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Segregated Populations of Hippocampal Principal CA1 Neurons Mediating Conditioning and Extinction of Contextual Fear
Open accessAbstract
Learning processes mediating conditioning and extinction of contextual fear require activation of several key signaling pathways in the hippocampus. Principal hippocampal CA1 neurons respond to fear conditioning by a coordinated activation of multiple protein kinases and immediate early genes, such as cFos, enabling rapid and lasting consolidation of contextual fear memory. The extracellular signal-regulated kinase (Erk) additionally acts as a central mediator of fear extinction. It is not known however, whether these molecular events take place in overlapping or nonoverlapping neuronal populations. By using mouse models of conditioning and extinction of fear, we set out to determine the time course of cFos and Erk activity, their cellular overlap, and regulation by afferent cholinergic input from the medial septum. Analyses of cFos(+) and pErk(+) cells by immunofluorescence revealed predominant nuclear activation of either protein during conditioning and extinction of fear, respectively. Transgenic cFos-LacZ mice were further used to label in vivo Fos(+) hippocampal cells during conditioning followed by pErk immunostaining after extinction. The results showed that these signaling molecules were activated in segregated populations of hippocampal principal neurons. Furthermore, immunotoxin-induced lesions of medial septal neurons, providing cholinergic input into the hippocampus, selectively abolished Erk activation and extinction of fear without affecting cFos responses and conditioning. These results demonstrate that extinction mechanisms based on Erk signaling involve a specific population of CA1 principal neurons distinctively regulated by afferent cholinergic input from the medial septum.
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“which, unlike cued extinction, requires direct involvement of the hippocampus (Tronson et al., 2009).”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Tronson et al., 2009
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Cites
The Neuropsychology of Anxiety
Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,953
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 2×
“Whereas the prefrontal cortex involves excitatory glutamatergic-mediated mechanisms to form new extinction memories (Milad and Quirk, 2002), and the amygdala recruits learning mechanisms involving both excitatory and inhibitory neurotransmission to regulate expression of fear (Falls et al.”
BackgroundContext and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083
Mitogen-activated protein kinases in synaptic plasticity and memory
Sweatt, J. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.04.001 · Cited by 1,013
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950
Localization of a Stable Neural Correlate of Associative Memory
Reijmers, L. G. J. E., Perkins, B. L., Matsuo, N., & Mayford, M. R. (2007) · Science · doi:10.1126/science.1143839 · Cited by 853
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673
Vinogradova, O. S. (2001) · Hippocampus · doi:10.1002/hipo.1073 · Cited by 550
Research works printed but not linked: 1
- 10.1210/me.16.7.1638 · DOI
Cited by
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Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453
Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs
Sotres-Bayón, F., Sierra‐Mercado, D., Pardilla‐Delgado, E., & Quirk, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.028 · Cited by 467
Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction
Rudenko, A., Dawlaty, M. M., Seo, J., Cheng, A. W., Meng, J., Le, T. T., Faull, K. F., Jaenisch, R., & Tsai, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.003 · Cited by 450
Opposite effects of fear conditioning and extinction on dendritic spine remodelling.
Lai, C. S. W., Franke, T. F., & Gan, W.-B. (2012) · Nature · doi:10.1038/nature10792 · Cited by 392
Distinct hippocampal engrams control extinction and relapse of fear memory
Lacagnina, A. F., Brockway, E. T., Crovetti, C. R., Shue, F., McCarty, M. J., Sattler, K. P., Lim, S. C., Santos, S. L., Denny, C. A., & Drew, M. R. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0361-z · Cited by 311
Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory
Maren, S. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.023 · Cited by 259
“A number of groups have shown that dis- rupting hippocampal function prior to extinction training impairs the acquisition of extinction (Corcoran et al., 2005; Fischer et al., 2004, 2007; Sananbenesi et al., 2007; Szapiro et al., 2003; Tronson et al., 2009; Vianna et al., 2001).”
