Dendritic spines: from structure to in vivo function

Two-photon laser scanning fluorescence microscopy

Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488 · see citing works

Imaging Intracellular Fluorescent Proteins at Nanometer Resolution

Betzig, E., Patterson, G. H., Sougrat, R., Lindwasser, O. W., Olenych, S. G., Bonifacino, J. S., Davidson, M. W., Lippincott‐Schwartz, J., & Hess, H. F. (2006) · Science · doi:10.1126/science.1127344 · Cited by 8,802 · see citing works

Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)

Rust, M. J., Bates, M., & Zhuang, X. (2006) · Nature Methods · doi:10.1038/nmeth929 · Cited by 8,109 · see citing works

Calcium signalling: dynamics, homeostasis and remodelling

Berridge, M., Bootman, M., & Roderick, H. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1155 · Cited by 5,747 · see citing works

Deep tissue two-photon microscopy

Helmchen, F., & Denk, W. T. (2005) · Nature Methods · doi:10.1038/nmeth818 · Cited by 4,165 · see citing works

Far-field optical nanoscopy

Hell, S. W. (2007) · Science · doi:10.1126/science.1137395 · Cited by 2,967 · see citing works

Structural basis of long-term potentiation in single dendritic spines

Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works

Small GTP-Binding Proteins

Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,481 · see citing works

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927 · see citing works

The molecular basis of CaMKII function in synaptic and behavioural memory

Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860 · see citing works

Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons

Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1× · see citing works

Imaging Calcium in Neurons

Grienberger, C., & Konnerth, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.011 · Cited by 1,344 · see citing works

Long-term dendritic spine stability in the adult cortex

Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · see citing works

Rapid formation and selective stabilization of synapses for enduring motor memories

Xu, T., Yu, X., Perlik, A. J., Tobin, W. F., Zweig, J. A., Tennant, K., Jones, T., & Zuo, Y. (2009) · Nature · doi:10.1038/nature08389 · Cited by 1,193 · see citing works

Stably maintained dendritic spines are associated with lifelong memories

Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182 · see citing works

Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells

Huang, B., Babcock, H. P., & Zhuang, X. (2010) · Cell · doi:10.1016/j.cell.2010.12.002 · Cited by 1,159 · see citing works

DENDRITIC COMPUTATION

London, M., & Häusser, M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135703 · Cited by 1,149 · see citing works

Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics

Harris, K., & Stevens, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02982.1989 · Cited by 1,073 · see citing works

Principles of two-photon excitation microscopy and its applications to neuroscience

Svoboda, K., & Yasuda, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.019 · Cited by 1,027 · see citing works

Synaptic AMPA receptor plasticity and behavior

Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993 · see citing works

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 990 · see citing works

RHO GTPASES in neuronal morphogenesis

Luo, L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044547 · Cited by 985 · see citing works

Dendritic spines as basic functional units of neuronal integration

Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950 · see citing works

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

Luján, R., Nusser, Z., Roberts, J. D. B., Shigemoto, R., & Somogyi, P. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01611.x · Cited by 863 · see citing works

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.

Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831 · see citing works

Structural dynamics of dendritic spines in memory and cognition

Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804 · see citing works

Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo

Lendvai, B., Stern, E. A., Chen, B., & Svoboda, K. (2000) · Nature · doi:10.1038/35009107 · Cited by 802 · see citing works

Ras and Rap control AMPA receptor trafficking during synaptic plasticity

Zhu, J. J., Qin, Y., Zhao, M., Van Aelst, L., & Malinow, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00897-8 · Cited by 769 · see citing works

Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1

Fiala, J. C., Feinberg, M., Popov, V., & Harris, K. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08900.1998 · Cited by 758 · see citing works

The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines

Peters, A., & Kaiserman‐Abramof, I. R. (1970) · American Journal of Anatomy · doi:10.1002/aja.1001270402 · Cited by 740 · see citing works

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons

Nakayama, A. Y., Harms, M. B., & Luo, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05329.2000 · Cited by 708 · see citing works

Activation of CaMKII in single dendritic spines during long-term potentiation

Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685 · see citing works

Development of long-term dendritic spine stability in diverse regions of cerebral cortex

Zuo, Y., Lin, A., Chang, P., & Gan, W.-B. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.001 · Cited by 684 · see citing works

Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

Shen, K., & Meyer, T. (1999) · Science · doi:10.1126/science.284.5411.162 · Cited by 673 · see citing works

Experience-dependent and cell-type-specific spine growth in the neocortex

Holtmaat, A., Wilbrecht, L., Knott, G. W., Welker, E., & Svoboda, K. (2006) · Nature · doi:10.1038/nature04783 · Cited by 631 · see citing works

An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses.

Moser, M., Trommald, M., & Andersen, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12673 · Cited by 615 · see citing works

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

Kennedy, M. B., Bennett, M. K., & Erondu, N. E. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.23.7357 · Cited by 610 · see citing works

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

Murakoshi, H., Wang, H., & Yasuda, R. (2011) · Nature · doi:10.1038/nature09823 · Cited by 564 · see citing works

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561 · see citing works

Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550 · cited 1× · see citing works

Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission

Heine, M., Groc, L., Frischknecht, R., Béïque, J.-C., Lounis, B., Rumbaugh, G., Huganir, R. L., Cognet, L., & Choquet, D. (2008) · Science · doi:10.1126/science.1152089 · Cited by 518 · see citing works

Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites

Finch, E., & Augustine, G. J. (1998) · Nature · doi:10.1038/25541 · Cited by 516 · see citing works

Small GTP-Binding Proteins

Takai, Y., Kaibuchi, K., Kikuchi, A., & Kawata, M. (1992) · International review of cytology · doi:10.1016/s0074-7696(08)61861-6 · Cited by 516 · see citing works

