Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus
Open accessAbstract
Studies of visual discrimination reversal learning have revealed striking neurochemical dissociations at the level of the orbitofrontal cortex (OFC) with serotoninergic, but not dopaminergic, integrity being important for successful reversal learning. These findings have considerable implications for disorders such as obsessive compulsive disorder and schizophrenia, in which reversal learning is impaired, and which are primarily treated with drugs targeting the dopaminergic and serotoninergic systems. Dysfunction in such disorders however, is not limited to the OFC and extends subcortically to other structures implicated in reversal learning, such as the medial caudate nucleus. Therefore, because the roles of the serotonin and dopamine within the caudate nucleus are poorly understood, this study compared the effects of selective serotoninergic or selective dopaminergic depletions of the marmoset medial caudate nucleus on serial discrimination reversal learning. All monkeys were able to learn novel stimulus–reward associations but, unlike control monkeys and monkeys with selective serotoninergic medial caudate depletions, dopamine-depleted monkeys were markedly impaired in their ability to reverse this association. This impairment was not perseverative in nature. These findings are the opposite of those seen in the OFC and provide evidence for a neurochemical double dissociation between the OFC and medial caudate in the regulation of reversal learning. Although the specific contributions of these monoamines within the OFC–striatal circuit remain to be elucidated, these findings have profound implications for the development of drugs designed to remediate some of the cognitive processes underlying impaired reversal learning.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Depletion of dopamine in the striatum, but not the OFC, caused reversal learning deficits in marmosets.
“Depletion of dopamine in this brain region, but not in the OFC, caused deficits in marmosets (Clarke et al 2011, Clarke et al 2007)”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Clarke et al 2011
Dopamine depletion in prefrontal cortex and striatum impairs cognitive control.
“and dopamine depletion in those brain areas impairs cognitive control (Clarke et al., 2011; Collins et al., 2000; Crofts et al., 2001; O'Neill and Brown, 2007).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Clarke et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Statistical Methods for Psychology.
Gudgeon, A. C., & Howell, D. C. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348956 · Cited by 8,277 · see citing works
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857 · see citing works
Detection Theory: A User's Guide
Macmillan, N. A., & Creelman, C. D. (1991) · Cited by 5,415 · see citing works
Barto, A. (1998) · IFAC Proceedings Volumes · doi:10.1016/s1474-6670(17)38315-5 · Cited by 2,172 · see citing works
A framework for mesencephalic dopamine systems based on predictive Hebbian learning
Montague, P., Dayan, P., & Sejnowski, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01936.1996 · Cited by 2,066 · see citing works
Zhang, B., Li, C., & Lin, N. (2020) · De Gruyter eBooks · doi:10.1515/9783110595567-011 · Cited by 1,939 · see citing works
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527 · see citing works
Self-citationNeuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427 · see citing works
Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity
Oades, R. D., & Halliday, G. M. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90011-7 · Cited by 1,001 · see citing works
Limbic lesions and the problem of stimulus--reinforcement associations.
Jones, B., & Mishkin, M. (1972) · Experimental Neurology · doi:10.1016/0014-4886(72)90030-1 · Cited by 864 · see citing works
Opponent interactions between serotonin and dopamine
Daw, N. D., Kakade, S., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00052-7 · Cited by 844 · see citing works
Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
Saxena, S., & Rauch, S. L. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70181-7 · Cited by 840 · see citing works
Neuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder
Saxena, S., Brody, A. L., Schwartz, J. M., & Baxter, L. R. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000297870 · Cited by 831 · see citing works
Cognitive Inflexibility After Prefrontal Serotonin Depletion
Clarke, H. F., Dalley, J. W., Crofts, H. S., Robbins, T. W., & Roberts, A. C. (2004) · Science · doi:10.1126/science.1094987 · Cited by 632 · see citing works
Self-citationOrbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat
McAlonan, K., & Brown, V. J. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.019 · Cited by 618 · see citing works
Dopamine-Mediated Stabilization of Delay-Period Activity in a Network Model of Prefrontal Cortex
Durstewitz, D., Seamans, J. K., & B, T. J. S. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1733 · Cited by 617 · see citing works
The orbital and medial prefrontal circuit through the primate basal ganglia
Haber, S., Kunishio, K., Mizobuchi, M., & Lynd-Balta, E. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04851.1995 · Cited by 605 · see citing works
Hornak, J., O'Doherty, J., Bramham, J., Rolls, E. T., Morris, R. G., Bullock, P. R., & Polkey, C. E. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/089892904322926791 · Cited by 603 · see citing works
Frank, M. J., & Claus, E. D. (2006) · Psychological Review · doi:10.1037/0033-295x.113.2.300 · Cited by 578 · see citing works
Behavioral effects of selective ablation of the caudate nucleus.
