: transcranial random noise stimulation (tRNS), whereby a random electrical oscillation spectrum is applied over the motor cortex. tRNS induces consistent excitability increases lasting 60 min after stimulation. These effects have been observed in 80 subjects through both physiological measures and behavioral tasks. Higher frequencies (100–640 Hz) appear to be responsible for generating this excitability increase, an effect that may be attributed to the repeated opening of Na+channels. In terms of efficacy tRNS appears to possess at least the same therapeutic potential as rTMS/tDCS in diseases such as depression, while furthermore avoiding the constraint of current flow direction sensitivity characteristic of tDCS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656
Self-citationSustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
Self-citationConsensus: Motor cortex plasticity protocols
Ziemann, U., Paulus, W., Nitsche, M. A., Pascual-Leone, A., Byblow, W. D., Berardelli, A., Siebner, H. R., Classen, J., Cohen, L. G., & Rothwell, J. C. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.006 · Cited by 639
Self-citationFunctional anatomy of human procedural learning determined with regional cerebral blood flow and PET
Grafton, S., Mazziotta, J., Presty, S., Friston, K., Frackowiak, R., & Phelps, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02542.1992 · Cited by 607 · cited 1×
“Regarding studies in the human, this is in line with previous observations of increased activation of the M1 during motor learning tasks (Grafton et al., 1992; Honda et al., 1998), showing that effects of motor training can be improved by cortical excitability enhancements.”
ResultDextromethorphan decreases the excitability of the human motor cortex
Ziemann, U., Chen, R., Cohen, L. G., & Hallett, M. (1998) · Neurology · doi:10.1212/wnl.51.5.1320 · Cited by 422
Paulus, W., Classen, J., Cohen, L. G., Large, C. H., Di Lazzaro, V., Nitsche, M., Pascual-Leone, A., Rosenow, F., Rothwell, J. C., & Ziemann, U. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.002 · Cited by 414
Self-citationDynamic cortical involvement in implicit and explicit motor sequence learning. A PET study
Honda, M. (1998) · Brain · doi:10.1093/brain/121.11.2159 · Cited by 370
Cited by
Rossi, S., Antal, A., Bestmann, S., Bikson, M., Brewer, C., Brockmöller, J., Carpenter, L. L., Cincotta, M., Chen, R., Daskalakis, J. D., et al. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.10.003 · Cited by 1,573
Self-citationAntal, A., Alekseichuk, I., Bikson, M., Brockmöller, J., Brunoni, A. R., Chen, R., Cohen, L. G., Dowthwaite, G., Ellrich, J., Flöel, A., et al. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.06.001 · Cited by 1,301
Self-citationTranscranial Electrical Stimulation: What We Know and Do Not Know About Mechanisms
Fertonani, A., & Miniussi, C. (2017) · The Neuroscientist · doi:10.1177/1073858416631966 · Cited by 470
Polanía, R., Nitsche, M. A., & Paulus, W. (2011) · Human Brain Mapping · doi:10.1002/hbm.21104 · Cited by 434
Self-citationTranscranial Electric Stimulation Entrains Cortical Neuronal Populations in Rats
Ozen, S., Sirota, A., Belluscio, M. A., Anastassiou, C. A., Stark, E., Koch, C., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5252-09.2010 · Cited by 425
Metadata
- Authors
- Terney, D., Chaieb, L., Moliadze, V., Antal, A., & Paulus, W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-12-24
- Volume
- 28
- Issue
- 52
- Pages
- 14147-14155
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2001430965
- Cited by
- 680
- References
- 8
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation. https://app.cochat.ai/papers/10.1523/jneurosci.4248-08.2008
- The paper
- Terney, D., Chaieb, L., Moliadze, V., Antal, A., & Paulus, W. (2008). Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4248-08.2008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