Experience leaves a lasting structural trace in cortical circuits

Hofer, S. B., Mrsic-Flogel, T. D., Bonhoeffer, T., & Hübener, M. (2009) · Nature · doi:10.1038/nature07487 · Cited by 514 · see citing works

Dendritic organization of sensory input to cortical neurons in vivo

Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature · doi:10.1038/nature08947 · Cited by 508 · see citing works

AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis

Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501 · see citing works

Dendritic discrimination of temporal input sequences in cortical neurons

Branco, T., Clark, B. A., & Häusser, M. (2010) · Science · doi:10.1126/science.1189664 · Cited by 497 · see citing works

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.013 · Cited by 490 · see citing works

Coincidence detection in single dendritic spines mediated by calcium release

Wang, S. S. ‐., Denk, W. T., & Häusser, M. (2000) · Nature Neuroscience · doi:10.1038/81792 · Cited by 485 · see citing works

Untitled work

Lisman (2001) · doi:10.1016/s0896-6273(01)00364-6 · Cited by 480 · see citing works

Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses

Müller, W. S., & Connor, J. A. (1991) · Nature · doi:10.1038/354073a0 · Cited by 479 · see citing works

Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo

Fu, M., Yu, X., Lu, J., & Zuo, Y. (2012) · Nature · doi:10.1038/nature10844 · Cited by 478 · see citing works

Electron Microscopy of Synaptic Contacts on Dendrite Spines of the Cerebral Cortex

Gray, E. G. (1959) · Nature · doi:10.1038/1831592a0 · Cited by 443 · see citing works

The small pyramidal neuron of the rat cerebral cortex: The synapses upon dendritic spines

Peters, A., & Kaiserman-Abramof, I. R. (1969) · Zeitschrift f�r Zellforschung und Mikroskopische Anatomie · doi:10.1007/bf00344370 · Cited by 441 · see citing works

Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

Zuo, Y., Yang, G., Kwon, E., & Gan, W.-B. (2005) · Nature · doi:10.1038/nature03715 · Cited by 436 · see citing works

Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic Spines

Emptage, N. J., Bliss, T., & Fine, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80683-2 · Cited by 435 · see citing works

The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine

Harvey, C. D., Yasuda, R., Zhong, H., & Svoboda, K. (2008) · Science · doi:10.1126/science.1159675 · Cited by 434 · see citing works

Spine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites

Noguchi, J., Matsuzaki, M., Ellis-Davies, G. C. R., & Kasai, H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.015 · Cited by 419 · see citing works

Regulation of Dendritic Spine Morphology by the Rho Family of Small GTPases: Antagonistic Roles of Rac and Rho

Tashiro, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.927 · Cited by 416 · see citing works

Live-cell imaging of dendritic spines by STED microscopy

Nägerl, U. V., Willig, K. I., Hein, B., Hell, S. W., & Bonhoeffer, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810028105 · Cited by 412 · see citing works

A new class of synaptic response involving calcium release in dendritic spines

Takechi, H., Eilers, J., & Konnerth, A. (1998) · Nature · doi:10.1038/25547 · Cited by 404 · see citing works

Functional mapping of single spines in cortical neurons in vivo.

Chen, X., Leischner, U., Rochefort, N. L., Nelken, I., & Konnerth, A. (2011) · Nature · doi:10.1038/nature10193 · Cited by 395 · see citing works

Opposite effects of fear conditioning and extinction on dendritic spine remodelling.

Lai, C. S. W., Franke, T. F., & Gan, W.-B. (2012) · Nature · doi:10.1038/nature10792 · Cited by 392 · see citing works

Extensive Turnover of Dendritic Spines and Vascular Remodeling in Cortical Tissues Recovering from Stroke

Brown, C. E., Li, P., Boyd, J. D., Delaney, K. R., & Murphy, T. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4295-06.2007 · Cited by 377 · see citing works

Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator

Mataga, N., Mizuguchi, Y., & Hensch, T. K. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.028 · Cited by 371 · see citing works

From form to function: calcium compartmentalization in dendritic spines

Yuste, R., Majewska, A. K., & Holthoff, K. (2000) · Nature Neuroscience · doi:10.1038/76609 · Cited by 370 · see citing works

Nanoscopy in a living mouse brain

Berning, S., Willig, K. I., Steffens, H., Dibaj, P., & Hell, S. W. (2012) · Science · doi:10.1126/science.1215369 · Cited by 363 · see citing works

A clustered plasticity model of long-term memory engrams.

Govindarajan, A., Kelleher, R. J., & Tonegawa, S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1937 · Cited by 355 · see citing works

The single dendritic branch as a fundamental functional unit in the nervous system

Branco, T., & Häusser, M. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.009 · Cited by 355 · see citing works

Locally synchronized synaptic inputs

Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., & Ikegaya, Y. (2012) · Science · doi:10.1126/science.1210362 · Cited by 352 · see citing works

Synaptic Integration Gradients in Single Cortical Pyramidal Cell Dendrites

Branco, T., & Häusser, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.006 · Cited by 351 · see citing works

CaMKIIβ Functions As an F-Actin Targeting Module that Localizes CaMKIIα/β Heterooligomers to Dendritic Spines

Shen, K., Teruel, M. N., Subramanian, K., & Meyer, T. (1998) · Neuron · doi:10.1016/s0896-6273(00)80569-3 · Cited by 350 · see citing works

The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP

Govindarajan, A., Israely, I., Huang, S.-Y., & Tonegawa, S. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.008 · Cited by 349 · see citing works

Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.

Chen, J. L., Villa, K. L., Cha, J. W., So, P. T. C., Kubota, Y., & Nedivi, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.030 · Cited by 341 · see citing works

Ca(2+) signaling in dendritic spines.