Divac, I., Rosvold, H. E., & Szwarcbart, M. K. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0024348 · Cited by 568 · see citing works
Chamberlain, S. R., Menzies, L., Hampshire, A., Suckling, J., Fineberg, N. A., del Campo, N., Aitken, M., Craig, K., Owen, A. M., Bullmore, E. T., et al. (2008) · Science · doi:10.1126/science.1154433 · Cited by 550 · see citing works
Self-citationSerotonin and dopamine: unifying affective, activational, and decision functions.
Cools, R., Nakamura, K., & Daw, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.121 · Cited by 464 · see citing works
Opponency revisited: competition and cooperation between dopamine and serotonin
Boureau, Y.-L., & Dayan, P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.151 · Cited by 456 · see citing works
Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder
Remijnse, P. L., Nielen, M. M. A., van Balkom, A. J. L. M., Cath, D. C., van Oppen, P., Uylings, H. B. M., & Veltman, D. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1225 · Cited by 408 · see citing works
Butter, C. M. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90075-4 · Cited by 395 · see citing works
Saxena, S. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00082-2 · Cited by 379 · see citing works
Cools, R., Frank, M. J., Gibbs, S. E. B., Miyakawa, A., Jagust, W. J., & D’Esposito, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4467-08.2009 · Cited by 365 · see citing works
Prefrontal Serotonin Depletion Affects Reversal Learning But Not Attentional Set Shifting
Clarke, H. F., Walker, S. C., Crofts, H. S., Dalley, J. W., Robbins, T. W., & Roberts, A. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3690-04.2005 · Cited by 358 · see citing works
Self-citationRole of dopamine in the motivational and cognitive control of behavior
Cools, R. (2008) · The Neuroscientist · doi:10.1177/1073858408317009 · Cited by 352 · see citing works
Clarke, H., Walker, S., Dalley, J., Robbins, T., & Roberts, A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj120 · Cited by 351 · see citing works
Self-citationMeunier, M. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00027-4 · Cited by 348 · see citing works
The Yin and Yang of dopamine release: a new perspective
GOTO, Y., OTANI, S., & GRACE, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.007 · Cited by 342 · see citing works
Reward prediction in primate basal ganglia and frontal cortex
Schultz, W., Tremblay, L., & Hollerman, J. R. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00071-9 · Cited by 318 · see citing works
Roberts, A., Robbins, T. W., & Everitt, B. J. (1988) · PubMed · Cited by 306 · see citing works
Self-citationBussey, T. J., Muir, J. L., Everitt, B. J., & Robbins, T. W. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.5.920 · Cited by 301 · see citing works
Self-citationBrain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine
Brody, A. L., Saxena, S., Silverman, D. H. S., Fairbanks, L. A., Phelps, M. E., Huang, S., Wu, H.-M., Maidment, K. M., Baxter, L. R., & Alborzian, S. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00034-7 · Cited by 292 · see citing works
Crofts, H. S. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.11.1015 · Cited by 284 · see citing works
Differential regulation of fronto-executive function by the monoamines and acetylcholine
Robbins, T., & Roberts, A. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm066 · Cited by 279 · see citing works
Self-citationRoberts, A. C., Robbins, T. W., & Everitt, B. (1988) · The Quarterly journal of experimental psychology. B, Comparative and physiological psychology · doi:10.1080/14640748808402328 · Cited by 278
Self-citationClarke, H. F., Robbins, T. W., & Roberts, A. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1521-08.2008 · Cited by 263 · see citing works
Self-citationBussey, T. J., Muir, J. L., Everitt, B. J., & Robbins, T. W. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.5.920 · Cited by 259 · see citing works
Self-citationErsche, K. D., Roiser, J. P., Robbins, T. W., & Sahakian, B. J. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1051-1 · Cited by 255 · see citing works
Self-citationReward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus
Nakamura, K., Matsumoto, M., & Hikosaka, O. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0021-08.2008 · Cited by 243 · see citing works
van der Kooy, D., & Hattori, T. (1980) · Brain Research · doi:10.1016/0006-8993(80)90250-4 · Cited by 243 · see citing works
Mehta, M. A., Swainson, R., Ogilvie, A. D., Sahakian, B., & Robbins, T. W. (2001) · Psychopharmacology · doi:10.1007/s002130100851 · Cited by 235 · see citing works
Self-citationClatworthy, P. L., Lewis, S. J. G., Brichard, L., Hong, Y. T., Izquierdo, D., Clark, L., Cools, R., Aigbirhio, F. I., Baron, J.-C., Fryer, T. D., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3266-08.2009 · Cited by 229 · see citing works
