Cited by 599Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

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Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

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Wakabayashi, Yoshihiro, Nakada, Tomoaki, Murata, Ken, Ohkura, Satoshi, Mogi, Kazutaka, Navarro, Victor M., Clifton, Donald K., Mori, Yuji, Tsukamura, Hiroko, Maeda, Kei-Ichiro, Steiner, Robert A., Okamura, Hiroaki·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.5848-09.2010PMC PMC6633939

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Abstract

Gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain are the final common pathway through which the brain regulates reproduction. GnRH secretion occurs in a pulsatile manner, and indirect evidence suggests the kisspeptin neurons in the arcuate nucleus (ARC) serve as the central pacemaker that drives pulsatile GnRH secretion. The purpose of this study was to investigate the possible coexpression of kisspeptin, neurokinin B (NKB), and dynorphin A (Dyn) in neurons of the ARC of the goat and evaluate their potential roles in generating GnRH pulses. Using double and triple labeling, we confirmed that all three neuropeptides are coexpressed in the same population of neurons. Using electrophysiological techniques to record multiple-unit activity (MUA) in the medial basal hypothalamus, we found that bursts of MUA occurred at regular intervals in ovariectomized animals and that these repetitive bursts (volleys) were invariably associated with discrete pulses of luteinizing hormone (LH) (and by inference GnRH). Moreover, the frequency of MUA volleys was reduced by gonadal steroids, suggesting that the volleys reflect the rhythmic discharge of steroid-sensitive neurons that regulate GnRH secretion. Finally, we observed that central administration of Dyn-inhibit MUA volleys and pulsatile LH secretion, whereas NKB induced MUA volleys. These observations are consistent with the hypothesis that kisspeptin neurons in the ARC drive pulsatile GnRH and LH secretion, and suggest that NKB and Dyn expressed in those neurons are involved in the process of generating the rhythmic discharge of kisspeptin.

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Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone
Belchetz, P. E., Plant, T. M., Nakai, Y., Keogh, E. J., & Knobil, E. (1978) · Science · doi:10.1126/science.100883 · Cited by 1,385
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“The pulsatile release of gonadotropin-releasing hormone (GnRH) is a prerequisite for sustaining normal gonadotropin secretion in mammals (Knobil, 1980; Karsch, 1984); however, the cellular and molecular mechanisms that generate the rhythmic discharge of GnRH are unknown.”
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“Finally, kisspeptin/ NKB/Dyn neurons in the ARC have been proposed to be a primary site of negative feedback action of E2 and P (Smith et al., 2005a,b, 2007; Burke et al., 2006; Foradori et al., 2006; Goodman et al., 2007), and we demonstrated here that E2 and P suppress the occurrence of MUA…”
BackgroundSelf-citation
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036 · cited 2×
“duces a prolonged activation of GnRH neurons in the mouse (Han et al., 2005; Pielecka-Fortuna et al., 2008).”
BackgroundResult
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction
Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., Serin, A., Mungan, N. O., Cook, J. R., Ozbek, M. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.306 · Cited by 961 · cited 2×
“Indeed, Topaloglu et al. (2009) have recently shown that mutations of either Trc3 or Tacr3, which encode NKB and NK3, respectively, produce gonadotropin deficiency and pubertal failure in humans.”
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“Kisspeptin neurons in the hypothalamus play a key role in the regulation of GnRH neurons (Oakley et al., 2009), but the precise nature of the interaction between kisspeptin and GnRH neurons is just emerging.”
Background
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
Navarro, V. M., Gottsch, M. L., Chavkin, C., Okamura, H., Clifton, D. K., & Steiner, R. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-09.2009 · Cited by 779 · cited 19×
“Finally, we tested the hypothesis that NKB and Dyn play crucial roles in driving GnRH pulse generator activity by analyzing the effects of centrally administered NKB, Dyn, and a KOR antagonist on pulsatile MUA and LH secretion.”
BackgroundResultInfluential