Sabatini, B., Maravall, M., & Svoboda, K. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00218-x · Cited by 340 · see citing works

Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo

Gray, N. W., Weimer, R. M., Bureau, I., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040370 · Cited by 338 · see citing works

Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons

Papa, M., Bundman, M. C., Greenberger, V., & Segal, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00001.1995 · Cited by 330 · see citing works

Delayed Stabilization of Dendritic Spines in Fragile X Mice

Cruz-Martin, A., Crespo, M., & Portera-Cailliau, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0577-10.2010 · Cited by 321 · see citing works

<i>In Vivo</i>Voltage-Sensitive Dye Imaging in Adult Mice Reveals That Somatosensory Maps Lost to Stroke Are Replaced over Weeks by New Structural and Functional Circuits with Prolonged Modes of Activation within Both the Peri-Infarct Zone and Distant Sites

Brown, C. E., Aminoltejari, K., Erb, H., Winship, I. R., & Murphy, T. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4249-08.2009 · Cited by 319 · see citing works

Dendritic spines of rat cerebellar Purkinje cells: serial electron microscopy with reference to their biophysical characteristics

Harris, K., & Stevens, J. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04455.1988 · Cited by 318 · see citing works

Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex

Keck, T., Mrsic-Flogel, T. D., Vaz Afonso, M., Eysel, U. T., Bonhoeffer, T., & Hübener, M. (2008) · Nature Neuroscience · doi:10.1038/nn.2181 · Cited by 315 · see citing works

Cytoplasmic actin in neuronal processes as a possible mediator of synaptic plasticity.

Fifková, E., & Delay, R. J. (1982) · The Journal of cell biology · doi:10.1083/jcb.95.1.345 · Cited by 309 · see citing works

Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons

Cash, S. S., & Yuste, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)81098-3 · Cited by 308 · see citing works

Dendritic spines and distributed circuits

Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.024 · Cited by 298 · see citing works

Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning

Matsuo, N., Reijmers, L. G. J. E., & Mayford, M. R. (2008) · Science · doi:10.1126/science.1149967 · Cited by 296 · see citing works

Rapid spine stabilization and synaptic enhancement at the onset of behavioural learning

Roberts, T. F., Tschida, K. A., Klein, M. E., & Mooney, R. (2010) · Nature · doi:10.1038/nature08759 · Cited by 296 · see citing works

Mechanisms of Calcium Influx into Hippocampal Spines: Heterogeneity among Spines, Coincidence Detection by NMDA Receptors, and Optical Quantal Analysis

Yuste, R., Majewska, A. K., Cash, S. S., & Denk, W. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01976.1999 · Cited by 288 · see citing works

Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide.

Kelly, P. T., & Cotman, C. W. (1978) · The Journal of Cell Biology · doi:10.1083/jcb.79.1.173 · Cited by 266 · see citing works

Independent regulation of calcium revealed by imaging dendritic spines

Guthrie, P. B., Segal, M., & Kater, S. B. (1991) · Nature · doi:10.1038/354076a0 · Cited by 262 · see citing works

Morphological variations in the dendritic spines of the neocortex

Jones, E. G., & Powell, T. P. S. (1969) · Journal of Cell Science · doi:10.1242/jcs.5.2.509 · Cited by 261 · see citing works

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259 · see citing works

Loss of Sensory Input Causes Rapid Structural Changes of Inhibitory Neurons in Adult Mouse Visual Cortex

Keck, T., Scheuß, V., Jacobsen, R. I., Wierenga, C. J., Eysel, U. T., Bonhoeffer, T., & Hübener, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.034 · Cited by 244 · see citing works

Maturation of rat visual cortex. II. A combined Golgi‐electron microscope study of pyramidal neurons

Miller, M. W., & Peters, A. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902030402 · Cited by 239 · see citing works

Local Calcium Release in Dendritic Spines Required for Long-Term Synaptic Depression

Miyata, M., Finch, E., Khiroug, L. S., Hashimoto, K., Hayasaka, S., Oda, S., Inouye, M., Takagishi, Y., Augustine, G. J., & Kano, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00099-4 · Cited by 239 · see citing works

Multiple periods of functional ocular dominance plasticity in mouse visual cortex

Tagawa, Y., Kanold, P. O., Majdan, M., & Shatz, C. J. (2005) · Nature Neuroscience · doi:10.1038/nn1410 · Cited by 235 · see citing works

Synaptic regulation of translation of dendritic mRNAs

Schuman, E. M., Dynes, J. L., & Steward, O. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1796-06.2006 · Cited by 230 · see citing works

The dendritic spine: a multifunctional integrative unit

Shepherd, G. M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.6.2197 · Cited by 221 · see citing works

Prior experience enhances plasticity in adult visual cortex

Hofer, S. B., Mrsic‐Flogel, T. D., Bonhoeffer, T., & Hübener, M. (2005) · Nature Neuroscience · doi:10.1038/nn1610 · Cited by 221 · see citing works

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

Makino, H., & Malinow, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.036 · Cited by 219 · see citing works

Selective dendritic transport of RNA in hippocampal neurons in culture

Davis, L. A., Banker, G. A., & Steward, O. (1987) · Nature · doi:10.1038/330477a0 · Cited by 216 · see citing works

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

Pan, F., Aldridge, G. M., Greenough, W. T., & Gan, W.-B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012496107 · Cited by 208 · see citing works

Cortical area and species differences in dendritic spine morphology

Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R. (2002) · Journal of Neurocytology · doi:10.1023/a:1024134312173 · Cited by 207 · see citing works

Quantitative fine-structural analysis of olfactory cortical synapses

Schikorski, T., & Stevens, C. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4107 · Cited by 204 · see citing works

In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons

Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature Protocols · doi:10.1038/nprot.2010.169 · Cited by 199 · see citing works

Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo

Mittmann, W., Wallace, D. J., Czubayko, U., Herb, J. T., Schaefer, A. T., Looger, L. L., Denk, W. T., & Kerr, J. N. D. (2011) · Nature Neuroscience · doi:10.1038/nn.2879 · Cited by 188 · see citing works

Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity

van Versendaal, D., Rajendran, R., Saiepour, M. H., Klooster, J., Smit‐Rigter, L. A., Sommeijer, J.-P., Zeeuw, C. I. D., Hofer, S. B., Heimel, J. A., & Levelt, C. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.015 · Cited by 187 · see citing works

In vivo two‐photon uncaging of glutamate revealing the structure–function relationships of dendritic spines in the neocortex of adult mice

Noguchi, J., Nagaoka, A., Watanabe, S., Ellis‐Davies, G. C. R., Kitamura, K., Kano, M., Matsuzaki, M., & Kasai, H. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.207100 · Cited by 173 · see citing works

Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease

Perez-Cruz, C., Nolte, M. W., van Gaalen, M. M., Rustay, N. R., Termont, A., Tanghe, A., Kirchhoff, F., & Ebert, U. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6142-10.2011 · Cited by 172 · see citing works

Remodeling of synaptic structures in the motor cortex following spinal cord injury

Kim, B. G., Dai, H., McAtee, M., Vicini, S., & Bregman, B. S. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.010 · Cited by 159 · see citing works

Postsynaptic signaling during plasticity of dendritic spines

Murakoshi, H., & Yasuda, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.12.002 · Cited by 158 · see citing works

Ca2+ signaling in dendritic spines

Bloodgood, B. L., & Sabatini, B. L. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.003 · Cited by 151 · see citing works

Visualization of Synaptic Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Living Neurons

Takao, K., Okamoto, K., Nakagawa, T., Neve, R. L., Nagai, T., Miyawaki, A., Hashikawa, T., Kobayashi, S., & Hayashi, Y. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0085-05.2005 · Cited by 150 · see citing works

TARPs differentially decorate AMPA receptors to specify neuropharmacology

Kato, A., Gill, M. B., Yu, H. Y., Nisenbaum, E. S., & Bredt, D. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.004 · Cited by 148 · see citing works

Dendritic coding of multiple sensory inputs in single cortical neurons in vivo

Varga, Z., Jia, H., Sakmann, B. J., & Konnerth, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112355108 · Cited by 144 · see citing works

Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.

Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., & Svoboda, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6403-09.2010 · Cited by 138 · see citing works

Autophosphorylation of αCaMKII Is Required for Ocular Dominance Plasticity

Taha, S. A., Hanover, J. L., Silva, A. J., & Stryker, M. P. (2002) · Neuron · doi:10.1016/s0896-6273(02)00966-2 · Cited by 119 · see citing works

Deficient Plasticity in the Primary Visual Cortex of α-Calcium/Calmodulin-Dependent Protein Kinase II Mutant Mice

Gordon, J. A., Cioffi, D., Silva, A. J., & Stryker, M. P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80181-6 · Cited by 111 · see citing works

Spine plasticity in the motor cortex

Yu, X., & Zuo, Y. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.010 · Cited by 106 · see citing works

Heterosynaptic Molecular Dynamics: Locally Induced Propagating Synaptic Accumulation of CaM Kinase II

Rose, J. K., Jin, S., & Craig, A. M. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.030 · Cited by 100 · see citing works

Optical monitoring of brain function in vivo: from neurons to networks

Garaschuk, O., Milos, R., Grienberger, C., Marandi, N., Adelsberger, H., & Konnerth, A. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0150-x · Cited by 93 · see citing works

Plasticity and specificity of cortical processing networks

Majewska, A. K., & Sur, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.04.002 · Cited by 83 · see citing works

The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo

Bestman, J. E., & Cline, H. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806296105 · Cited by 81 · see citing works

Subcellular Topography of Visually Driven Dendritic Activity in the Vertebrate Visual System

Bollmann, J. H., & Engert, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.018 · Cited by 79 · see citing works

The discovery of dendritic spines by Cajal in 1888 and its relevance in the present neuroscience

García-López, P., García‐Marín, V., & Freire, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.002 · Cited by 77 · see citing works

A NOTE ON THE DENDRITIC SPINE APPARATUS.

Gray, E. G., & Guillery, R. W. (1963) · PubMed · Cited by 64 · see citing works

Structure and molecular organization of dendritic spines.

Tashiro, A., & Yuste, R. (2003) · PubMed · doi:10.14670/hh-18.617 · Cited by 60 · see citing works

Precise Subcellular Input Retinotopy and Its Computational Consequences in an Identified Visual Interneuron

Peron, S., Jones, P. W., & Gabbiani, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.010 · Cited by 49 · see citing works

Monocular deprivation in adult mice alters visual acuity and single-unit activityPreprint

Fischer, Q. S., Graves, A., Evans, S., Lickey, M. E., & Pham, T. A. (2007) · Learning & Memory · doi:10.1101/lm.392107 · Cited by 45 · see citing works

Rapid experience-dependent plasticity of synapse function and structure in ferret visual cortex in vivo

Yu, H., Majewska, A. K., & Sur, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108270109 · Cited by 44 · see citing works

Dendritic Design Implements Algorithm for Synaptic Extraction of Sensory Information

Ogawa, H., Cummins, G. I., Jacobs, G. A., & Oka, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5354-07.2008 · Cited by 34 · see citing works

Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo

Mower, A. F., Kwok, S., Yu, H., Majewska, A. K., Okamoto, K., Hayashi, Y., & Sur, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108261109 · Cited by 32 · see citing works

The relationship between dendritic branch dynamics and CPEB-labeled RNP granules captured in vivo

Bestman, J. E. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.010.2009 · Cited by 21 · see citing works

Study of Golgi‐impregnated material using the confocal tandem scanning reflected light microscope

Freire, M., & BOYDE, A. (1990) · Journal of Microscopy · doi:10.1111/j.1365-2818.1990.tb03002.x · Cited by 21 · see citing works

Observations on Clustered Synaptic Plasticity and Highly Structured Input Patterns

Magee, J. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.12.009 · Cited by 14 · see citing works

Synapses Let Loose for a Change: Inhibitory Synapse Pruning throughout Experience-Dependent Cortical Plasticity

Gambino, F., & Holtmaat, A. J. D. G. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.005 · Cited by 7 · see citing works

Sex differences in stress-related psychiatric disorders: neurobiological perspectives

Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737 · see citing works

Spine Dynamics: Are They All the Same?

