Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy
Open accessAbstract
Stress is known to induce dendritic hypertrophy in the basolateral amygdala (BLA) and to enhance anxiety. Stress also leads to secretion of glucocorticoids (GC), and the BLA has a high concentration of glucocorticoid receptors. This raises the possibility that stress-induced elevation in GC secretion might directly affect amygdaloid neurons. To address the possible effects of GC on neurons of amygdala and on anxiety, we used rats treated either acutely with a single dose or chronically with 10 daily doses of high physiological levels of corticosterone (the rat-specific glucocorticoid). Behavior and morphological changes in neurons of BLA were measured 12 days after the initiation of treatment in both groups. A single acute dose of corticosterone was sufficient to induce dendritic hypertrophy in the BLA and heightened anxiety, as measured on an elevated plus maze. Moreover, this form of dendritic hypertrophy after acute treatment was of a magnitude similar to that caused by chronic treatment. Thus, plasticity of BLA neurons is sufficiently sensitive so as to be saturated by a single day of stress. The effects of corticosterone were specific to anxiety, as neither acute nor chronic treatment caused any change in conditioned fear or in general locomotor activity in these animals.
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Neuronal and synaptic remodeling in BLA PNs, along with enhanced glutamatergic transmission, has been repeatedly associated with the negative consequence of stress.
“Neuronal and synaptic remodeling in BLA PNs, along with enhanced glutamatergic transmission, has been repeatedly associated with the negative consequence of stress (14,33,34,40), and prevention of these changes is paralleled by a protection against stress-induced increases in anxiety-like behavior (26,41).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [40]
Repeated high-dose glucocorticoid treatment mimics chronic stress and induces dendritic lengthening in basolateral amygdala.
“Yet, repeated high dose glucocorticoids treatment mimics chronic stress and induces dendritic lengthening in BlA.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [36]
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- Authors
- Mitra, R., & Sapolsky, R. M.
- Affiliations
- Stanford University (US)
- Rockefeller University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-04-08
- Volume
- 105
- Issue
- 14
- Pages
- 5573-5578
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2291109
- OpenAlex
- W2141747860
- Cited by
- 409
- References
- 61
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 16 · 2023: 12 · 2022: 23 · 2021: 28 · 2020: 19 · 2019: 26 · 2018: 25 · 2017: 20 · 2016: 39 · 2015: 19 · 2014: 26 · 2013: 23 · 2012: 29
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (R01 AGO20633)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- corticosterone, glucocorticoids, anxiety, basolateral amygdala, neuroplasticity, stress, glucocorticoid receptor, elevated plus maze, fear conditioning, locomotor activity
- MeSH terms
- Amygdala, Animals, Anxiety, Corticosterone, Dendrites, Hypertrophy, Neuronal Plasticity, Stress, Physiological, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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