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“As a consequence, considering this limitation, the above observations would essentially be in keeping with previous reports documenting inhibitory actions of senktide (or NKB) in gonadectomized mice, rats, and goats [22,56,76].”
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Oestrogen‐Induced Activation of Preoptic Kisspeptin Neurones May be Involved in the Luteinising Hormone Surge in Male and Female Japanese Monkeys
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GPR54-Dependent Stimulation of Luteinizing Hormone Secretion by Neurokinin B in Prepubertal Rats
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Background
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Effects and Interactions of Tachykinins and Dynorphin on FSH and LH Secretion in Developing and Adult Rats
Ruíz-Pino, F., García-Galiano, D., Manfredi-Lozano, M., León, S., Sanchez-Garrido, M. A., Roa, J., Pinilla, L., Navarro, V. M., & Tena‐Sempere, M. (2014) · Endocrinology · doi:10.1210/en.2014-1026 · Cited by 58
Impact of psychosocial stress on gonadotrophins and sexual behaviour in females: role for cortisol?
Ralph, C. R., Lehman, M. N., Goodman, R. L., & Tilbrook, A. J. (2016) · Reproduction · doi:10.1530/rep-15-0604 · Cited by 56
Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology
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The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio)
Zhou, W., Li, S., Liu, Y., Qi, X., Chen, H., Cheng, C. H. K., Liu, X., Zhang, Y., & Lin, H. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.04.007 · Cited by 55
“…projections to the GnRH terminals in the median eminence where TACR3 is expressed (Abel et al., 1999; Duarte et al., 2006; Foradori et al., 2006; Goodman et al., 2007; Navarro et al., 2009; Pillon et al., 2003; Ramaswamy et al., 2010; Sandoval-Guzmán and Rance, 2004; Wakabayashi et al., 2010).”
The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach
Voliotis, M., Li, X. F., De Burgh, R., Lass, G., Lightman, S. L., O'Byrne, K. T., & Tsaneva-Atanasova, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0828-19.2019 · Cited by 54
“On the contrary, administration of NKB or Dyn modulates MUA volley frequency in the ovariectomized goat (Wakabayashi et al., 2010), suggesting a more active role for these neuropeptides in the generation of the pulses.”
BackgroundMethod
Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice
Ruka, K. A., Burger, L. L., & Moenter, S. M. (2015) · Endocrinology · doi:10.1210/en.2015-1688 · Cited by 52
Kisspeptin and the regulation of the reproductive axis in domestic animals
Scott, C., Rose, J., Gunn, A. J., & McGrath, B. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0485 · Cited by 56
A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals
Bianco, S. D. C. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00149 · Cited by 57
“WITH ICPP”
Background
Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
Noritake, K., Matsuoka, T., Ohsawa, T., SHIMOMURA, K., Sanbuissho, A., Uenoyama, Y., Maeda, K., & Tsukamura, H. (2011) · Journal of Reproduction and Development · doi:10.1262/jrd.11-002s · Cited by 53
“Most kisspeptin neurons have neurokinin B (NKB) and dynorphin (Dyn) in sheep [12], goats [13] and rodents [14], and thus the neurons have been called KNDy neurons [15].”
Background
Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats
Matsuzaki, T., Iwasa, T., Kinouchi, R., Yoshida, S., Murakami, M., Gereltsetseg, G., Yamamoto, S., Kuwahara, A., Yasui, T., & Irahara, M. (2011) · Endocrine Journal · doi:10.1507/endocrj.k11e-131 · Cited by 52
Tachykinin: recent developments and novel roles in health and disease
Onaga, T. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0008 · Cited by 53
Organizational and activational effects of sex steroids on kisspeptin neuron development
Poling, M. C., & Kauffman, A. S. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.06.001 · Cited by 54
“(2010)), and is further supported by the proposed autocrine/paracrine actions of NKB and dynorphin on ARC kisspeptin neurons (Goodman et al., 2007; Navarro et al., 2009a; Wakabayashi et al., 2010).”
Background
Aconitum-Derived Bulleyaconitine A Exhibits Antihypersensitivity Through Direct Stimulating Dynorphin A Expression in Spinal Microglia
Li, T., Fan, H. J., & Wang, Y. (2016) · Journal of Pain · doi:10.1016/j.jpain.2015.12.015 · Cited by 53
Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion
Wang, H., Zhang, W.-D., Yuan, B., & Zhang, J. (2021) · Animals · doi:10.3390/ani11041134 · Cited by 57
“GnRH is released in a pulsed manner under physiological conditions such as the regulation by kisspeptin, neurokinin B (NKB), dynorphin (Dyn), γ—aminobutyric acid (GABA) and glutamate [33,34].”
Background
Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges
Ruohonen, S. T., POUTANEN, M. H., & Tena‐Sempere, M. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.06.038 · Cited by 52
Expanding the role of tachykinins in the neuroendocrine control of reproduction