BackgroundKeiser, A. A., Turnbull, L. M., Darian, M. A., Feldman, D. E., Song, I., & Tronson, N. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.174 · Cited by 237
The roles of protein kinases in learning and memoryPreprint
Giese, K.-P., & Mizuno, K. (2013) · Learning & Memory · doi:10.1101/lm.028449.112 · Cited by 238
Ognjanovski, N., Schaeffer, S. M., Wu, J., Mofakham, S., Maruyama, D., Żochowski, M., & Aton, S. J. (2017) · Nature Communications · doi:10.1038/ncomms15039 · Cited by 242
HDAC1 Regulates Fear Extinction in Mice
Bahari‐Javan, S., Maddalena, A., Kerimoglu, C., Wittnam, J. L., Held, T., Bähr, M., Burkhardt, S., Delalle, I., Kügler, S., Fischer, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0079-12.2012 · Cited by 195
Fear Extinction Causes Target-Specific Remodeling of Perisomatic Inhibitory Synapses
Trouche, S. G., Sasaki, J. M., Tu, T., & Reijmers, L. G. J. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.047 · Cited by 192
Bernier, B. E., Lacagnina, A. F., Ayoub, A., Shue, F., Zemelman, B. V., Krasne, F. B., & Drew, M. R. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3029-16.2017 · Cited by 168
Hippocampal pyramidal cells: the reemergence of cortical lamination
Slomianka, L., Amrein, I., Knuesel, I., Sørensen, J. C. H., & Wolfer, D. P. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0322-0 · Cited by 153
Sangha, S., Diehl, M. M., Bergstrom, H. C., & Drew, M. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.006 · Cited by 151
Reactivation of recall-induced neurons contributes to remote fear memory attenuation
Khalaf, O., Resch, S., Dixsaut, L., Gorden, V., Glauser, L., & Gräff, J. (2018) · Science · doi:10.1126/science.aas9875 · Cited by 146
A hippocampal insulin‐growth factor 2 pathway regulates the extinction of fear memories
Agís‐Balboa, R. C., Arcos-Díaz, D. P., Wittnam, J. L., Govindarajan, N., Blom, K., Burkhardt, S., Haladyniak, U., Agbemenyah, H. Y., Zovoilis, A., Salinas-Riester, G., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.293 · Cited by 150
Moustafa, A. A., Gilbertson, M. W., Orr, S. P., Herzallah, M. M., Servatius, R. J., & Myers, C. E. (2012) · Brain and Cognition · doi:10.1016/j.bandc.2012.10.005 · Cited by 134
The learning of fear extinction
Furini, C., Myskiw, J., & Izquierdo, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.016 · Cited by 124
Fear conditioning and extinction: emotional states encoded by distinct signaling pathways
Tronson, N. C., Corcoran, K. A., Jovasevic, V., & Radulović, J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.003 · Cited by 124
Brain sites involved in fear memory reconsolidation and extinction of rodents
Baldi, E., & Bucherelli, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.003 · Cited by 123
Anderson, M. C., & Floresco, S. B. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01131-1 · Cited by 105
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107
Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Kutlu, M. G., & Gould, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.029 · Cited by 97
Gao, C., Gill, M. B., Tronson, N. C., Guedea, A. L., Guzmán, Y. F., Huh, K. H., Corcoran, K. A., Swanson, G. T., & Radulović, J. (2009) · Hippocampus · doi:10.1002/hipo.20705 · Cited by 96
Cholinergic regulation of fear learning and extinction
Wilson, M. A., & Fadel, J. R. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23840 · Cited by 106
Lonsdorf, T. B., Haaker, J., & Kalisch, R. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu018 · Cited by 89
Koshibu, K., Gräff, J., & Mansuy, I. M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.023 · Cited by 95
Kaur, S., Thankachan, S., Begum, S., Liu, M., Blanco‐Centurion, C., & Shiromani, P. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006346 · Cited by 88
Molecular Specificity of Multiple Hippocampal Processes Governing Fear Extinction
Radulović, J., & Tronson, N. C. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.1.1 · Cited by 83
Temporal Control of Immediate Early Gene Induction by Light
Schoenenberger, P., Gerosa, D., & Oertner, T. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008185 · Cited by 81
Hippocampal network oscillations at the interplay between innate anxiety and learned fear
Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72
