Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.
Open accessAbstract
The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In αCaMKII-T286A defective mice, chessboard trimming failed to increase stabilization of new persistent spines at the border between spared and deprived barrels.
“In αCaMKII-T286A defective mice, chessboard trimming failed to increase stabilization of new persistent spines at the border between spared and deprived barrels (Wilbrecht et al., 2010).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Wilbrecht et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042 · see citing works
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE
Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.1003 · Cited by 2,628 · see citing works
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
The structural organization of layer IV in the somatosensory region (S I) of mouse cerebral cortex
Woolsey, T. A., & Van der Loos, H. (1970) · Brain Research · doi:10.1016/0006-8993(70)90079-x · Cited by 2,254 · see citing works
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927 · see citing works
Self-citationThe molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860 · see citing works
ScanImage: Flexible software for operating laser scanning microscopes
Pologruto, T. A., Sabatini, B. L., & Svoboda, K. (2003) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-2-13 · Cited by 1,297 · see citing works
Self-citationLong-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · cited 1× · see citing works
“In the adult barrel cortex, a subset of dendritic spines appear and disappear over days (Grutzendler et al., 2002; Trachtenberg et al., 2002; Holtmaat et al., 2005).”
BackgroundTransient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works
Self-citationAutophosphorylation at Thr <sup>286</sup> of the α Calcium-Calmodulin Kinase II in LTP and Learning
Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055 · see citing works
The subcellular organization of neocortical excitatory connections
Petreanu, L., Mao, T., Sternson, S. M., & Svoboda, K. (2009) · Nature · doi:10.1038/nature07709 · Cited by 1,047 · see citing works
Self-citationMerzenich, M. M., Kaas, J. H., Wall, J., Nelson, R. J., Sur, M., & Felleman, D. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90024-6 · Cited by 1,042 · see citing works
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
Holtmaat, A. J. D. G., Bonhoeffer, T., Chow, D. K., Chuckowree, J. A., Paola, V. D., Hofer, S. B., Hübener, M., Keck, T., Knott, G. W., Lee, W.-C. A., et al. (2009) · Nature Protocols · doi:10.1038/nprot.2009.89 · Cited by 998 · see citing works
Self-citationExperience-dependent and cell-type-specific spine growth in the neocortex
Holtmaat, A., Wilbrecht, L., Knott, G. W., Welker, E., & Svoboda, K. (2006) · Nature · doi:10.1038/nature04783 · Cited by 631 · see citing works
Self-citationSpine growth precedes synapse formation in the adult neocortex in vivo
Knott, G. W., Holtmaat, A., Wilbrecht, L., Welker, E., & Svoboda, K. (2006) · Nature Neuroscience · doi:10.1038/nn1747 · Cited by 563 · see citing works
Self-citationExperience leaves a lasting structural trace in cortical circuits
Hofer, S. B., Mrsic-Flogel, T. D., Bonhoeffer, T., & Hübener, M. (2009) · Nature · doi:10.1038/nature07487 · Cited by 514 · see citing works
Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex
Xu, H., Pan, F., Yang, G., & Gan, W. (2007) · Nature Neuroscience · doi:10.1038/nn1883 · Cited by 406 · see citing works
Interdigitated Paralemniscal and Lemniscal Pathways in the Mouse Barrel Cortex
Bureau, I., Paul, F. V. S., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040382 · Cited by 274 · see citing works
Self-citationGlazewski, S., & Fox, K. D. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1714 · Cited by 236 · see citing works
