Emotional Autobiographical Memories in Amnesic Patients with Medial Temporal Lobe Damage
Open accessAbstract
The recollection of emotional autobiographical memories has received little attention in patients with memory disorders. Here, we addressed this topic in amnesic patients with damage to the hippocampus (HC group;n= 8) or the hippocampus, amygdala, and surrounding cortices (HC+ group;n= 2). These patients were asked to recollect emotional events from their lives. HC patients produced recollections that were strikingly similar to those of brain-damaged (n= 10) and healthy (n= 25) comparison participants, in terms of both quantity and quality. In contrast, HC+ patients produced a lower proportion of unpleasant memories compared with the other participants. Specifically, the ratings and words used to describe recollections in the HC+ patients were more affectively positive. All groups produced more memories from between 10 and 30 years of age (the so-called autobiographical memory “bump”) compared with other time periods in their lives. These results suggest that structures surrounding the hippocampus, but not the hippocampus itself, may be necessary for the recollection of highly emotional, unpleasant autobiographical memories. The amygdala and surrounding cortices of the medial temporal lobe may be a necessary component in the neural circuitry necessary for vivid recollection of unpleasant emotional events.
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In amnestic populations with complete impairments in declarative memory, procedural learning can be fully spared.
“in amnestic populations with complete impairments in declarative memory, both procedural learning (as described above) and affective memories can be fully spared. 54”
From Domains of cognition and their assessment (2019) · cites this paper as [54]
In amnestic populations with complete impairments in declarative memory, affective memories can be fully spared.
“in amnestic populations with complete impairments in declarative memory, both procedural learning (as described above) and affective memories can be fully spared. 54”
From Domains of cognition and their assessment (2019) · cites this paper as [54]
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- Authors
- Buchanan, T. W., Tranel, D., & Adolphs, R.
- Affiliations
- University of Iowa (US)
- California Institute of Technology (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-03-23
- Volume
- 25
- Issue
- 12
- Pages
- 3151-3160
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725089
- OpenAlex
- W2062504721
- Cited by
- 78
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 7
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
- Funders
- U.S. Public Health Service (R01 067681, P01 19632)
- National Institute on Aging
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Developmental and Educational Psychology › Identity, Memory, and Therapy
- Keywords
- amnesia, medial temporal lobe, hippocampus, amygdala, recollection, emotional memory
- MeSH terms
- Adult, Age Factors, Aged, Amnesia, Analysis of Variance, Brain Mapping, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, Temporal Lobe
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