Marissal, T., Bonifazi, P., Picardo, M. A., Nardou, R., Petit, L. F., Baude, A., Fishell, G., Ben‐Ari, Y., & Cossart, R. (2012) · Nature Communications · doi:10.1038/ncomms2318 · Cited by 79
The role of basal forebrain cholinergic neurons in fear and extinction memory
Knox, D. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.001 · Cited by 81
Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder
Chen, L. W., Sun, D., Davis, S. L., Haswell, C. C., Dennis, E. L., Swanson, C. A., Whelan, C. D., Gutman, B. A., Jahanshad, N., Iglesias, J. E., et al. (2018) · Depression and Anxiety · doi:10.1002/da.22833 · Cited by 75
Wang, M. E., Fraize, N., Yin, L. X., Yuan, R. K., Petsagourakis, D., Wann, E. G., & Muzzio, I. A. (2013) · Hippocampus · doi:10.1002/hipo.22105 · Cited by 83
Sex differences in fear extinction and involvements of extracellular signal-regulated kinase (ERK)
Matsuda, S., Matsuzawa, D., Ishii, D., Tomizawa, H., Sutoh, C., & Shimizu, E. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.05.009 · Cited by 72
Ozawa, M., Davis, P. W., Ni, J., Maguire, J. L., Papouin, T., & Reijmers, L. G. J. E. (2020) · Nature Communications · doi:10.1038/s41467-020-18199-w · Cited by 61
Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala
Kwapis, J. L., Jarome, T. J., Lee, J. L. C., Gilmartin, M. R., & Helmstetter, F. J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.09.007 · Cited by 66
Knox, D., & Keller, S. M. (2015) · Hippocampus · doi:10.1002/hipo.22553 · Cited by 70
Nicotine addiction and psychiatric disorders
Kutlu, M. G., Parikh, V., & Gould, T. J. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.08.004 · Cited by 65
Behavioral mechanisms of context fear generalization in micePreprint
Huckleberry, K. A., Ferguson, L. B., & Drew, M. R. (2016) · Learning & Memory · doi:10.1101/lm.042374.116 · Cited by 71
A mismatch-based model for memory reconsolidation and extinction in attractor networks
Osan, R., Tort, A. B. L., & Amaral, O. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023113 · Cited by 63
Mesic, I., Guzmán, Y. F., Guedea, A. L., Jovasevic, V., Corcoran, K. A., Leaderbrand, K., Nishimori, K., Contractor, A., & Radulović, J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.81 · Cited by 64
The MAP(K) of fear: From memory consolidation to memory extinction
Cestari, V., Rossi‐Arnaud, C., Saraulli, D., & Costanzi, M. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.09.007 · Cited by 62
A translational perspective on neural circuits of fear extinction: Current promises and challenges
Sevenster, D., Visser, R. M., & D’Hooge, R. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.07.002 · Cited by 64
Neural substrates of appetitive and aversive prediction error
Iordanova, M. D., Yau, J. O.-Y., McDannald, M. A., & Corbit, L. H. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.029 · Cited by 63
Extinction of Learned Fear Induces Hippocampal Place Cell Remapping
Wang, M. E., Yuan, R. K., Keinath, A. T., Ramos‐Álvarez, M. M., & Muzzio, I. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4477-14.2015 · Cited by 53
The anaphase promoting complex is required for memory function in micePreprint
Kuczera, T., Stilling, R. M., Hsia, H., Bahari‐Javan, S., Irniger, S., Nasmyth, K., Sananbenesi, F., & Fischer, A. (2010) · Learning & Memory · doi:10.1101/lm.1998411 · Cited by 51
Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse
Zaki, Y., Mau, W., Cincotta, C., Monasterio, A., Odom, E. I., Doucette, E., Grella, S. L., Merfeld, E., Shpokayte, M., & Ramirez, S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01407-0 · Cited by 56
Corcoran, K. A., Leaderbrand, K., & Radulović, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3338-13.2013 · Cited by 46
Modulation of the extinction of fear learning
Myskiw, J. D. C., Izquierdo, I., & Furini, C. R. G. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.04.006 · Cited by 44
Generating new neurons to circumvent your fears: the role of IGF signaling
Agís‐Balboa, R. C., & Fischer, A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1316-2 · Cited by 43
Zhong, T., Qing, Q. J., Yang, Y., Zou, W. Y., Ye, Z., Yan, J. Q., & Guo, Q. L. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu184 · Cited by 43
