CoChat
Sign Up
Cited by 37

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

A conserved cysteine‐based redox mechanism sustains TFEB/HLH‐30 activity under persistent stress

Martina, José A, Guerrero‐Gómez, David, Gómez‐Orte, Eva, Antonio Bárcena, José, Cabello, Juan, Miranda‐Vizuete, Antonio, Puertollano, Rosa·2021·The EMBO Journal
DOI 10.15252/embj.2020105793
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.15252/embj.2020105793

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 3 references

Research works printed but not linked: 77

  1. Aladzsity I, Toth ML, Sigmond T, Szabo E, Bicsak B, Barna J, Regos A, Orosz L, Kovacs AL, Vellai T (2007) Autophagy genes unc‐51 and bec‐1 are required for normal cell size in Caenorhabditis elegans. Genetics 177: 655–660 · DOI
  2. Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, Bai X, Zhang Z, Huo W, Zhao X et al (2016) Deacetylation of TFEB promotes fibrillar Abeta degradation by upregulating lysosomal biogenesis in microglia. Protein Cell 7: 417–433 · DOI
  3. Bar DZ, Charar C, Dorfman J, Yadid T, Tafforeau L, Lafontaine DL, Gruenbaum Y (2016) Cell size and fat content of dietary‐restricted Caenorhabditis elegans are regulated by ATX‐2, an mTOR repressor. Proc Natl Acad Sci USA 113: E4620–4629
  4. Bazopoulou D, Knoefler D, Zheng Y, Ulrich K, Oleson BJ, Xie L, Kim M, Kaufmann A, Lee YT, Dou Y et al (2019) Developmental ROS individualizes organismal stress resistance and lifespan. Nature 576: 301–305 · DOI
  5. Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M et al (2017) Transaldolase inhibition impairs mitochondrial respiration and induces a starvation‐like longevity response in Caenorhabditis elegans. PLoS Genet 13: e1006695 · DOI
  6. Bleicken S, Zeth K (2009) Conformational changes and protein stability of the pro‐apoptotic protein Bax. J Bioenerg Biomembr 41: 29–40 · DOI
  7. Brady OA, Jeong E, Martina JA, Pirooznia M, Tunc I, Puertollano R (2018) The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage. Elife 7: e40856
  8. Brigelius‐Flohe R, Flohe L (2011) Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 15: 2335–2381 · DOI
  9. Butturini E, Cozzolino F, Boriero D, Carcereri de Prati A, Monti M, Rossin M, Canetti D, Cellini B, Pucci P, Mariotto S (2018) S‐glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia. Free Radic Biol Med 117: 191–201 · DOI
  10. Campbell GR, Rawat P, Bruckman RS, Spector SA (2015) Human immunodeficiency virus type 1 nef inhibits autophagy through transcription factor EB sequestration. PLoS Pathog 11: e1005018 · DOI
  11. Carvalho AN, Marques C, Guedes RC, Castro‐Caldas M, Rodrigues E, van Horssen J, Gama MJ (2016) S‐Glutathionylation of Keap1: a new role for glutathione S‐transferase pi in neuronal protection. FEBS Lett 590: 1455–1466 · DOI
  12. Cassada RC, Russell RL (1975) The dauerlarva, a post‐embryonic developmental variant of the nematode Caenorhabditis elegans. Dev Biol 46: 326–342 · DOI
  13. Ferron M, Settembre C, Shimazu J, Lacombe J, Kato S, Rawlings DJ, Ballabio A, Karsenty G (2013) A RANKL‐PKCbeta‐TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev 27: 955–969 · DOI
  14. Gomez‐Orte E, Saenz‐Narciso B, Zheleva A, Ezcurra B, de Toro M, Lopez R, Gastaca I, Nilsen H, Sacristan MP, Schnabel R et al (2019) Disruption of the Caenorhabditis elegans Integrator complex triggers a non‐conventional transcriptional mechanism beyond snRNA genes. PLoS Genet 15: e1007981 · DOI
  15. Gray MA, Choy CH, Dayam RM, Ospina‐Escobar E, Somerville A, Xiao X, Ferguson SM, Botelho RJ (2016) Phagocytosis enhances lysosomal and bactericidal properties by activating the transcription factor TFEB. Curr Biol 26: 1955–1964 · DOI
  16. Guerrero‐Gomez D, Mora‐Lorca JA, Saenz‐Narciso B, Naranjo‐Galindo FJ, Munoz‐Lobato F, Parrado‐Fernandez C, Goikolea J, Cedazo‐Minguez A, Link CD, Neri C et al (2019) Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy‐dependent protein degradation. Cell Death Differ 26: 1545–1565 · DOI
