Cited by 679Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Neuronal differentiation in the adult hippocampus recapitulates embryonic development

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Espósito, M. Soledad, Piatti, Verónica C., Laplagne, Diego A., Morgenstern, Nicolás A., Ferrari, Carina C., Pitossi, Fernando J., Schinder, Alejandro F.·2005·The Journal of Neuroscience

Abstract

In the adult hippocampus and olfactory bulb, neural progenitor cells generate neurons that functionally integrate into the existing circuits. To understand how neuronal differentiation occurs in the adult hippocampus, we labeled dividing progenitor cells with a retrovirus expressing green fluorescent protein and studied the morphological and functional properties of their neuronal progeny over the following weeks. During the first week neurons had an irregular shape and immature spikes and were synaptically silent. Slow GABAergic synaptic inputs first appeared during the second week, when neurons exhibited spineless dendrites and migrated into the granule cell layer. In contrast, glutamatergic afferents were detected by the fourth week in neurons displaying mature excitability and morphology. Interestingly, fast GABAergic responses were the latest to appear. It is striking that neuronal maturation in the adult hippocampus follows a precise sequence of connectivity (silent --> slow GABA --> glutamate --> fast GABA) that resembles hippocampal development. We conclude that, unlike what is observed in the olfactory bulb, the hippocampus maintains the same developmental rules for neuronal integration through adulthood.

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Crossref · 10.1523/jneurosci.3114-05.2005

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  • New granule neurons receive local inhibitory input.

    “In addition to glutamatergic input, new granule neurons also receive local inhibitory input (Espósito et al., 2005; Ge et al., 2006)”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Espósito et al., 2005

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Authors
Espósito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J., & Schinder, A. F.
Affiliations
Fundación Instituto Leloir (AR)
Corresponding author
Schinder, Alejandro F.
Venue
The Journal of Neuroscience
Published
2005-11-02
Volume
25
Issue
44
Pages
10074-10086
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2111004700
Cited by
679
References
72
Citations by year
2026: 7 · 2025: 21 · 2024: 15 · 2023: 10 · 2022: 10 · 2021: 29 · 2020: 32 · 2019: 42 · 2018: 34 · 2017: 40 · 2016: 45 · 2015: 53 · 2014: 44 · 2013: 40 · 2012: 36
FWCI
7.96
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Funders
  • Consejo Nacional de Investigaciones Científicas y Técnicas
  • Third World Academy of Sciences
  • National Institutes of Health
  • Agencia Nacional de Promoción Científica y Tecnológica (CONICET)
  • Fogarty International Center (R03TW06130-01, R03TW006130)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
adult hippocampus, neuronal differentiation, neural progenitor cells, neuronal maturation, glutamatergic afferents, granular layer, olfactory bulb, synaptic connectivity, dendritic spine development, excitability
MeSH terms
Aging, Animals, Cell Differentiation, Cell Movement, Female, Hippocampus, Mice, Inbred C57BL, Neurons, Mice

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