Self-citationA Comparison of Experience-Dependent Plasticity in the Visual and Somatosensory Systems
Fox, K. D., & Wong, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.013 · Cited by 232 · see citing works
Self-citationAutophosphorylation of αCaMKII Is Required for Ocular Dominance Plasticity
Taha, S. A., Hanover, J. L., Silva, A. J., & Stryker, M. P. (2002) · Neuron · doi:10.1016/s0896-6273(02)00966-2 · Cited by 119 · see citing works
The role of α-CaMKII autophosphorylation in neocortical experience-dependent plasticity
Glazewski, S., Giese, K.-P., Silva, A. J., & Fox, K. D. (2000) · Nature Neuroscience · doi:10.1038/78820 · Cited by 114 · see citing works
Self-citationHardingham, N. R., Glazewski, S., Pakhotin, P. I., Mizuno, K., Chapman, P. F., Giese, K.-P., & Fox, K. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04428.2003 · Cited by 99 · see citing works
Self-citationThe effect of vibrissa deprivation pattern on the form of plasticity induced in rat barrel cortex
Fox, K. D., & WALLACE, H. (1999) · Somatosensory & Motor Research · doi:10.1080/08990229970564 · Cited by 67 · see citing works
Self-citationLi, X., Glazewski, S., Lin, X., Elde, R. P., & Fox, K. D. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903570310 · Cited by 48 · see citing works
Self-citationOrigins of Cortical Layer V Surround Receptive Fields in the Rat Barrel Cortex
Wright, N. F., & Fox, K. D. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00560.2009 · Cited by 32 · see citing works
Self-citationWright, N. F., Glazewski, S., Hardingham, N. R., Phillips, K. G., Pervolaraki, E., & Fox, K. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2188 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Microglia: Dynamic Mediators of Synapse Development and Plasticity
Wu, Y., Dissing-Olesen, L., MacVicar, B. A., & Stevens, B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.008 · Cited by 661 · see citing works
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Experience-dependent structural plasticity in the cortex
Fu, M., & Zuo, Y. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.001 · Cited by 322 · see citing works
Dendritic spines: from structure to in vivo function
Rochefort, N. L., & Konnerth, A. (2012) · The EMBO Reports · doi:10.1038/embor.2012.102 · Cited by 299 · see citing works
Learning-related feedforward inhibitory connectivity growth required for memory precision
Ruediger, S., Vittori, C. G., Bednarek, E., Genoud, C., Strata, P., Sacchetti, B., & Caroni, P. (2011) · Nature · doi:10.1038/nature09946 · Cited by 282 · see citing works
Long-term effects of motor training on resting-state networks and underlying brain structure
Taubert, M., Lohmann, G., Margulies, D. S., Villringer, A., & Ragert, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.078 · Cited by 281 · see citing works
Structural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions
Pérez‐Alvarez, A., Navarrete, M., Covelo, A., Martín, E. D., & Araque, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2401-14.2014 · Cited by 277 · see citing works
Functional and structural underpinnings of neuronal assembly formation in learning
Holtmaat, A., & Caroni, P. (2016) · Nature Neuroscience · doi:10.1038/nn.4418 · Cited by 239 · see citing works
Self-citationThe Relationship between PSD-95 Clustering and Spine Stability <i>In Vivo</i>
Cane, M., Maco, B., Knott, G., & Holtmaat, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-13.2014 · Cited by 216 · see citing works
Self-citationExpansion and Renormalization of Human Brain Structure During Skill Acquisition
Wenger, E., Brozzoli, C., Lindenberger, U., & Lövdén, M. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.09.008 · Cited by 203 · see citing works
Altered synaptic dynamics during normal brain aging.