Berry, K., & Nedivi, E. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.008 · Cited by 464 · see citing works

Dendritic Spines: The Locus of Structural and Functional Plasticity

Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465 · see citing works

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution

Gao, R., Asano, S. M., Upadhyayula, S., Pisarev, I., Milkie, D. E., Liu, T., Singh, V. P., Graves, A. R., Huynh, G. H., Zhao, Y., et al. (2019) · Science · doi:10.1126/science.aau8302 · Cited by 375 · see citing works

Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models

Martínez‐Cerdeño, V. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22417 · Cited by 256 · see citing works

Dendritic spines: Revisiting the physiological role

Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 255 · see citing works

Super-resolution Microscopy Approaches for Live Cell Imaging

Godin, A. G., Lounis, B., & Cognet, L. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.08.028 · Cited by 247 · see citing works

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236 · see citing works

Structural plasticity of the hippocampus in response to estrogens in female rodents

Sheppard, P. A. S., Choleris, E., & Galea, L. A. M. (2019) · Molecular Brain · doi:10.1186/s13041-019-0442-7 · Cited by 190 · see citing works

Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

Comer, A. L., Jinadasa, T., Sriram, B., Phadke, R. A., Kretsge, L. N., Nguyen, T. P. H., Antognetti, G., Gilbert, J. P., Lee, J., Newmark, E., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000604 · Cited by 159 · see citing works

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies

van Berlekom, A. B., Muflihah, C. H., Snijders, G. J. L., MacGillavry, H. D., Middeldorp, J., Hol, E. M., Kahn, R. S., & de Witte, L. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz060 · Cited by 149 · see citing works

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease

Hashimoto, S., & Saido, T. C. (2018) · Open Biology · doi:10.1098/rsob.180024 · Cited by 129 · see citing works

Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network

Ys, K., Im, S.-K., Oh, S., Jeong, S., Yoon, E.-S., Lee, C. J., Choi, N., & Hur, E. (2017) · Nature Communications · doi:10.1038/ncomms14346 · Cited by 125 · see citing works

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology

Chang, P. K.-Y., Khatchadourian, A., McKinney, R. A., & Maysinger, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0244-5 · Cited by 124 · see citing works

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

Sigler, A., Oh, W. C., Imig, C., Altas, B., Kawabe, H., Cooper, B. H., Kwon, H., Rhee, J., & Brose, N. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.029 · Cited by 123 · see citing works

Neuronal plasticity affects correlation between the size of dendritic spine and its postsynaptic density

Borczyk, M., Śliwińska, M. A., Cały, A., Bernaś, T., & Radwańska, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-38412-7 · Cited by 120 · see citing works

Neuronal cytoskeleton in synaptic plasticity and regeneration

Gordon‐Weeks, P. R., & Fournier, A. E. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12502 · Cited by 114 · see citing works

Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

Jimenez-Mateos, E. M., Engel, T., Merino‐Serrais, P., Fernaud-Espinosa, I., Rodriguez-Alvarez, N., Reynolds, J. R., Reschke, C. R., Conroy, R. M., McKiernan, R. C., DeFelipe, J., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0798-5 · Cited by 109 · see citing works

Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice

Iñiguez, S. D., Aubry, A., Riggs, L. M., Alipio, J. B., Zanca, R. M., Flores-Ramirez, F. J., Hernandez, M. A., Nieto, S. J., Musheyev, D., & Serrano, P. A. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.07.001 · Cited by 105 · see citing works

Toxicity assessment due to prenatal and lactational exposure to lead, cadmium and mercury mixtures

Zhou, F., Yin, G., Gao, Y., Liu, D., Xie, J., Ouyang, L., Fan, Y., Yu, H. K., Zha, Z., Wang, K., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.105192 · Cited by 104 · see citing works

Actin filaments and microtubules in dendritic spines

Shirao, T., & González-Billault, C. E. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12313 · Cited by 103 · see citing works

Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia

Parellada, E., & Gassó, P. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01385-9 · Cited by 106 · see citing works

Dendritic function in vivo

Grienberger, C., Chen, X., & Konnerth, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.002 · Cited by 97 · see citing works

Dendritic spine dysgenesis in Rett syndrome

Xu, X., Miller, E. C., & Pozzo‐Miller, L. D. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00097 · Cited by 94 · see citing works

In vivo mouse and live cell STED microscopy of neuronal actin plasticity using far-red emitting fluorescent proteins

Wegner, W., Ilgen, P., Gregor, C., van Dort, J., Mott, A. C., Steffens, H., & Willig, K. I. (2017) · Scientific Reports · doi:10.1038/s41598-017-11827-4 · Cited by 95 · see citing works

Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐ AD mice

Baglietto‐Vargas, D., Chen, Y., Suh, D., Ager, R. R., Rodríguez‐Ortiz, C. J., Medeiros, R., Myczek, K., Green, K. N., Baram, T. Z., & LaFerla, F. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13195 · Cited by 93 · see citing works

Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms

Hu, F., Li, T., Gong, H., Chen, Z., Jin, Y., Xu, G., & Wang, M. (2017) · Advanced Science · doi:10.1002/advs.201600493 · Cited by 87 · see citing works

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

Walker, C. K., & Herskowitz, J. H. (2021) · The Neuroscientist · doi:10.1177/1073858420945964 · Cited by 86 · see citing works

Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling

Chazeau, A., & Giannone, G. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2214-1 · Cited by 85 · see citing works