Neural reinstatement reveals divided organization of fear and extinction memories in the human brain
Hennings, A. C., McClay, M., Drew, M. R., Lewis‐Peacock, J. A., & Dunsmoor, J. E. (2021) · Current Biology · doi:10.1016/j.cub.2021.11.004 · Cited by 48
Zabik, N. L., Iadipaolo, A. S., Marusak, H. A., Peters, C., Burghardt, K. J., & Rabinak, C. A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24860 · Cited by 44
Spatial Representation of Hippocampal Place Cells in a T-Maze with an Aversive Stimulation
Okada, S., Igata, H., Sasaki, T., & Ikegaya, Y. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00101 · Cited by 38
Sharko, A. C., Fadel, J. R., Kaigler, K. F., & Wilson, M. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.008 · Cited by 38
Kinoshita, K.-I., Tada, Y., Muroi, Y., Unno, T., & Ishii, T. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.07.017 · Cited by 34
ERK-associated changes of AP-1 proteins during fear extinction
Guedea, A. L., Schrick, C., Guzmán, Y. F., Leaderbrand, K., Jovasevic, V., Corcoran, K. A., Tronson, N. C., & Radulović, J. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.03.009 · Cited by 33
Ishikawa, S., Saito, Y., Yanagawa, Y., Otani, S., Hiraide, S., Shimamura, K., Matsumoto, M., & Togashi, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07921.x · Cited by 33
Fukushima, H., Zhang, Y., & Kida, S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1854-20.2020 · Cited by 35
Computational Models of Conditioning
Schmajuk, N. A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511760402 · Cited by 33
Johnson, Z. V., Revis, A. A., Burdick, M. A., & Rhodes, J. S. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.013 · Cited by 31
Baldi, E., & Bucherelli, C. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.02.004 · Cited by 32
Motanis, H., & Maroun, M. (2011) · Hippocampus · doi:10.1002/hipo.20915 · Cited by 31
Gupta, S. C., Hillman, B. G., Prakash, A., Ugale, R. R., Stairs, D. J., & Dravid, S. M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12197 · Cited by 31
Kwon, W., Kim, H., Jeong, J., Sung, Y., Choi, M., Park, S., Lee, J., Jang, S., Kim, S. H., Lee, S., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201601340rr · Cited by 30
Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction
Kellis, D. M., Kaigler, K. F., Witherspoon, E., Fadel, J. R., & Wilson, M. A. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100279 · Cited by 29
The forebrain medial septal region and nociception
Ang, S. T., Ariffin, M. Z., & Khanna, S. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.017 · Cited by 31
Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit
Yousuf, H., Ehlers, V. L., Sehgal, M., Song, C., & Moyer, J. R. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107132 · Cited by 28
Sui, L., Huang, S., Peng, B.-B., Ren, J., Tian, F., & Wang, Y. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1183-5 · Cited by 25
Mount, R. A., Hansen, K., Sridhar, S., Mohammed, A., Abdulkerim, M., Kessel, R. M., Nazer, B., Gritton, H. J., & Han, X. (2021) · eLife · doi:10.7554/elife.56491 · Cited by 21
Sakurai, T., Kitadate, K., Nishioka, H., Fujii, H., Ogasawara, J., Kizaki, T., Sato, S., Fujiwara, T., Akagawa, K., Izawa, T., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300086x · Cited by 22
Sonic hedgehog signaling regulates amygdalar neurogenesis and extinction of fear memory
Hung, H.-C., Hsiao, Y., & Gean, P. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.07.005 · Cited by 19
Levy, R. J., Kvajo, M., Li, Y., Tsvetkov, E., Dong, W., Yoshikawa, Y., Kataoka, T., Bolshakov, V. Y., Karayiorgou, M., & Gogos, J. A. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.75 · Cited by 19
Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction
Spencer-Segal, J. L., Singer, B. H., Laborc, K. F., Somayaji, K., Watson, S. J., Standiford, T. J., & Akil, H. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104679 · Cited by 22
Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear
Ziółkowska, M., Borczyk, M., Cały, A., Nalberczak‐Skóra, M., Śliwińska, M. A., Robacha, M., Łukasiewicz, K., Skonieczna, E., Tomaszewski, K. F., Tomaszewski, K. F., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002106 · Cited by 18
Generalization and recovery of post-retrieval amnesia.