Fergani, C., & Navarro, V. M. (2016) · Reproduction · doi:10.1530/rep-16-0378 · Cited by 52
Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons
Hu, Q., Jin, J., Zhou, H., Yu, D., Qian, W., Zhong, Y., Zhang, J., Tang, C., Liu, P., Zhou, Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.135 · Cited by 52
Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep
Li, Q., Millar, R. P., Clarke, I. J., & Smith, J. T. (2015) · Neuroendocrinology · doi:10.1159/000377702 · Cited by 49
Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat
Murakawa, H., Iwata, K., Takeshita, T., & Ozawa, H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.008 · Cited by 50
Kisspeptin mRNA expression is increased in the posterior hypothalamus in the rat model of polycystic ovary syndrome
Matsuzaki, T., Tungalagsuvd, A., Iwasa, T., Munkhzaya, M., Yanagihara, R., Tokui, T., Yano, K., Mayila, Y., Kato, T., Kuwahara, A., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0282 · Cited by 52
Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing
Li, T.-F., Gong, N., & Wang, Y. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00367 · Cited by 51
Immunocytochemical localization of kisspeptin neurons in the rat forebrain with special reference to sexual dimorphism and interaction with GnRH neurons
Xu, Z., Kaga, S., Mochiduki, A., Tsubomizu, J., Adachi, S., Sakai, T., Inoue, K., & Adachi, A. A. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej11-0193 · Cited by 52
Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys
Garcia, J. P., Guerriero, K. A., Keen, K. L., Kenealy, B. P., Seminara, S. B., & Terasawa, E. (2017) · Endocrinology · doi:10.1210/en.2017-00500 · Cited by 50
“Based on the findings in rodents and ruminants that ne rly 100 % of kisspeptin neurons in the arcuate nucleus (ARC) express NKB and dynorphin (29 , 30), and stimulatory kisspeptin and NKB signaling and inhibitory dynorphin signaling ap pear to form a GnRH pulse-generating network (5, 30-32), this group of neurons in t…”
Background
Neurokinin B Regulates Gonadotropin Secretion, Ovarian Follicle Growth, and the Timing of Ovulation in Healthy Women
Skorupskaite, K., George, J. T., Veldhuis, J. D., & Anderson, R. A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01306 · Cited by 49
“(15, 16), goats (17), and monkeys (18).”
Male Effect Pheromone Tickles the Gonadotrophin‐Releasing Hormone Pulse Generator
Okamura, H., Murata, K., Sakamoto, K., Wakabayashi, Y., Ohkura, S., Takeuchi, Y., & Mori, Y. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02037.x · Cited by 49
Gonadotrophin‐Releasing Hormone Release into the Hypophyseal Portal Blood of the Ewe Mirrors Both Pulsatile and Continuous Intravenous Infusion of K isspeptin: An Insight into K isspeptin's Mechanism of Action
Caraty, A., Lomet, D., Sébert, M., Guillaume, D., Beltramo, M., & Evans, N. P. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12030 · Cited by 47
The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus
Plant, T. M. (2019) · F1000Research · doi:10.12688/f1000research.18356.2 · Cited by 69
“…ICV injection of dynorphin to ovariectomized animals interrupted spontaneous volleys of MUA whereas administration of a KOR antagonist (nor-binaltorphimine, or nor-BNI) resulted in a marked acceleration in this electrophysiological parameter and an increase in the duration of the volley 81,82VI .”
Background
Hypothalamic Kisspeptin Neurons and the Control of Homeostasis
Rønnekleiv, O. K., Qiu, J., & Kelly, M. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab253 · Cited by 48
Kisspeptin-neuron control of LH pulsatility and ovulation
Stevenson, H., Bartram, S., Charalambides, M. M., Murthy, S., Petitt, T., Pradeep, A., Vineall, O., Abaraonye, I., Lancaster, A., Koysombat, K., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.951938 · Cited by 48
“The activity of KP-neurons is episodic as indicated by studies measuring multiple unit activity (MUA) near ARC KP-neurons in goats (18, 19) and rats (20), as well as calcium activity in ARC KP-neurons in female mice (21).”
Background
Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production
Qi, X., Salem, M., Zhou, W., Sato-Shimizu, M., Ye, G., Smitz, J. E. J., & Peng, C. (2016) · Endocrinology · doi:10.1210/en.2016-1354 · Cited by 48
Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe
Weems, P. W., Coolen, L. M., Hileman, S. M., Hardy, S. L., McCosh, R. B., Goodman, R. L., & Lehman, M. N. (2018) · Endocrinology · doi:10.1210/en.2018-00435 · Cited by 45
Central Administration of Neurokinin B Activates Kisspeptin/NKB Neurons in the Arcuate Nucleus and Stimulates Luteinizing Hormone Secretion in Ewes During the Non-Breeding Season
Sakamoto, K., MURATA, K., Wakabayashi, Y., Yayou, K., Ohkura, S., Takeuchi, Y., Mori, Y., & OKAMURA, H. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.2011-038 · Cited by 46
“Immunohistochemistry for Kisspeptin/NKB Free-floating sections were processed for double-labeling immunohistochemistry using a monoclonal antibody to kisspeptin ([Cys36]rat kisspeptin (36-52), Takeda #254) [7, 16] and a polyclonal antibody to NKB (a full length of human NKB, Peninsula Laboratories, San Carlos, CA, USA…”