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium

Bell, M. K., Bartol, T., B, T. J. S. A., & Rangamani, P. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201812261 · Cited by 80 · see citing works

Relation between gamma oscillations and neuronal plasticity in the visual cortex

Galuske, R. A. W., Munk, M. H. J., & Singer, W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901277116 · Cited by 83 · see citing works

Lead, cadmium, arsenic, and mercury combined exposure disrupted synaptic homeostasis through activating the Snk-SPAR pathway

Zhou, F., Xie, J., Zhang, S., Yin, G., Gao, Y., Zhang, Y., Bo, D., Li, Z., Liu, S., Feng, C., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.07.116 · Cited by 83 · see citing works

Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex

Blumenstock, S., Rodrigues, E. F., Peters, F., Blázquez‐Llorca, L., Schmidt, F., Giese, A., & Herms, J. W. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607305 · Cited by 77 · see citing works

The structure and function of actin cytoskeleton in mature glutamatergic dendritic spines

Bellot, A., Guivernau, B., Tajes, M., Bosch-Morató, M., Valls-Comamala, V., & Muñoz, F. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.024 · Cited by 74 · see citing works

Altered Synapse Stability in the Early Stages of Tauopathy

Jackson, J., Witton, J., Johnson, J. D., Ahmed, Z., Ward, M., Randall, A. D., Hutton, M. L., Isaac, J. T. R., O’Neill, M. J., & Ashby, M. C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.013 · Cited by 71 · see citing works

Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

Chakroborty, S., Hill, E. S., Christian, D. T., Helfrich, R., Riley, S., Schneider, C., Kapecki, N., Mustaly-Kalimi, S., Seiler, F. A., Peterson, D. A., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0307-7 · Cited by 71 · see citing works

The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory

Stacho, M., & Manahan‐Vaughan, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.806356 · Cited by 70 · see citing works

Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells

Bosch, C., Masachs, N., Exposito-Alonso, D., Martínez, A., Teixeira, C. M., Fernaud, I., Pujadas, L., Ulloa, F., Comella, J. X., DeFelipe, J., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw216 · Cited by 70 · see citing works

MicroRNAs in the pathophysiology and treatment of status epilepticus

Henshall, D. C. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00037 · Cited by 69 · see citing works

FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons

Bosch, C., Martínez, A., Masachs, N., Teixeira, C. M., Fernaud, I., Ulloa, F., Pérez-Martínez, E., Lois, C., Comella, J. X., DeFelipe, J., et al. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00060 · Cited by 67 · see citing works

Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability

Nagayoshi, Y., Chujo, T., Hirata, S., Nakatsuka, H., Chen, C.-W., Takakura, M., Miyauchi, K., Ikeuchi, Y., Carlyle, B. C., Kitchen, R. R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf3072 · Cited by 67 · see citing works

The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling

Zhang, Z., Ye, M., Li, Q., You, Y., Yu, H., Ma, Y., Mei, L., Sun, X., Wang, L., Yue, W., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.091 · Cited by 66 · see citing works

Synaptic modifications in learning and memory – A dendritic spine story

Ma, S., & Zuo, Y. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.015 · Cited by 64 · see citing works

Impairments of glutamatergic synaptic transmission in Alzheimer’s disease

Zott, B., & Konnerth, A. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.013 · Cited by 64 · see citing works

Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies

Ofer, N., Berger, D. R., Kasthuri, N., Lichtman, J. W., & Yuste, R. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22829 · Cited by 65 · see citing works

Differential dendritic remodeling in prelimbic cortex of male and female rats during recovery from chronic stress

Moench, K. M., & Wellman, C. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.049 · Cited by 63 · see citing works

Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice

Hinkle, J. J., Olschowka, J. A., Love, T. M., Williams, J. P., & O’Banion, M. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55366-6 · Cited by 61 · see citing works

The interplay of microRNA and neuronal activity in health and disease

Eacker, S. M., Dawson, T. M., & Dawson, V. L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00136 · Cited by 60 · see citing works

Isoflurane Reversibly Destabilizes Hippocampal Dendritic Spines by an Actin-Dependent Mechanism

Platholi, J., Herold, K. F., Hemmings, H. C., & Halpain, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102978 · Cited by 57 · see citing works

Fluorescent labeling of dendritic spines in cell cultures with the carbocyanine dye “DiI”

Cheng, C., Trzcinski, O., & Doering, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00030 · Cited by 56 · see citing works

L‐3‐n‐butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP / PS 1 Mouse Model of Alzheimer's Disease

Zhang, Y., Huang, L., Shi, S., Xu, S., Wang, X., & Peng, Y. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12594 · Cited by 56 · see citing works

Reactivation of the Same Synapses during Spontaneous Up States and Sensory Stimuli

Chen, X., Rochefort, N. L., Sakmann, B. J., & Konnerth, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.042 · Cited by 55 · see citing works

Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology

Stanika, R. I., Campiglio, M., Pinggera, A., Lee, A., Striessnig, J., Flucher, B. E., & Obermair, G. J. (2016) · Scientific Reports · doi:10.1038/srep34528 · Cited by 55 · see citing works

Developmental Lead Exposure Alters Synaptogenesis through Inhibiting Canonical Wnt Pathway In Vivo and In Vitro

Hu, F., Xu, L., Liu, Z.-H., Ge, M.-M., Ruan, D.-Y., & Wang, H.-L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101894 · Cited by 54 · see citing works

In Vivo Imaging of Gray Matter Microstructure in Major Psychiatric Disorders: Opportunities for Clinical Translation

Nazeri, A., Schifani, C., Anderson, J. A. E., Ameis, S. H., & Voineskos, A. N. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.03.003 · Cited by 54 · see citing works

Microglia Provide Structural Resolution to Injured Dendrites after Severe Seizures

