Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear
Open accessAbstract
Learning processes mediating conditioning and extinction of contextual fear require activation of several key signaling pathways in the hippocampus. Principal hippocampal CA1 neurons respond to fear conditioning by a coordinated activation of multiple protein kinases and immediate early genes, such as cFos, enabling rapid and lasting consolidation of contextual fear memory. The extracellular signal-regulated kinase (Erk) additionally acts as a central mediator of fear extinction. It is not known however, whether these molecular events take place in overlapping or nonoverlapping neuronal populations. By using mouse models of conditioning and extinction of fear, we set out to determine the time course of cFos and Erk activity, their cellular overlap, and regulation by afferent cholinergic input from the medial septum. Analyses of cFos(+) and pErk(+) cells by immunofluorescence revealed predominant nuclear activation of either protein during conditioning and extinction of fear, respectively. Transgenic cFos-LacZ mice were further used to label in vivo Fos(+) hippocampal cells during conditioning followed by pErk immunostaining after extinction. The results showed that these signaling molecules were activated in segregated populations of hippocampal principal neurons. Furthermore, immunotoxin-induced lesions of medial septal neurons, providing cholinergic input into the hippocampus, selectively abolished Erk activation and extinction of fear without affecting cFos responses and conditioning. These results demonstrate that extinction mechanisms based on Erk signaling involve a specific population of CA1 principal neurons distinctively regulated by afferent cholinergic input from the medial septum.
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Contextual fear extinction requires direct involvement of the hippocampus.
“which, unlike cued extinction, requires direct involvement of the hippocampus (Tronson et al., 2009).”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Tronson et al., 2009
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- Authors
- Tronson, N. C., Schrick, C., Guzman, Y. F., Huh, K. H., Srivastava, D. P., Penzes, P., Guedea, A. L., Gao, C., & Radulovic, J.
- Affiliations
- Northwestern University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-03-18
- Volume
- 29
- Issue
- 11
- Pages
- 3387-3394
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2892108
- OpenAlex
- W2109078253
- Cited by
- 136
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 13 · 2012: 8
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Northwestern University
- National Institute of Mental Health (R01MH073669, MH073669)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- contextual fear, fear extinction, fear conditioning, CA1 pyramidal neurons, c-fos, extracellular signal-regulated kinase, ERK signaling, medial septum, cholinergic input, fear memory consolidation
- MeSH terms
- Animals, Conditioning, Psychological, Extinction, Psychological, Fear, Hippocampus, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Mice
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