Cited by 138Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.

Open access
Wilbrecht, Linda, Holtmaat, Anthony, Wright, Nick, Fox, Kevin, Svoboda, Karel·2010·The Journal of Neuroscience

Abstract

The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1523/jneurosci.6403-09.2010

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In αCaMKII-T286A defective mice, chessboard trimming failed to increase stabilization of new persistent spines at the border between spared and deprived barrels.

    “In αCaMKII-T286A defective mice, chessboard trimming failed to increase stabilization of new persistent spines at the border between spared and deprived barrels (Wilbrecht et al., 2010).”

    From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Wilbrecht et al., 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., & Svoboda, K.
Affiliations
  • Howard Hughes Medical Institute (US)
  • University of Geneva (CH)
Venue
The Journal of Neuroscience
Published
2010-04-06
Volume
30
Issue
14
Pages
4927-4932
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2012985621
Cited by
138
References
27
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 13
FWCI
7.12
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • Medical Research Council
  • National Institute of Mental Health
  • National Institute of Neurological Disorders and Stroke (R01NS038259)
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD047104)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
structural plasticity, experience-dependent plasticity, barrel cortex, whisker trimming, CaMKIIα, autophosphorylation, layer 5 neurons, barrel columns, cortical circuits, sensory deprivation
MeSH terms
Animals, Cerebral Cortex, Learning, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neuronal Plasticity, Synapses, Vibrissae, Dendritic Spines, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review