Eyo, U. B., Haruwaka, K., Mo, M., Campos-Salazar, A. B., Wang, L., Speros, X. S., Sabu, S., Xu, P., & Wu, L. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.109080 · Cited by 53 · see citing works

Experience-Dependent Structural Plasticity in the Visual System

Berry, K., & Nedivi, E. (2016) · Annual Review of Vision Science · doi:10.1146/annurev-vision-111815-114638 · Cited by 52 · see citing works

Depletion of microglia in developing cortical circuits reveals its critical role in glutamatergic synapse development, functional connectivity, and critical period plasticity

Ma, X., Chen, K., Cui, Y., Huang, G., Nehme, A., Zhang, L., Li, H., Wei, J., Liong, K., Liu, Q., et al. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24641 · Cited by 50 · see citing works

Effects of General Anesthetics on Synaptic Transmission and Plasticity

Platholi, J., & Hemmings, H. C. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210803105232 · Cited by 54 · see citing works

The brain: a concept in flux

Pagán, O. R. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0383 · Cited by 54 · see citing works

Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus

Glasgow, S. D., Wong, E. W., Thompson‐Steckel, G., Marçal, N., Séguéla, P., Ruthazer, E. S., & Kennedy, T. E. (2020) · Molecular Brain · doi:10.1186/s13041-020-00597-2 · Cited by 50 · see citing works

Dorsal Hippocampal Actin Polymerization Is Necessary for Activation of G-Protein-Coupled Estrogen Receptor (GPER) to Increase CA1 Dendritic Spine Density and Enhance Memory Consolidation

Kim, J., Schalk, J. C., Koss, W. A., Gremminger, R., Taxier, L. R., Gross, K. S., & Frick, K. M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2687-18.2019 · Cited by 48 · see citing works

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease

Bevan, R. J., Hughes, T. R., Williams, P. A., Good, M. A., Morgan, B. P., & Morgan, J. E. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01094-2 · Cited by 47 · see citing works

Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines

Ohadi, D., Schmitt, D. L., Calabrese, B., Halpain, S., Zhang, J., & Rangamani, P. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.10.003 · Cited by 45 · see citing works

Mind the (sr)GAP – roles of Slit–Robo GAPs in neurons, brains and beyond

Lucas, B. G., & Hardin, J. D. (2017) · Journal of Cell Science · doi:10.1242/jcs.207456 · Cited by 43 · see citing works

Quantitative 3-D morphometric analysis of individual dendritic spines

Basu, S., Saha, P. K., Roszkowska, M., Magnowska, M., Bączyńska, E., Das, N., Plewczyński, D., & Włodarczyk, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-21753-8 · Cited by 40 · see citing works

Constraint-induced movement therapy improves functional recovery after ischemic stroke and its impacts on synaptic plasticity in sensorimotor cortex and hippocampus

Hu, J., Li, C., Yan, H., Liu, P., Gao, B., Wang, Y., & Bai, Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.04.006 · Cited by 41 · see citing works

Stress-induced alterations in prefrontal dendritic spines: Implications for post-traumatic stress disorder

Moench, K. M., & Wellman, C. L. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.12.035 · Cited by 41 · see citing works

Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice

Yang, E.-J., Mahmood, U., Kim, H.-J., Choi, M., Choi, Y., Lee, J., Cho, J., Hyun, J. W., Kim, Y. S., Chang, M., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.016 · Cited by 41 · see citing works

Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability

Bertan, F., Wischhof, L., Sosulina, L., Mittag, M., Dalügge, D., Fornarelli, A., Gardoni, F., Marcello, E. E., Luca, M. D., Fuhrmann, M., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0584-2 · Cited by 41 · see citing works

E stradiol rapidly increases GluA2‐mushroom spines and decreases GluA2‐filopodia spines in hippocampus CA1

Avila, J. A., Alliger, A. A., Carvajal, B. V., Zanca, R. M., Serrano, P. A., & Luine, V. N. (2017) · Hippocampus · doi:10.1002/hipo.22768 · Cited by 40 · see citing works

Dendritic spine remodeling and plasticity under general anesthesia

Granak, S., Höschl, C., & Ovsepian, S. V. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02308-6 · Cited by 37 · see citing works

Characterizing the Quantum-Confined Stark Effect in Semiconductor Quantum Dots and Nanorods for Single-Molecule Electrophysiology

Kuo, Y., Li, J., Michalet, X., Chizhik, A., Meir, N., Bar-Elli, O., Chan, E., Oron, D., Enderlein, J., & Weiss, S. (2018) · ACS Photonics · doi:10.1021/acsphotonics.8b00617 · Cited by 37 · see citing works

The human medial amygdala: structure, diversity, and complexity of dendritic spines

Dall’Oglio, A., Dutra, A. C. L., Moreira, J. E., & Rasia‐Filho, A. A. (2015) · Journal of Anatomy · doi:10.1111/joa.12358 · Cited by 36 · see citing works

Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A

Lin, L.-F., Lo, L. H.-Y., Lyu, Q., & Lai, K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.772442 · Cited by 36 · see citing works

C. elegans neurons have functional dendritic spines

Cuentas-Condori, A., Mulcahy, B., He, S., Palumbos, S. D., Zhen, M., & Miller, D. M. (2019) · eLife · doi:10.7554/elife.47918 · Cited by 36 · see citing works

Stress during pregnancy alters dendritic spine density and gene expression in the brain of new-born lambs

Petit, B., Boissy, A., Zanella, A. J., Chaillou, É., Andanson, S., Bes, S., Lévy, F., & Coulon, M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.025 · Cited by 33 · see citing works

Effects of dihydrotestosterone on synaptic plasticity of hippocampus in male SAMP8 mice

Li, S., Kang, L., Zhang, C., Xie, G., Li, N., Zhang, Y., Du, J., & Cui, H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.04.014 · Cited by 35 · see citing works

Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents

Luine, V. N., Serrano, P. A., & Frankfurt, M. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.04.007 · Cited by 34 · see citing works