  17. Hallsson JH, Haflidadottir BS, Stivers C, Odenwald W, Arnheiter H, Pignoni F, Steingrimsson E (2004) The basic helix‐loop‐helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development. Genetics 167: 233–241 · DOI
  18. Hashimoto K, Panchenko AR (2010) Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states. Proc Natl Acad Sci USA 107: 20352–20357 · DOI
  19. Jeon D, Park HJ, Kim HS (2018) Protein S‐glutathionylation induced by hypoxia increases hypoxia‐inducible factor‐1alpha in human colon cancer cells. Biochem Biophys Res Commun 495: 212–216 · DOI
  20. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf‐2, an insulin receptor‐like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942–946 · DOI
  21. Koba H, Jin S, Imada N, Ishikawa T, Ninagawa S, Okada T, Sakuma T, Yamamoto T, Mori K (2020) Reinvestigation of disulfide‐bonded oligomeric forms of the unfolded protein response transducer ATF6. Cell Struct Funct 45: 9–21 · DOI
  22. Kumsta C, Chang JT, Schmalz J, Hansen M (2017) Hormetic heat stress and HSF‐1 induce autophagy to improve survival and proteostasis in C. elegans. Nat Commun 8: 14337 · DOI · Paper page
  23. Labed SA, Wani KA, Jagadeesan S, Hakkim A, Najibi M, Irazoqui JE (2018) Intestinal epithelial wnt signaling mediates acetylcholine‐triggered host defense against infection. Immunity 48(5): 963–978 · DOI
  24. Labunskyy VM, Gladyshev VN (2013) Role of reactive oxygen species‐mediated signaling in aging. Antioxid Redox Signal 19: 1362–1372 · DOI
  25. Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE et al (2013) The TFEB orthologue HLH‐30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun 4: 2267 · DOI · Paper page
  26. Lermant A, Murdoch CE (2019) Cysteine glutathionylation acts as a redox switch in endothelial cells. Antioxidants (Basel) 8: 315 · DOI
  27. Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates 3rd JR, Ruvkun G et al (2018) DAF‐16/FOXO and HLH‐30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun 9: 4400 · DOI
  28. Liu Y, Kaval KG, van Hoof A, Garsin DA (2019) Heme peroxidase HPX‐2 protects Caenorhabditis elegans from pathogens. PLoS Genet 15: e1007944
  29. Martina JA, Chen Y, Gucek M, Puertollano R (2012) MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8: 903–914 · DOI · Paper page
  30. Martina JA, Diab HI, Brady OA, Puertollano R (2016) TFEB and TFE3 are novel components of the integrated stress response. EMBO J 35: 479–495 · DOI · Paper page
  31. Martina JA, Diab HI, Lishu L, Jeong AL, Patange S, Raben N, Puertollano R (2014) The nutrient‐responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal 7: ra9 · DOI · Paper page
  32. Martina JA, Puertollano R (2013) Rag GTPases mediate amino acid‐dependent recruitment of TFEB and MITF to lysosomes. J Cell Biol 200: 475–491 · DOI · Paper page
  33. Martina JA, Puertollano R (2018) Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress. J Biol Chem 293: 12525–12534 · DOI · Paper page
  34. Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto‐Rosato A, Prezioso C, Forrester A et al (2015) Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol 17: 288–299 · DOI
  35. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for dauer development and life‐span extension in C. elegans. Science 301: 1387–1391 · DOI · Paper page
  36. Meng FG, Zeng X, Hong YK, Zhou HM (2001) Dissociation and unfolding of GCN4 leucine zipper in the presence of sodium dodecyl sulfate. Biochimie 83: 953–956 · DOI
  37. Miller AJ, Levy C, Davis IJ, Razin E, Fisher DE (2005) Sumoylation of MITF and its related family members TFE3 and TFEB. J Biol Chem 280: 146–155 · DOI
  38. Morck C, Pilon M (2006) C. elegans feeding defective mutants have shorter body lengths and increased autophagy. BMC Dev Biol 6: 39 · DOI · Paper page