Mostany, R., Anstey, J. E., Crump, K. L., Maco, B., Knott, G., & Portera-Cailliau, C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4825-12.2013 · Cited by 179 · see citing works
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Frank, A. C., Huang, S., Zhou, M., Gdalyahu, A., Kastellakis, G., Silva, T. K., Lu, E. D., Wen, X., Poirazi, P., Trachtenberg, J. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02751-2 · Cited by 178 · see citing works
Calmodulin kinases: essential regulators in health and disease
Takemoto‐Kimura, S., Suzuki, K., Horigane, S., Kamijo, S., Inoue, M., Sakamoto, M., Fujii, H., & Bito, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14020 · Cited by 171 · see citing works
Wainwright, S. R., & Galea, L. A. M. (2013) · Neural Plasticity · doi:10.1155/2013/805497 · Cited by 164 · see citing works
Bednarek, E., & Caroni, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.034 · Cited by 160 · see citing works
Nagappan, P. G., Chen, H., & Wang, D. Y. (2020) · Military Medical Research · doi:10.1186/s40779-020-00259-3 · Cited by 148 · see citing works
LTP-Induced Long-Term Stabilization of Individual Nascent Dendritic Spines
Hill, T. C., & Zito, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1404-12.2013 · Cited by 129 · see citing works
Parietofrontal integrity determines neural modulation associated with grasping imagery after stroke
Buch, E. R., Shanechi, A. M., Fourkas, A. D., Weber, C., Birbaumer, N., & Cohen, L. G. (2012) · Brain · doi:10.1093/brain/awr331 · Cited by 132 · see citing works
Alberati, D., Moreau, J., Lengyel, J., Hauser, N., Mory, R., Borroni, E., Pinard, E., Knoflach, F., Schlotterbeck, G., Hainzl, D., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.008 · Cited by 127 · see citing works
Radley, J. J., Anderson, R. M., Hamilton, B. A., Alcock, J. A., & Romig‐Martin, S. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0287-13.2013 · Cited by 121 · see citing works
An algorithm to predict the connectome of neural microcircuits
Reimann, M., King, J. G., Muller, E. B., Ramaswamy, S., & Markram, H. (2015) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2015.00120 · Cited by 117 · see citing works
Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor 1
Akbik, F. V., Bhagat, S. M., Patel, P. R., Cafferty, W. B. J., & Strittmatter, S. M. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.027 · Cited by 114 · see citing works
Gdalyahu, A., Lázaro, M. T., Peñagarikano, O., Golshani, P., Trachtenberg, J. T., & Gescwind, D. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125633 · Cited by 92 · see citing works
Jacob, V., Petreanu, L., Wright, N. F., Svoboda, K., & Fox, K. D. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.034 · Cited by 89 · see citing works
Self-citationMontey, K. L., & Quinlan, E. M. (2011) · Nature Communications · doi:10.1038/ncomms1312 · Cited by 88 · see citing works
Spatiotemporal dynamics of dendritic spines in the living brain
Chen, C.-C., Lu, J., & Zuo, Y. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00028 · Cited by 88 · see citing works
Muñoz-Cuevas, F. J., Athilingam, J., Piscopo, D., & Wilbrecht, L. (2013) · Nature Neuroscience · doi:10.1038/nn.3498 · Cited by 85 · see citing works
Self-citationOld dogs learning new tricks: Neuroplasticity beyond the juvenile period
Lillard, A. S., & Erişir, A. (2011) · Developmental Review · doi:10.1016/j.dr.2011.07.008 · Cited by 85 · see citing works
Dendritic structural plasticity
Tavosanis, G. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20951 · Cited by 84 · see citing works
Chen, K., Zhang, L., Tan, M., Lai, C. S. W., Li, A., Ren, C., & So, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.41 · Cited by 75 · see citing works
Fauth, M. J., Wörgötter, F., & Tetzlaff, C. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004031 · Cited by 74 · see citing works
Cerri, C., Fabbri, A., Vannini, E., Spolidoro, M., Costa, M., Maffei, L., Fiorentini, C., & Caleo, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2617-11.2011 · Cited by 73 · see citing works
Treatments for smell and taste disorders: A critical review
Doty, R. L. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63855-7.00025-3 · Cited by 71 · see citing works
Harding-Forrester, S., & Feldman, D. E. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63622-5.00004-8 · Cited by 72 · see citing works