BackgroundMethodResultInfluential
Keeping Puberty on Time
Tena‐Sempere, M. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-396968-2.00011-7 · Cited by 51
“Of note, the coexpression of NKB and kisspeptins in the ARC have been documented in numerous species, including sheep (Goodman et al., 2007), goat, mouse (Navarro, Gottsch, et al., 2009; Wakabayashi et al., 2010), rat (Burke, Letts, Krajewski, & Rance, 2006), and monkey (Ramaswamy et al., 2010).”
Background
Morphological Evidence for Enhanced Kisspeptin and Neurokinin B Signaling in the Infundibular Nucleus of the Aging Man
Molnár, C. S., Vida, B., Sipos, M. T., Ciofi, P., Borsay, B. Á., Racz, K., Herczeg, L., Bloom, S. R., Ghatei, M. A., Dhillo, W. S., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1739 · Cited by 46
Effects of Brief Exposure of Male Pheromone on Multiple-Unit Activity at Close Proximity to Kisspeptin Neurons in the Goat Arcuate Nucleus
MURATA, K., Wakabayashi, Y., Sakamoto, K., TANAKA, T., Takeuchi, Y., Mori, Y., & OKAMURA, H. (2010) · Journal of Reproduction and Development · doi:10.1262/jrd.10-070e · Cited by 46
“Lehman MN, Coolen LM, Goodman RL. Minireview: Kisspeptin/Neurokinin B/ Dynorphin (KNDy) cells of the arcuate nucleus: A central node in the control of gonadotropin-releasing hormone secretion.”
BackgroundMethodInfluential
Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non‐rodent mammals
Matsuda, F., Ohkura, S., Magata, F., Munetomo, A., Chen, J., Sato, M., Inoue, N., Uenoyama, Y., & Tsukamura, H. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14124 · Cited by 48
“cerebroventricular injection of NKB increased MUA volley frequency, while that of Dyn decreased the frequency.(50) It should be noted that the anterior”
Background
Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish
Hu, G., Lin, C., He, M., & Wong, A. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.08.009 · Cited by 45
Challenges and controversies in diagnosis and management of gonadotropin dependent precocious puberty: An Indian perspective
Dutta, D., Kumar, M., & Mukhopadhyay, S. (2015) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.149316 · Cited by 45
“Neurokinin B and dynorphin from the same neurons stimulate and inhibit the release of kisspeptin respectively, and hence these kisspeptin, neurokinin and dynorphin neurons have now been recognized to be central to puberty initiation.[9,10]”
Background
Estrus Synchronization in the Sheep and Goat
Habeeb, H. M. H., & Kutzler, M. A. (2021) · Veterinary Clinics of North America Food Animal Practice · doi:10.1016/j.cvfa.2020.10.007 · Cited by 44
Effects of Neurokinin B Administration on Reproductive Hormone Secretion in Healthy Men and Women
Jayasena, C. N., Comninos, A. N., Silva, A. D., Abbara, A., Veldhuis, J. D., Nijher, G. M. K., Ganiyu‐Dada, Z., Vaal, M. L., Stamp, G. W. H., Ghatei, M. A., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2880 · Cited by 44
“inhibits LH secretion but increases the frequency of multiunit volleys (a surrogate measure of neuronal activity) in the arcuate nucleus (9).”
Background
Kisspeptin and the Preovulatory Gonadotrophin‐Releasing Hormone/Luteinising Hormone Surge in the Ewe: Basic Aspects and Potential Applications in the Control of Ovulation
Caraty, A., Franceschini, I., & Hoffman, G. E. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02022.x · Cited by 43
Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human
Hrabovszky, E., & Liposits, Z. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00130 · Cited by 44
“For example, central administration of NKB increases the frequencies of multiunit activity volleys and LH secretory pulses in ovariectomized goats, likely via acting on this NK3 autoreceptor (43).”
BackgroundInfluential
Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice
Kreisman, M. J., McCosh, R. B., Tian, K., Song, C. I., & Breen, K. M. (2020) · Neuroendocrinology · doi:10.1159/000502978 · Cited by 42
Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat
Mittelman‐Smith, M. A., Krajewski, S. J., McMullen, N. T., & Rance, N. E. (2015) · Endocrinology · doi:10.1210/en.2014-1974 · Cited by 42
The roles of kisspeptin in the mechanism underlying reproductive functions in mammals
Uenoyama, Y., Inoue, N., Maeda, K., & Tsukamura, H. (2018) · Journal of Reproduction and Development · doi:10.1262/jrd.2018-110 · Cited by 44
Sex Differences in the Neurokinin B System in the Human Infundibular Nucleus
Taziaux, M., Swaab, D. F., & Bakker, J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1554 · Cited by 42
“NKB neurons have also been described in the INF/arcuate nucleus (ARC) of the monkey (15, 16), sheep (9, 10, 17), goat (18), rat (7, 8, 19), and mouse (20).”
Background
Neurokinin B signalling in the human reproductive axis
Topaloglu, A. K., & Semple, R. K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.014 · Cited by 41