Self-citationPorras, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00333-5 · Cited by 222 · see citing works
Evers, E. A. T., Cools, R., Clark, L., van der Veen, F. M., Jolles, J., Sahakian, B. J., & Robbins, T. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300663 · Cited by 208 · see citing works
Self-citationA Theory of Dopamine Function and Its Role in Cognitive Deficits in Schizophrenia
Cohen, J. D., & Servan‐Schreiber, D. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.1.85 · Cited by 199 · see citing works
Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
Denys, D., van der Wee, N., Janssen, J., De Geus, F., & Westenberg, H. G. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.023 · Cited by 195 · see citing works
The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex
Schilman, E. A., Uylings, H. B. M., Graaf, Y. G.-D., Joel, D., & Groenewegen, H. J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.024 · Cited by 187 · see citing works
Brigman, J. L., Mathur, P., Harvey-White, J., Izquierdo, A., Saksida, L. M., Bussey, T. J., Fox, S., Deneris, E., Murphy, D. L., & Holmes, A. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp266 · Cited by 184 · see citing works
Roberts, A., Tomic, D. L., Parkinson, C. H., Roeling, T. A. P., Cutter, D. J., Robbins, T. W., & Everitt, B. J. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21300 · Cited by 181 · see citing works
Self-citationDopamine DRD2 Polymorphism Alters Reversal Learning and Associated Neural Activity
Jocham, G., Klein, T. A., Neumann, J., von Cramon, D. Y., Reuter, M., & Ullsperger, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5195-08.2009 · Cited by 178 · see citing works
Modulation of dopamine release by striatal 5‐HT2C receptors
Alex, K. D., Yavanian, G. J., McFarlane, H. G., Pluto, C. P., & Pehek, E. A. (2005) · Synapse · doi:10.1002/syn.20109 · Cited by 172 · see citing works
Cools, R., Robinson, O. J., & Sahakian, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301598 · Cited by 172 · see citing works
Lapiz-Bluhm, M. D. S., Soto-Piña, A. E., Hensler, J. G., & Morilak, D. A. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1224-6 · Cited by 163 · see citing works
Cools, R., Calder, A. J., Lawrence, A. D., Clark, L., Bullmore, E., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2215-5 · Cited by 161 · see citing works
Self-citationSchweimer, J. V., & Hauber, W. (2005) · Learning & Memory · doi:10.1101/lm.90605 · Cited by 149 · see citing works
Lee, B., Groman, S., London, E. D., & Jentsch, J. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301337 · Cited by 148 · see citing works
Adams, K. H., Hansen, E. S., Pinborg, L. H., Hasselbalch, S. G., Svarer, C., Holm, S., Bolwig, T. G., & Knudsen, G. M. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005055 · Cited by 147 · see citing works
Coding of Task Reward Value in the Dorsal Raphe Nucleus
Bromberg-Martin, E. S., Hikosaka, O., & Nakamura, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0015-10.2010 · Cited by 143 · see citing works
Collins, P., Wilkinson, L. S., Everitt, B. J., Robbins, T. W., & Roberts, A. C. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.3 · Cited by 129 · see citing works
Self-citationRemijnse, P. L., Nielen, M. M. A., van Balkom, A. J. L. M., Hendriks, G.-J., Hoogendijk, W. J., Uylings, H. B. M., & Veltman, D. J. (2009) · Psychological Medicine · doi:10.1017/s0033291708005072 · Cited by 127 · see citing works
Izquierdo, A., Wiedholz, L. M., Millstein, R. A., YANG, R., Bussey, T. J., Saksida, L. M., & HOLMES, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.029 · Cited by 119 · see citing works
van der Veen, F. M., Evers, E. A. T., Deutz, N. E. P., & Schmitt, J. A. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301212 · Cited by 118 · see citing works
Dodds, C. M., Muller, U., Clark, L., van Loon, A., Cools, R., & Robbins, T. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1153-08.2008 · Cited by 113 · see citing works
Self-citationvan Schouwenburg, M. R., Aarts, E., & Cools, R. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791293097 · Cited by 113 · see citing works
Presynaptic control of serotonin on striatal dopamine function
Navailles, S., & Deurwaerdère, P. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2029-y · Cited by 109 · see citing works
Fox, M. T., Barense, M. D., & Baxter, M. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00676.2003 · Cited by 103 · see citing works
Abdul-Monim, Z., Reynolds, G. P., & Neill, J. C. (2003) · Journal of Psychopharmacology · doi:10.1177/0269881103017001700 · Cited by 101 · see citing works
Ultrastructure and synaptic targets of the raphe-nigral projection in the rat
Corvaja, N., Doucet, G., & Bolam, J. P. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90510-m · Cited by 101 · see citing works
O’Neill, M. J., & Brown, V. J. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.03.003 · Cited by 99 · see citing works