Alfei, J. M., Monti, R. I. F., Molina, V. A., Bundel, D. D., Luyten, L., & Beckers, T. (2020) · Journal of Experimental Psychology General · doi:10.1037/xge0000765 · Cited by 21
Ju, X., Wang, S., Yan, P., Zhu, C., Hu, X., Dong, J., & Tan, Z. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.599399 · Cited by 17
Skilling, Q. M., Eniwaye, B., Clawson, B. C., Shaver, J. J., Ognjanovski, N., Aton, S. J., & Żochowski, M. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009424 · Cited by 16
Ventral hippocampal interneurons govern extinction and relapse of contextual associations
Lacagnina, A. F., Dong, T. N., Iyer, R. R., Boesch, L. F., Khan, S. R., Mohamed, M. K., & Clem, R. L. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114880 · Cited by 17
D’Amico, D., Gener, T., de Lagrán, M. M., Sanchez-Vives, M. V., Santos, M., & Dierssen, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.154 · Cited by 15
Dai, Z., Liu, Y., Nie, L.-N., Chen, W., Xu, X., Li, Y., Zhang, J., Shen, F., Sui, N., & Liang, J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01477-0 · Cited by 15
Extinction and discrimination in a Bayesian model of context fear conditioning ( BaconX )
Krasne, F. B., Zinn, R., Vissel, B., & Fanselow, M. S. (2021) · Hippocampus · doi:10.1002/hipo.23298 · Cited by 13
Li, L., Gao, X., & Zhou, Q. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.04.011 · Cited by 13
Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory
Siddiqui, S. A., Singh, S. K., Ugale, R. R., Ranjan, V., Kanojia, R., Saha, S., Tripathy, S., Kumar, S., Mehrotra, S., Modi, D. R., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.05.011 · Cited by 13
Hippocampus Modulates Vocalizations Responses at Early Auditory Centers
Leong, A. T. L., Wong, E. C., Wang, X., & Wu, E. X. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.119943 · Cited by 14
Li, Y., Zhi, W., Qi, B., Wang, L., & Hu, X. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1216524 · Cited by 16
Nucleus reuniens inactivation does not impair consolidation or reconsolidation of fear extinctionPreprint
Vasudevan, K., Ramanathan, K. R., Vierkant, V., & Maren, S. (2022) · Learning & Memory · doi:10.1101/lm.053611.122 · Cited by 11
Mohammadi-Farani, A., Limoee, M., & Shirooie, S. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000633 · Cited by 11
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Metadata
- Authors
- Tronson, N. C., Schrick, C., Guzman, Y. F., Huh, K. H., Srivastava, D. P., Penzes, P., Guedea, A. L., Gao, C., & Radulovic, J.
- Affiliations
- Northwestern University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-03-18
- Volume
- 29
- Issue
- 11
- Pages
- 3387-3394
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2892108
- OpenAlex
- W2109078253
- Cited by
- 136
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 13 · 2012: 8
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Northwestern University
- National Institute of Mental Health (R01MH073669, MH073669)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- contextual fear, fear extinction, fear conditioning, CA1 pyramidal neurons, c-fos, extracellular signal-regulated kinase, ERK signaling, medial septum, cholinergic input, fear memory consolidation
- MeSH terms
- Animals, Conditioning, Psychological, Extinction, Psychological, Fear, Hippocampus, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Mice
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