Active endocannabinoids are secreted on extracellular membrane vesicles
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EVs isolated under short ATP stimulation are negative for apoptotic markers and are not contaminated by intracellular organelles derived from damaged cells.
“Our previous evidence indicates that EVs isolated under short ATP stimulation are negative for apoptotic markers and are not contaminated by intracellular organelles derived from damaged cells, as indicated by electron microscopy [6, 78] and western blot analysis [29].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [29]
The Figure 1C legend reports that Western blots of EV-enriched fractions lacked mitochondrial, Golgi and nuclear markers, supporting the absence of detectable contamination by those cellular components. The paper describes EV collection after 1 hour of ATP exposure, but our copy does not report testing the EVs for apoptotic markers. (LLM, conf=0.84)
Experimental — accuracy not yet measuredFusion of EVs with the neuron membrane is consistent with previous studies showing that EVs of microglia and neuron origin efficiently bind to the cell surface of neurons but are only rarely, if ever, internalized.
“Fusion of EVs with the neuron membrane is consistent with previous studies showing that EVs of microglia and neuron origin efficiently bind to the cell surface of neurons but are only rarely [13], if ever [29], internalized.”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [29]
At GABAergic terminals, MVs-associated endocannabinoids stimulate cannabinoid receptor type 1 (CB1) and rapidly decrease spontaneous GABA release.
“This has been clearly proved at GABAergic terminals, where MVs-associated endocannabinoids stimulate cannabinoid receptor type 1 (CB1) and rapidly decrease spontaneous GABA release [29].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [29]
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Cites
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Exosomes and Ectosomes in Intercellular Communication
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- Authors
- Gabrielli, M., Battista, N., Riganti, L., Prada, I., Antonucci, F., Cantone, L., Matteoli, M., Maccarrone, M., & Verderio, C.
- Venue
- The EMBO Reports
- Published
- 2015-01-07
- Volume
- 16
- Issue
- 2
- Pages
- 213-220
- ISSN
- 1469-221X
- 1469-3178
- Cited by
- 221
- References
- 4
- Language
- en
- Funders
- FISM (2012/R/17)
- Ministero dell'Istruzione, dell'Università e della Ricerca (PRIN 2010‐2011)
- POR‐FESR Cariplo (42708181)
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