Walker, S. C., Robbins, T. W., & Roberts, A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn136 · Cited by 95 · see citing works
Self-citationThe Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective
Goto, Y., & Grace, A. A. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78002-3 · Cited by 94 · see citing works
Joel, D., & Avisar, A. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00201-7 · Cited by 84 · see citing works
Parry, B. L., Mostofi, N., LeVeau, B., Nahum, H. C., Golshan, S., Laughlin, G. A., & Gillin, J. C. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(98)00128-0 · Cited by 83 · see citing works
An analysis of visual object reversal learning in the marmoset after amphetamine and haloperidol
Ridley, R. M., Haystead, T., & Baker, H. F. (1981) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(81)90401-9 · Cited by 81 · see citing works
Dopamine D2receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice
Kruzich, P. J., & Grandy, D. K. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-12 · Cited by 79 · see citing works
Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys
Izquierdo, A., Newman, T. K., Higley, J. D., & Murray, E. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706583104 · Cited by 77 · see citing works
Masaki, D., Yokoyama, C., Kinoshita, S., Tsuchida, H., Nakatomi, Y., Yoshimoto, K., & Fukui, K. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0559-0 · Cited by 73 · see citing works
Joel, D., & Doljansky, J. T. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300010 · Cited by 72 · see citing works
The dopamine D3/D2 receptor agonist 7-OH-DPAT induces cognitive impairment in the marmoset
Smith, A. G., Neill, J. C., & Costall, B. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00230-5 · Cited by 71 · see citing works
Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat
McLean, S. L., Woolley, M. L., Thomas, D. W., & Neill, J. C. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1618-0 · Cited by 68 · see citing works
The effect of rat anterior cingulate inactivation on cognitive flexibility.
Ragozzino, M. E., & Rozman, S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.4.698 · Cited by 63 · see citing works
Perseveration of responding and nonresponding in monkeys with orbital frontal ablations.
McEnaney, K. W., & Butter, C. M. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0027639 · Cited by 63 · see citing works
Flaisher-Grinberg, S., Klavir, O., & Joel, D. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570800847x · Cited by 63 · see citing works
Danet, M., Lapiz-Bluhm, S., & Morilak, D. A. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000039 · Cited by 63 · see citing works
Joel, D., Doljansky, J. T., Roz, N., & Rehavi, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.037 · Cited by 58 · see citing works
Schilman, E. A., Klavir, O., Winter, C., Sohr, R., & Joel, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.208 · Cited by 56 · see citing works
Arakawa, R., Okumura, M., Ito, H., Seki, C., Takahashi, H., Takano, H., Nakao, R., Suzuki, K., Okubo, Y., Halldin, C., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.051292 · Cited by 50 · see citing works
Evers, E. A. T., Sambeth, A., Ramaekers, J. G., Riedel, W. J., & van der Veen, F. M. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791293060 · Cited by 31 · see citing works
Vallender, E. J., Lynch, L. J., Novak, M. A., & Miller, G. M. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30835 · Cited by 31 · see citing works
An involvement of dopamine in higher order choice mechanisms in the monkey
Ridley, R. M., Haystead, T., & Baker, H. F. (1981) · Psychopharmacology · doi:10.1007/bf00431652 · Cited by 22 · see citing works
Arakawa, R., Okumura, M., Ito, H., Seki, C., Takahashi, H., Takano, H., Nakao, R., Suzuki, K., Okubo, Y., Suhara, T., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.030
Flagged first, then by citations
Cited by
Sorted by citations
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921 · see citing works
Self-citationThe neural basis of reversal learning: An updated perspective
Izquierdo, A., Brigman, J. L., Radke, A. K., Rudebeck, P. H., & Holmes, A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.021 · Cited by 670 · see citing works
Neurophysiology of performance monitoring and adaptive behavior
Ullsperger, M., Danielmeier, C., & Jocham, G. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2012 · Cited by 634 · see citing works
Obsessive-compulsive disorder: Puzzles and prospects
Robbins, T. W., Vaghi, M. M., & Banca, P. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.046 · Cited by 510 · see citing works
Self-citationFloresco, S. B. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00062 · Cited by 336 · see citing works
Reversal learning as a measure of impulsive and compulsive behavior in addictions
Izquierdo, A., & Jentsch, J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2579-7 · Cited by 306 · see citing works