Inhibition of glial D‐serine release rescues synaptic damage after brain injury

Tapanes, S. A., Arizanovska, D., Díaz, M. M., Folorunso, O. O., Harvey, T. L., Brown, S. E., Radzishevsky, I. S., Close, L. N., Jagid, J. R., Cordeiro, J. G., et al. (2022) · Glia · doi:10.1002/glia.24161 · Cited by 33 · see citing works

Geometric Control of Frequency Modulation of cAMP Oscillations due to Calcium in Dendritic Spines

Ohadi, D., & Rangamani, P. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.10.004 · Cited by 34 · see citing works

Mechanisms for localising calcineurin and CaMKII in dendritic spines

Penny, C. J., & Gold, M. G. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.05.010 · Cited by 34 · see citing works

KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization

Zheng, R., Du, Y.-L., Wang, X., Liao, T., Zhang, Z., Wang, N., Li, X., Shen, Y., Shi, L., Luo, J., et al. (2022) · eLife · doi:10.7554/elife.72483 · Cited by 33 · see citing works

γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor

Restrepo, L. J., DePew, A. T., Moese, E. R., Tymanskyj, S. R., Parisi, M. J., Aimino, M. A., Duhart, J. C., Fei, H., & Mosca, T. J. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.05.006 · Cited by 26 · see citing works

Spikar, a novel drebrin‐binding protein, regulates the formation and stabilization of dendritic spines

Yamazaki, H., Kojima, N., Kato, K., Hirose, E., Iwasaki, T., Mizui, T., Takahashi, H., Hanamura, K., Roppongi, R. T., Koibuchi, N., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12486 · Cited by 32 · see citing works

Glioma-Derived TSP2 Promotes Excitatory Synapse Formation and Results in Hyperexcitability in the Peritumoral Cortex of Glioma

Wang, Y.-H., Huang, T.-L., Chen, X., Yu, S., Li, W., Chen, T., Li, Y., Kuang, Y.-Q., & Shu, H. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa149 · Cited by 32 · see citing works

What is the experience of men and women with congestive heart failure?

Costello, J. F., & Boblin, S. L. (2004) · PubMed · Cited by 32 · see citing works

Knowing a synapse when you see one

Burette, A. C., Collman, F., Micheva, K. D., Smith, S. J., & Weinberg, R. J. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00100 · Cited by 30 · see citing works

Postsynaptic assembly: A role for Wnt signaling

Stamatakou, E., & Salinas, P. C. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22138 · Cited by 31 · see citing works

The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer’s disease

Gordon‐Weeks, P. R. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.06.015 · Cited by 31 · see citing works

Early postnatal stress suppresses the developmental trajectory of hippocampal pyramidal neurons: the role of CRHR1

Liu, R., Yang, X., Liao, X.-M., Xie, X., Su, Y., Li, J., Wang, X., & Si, T. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1182-4 · Cited by 32 · see citing works

Spatial control of membrane traffic in neuronal dendrites

Radler, M. R., Suber, A., & Spiliotis, E. T. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103492 · Cited by 30 · see citing works

The remembrance of the things past: Conserved signalling pathways link protozoa to mammalian nervous system

Plattner, H., & Verkhratsky, A. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.04.001 · Cited by 30 · see citing works

Up-regulation of the p75 neurotrophin receptor is an essential mechanism for HIV-gp120 mediated synaptic loss in the striatum

Speidell, A. P., Asuni, G. P., Wakulski, R., & Mocchetti, I. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.023 · Cited by 29 · see citing works

Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation

Qi, B., Song, Y., Chen, C., Zhao, L., Ma, W., Meng, S., Zhuang, X., Lin, H., Liang, J., Cui, Y., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109603 · Cited by 28 · see citing works

Traumatic Stress Produces Delayed Alterations of Synaptic Plasticity in Basolateral Amygdala

Zhang, H., Meng, S., Guo, X., Zhang, J., Zhang, W., Chen, Y., Lü, L., Yang, J., & Xue, Y.-X. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02394 · Cited by 29 · see citing works

Calcium influx and postsynaptic proteins coordinate the dendritic filopodium‐spine transition

Hu, H., & Hsueh, Y. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22181 · Cited by 28 · see citing works

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models

Trujillo‐Estrada, L., Nguyen, C. M., da Cunha, C., Cai, L., Forner, S., Martini, A. C., Ager, R. R., Prieto, G. A., Cotman, C. W., Baglietto‐Vargas, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12919 · Cited by 27 · see citing works

Artificial Intelligence and the detection of pediatric concussion using epigenomic analysis

Bahado-Singh, R. O., Vishweswaraiah, S., Er, A., Aydas, B., Türkoğlu, O., Taşkın, B. D., Duman, M., Yılmaz, D., & Radhakrishna, U. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146510 · Cited by 27 · see citing works

Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease

Stefen, H., Chaichim, C., Power, J., & Fath, T. (2016) · Neural Plasticity · doi:10.1155/2016/2371970 · Cited by 26 · see citing works

Imaging of calcium inside dendrites and spines: goals, issues and perspectives

Segal, M. (1995) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)00190-r · Cited by 4 · see citing works

Intravital imaging of dendritic spine plasticity

Lai, C. S. W. (2014) · IntraVital · doi:10.4161/21659087.2014.984504 · Cited by 2 · see citing works

Dentritic spines : structure, dynamics and regulation

Hering, H., & Sheng, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35104061 · Cited by 961 · see citing works

Methods of dendritic spine detection: From Golgi to high-resolution optical imaging

Mancuso, J. J., Chen, Y., Li, X., Xue, Z., & Wong, S. T. C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.010 · Cited by 76 · see citing works

Genesis of dendritic spines: insights from ultrastructural and imaging studies

Yuste, R., & Bonhoeffer, T. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1300 · Cited by 628 · see citing works