Stacho, M., & Manahan‐Vaughan, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.806356 · Cited by 70 · see citing works
Portera‐Cailliau, C. (2011) · The Neuroscientist · doi:10.1177/1073858410395322 · Cited by 68 · see citing works
Greenhill, S., Ranson, A., & Fox, K. D. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.025 · Cited by 60 · see citing works
Self-citationGambino, F., & Holtmaat, A. J. D. G. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.020 · Cited by 63 · see citing works
Self-citationBarrera, K., Chu, P., Abramowitz, J. M., Steger, R., Ramos, R. L., & Brumberg, J. C. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22060 · Cited by 59 · see citing works
Wang, D., Zhao, J. W., Gao, Z., Chen, N., Wen, B., Lu, W., Lei, Z., Chen, C., Liu, Y., Feng, J., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00320 · Cited by 54 · see citing works
Alteration of Synaptic Network Dynamics by the Intellectual Disability Protein PAK3
Dubos, A., Combeau, G., Bernardinelli, Y., Barnier, J., Hartley, O., Gaertner, H., Boda, B., & Muller, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3252-11.2012 · Cited by 54 · see citing works
Swanson, A. M., DePoy, L. M., & Gourley, S. L. (2017) · Nature Communications · doi:10.1038/s41467-017-01915-4 · Cited by 54 · see citing works
Cortical dendritic spine development and plasticity: insights from in vivo imaging
Moyer, C. E., & Zuo, Y. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.06.002 · Cited by 50 · see citing works
Johnston, D. G., Denizet, M., Mostany, R., & Portera‐Cailliau, C. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs092 · Cited by 48 · see citing works
Zheng, M., Chen, R., Chen, H., Zhang, Y., Chen, J., Lin, P., Lan, Q., Yuan, Q., Lai, Y., Jiang, X., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00013 · Cited by 50 · see citing works
Building and remodeling synapses
Benson, D. L., & Huntley, G. W. (2010) · Hippocampus · doi:10.1002/hipo.20872 · Cited by 48 · see citing works
Epac2-mediated dendritic spine remodeling: Implications for disease
Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 47 · see citing works
Radley, J. J. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00007 · Cited by 47 · see citing works
Large-Scale Axonal Reorganization of Inhibitory Neurons following Retinal Lesions
Marik, S. A., Yamahachi, H., Borgloh, S. M. Z. A., & Gilbert, C. D. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4345-13.2014 · Cited by 45 · see citing works
Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease
Srivastava, D. P., & Penzes, P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00077 · Cited by 44 · see citing works
Kass, M. D., Moberly, A. H., Rosenthal, M. C., Guang, S. A., & McGann, J. P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1442-12.2013 · Cited by 41 · see citing works
Bourjaily, M. A., & Miller, P. C. (2011) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2011.00037 · Cited by 40 · see citing works
Zwamborn, R. A. J., Snijders, C., An, N., Thomson, A. C., Rutten, B. P. F., & de Nijs, L. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.005 · Cited by 39 · see citing works
Зуева, М. В. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00135 · Cited by 39 · see citing works
Liu, Y., Gao, Z., Chen, C., Wen, B., Huang, L. T., Ge, R., Zhao, S., Fan, R., Feng, J., Lu, W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21207 · Cited by 38 · see citing works
The Schizophrenia Susceptibility GeneDysbindinRegulates Dendritic Spine Dynamics
Jia, J., Hu, Z., Nordman, J. C., & Li, Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0184-14.2014 · Cited by 37 · see citing works
Boivin, J. R., Piekarski, D. J., Thomas, A. W., & Wilbrecht, L. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.01.007 · Cited by 35 · see citing works
Self-citationCorrelative two-photon and light sheet microscopy
Silvestri, L., Mascaro, A. L. A., Costantini, I., Sacconi, L., & Pavone, F. S. (2013) · Methods · doi:10.1016/j.ymeth.2013.06.013 · Cited by 36 · see citing works
Nielsen, R. M., Li, W., Szepesi, Z., & Li, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0244-14.2015 · Cited by 35 · see citing works
Coultrap, S. J., Barcomb, K., & Bayer, K. U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037176 · Cited by 33 · see citing works
Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo
Mower, A. F., Kwok, S., Yu, H., Majewska, A. K., Okamoto, K., Hayashi, Y., & Sur, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108261109 · Cited by 32 · see citing works
Kim, S. K., Eto, K., & Nabekura, J. (2012) · Neural Plasticity · doi:10.1155/2012/640259 · Cited by 33 · see citing works
Optical imaging of structural and functional synaptic plasticity in vivo
Holtmaat, A. J. D. G., Randall, J., & Cane, M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.020 · Cited by 30 · see citing works
Self-citationRavindranath, O., Calabro, F. J., Foran, W., & Luna, B. (2022) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2022.101162 · Cited by 27 · see citing works
Changes of Synaptic Structures Associated with Learning, Memory and Diseases
Yang, Y., Lu, J., & Zuo, Y. (2018) · Brain Science Advances · doi:10.26599/bsa.2018.2018.9050012 · Cited by 27 · see citing works
Layer 4 Pyramidal Neurons Exhibit Robust Dendritic Spine PlasticityIn Vivoafter Input Deprivation
Miquelajáuregui, A., Kribakaran, S., Mostany, R., Badaloni, A., Consalez, G. G., & Portera‐Cailliau, C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5215-14.2015 · Cited by 25 · see citing works
Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition
Starkey, H. D. V., Sonntag, W. E., & Freeman, W. M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12165 · Cited by 25 · see citing works
Frantz, M. G., Kast, R. J., Dorton, H. M., CHAPMAN, K. S. M., & McGee, A. W. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv014 · Cited by 23 · see citing works
Multicontact Co-operativity in Spike-Timing–Dependent Structural Plasticity Stabilizes Networks
Deger, M., Seeholzer, A., & Wulfram Gerstner, B. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx339 · Cited by 27 · see citing works
Ojha, P., & Dixit, A. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13626 · Cited by 24 · see citing works
Kasai, H. (2023) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.99.018 · Cited by 23 · see citing works
The cellular and molecular basis of in vivo synaptic plasticity in rodents
Cheyne, J. E., & Montgomery, J. M. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00416.2019 · Cited by 23 · see citing works
Chandrasekaran, S., Navlakha, S., Audette, N. J., McCreary, D. D., Suhan, J., Bar‐Joseph, Z., & Barth, A. L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1573-15.2015 · Cited by 21 · see citing works
Schubert, V., Lebrecht, D., & Holtmaat, A. J. D. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1032-13.2013 · Cited by 21 · see citing works
Self-citationPetanjek, Z., Banovac, I., Sedmak, D., & Hladnik, A. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_4 · Cited by 23 · see citing works
Emergence of functional subnetworks in layer 2/3 cortex induced by sequential spikes in vivo
Kim, T.-K., Oh, W. C., Choi, J. H., & Kwon, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513410113 · Cited by 22 · see citing works
Nogo Receptor 1 Limits Tactile Task Performance Independent of Basal Anatomical Plasticity
Park, J. I., Frantz, M. G., Kast, R. J., CHAPMAN, K. S. M., Dorton, H. M., Stephany, C.-É., Arnett, M. T., Herman, D. H., & McGee, A. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112678 · Cited by 20 · see citing works
Rat psychomotor vigilance task with fast response times using a conditioned lick behavior
Walker, J. L., Walker, B. M., Monjaraz-Fuentes, F., & Rector, D. M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.041 · Cited by 19 · see citing works
Smirnov, M. S., Evans, P. R., Garrett, T. R., Yan, L., & Yasuda, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170586 · Cited by 16 · see citing works
Neuronal imaging with ultrahigh dynamic range multiphoton microscopy
Yang, R., Weber, T. D., Witkowski, E. D., Davison, I. G., & Mertz, J. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-06065-7 · Cited by 17 · see citing works
Sterratt, D. C., Groen, M. R., Meredith, R. M., & Arjen Van Ooyen, B. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002545 · Cited by 17 · see citing works
Lebida, K., & Mozrzymas, J. W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0174-y · Cited by 16 · see citing works
Reduced sensory-evoked structural plasticity in the aging barrel cortex
