Cited by 175Fatty Acid Research and HealthLipid metabolism and biosynthesisLipid Membrane Structure and Behavior

Lipids in Psychiatric Disorders and Preventive Medicine

Open access
Schneider, Miriam, Levant, Beth, Reichel, Martin, Gulbins, Erich, Kornhuber, Johannes, Müller, Christian P.·2017·Neuroscience & Biobehavioral Reviews

Abstract

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable proportion of the human population and severely compromise quality of life. Therefore, measures to prevent the manifestation, and treatments to ameliorate the symptoms, of these disorders are in high demand. Brain lipids determine the localization and function of proteins in the cell membrane of neurons. Lipids may also act as neurotransmitters or other signalling molecules. The lipid composition of the brain can be influenced by nutrition, environmental factors, and by behavioural activity. Thus, lipids represent a target for preventive medicine of psychiatric disorders. Here we review how brain lipids contribute to normal behaviour and to major psychiatric disorders with the focus on phospholipids/fatty acids, sphingolipids, and endocannabinoids. Accumulating evidence suggests a crucial role for membrane forming and signalling lipids in the brain in the etiopathologies of depression, bipolar disorders, schizophrenia, and drug addiction. Lipids also represent potential preventive interventions for these psychiatric disorders by either targeted dietary supplementation or pharmacological manipulation of lipid regulating enzymes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2016.06.002

Cites

474 of 474 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

Research works printed but not linked: 1

  1. Gulbins, E., Walter, S., Becker, K.A., Halmer, R., Liu, Y., Müller, C.P., Fassbender, K., Kornhuber, J., 2015. Ceramide in neurogenesis and major depression. J. Neurochem. 134 (2), 183-192.

Cited by

Sorted by citations

Authors
Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P.
Affiliations
  • Heidelberg University (DE)
  • University of Kansas Medical Center (US)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • University of Duisburg-Essen (DE)
Corresponding author
Müller, Christian P.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2017-05
Volume
76
Issue
Pt B
Pages
336-362
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2421177106
Cited by
175
References
474
Citations by year
2026: 14 · 2025: 12 · 2024: 23 · 2023: 20 · 2022: 20 · 2021: 17 · 2020: 24 · 2019: 16 · 2018: 15 · 2017: 12 · 2016: 2
FWCI
2.02
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • German National Science Foundation (KO 947/15-1, GU 335/29-1, MU 2789/8-1, FOR926)
  • Interdisciplinary Center for Clinical Research Erlangen
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
brain lipids, mental illness, depression, bipolar disorder, schizophrenia, drug addiction, phospholipids, fatty acids, sphingolipids, endocannabinoids, lipid signaling, membrane lipids, dietary supplementation, lipid metabolism enzymes
MeSH terms
Mental Disorders, Brain, Humans, Lipids, Quality of Life

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review