  39. Muhle‐Goll C, Gibson T, Schuck P, Schubert D, Nalis D, Nilges M, Pastore A (1994) The dimerization stability of the HLH‐LZ transcription protein family is modulated by the leucine zippers: a CD and NMR study of TFEB and c‐Myc. Biochemistry 33: 11296–11306 · DOI
  40. Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia‐Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RJ, Lassen KG et al (2017) Transcription factor TFEB cell‐autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Sci Rep 7: 13938 · DOI
  41. Najibi M, Moreau JA, Honwad HH, Irazoqui JE (2019) A novel PHOX/CD38/MCOLN1/TFEB axis important for macrophage activation during bacterial phagocytosis. bioRxiv https://doi.org/10.1101/669325 [PREPRINT] · DOI
  42. Napolitano G, Esposito A, Choi H, Matarese M, Benedetti V, Di Malta C, Monfregola J, Medina DL, Lippincott‐Schwartz J, Ballabio A (2018) mTOR‐dependent phosphorylation controls TFEB nuclear export. Nat Commun 9: 3312 · DOI · Paper page
  43. Nezich CL, Wang C, Fogel AI, Youle RJ (2015) MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol 210: 435–450 · DOI · Paper page
  44. O'Rourke EJ, Ruvkun G (2013) MXL‐3 and HLH‐30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol 15: 668–676 · DOI
  45. Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A et al (2016) TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy 12: 1240–1258 · DOI · Paper page
  46. Pastore N, Vainshtein A, Klisch TJ, Armani A, Huynh T, Herz NJ, Polishchuk EV, Sandri M, Ballabio A (2017) TFE3 regulates whole‐body energy metabolism in cooperation with TFEB. EMBO Mol Med 9: 605–621 · DOI
  47. Perez‐Riverol Y, Csordas A, Bai J, Bernal‐Llinares M, Hewapathirana S, Kundu DJ, Inuganti A, Griss J, Mayer G, Eisenacher M et al (2019) The PRIDE database and related tools and resources in 2019: improving support for quantification data. Nucleic Acids Res 47: D442–D450 · DOI
  48. Pogenberg V, Ogmundsdottir MH, Bergsteinsdottir K, Schepsky A, Phung B, Deineko V, Milewski M, Steingrimsson E, Wilmanns M (2012) Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev 26: 2647–2658 · DOI · Paper page
  49. Poole LB, Karplus PA, Claiborne A (2004) Protein sulfenic acids in redox signaling. Annu Rev Pharmacol Toxicol 44: 325–347 · DOI
  50. Puertollano R, Ferguson SM, Brugarolas J, Ballabio A (2018) The complex relationship between TFEB transcription factor phosphorylation and subcellular localization. EMBO J 37: e98804 · DOI
  51. Raben N, Puertollano R (2016) TFEB and TFE3: linking lysosomes to cellular adaptation to stress. Annu Rev Cell Dev Biol 32: 255–278 · DOI · Paper page
  52. Raizen DM, Lee RY, Avery L (1995) Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics 141: 1365–1382 · DOI
  53. Rehder DS, Borges CR (2010) Cysteine sulfenic acid as an intermediate in disulfide bond formation and nonenzymatic protein folding. Biochemistry 49: 7748–7755 · DOI
  54. Rehli M, Den Elzen N, Cassady AI, Ostrowski MC, Hume DA (1999) Cloning and characterization of the murine genes for bHLH‐ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics 56: 111–120 · DOI
  55. Roczniak‐Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM (2012) The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal 5: ra42 · DOI
  56. Roman C, Matera AG, Cooper C, Artandi S, Blain S, Ward DC, Calame K (1992) mTFE3, an X‐linked transcriptional activator containing basic helix‐loop‐helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization. Mol Cell Biol 12: 817–827
  57. Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS et al (2009) A gene network regulating lysosomal biogenesis and function. Science 325: 473–477 · DOI · Paper page
  58. Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Klisch TJ et al (2013) TFEB controls cellular lipid metabolism through a starvation‐induced autoregulatory loop. Nat Cell Biol 15: 647–658 · DOI · Paper page