The touchscreen operant platform for assessing executive function in rats and mice
Mar, A. C., Horner, A. E., Nilsson, S. R. O., Alsiö, J., Kent, B. A., Kim, C. H., Holmes, A., Saksida, L. M., & Bussey, T. J. (2013) · Nature Protocols · doi:10.1038/nprot.2013.123 · Cited by 259 · see citing works
Serotonin Selectively Modulates Reward Value in Human Decision-Making
Seymour, B., Daw, N. D., Roiser, J. P., Dayan, P., & Dolan, R. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0053-12.2012 · Cited by 252 · see citing works
Compulsivity in obsessive–compulsive disorder and addictions
Figee, M., Pattij, T., Willuhn, I., Luigjes, J., van den Brink, W., Goudriaan, A. E., Potenza, M. N., Robbins, T. W., & Denys, D. A. J. P. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.003 · Cited by 246 · see citing works
Self-citationActivity patterns of serotonin neurons underlying cognitive flexibility
Matias, S., Lottem, E., Dugué, G. P., & Mainen, Z. F. (2017) · eLife · doi:10.7554/elife.20552 · Cited by 239 · see citing works
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209 · see citing works
Twenty-Five Lessons from Computational Neuromodulation
Dayan, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.027 · Cited by 190 · see citing works
Puig, M. V., Rose, J., Schmidt, R., & Freund, N. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00093 · Cited by 182 · see citing works
Prefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Reversal learning and dopamine: a Bayesian perspective
Costa, V. D., Tran, V. L., Turchi, J., & Averbeck, B. B. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1989-14.2015 · Cited by 170 · see citing works
Active Vision in Marmosets: A Model System for Visual Neuroscience
Mitchell, J. F., Reynolds, J. H., & Miller, C. T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3899-13.2014 · Cited by 160 · see citing works
Prefrontal dopamine in associative learning and memory
Puig, M. V., Antzoulatos, E. G., & Miller, E. K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.026 · Cited by 138 · see citing works
Reward, interrupted: Inhibitory control and its relevance to addictions
Jentsch, J. D., & Pennington, Z. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.022 · Cited by 134 · see citing works
Ersche, K. D., Roiser, J. P., Abbott, S., Craig, K. J., Müller, U., Suckling, J., Ooi, C., Shabbir, S. S., Clark, L., Sahakian, B. J., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.033 · Cited by 128 · see citing works
Self-citationEffects of chronic stress on cognitive function – From neurobiology to intervention
Girotti, M., Bulin, S. E., & Carreno, F. R. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100670 · Cited by 142 · see citing works
Davis, C. M., DeCicco-Skinner, K. L., Roma, P. G., & Hienz, R. D. (2014) · Radiation Research · doi:10.1667/rr13359.1 · Cited by 101 · see citing works
Androgen Regulation of the Mesocorticolimbic System and Executive Function
Tobiansky, D. J., Wallin-Miller, K. G., Floresco, S., Wood, R. I., & Soma, K. K. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00279 · Cited by 96 · see citing works
The Importance of Serotonin for Orbitofrontal Function
Roberts, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.037 · Cited by 89 · see citing works
Self-citationReser, D. H., Burman, K. J., Yu, H., Chaplin, T. A., Richardson, K. E., Worthy, K. H., & Rosa, M. G. P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs177 · Cited by 88 · see citing works
Gilmour, G., Arguello, P. A., Bari, A., Brown, V. J., Carter, C., Floresco, S., Jentsch, J. D., Tait, D. S., Young, J. W., & Robbins, T. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.04.006 · Cited by 78 · see citing works
Self-citationBarlow, R. L., Alsiö, J., Jupp, B., Rabinovich, R., Shrestha, S., Roberts, A. C., Robbins, T. W., & Dalley, J. W. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.335 · Cited by 77 · see citing works
Self-citationRoberts, C., Sahakian, B. J., & Robbins, T. W. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.001 · Cited by 61 · see citing works
Self-citationDonegan, J. J., Boley, A. M., Yamaguchi, J., Toney, G. M., & Lodge, D. J. (2019) · Nature Communications · doi:10.1038/s41467-019-10800-1 · Cited by 59 · see citing works
Subcortical Dopamine and Cognition in Schizophrenia: Looking Beyond Psychosis in Preclinical Models
Conn, K., Burne, T. H. J., & Kesby, J. P. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00542 · Cited by 63 · see citing works
Donegan, J. J., Tyson, J. A., Branch, S. Y., Beckstead, M. J., Anderson, S. A., & Lodge, D. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.121 · Cited by 60 · see citing works
Verharen, J. P. H., Adan, R. A. H., & Vanderschuren, L. J. M. J. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0454-0 · Cited by 57 · see citing works
The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia
Hvoslef‐Eide, M., Mar, A. C., Nilsson, S. R. O., Alsiö, J., Heath, C. J., Saksida, L. M., Robbins, T. W., & Bussey, T. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4007-x · Cited by 59 · see citing works