Authors: Wakabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, V. M., Clifton, D. K., Mori, Y., Tsukamura, H., Maeda, K.-I., Steiner, R. A., & Okamura, H.
Affiliations: Institute of Agrobiological Sciences (JP)
Nagoya University (JP)
University of Washington (US)
The University of Tokyo (JP)
ORCID: Wakabayashi, Yoshihiro
Nakada, Tomoaki
Ohkura, Satoshi
Mogi, Kazutaka
Navarro, Victor M.
Tsukamura, Hiroko
Steiner, Robert A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-02-24
Volume: 30
Issue: 8
Pages: 3124-3132
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5848-09.2010
PMC: PMC6633939
OpenAlex: W2045555035
Cited by: 597
References: 42
Citations by year: 2026: 12 · 2025: 27 · 2024: 19 · 2023: 24 · 2022: 32 · 2021: 36 · 2020: 38 · 2019: 36 · 2018: 42 · 2017: 39 · 2016: 42 · 2015: 42 · 2014: 54 · 2013: 48 · 2012: 47
FWCI: 58.30
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u54hd012629-31)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049651, U54-HD-12629, U54HD-012629)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: kisspeptin neurons, arcuate nucleus, neurokinin B, dynorphin A, pulsatile GnRH secretion, luteinizing hormone, multi-unit activity, goats, neuroendocrine regulation of reproduction
MeSH terms: Action Potentials, Animals, Arcuate Nucleus of Hypothalamus, Biological Clocks, Dynorphins, Electrophysiology, Female, Goats, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Neurons, Neurosecretory Systems, Ovariectomy, Periodicity, Proteins, Reproduction, Gonadal Steroid Hormones, Neurokinin B, Tumor Suppressor Proteins, Estrous Cycle, Kisspeptins

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Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

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