  59. Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P et al (2011) TFEB links autophagy to lysosomal biogenesis. Science 332: 1429–1433 · DOI · Paper page
  60. Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC et al (2012) A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 31: 1095–1108 · DOI · Paper page
  61. Sha Y, Rao L, Settembre C, Ballabio A, Eissa NT (2017) STUB1 regulates TFEB‐induced autophagy‐lysosome pathway. EMBO J 36: 2544–2552 · DOI
  62. Sharma M, Pandey R, Saluja D (2018) ROS is the major player in regulating altered autophagy and lifespan in sin‐3 mutants of C. elegans. Autophagy 14: 1239–1255 · DOI
  63. Slade L, Biswas D, Ihionu F, El Hiani Y, Kienesberger PC, Pulinilkunnil T (2020) A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells. Biochem J 477: 137–160 · DOI
  64. Song W, Wang F, Savini M, Ake A, di Ronza A, Sardiello M, Segatori L (2013) TFEB regulates lysosomal proteostasis. Hum Mol Genet 22: 1994–2009 · DOI · Paper page
  65. Steingrimsson E, Copeland NG, Jenkins NA (2004) Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet 38: 365–411 · DOI
  66. Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland NG, Jenkins NA (2002) Mitf and Tfe3, two members of the Mitf‐Tfe family of bHLH‐Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci USA 99: 4477–4482 · DOI
  67. Stiernagle T (2006) Maintenance of C. elegans. WormBook 1–11 · DOI
  68. Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G (2000) A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci USA 97: 460–465 · DOI
  69. Visvikis O, Ihuegbu N, Labed SA, Luhachack LG, Alves AF, Wollenberg AC, Stuart LM, Stormo GD, Irazoqui JE (2014) Innate host defense requires TFEB‐mediated transcription of cytoprotective and antimicrobial genes. Immunity 40: 896–909 · DOI
  70. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J et al (2016) The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev 30: 2551–2564 · DOI
  71. Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S et al (2017) Small‐molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun 8: 2270 · DOI
  72. Wang H, Wang N, Xu D, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G et al (2019) Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis. Autophagy 16: 1683–1696 · DOI
  73. Wang L, Qu G, Gao Y, Su L, Ye Q, Jiang F, Zhao B, Miao J (2018) A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap‐1 S‐glutathionylation and inducing apoptosis. RSC Advances 8: 792–804 · DOI
  74. Wang Y, Huang Y, Liu J, Zhang J, Xu M, You Z, Peng C, Gong Z, Liu W (2020) Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB. EMBO Rep 21: e48335
  75. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R (2016) Glutathione adducts induced by ischemia and deletion of glutaredoxin‐1 stabilize HIF‐1alpha and improve limb revascularization. Proc Natl Acad Sci USA 113: 6011–6016 · DOI
  76. Zhang J, Wang J, Zhou Z, Park JE, Wang L, Wu S, Sun X, Lu L, Wang T, Lin Q et al (2018) Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors. Autophagy 14: 1043–1059
  77. Zhang X, Yu L, Xu H (2016) Lysosome calcium in ROS regulation of autophagy. Autophagy 12: 1954–1955 · DOI

Cited by

Sorted by citations

See all 37

Metadata

Authors
Martina, J. A., Guerrero‐Gómez, D., Gómez‐Orte, E., Antonio Bárcena, J., Cabello, J., Miranda‐Vizuete, A., & Puertollano, R.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2020-12-14
Volume
40
Issue
3
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.15252/embj.2020105793
Cited by
37
References
3
Language
en
Licence
Funders
  • HHS | NIH | National Heart, Lung, and Blood Institute (Intramural Program)
  • Ministerio de Ciencia, Innovación y Universidades (PGC2018‐094276‐B‐I00, BFU2016‐80006‐P)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review