Voglewede, R., Vandemark, K., Davidson, A. M., DeWitt, A. R., Heffler, M. D., Trimmer, E. H., & Mostany, R. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.06.006 · Cited by 14 · see citing works
Insights into age-old questions of new dendritic spines: From form to function
Parajuli, L. K., Tanaka, S., & Okabe, S. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.014 · Cited by 14 · see citing works
Weiler, N. C., Collman, F., Vogelstein, J. T., Burns, R. C., & Smith, S. J. (2014) · Scientific Data · doi:10.1038/sdata.2014.46 · Cited by 13 · see citing works
Huang, C. C., Muszynski, K., Bolshakov, V. Y., & Balu, D. T. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0465-y · Cited by 13 · see citing works
Brown, C. E., Sweetnam, D., Beange, M., Nahirney, P. C., & Nashmi, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4568-11.2012 · Cited by 12 · see citing works
Seaton, G., Hodges, G., de Haan, A. M., Grewal, A., Pandey, A., Kasai, H., & Fox, K. D. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2297-19.2020 · Cited by 10 · see citing works
Self-citationYong, Z., Yan, L., Gao, X., Gong, Z., & Su, R. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.026 · Cited by 12 · see citing works
Stimulus intensity determines experience‐dependent modifications in neocortical neuron firing rates
Glazewski, S., & Barth, A. L. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12805 · Cited by 11 · see citing works
Repetitive Sensory Stimulation Potentiates and Recruits Sensory-Evoked Cortical Population Activity
Williams, L. E., Küffer, L., Bawa, T., Husi, E., Pagès, S., & Holtmaat, A. J. D. G. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2189-23.2024 · Cited by 10 · see citing works
Self-citationExperience-dependent structural plasticity of pyramidal neurons in the developing sensory cortices
Wang, M., & Yu, X. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102724 · Cited by 9 · see citing works
Npas4 Expression in Two Experimental Models of the Barrel Cortex Plasticity
Kaliszewska, A., & Kossut, M. M. (2015) · Neural Plasticity · doi:10.1155/2015/175701 · Cited by 9 · see citing works
Lu, H., Garg, S., Lenz, M., & Vlachos, A. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.07.008 · Cited by 10 · see citing works
Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex
Sequeira, M. K., Swanson, A. M., Kietzman, H. W., & Gourley, S. L. (2023) · iScience · doi:10.1016/j.isci.2023.106240 · Cited by 8 · see citing works
Is Lesion-Induced Synaptic Rewiring Driven by Activity Homeostasis?
Butz‐Ostendorf, M., & van Ooyen, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803784-3.00004-4 · Cited by 8 · see citing works
Unique Sensory and Motor Behavior in Thy1-GFP-M Mice before and after Spinal Cord Injury
Faw, T. D., Lerch, J. K., Thaxton, T. T., Deibert, R. J., Fisher, L. C., & Basso, D. M. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5395 · Cited by 7 · see citing works
Velez, D. X. F., Arreola, M. A., Huh, C. Y. L., Green, K., & Gandhi, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-15503-0 · Cited by 6 · see citing works
Hebb and the art of spine remodeling
Ziv, N. E. (2010) · F1000 Biology Reports · doi:10.3410/b2-69 · Cited by 6 · see citing works
Inberg, S., Iosilevskii, Y., Calatayud-Sanchez, A., Setty, H., Oren‐Suissa, M., Krieg, M., & Podbilewicz, B. (2025) · eLife · doi:10.7554/elife.83973 · Cited by 5 · see citing works
- Authors
- Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Geneva (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-04-06
- Volume
- 30
- Issue
- 14
- Pages
- 4927-4932
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2910869
- OpenAlex
- W2012985621
- Cited by
- 138
- References
- 27
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 13
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Medical Research Council
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke (R01NS038259)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD047104)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- structural plasticity, experience-dependent plasticity, barrel cortex, whisker trimming, CaMKIIα, autophosphorylation, layer 5 neurons, barrel columns, cortical circuits, sensory deprivation
- MeSH terms
- Animals, Cerebral Cortex, Learning, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neuronal Plasticity, Synapses, Vibrissae, Dendritic Spines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review