Self-citationGroman, S. M., James, A. S., Seu, E., Crawford, M. A., Harpster, S. N., & Jentsch, J. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.002 · Cited by 59 · see citing works
The rat's not for turning: Dissociating the psychological components of cognitive inflexibility
Nilsson, S. R. O., Alsiö, J., Somerville, E. M., & Clifton, P. G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.015 · Cited by 58 · see citing works
The Ultimate Intra-/Extra-Dimensional Attentional Set-Shifting Task for Mice
Scheggia, D., Bebensee, A., Weinberger, D. R., & Papaleo, F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.021 · Cited by 58 · see citing works
McCurdy, L. Y., Sareen, P., Davoudian, P. A., & Nitabach, M. N. (2021) · Nature Communications · doi:10.1038/s41467-021-21388-w · Cited by 67 · see citing works
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54 · see citing works
Self-citationMethamphetamine-induced increases in putamen gray matter associate with inhibitory control
Groman, S. M., Morales, A. M., Lee, B., London, E. D., & Jentsch, J. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3159-9 · Cited by 53 · see citing works
Sala‐Bayo, J., Fiddian, L., Nilsson, S. R. O., Hervig, M. E.-S., McKenzie, C., Mareschi, A., Boulos, M., Zhukovsky, P., Nicholson, J. R., Dalley, J. W., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0612-4 · Cited by 48 · see citing works
Self-citationEffect of lysergic acid diethylamide (LSD) on reinforcement learning in humans
Kanen, J. W., Luo, Q., Kandroodi, M. R., Cardinal, R. N., Robbins, T. W., Nutt, D. J., Carhart-Harris, R. L., & den Ouden, H. E. M. (2022) · Psychological Medicine · doi:10.1017/s0033291722002963 · Cited by 49 · see citing works
Self-citationAnabolic–androgenic steroids impair set-shifting and reversal learning in male rats
Wallin-Miller, K. G., & Wood, R. I. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.002 · Cited by 46 · see citing works
Voon, V., & Dalley, J. W. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5013 · Cited by 46 · see citing works
Sex Differences in Cognitive Flexibility and Resting Brain Networks in Middle-Aged Marmosets
LaClair, M., Febo, M., Nephew, B. C., Gervais, N. J., Poirier, G. L., Workman, K. P., Chumachenko, S. Y., Payne, L., Moore, M. C., King, J. A., et al. (2019) · eNeuro · doi:10.1523/eneuro.0154-19.2019 · Cited by 43 · see citing works
Skelin, I., Hakstol, R., VanOyen, J., Mudiayi, D., Molina, L. A., Holec, V., Hong, N. S., Euston, D. R., McDonald, R. J., & Gruber, A. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12518 · Cited by 42 · see citing works
Cognitive control and the dopamine D2-like receptor: a dimensional understanding of addiction
Groman, S. M., & Jentsch, J. D. (2011) · Depression and Anxiety · doi:10.1002/da.20897 · Cited by 41 · see citing works
Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets
Mimura, K., Nagai, Y., Inoue, K., Matsumoto, J., Hori, Y., Sato, C., Kimura, K., Okauchi, T., Hirabayashi, T., Nishijo, H., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103066 · Cited by 40 · see citing works
Modeling Deficits in Attention, Inhibition, and Flexibility in HAND
Moran, L. M., Booze, R. M., & Mactutus, C. F. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9539-z · Cited by 38 · see citing works
Sex differences in cognitive aging: a 4-year longitudinal study in marmosets
Rothwell, E. S., Workman, K. P., Wang, D., & Agnès Lacreuse, A. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.09.015 · Cited by 36 · see citing works
Horst, N. K., Jupp, B., Roberts, A., & Robbins, T. W. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0272-9 · Cited by 38 · see citing works
Self-citationKlanker, M., Sandberg, T., Joosten, R., Willuhn, I., Feenstra, M., & Denys, D. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.08.011 · Cited by 37 · see citing works
Dopamine D 3 Receptor Availability Is Associated with Inflexible Decision Making
Groman, S. M., Smith, N. J., Petrullli, J. R., Massi, B., Chen, L., Ropchan, J. R., Huang, Y. H., Lee, D., Morris, E. D., & Taylor, J. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3253-15.2016 · Cited by 37 · see citing works
Zhukovsky, P., Puaud, M., Jupp, B., Sala‐Bayo, J., Alsiö, J., Xia, J., Searle, L., Morris, Z. S., Sabir, A., Giuliano, C., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0381-0 · Cited by 33 · see citing works
Self-citationTakemoto, A., Miwa, M., Koba, R., Yamaguchi, C., Suzuki, H., & Nakamura, K. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.10.001 · Cited by 34 · see citing works
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans
Kanen, J. W., Apergis-Schoute, A. M., Yellowlees, R., Arntz, F. E., van der Flier, F. E., Price, A., Cardinal, R. N., Christmas, D. M., Clark, L., Sahakian, B. J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01240-9 · Cited by 34 · see citing works
