The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila
Open accessAbstract
In Drosophila, formation of aversive olfactory long-term memory (LTM) requires multiple training sessions pairing odor and electric shock punishment with rest intervals. In contrast, here we show that a single 2 min training session pairing odor with a more ethologically relevant sugar reinforcement forms long-term appetitive memory that lasts for days. Appetitive LTM has some mechanistic similarity to aversive LTM in that it can be disrupted by cycloheximide, the dCreb2-b transcriptional repressor, and the crammer and tequila LTM-specific mutations. However, appetitive LTM is completely disrupted by the radish mutation that apparently represents a distinct mechanistic phase of consolidated aversive memory. Furthermore, appetitive LTM requires activity in the dorsal paired medial neuron and mushroom body α′β′ neuron circuit during the first hour after training and mushroom body αβ neuron output during retrieval, suggesting that appetitive middle-term memory and LTM are mechanistically linked. Last, experiments feeding and/or starving flies after training reveals a critical motivational drive that enables appetitive LTM retrieval.
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Citations
Cites
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MethodGenetic dissection of consolidated memory in Drosophila
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A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
Krashes, M. J., DasGupta, S., Vreede, A., White, B., Armstrong, J. D., & Waddell, S. (2009) · Cell · doi:10.1016/j.cell.2009.08.035 · Cited by 598
Self-citationLayered reward signalling through octopamine and dopamine in Drosophila
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Self-citationActivity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila
Owald, D., Felsenberg, J., Talbot, C. B., Das, G., Perisse, E., Huetteroth, W., & Waddell, S. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.025 · Cited by 401
Self-citationOrganization and Functional Roles of the Central Complex in the Insect Brain
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Self-citationIntegration of Parallel Opposing Memories Underlies Memory Extinction
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Self-citationA single pair of neurons links sleep to memory consolidation in Drosophila melanogaster
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Reward signal in a recurrent circuit drives appetitive long-term memory formation
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Fasting Launches CRTC to Facilitate Long-Term Memory Formation in Drosophila
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Availability of food determines the need for sleep in memory consolidation
Chouhan, N. S., Griffith, L. C., Haynes, P., & Sehgal, A. (2021) · Nature · doi:10.1038/s41586-020-2997-y · Cited by 76
The role of histone deacetylase 6 in synaptic plasticity and memory
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Metadata
- Authors
- Krashes, M. J., & Waddell, S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-03-19
- Volume
- 28
- Issue
- 12
- Pages
- 3103-3113
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2063287091
- Cited by
- 291
- References
- 8
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
