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Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

Kumsta, Caroline, Chang, Jessica T., Schmalz, Jessica, Hansen, Malene·2017·Nature Communications
DOI 10.1038/ncomms14337PMC PMC5316864
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Abstract

Stress-response pathways have evolved to maintain cellular homeostasis and to ensure the survival of organisms under changing environmental conditions. Whereas severe stress is detrimental, mild stress can be beneficial for health and survival, known as hormesis. Although the universally conserved heat-shock response regulated by transcription factor HSF-1 has been implicated as an effector mechanism, the role and possible interplay with other cellular processes, such as autophagy, remains poorly understood. Here we show that autophagy is induced in multiple tissues of Caenorhabditis elegans following hormetic heat stress or HSF-1 overexpression. Autophagy-related genes are required for the thermoresistance and longevity of animals exposed to hormetic heat shock or HSF-1 overexpression. Hormetic heat shock also reduces the progressive accumulation of PolyQ aggregates in an autophagy-dependent manner. These findings demonstrate that autophagy contributes to stress resistance and hormesis, and reveal a requirement for autophagy in HSF-1-regulated functions in the heat-shock response, proteostasis and ageing.

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  • SQSTM1 upregulation, and at least transient increases in the amount of SQSTM1, is seen in some situations where there is an increase in autophagic flux.

    “For example, SQSTM1 upregulation, and at least transient increases in the amount of SQSTM1, is seen in some situations where there is an increase in autophagic flux [571-573].”

    From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [572]

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Metadata

Authors
Kumsta, C., Chang, J. T., Schmalz, J., & Hansen, M.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2017-02-15
Volume
8
Issue
1
ISSN
2041-1723
DOI
10.1038/ncomms14337
PMC
PMC5316864
Cited by
293
References
5
Language
en
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