Self-citationvan den Bosch, R., Lambregts, B. I. H. M., Määttä, J. I., Hofmans, L., Papadopetraki, D., Westbrook, A., Verkes, R., Booij, J., & Cools, R. (2022) · Nature Communications · doi:10.1038/s41467-022-32679-1 · Cited by 34 · see citing works
Oestradiol Modulation of Cognition in Adult Female Marmosets (Callithrix jacchus)
Agnès Lacreuse, A., Chang, J., Metevier, C. M., LaClair, M., Meyer, J. S., & Ferris, C. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12147 · Cited by 33 · see citing works
Selective Role of the Putamen in Serial Reversal Learning in the Marmoset
Jackson, S. A. W., Horst, N. K., Axelsson, S. F. A., Horiguchi, N., Cockcroft, G. J., Robbins, T. W., & Roberts, A. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy276 · Cited by 32 · see citing works
Self-citationDopamine release in human associative striatum during reversal learning
Grill, F., Guitart‐Masip, M., Johansson, J. J., Jonasson, L. S., Axelsson, J., Nyberg, L. H., & Rieckmann, A. (2024) · Nature Communications · doi:10.1038/s41467-023-44358-w · Cited by 32 · see citing works
Effects of methylphenidate on reinforcement learning depend on working memory capacity
Kandroodi, M. R., Cook, J. L., Swart, J. C., Froböse, M. I., Geurts, D. E. M., Vahabie, A., Ahmadabadi, M. N., Cools, R., & den Ouden, H. E. M. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05974-w · Cited by 32 · see citing works
Kesby, J. P., Markou, A., & Semenova, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.034 · Cited by 32 · see citing works
Bowirrat, A., Chen, T. J. H., Oscar‐Berman, M., Madigan, M. A., Chen, A. L., Bailey, J. A., Braverman, E. R., Kerner, M., Giordano, J., Morse, S. A., et al. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8247-z · Cited by 30 · see citing works
McGaughy, J. A., Amaral, A. C. S., Rushmore, J., Mokler, D. J., Morgane, P. J., Rosene, D. L., & Galler, J. R. (2014) · Developmental Neuroscience · doi:10.1159/000366057 · Cited by 30 · see citing works
Lui, L. L., & Rosa, M. G. P. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.09.012 · Cited by 30 · see citing works
Compulsivity in opioid dependence
Tolomeo, S., Matthews, K., Steele, J. D., & Baldacchino, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.007 · Cited by 29 · see citing works
Kangas, B. D., Bergman, J., & Coyle, J. T. (2016) · Animal Cognition · doi:10.1007/s10071-016-0959-4 · Cited by 28 · see citing works
Talpos, J. C., & Shoaib, M. C. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_6 · Cited by 27 · see citing works
Parr, A. C., Sydnor, V. J., Calabro, F. J., & Luna, B. (2024) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2024.101399 · Cited by 27 · see citing works
Takaji, M., Takemoto, A., Yokoyama, C., Watakabe, A., Mizukami, H., Ozawa, K., Onoe, H., Nakamura, K., & Yamamori, T. (2016) · Scientific Reports · doi:10.1038/srep35809 · Cited by 26 · see citing works
Pastuzyn, E. D., Chapman, D. E., Wilcox, K. S., & Keefe, K. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.265 · Cited by 25 · see citing works
Zhukovsky, P., Alsiö, J., Jupp, B., Xia, J., Guiliano, C., Jenner, L., Griffiths, J., Riley, E., Ali, S., Roberts, A., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4569-x · Cited by 24 · see citing works
Self-citationRuan, Y., Li, K.-Y., Zheng, R., Yan, Y., Wang, Z., Chen, Y., Liu, Y., Tian, J., Zhu, L., Lou, H., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110437 · Cited by 22 · see citing works
Neuropsychopharmacology of Cognitive Flexibility
Cools, R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00253-0 · Cited by 23 · see citing works
Dopamine, Salience, and Response Set Shifting in Prefrontal Cortex
Shiner, T., Symmonds, M., Guitart‐Masip, M., Fleming, S. M., Friston, K. J., & Dolan, R. J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu210 · Cited by 21 · see citing works
Excessive state switching underlies reversal learning deficits in cocaine users
Patzelt, E. H., Kurth-Nelson, Z. L., Lim, K. O., & MacDonald, A. W. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.09.029 · Cited by 22 · see citing works
Regionally distinct phasic dopamine release patterns in the striatum during reversal learning
Klanker, M., Fellinger, L., Feenstra, M. G. P., Willuhn, I., & Denys, D. A. J. P. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.011 · Cited by 19 · see citing works
Wang, J., Zhuang, J.-Y., Fu, L., Lei, Q., Fan, M., & Zhang, W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237032 · Cited by 19 · see citing works
Brožka, H., Radostová, D., Pištíková, A., Valeš, K., & Stuchlı́k, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00122 · Cited by 18 · see citing works
Cell-based therapies for the treatment of schizophrenia
Donegan, J. J., & Lodge, D. J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.08.010 · Cited by 18 · see citing works
Lear, A., Baker, S. N., Clarke, H. F., Roberts, A., Schmid, M. C., & Jarrett, W. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100049 · Cited by 17 · see citing works
Self-citationThe Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals
Groman, S. M. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_127 · Cited by 17 · see citing works
Thomson, D. M., Openshaw, R. L., Mitchell, E. J., Kouskou, M., Millan, M. J., la Cour, C. M., MORRIS, B. J., & Pratt, J. A. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12710 · Cited by 16 · see citing works
Task‐dependent function of striatal cholinergic interneurons in behavioural flexibility
Okada, K., Nishizawa, K., Setogawa, S., Hashimoto, K., & Kobayashi, K. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13768 · Cited by 16 · see citing works
Cognitive flexibility in humans and other laboratory animals
Highgate, Q., & Schenk, S. (2020) · Journal of the Royal Society of New Zealand · doi:10.1080/03036758.2020.1784240 · Cited by 16 · see citing works
Zmigrod, L., & Robbins, T. W. (2021) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01784 · Cited by 16 · see citing works
Self-citationBonnavion, P., Fernández, E. P., Varin, C., & d’Exaerde, A. D. K. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.009 · Cited by 15 · see citing works
van der Merwe, R. K., Nadel, J. A., Copes‐Finke, D., Pawelko, S. S., Scott, J. S., Ghanem, M. M., Fox, M., Morehouse, C., McLaughlin, R., Maddox, C., et al. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15910 · Cited by 14 · see citing works
Weismüller, B., Ghio, M., Logmin, K., Hartmann, C. J., Schnitzler, A., Pollok, B., Südmeyer, M., & Bellebaum, C. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2018.05.010 · Cited by 14 · see citing works
Zhai, S., Otsuka, S., Xu, J., Clarke, V. R. J., Tkatch, T., Wokosin, D. L., Xie, Z., Tanimura, A., Agarwal, H. K., Ellis‐Davies, G. C. R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114540 · Cited by 12 · see citing works
Young, M. K., Conn, K., Das, J., Zou, S., Alexander, S., Burne, T. H. J., & Kesby, J. P. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.08.005 · Cited by 13 · see citing works
NMDA receptor deletion on dopamine neurons disrupts visual discrimination and reversal learning
Radke, A. K., Zweifel, L. S., & Holmes, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.02.001 · Cited by 12 · see citing works
Oros, N., Chiba, A. A., Nitz, D. A., & Krichmar, J. L. (2014) · Learning & Memory · doi:10.1101/lm.032433.113 · Cited by 12 · see citing works
Nilsson, S. R. O., Somerville, E. M., & Clifton, P. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077762 · Cited by 11 · see citing works
Improved visual discrimination learning in mice with partial 5-HT2B gene deletion
Radke, A. K., Piantadosi, P. T., Uhl, G. R., Hall, F. S., & Holmes, A. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135378 · Cited by 11 · see citing works
Mastrogiacomo, R., Trigilio, G., Devroye, C., Dautan, D., Ferretti, V., Losi, G., Caffino, L., Orso, G., Marotta, R., Maltese, F., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01683-8 · Cited by 10 · see citing works
Delaney, J., Nathani, S., Tan, V., Chavez, C., Orr, A., Paek, J., Faraji, M., Setlow, B., & Urs, N. M. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01868-5 · Cited by 9 · see citing works
Boomhower, S. R., & Newland, M. C. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.02.001 · Cited by 9 · see citing works
Bari, B. A., Moerke, M. J., Jedema, H. P., Effinger, D. P., Cohen, J. Y., & Bradberry, C. W. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000492 · Cited by 9 · see citing works
Arad, M., & Weiner, I. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.004 · Cited by 9 · see citing works
Maith, O., Baladron, J., Einhäuser, W., & Hamker, F. H. (2023) · iScience · doi:10.1016/j.isci.2023.106599 · Cited by 8 · see citing works
- Authors
- Clarke, H. F., Hill, G. J., Robbins, T. W., & Roberts, A. C.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Clarke, Hannah F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-03-16
- Volume
- 31
- Issue
- 11
- Pages
- 4290-4297
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3083841
- OpenAlex
- W1966180070
- Cited by
- 144
- References
- 94
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 3 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 7
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- Wellcome Trust (75491, 076274/Z/04/Z, 093875)
- University of Cambridge
- Medical Research Council
- Newnham College, University of Cambridge
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- reversal learning, dopamine, serotonin, marmoset, orbitofrontal cortex, perseveration, obsessive-compulsive disorder, schizophrenia, cognitive impairment
- MeSH terms
- Analysis of Variance, Animals, Callithrix, Caudate Nucleus, Chromatography, High Pressure Liquid, Discrimination Learning, Dopamine, Female, Male, Photic Stimulation, Reversal Learning, Reward, Serotonin, Visual Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review