Extracellular vesicles: lipids as key components of their biogenesis and functions

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Membrane vesicles as conveyors of immune responses

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426 · see citing works

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

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Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works

Endosome maturation

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Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,934 · see citing works

Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742 · see citing works

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

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Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, M., Moita, C. F., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L. F., Théry, C., & Raposo, G. (2013) · Journal of Cell Science · doi:10.1242/jcs.128868 · Cited by 1,472 · see citing works

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

Boilard, É., Nigrovic, P. A., Larabee, K. S., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold‐O’Donnell, E., Farndale, R. W., Ware, J. L., et al. (2010) · Science · doi:10.1126/science.1181928 · Cited by 1,088 · see citing works

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works

Lipids in exosomes: current knowledge and the way forward

Skotland, T., Sandvig, K., & Llorente, A. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.03.001 · Cited by 1,030 · see citing works

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Muralidharan-Chari, V., Clancy, J., Plou, C., Romao, M., Chavrier, P., Raposo, G., & D'Souza-Schorey, C. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.059 · Cited by 912 · see citing works

Microautophagy of Cytosolic Proteins by Late Endosomes

Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902 · see citing works

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer*

Kahlert, C., Melo, S., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J.-H., Weitz, J., Chin, L., Futreal, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.532267 · Cited by 896 · see citing works

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

Record, M., Carayon, K., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.004 · Cited by 853 · see citing works

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Besse, B., Charrier, M., Lapierre, V., Dansin, É., Lantz, O. J., Planchard, D., Chevalier, T. L., Livartoski, A., Barlési, F., Laplanche, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1071008 · Cited by 802 · see citing works

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.-K., & Simons, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.074088 · Cited by 775 · see citing works

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

Llorente, A., Skotland, T., Sylvänne, T., Kauhanen, D., Róg, T., Orłowski, A., Vattulainen, I., Ekroos, K., & Sandvig, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.011 · Cited by 771 · see citing works

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

Haraszti, R. A., Didiot, M., Sapp, E., Leszyk, J., Shaffer, S. A., Rockwell, H. E., Gao, F., Narain, N. R., DiFiglia, M., Kiebish, M. A., et al. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.32570 · Cited by 746 · see citing works

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705 · see citing works

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

Zhao, Z., Yang, Y., Zeng, Y., & He, M. (2015) · Lab on a Chip · doi:10.1039/c5lc01117e · Cited by 681 · see citing works

Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization

Laulagnier, K., Motta, C., Hamdi, S. M., Sébastien, R. O. Y., Fauvelle, F., Pageaux, J., Kobayashi, T., Salles, J., Perret, B., Bonnerot, C., et al. (2004) · Biochemical Journal · doi:10.1042/bj20031594 · Cited by 651 · see citing works

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G. J., Paillasse, M. R., de Médina, P., Monsarrat, B., Perret, B., Silvente‐Poirot, S., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003657 · Cited by 635 · see citing works

Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 623 · see citing works

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

Kobayashi, T., Beuchat, M.-H., Lindsay, M. R., Frias, S., Palmiter, R. D., Sakuraba, H., Parton, R. G., & Gruenberg, J. E. (1999) · Nature Cell Biology · doi:10.1038/10084 · Cited by 620 · see citing works

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

Freeman, G. J., Casasnovas, J. M., Umetsu, D. T., & DeKruyff, R. H. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00903.x · Cited by 613 · see citing works

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

Ghossoub, R., Lembo, F., Rubio, A., Baron, C. L., Bouchet, J., Vitale, N., Slavík, J., Machala, M., & Zimmermann, P. (2014) · Nature Communications · doi:10.1038/ncomms4477 · Cited by 601 · see citing works

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

Mathivanan, S., Lim, J. W. E., Tauro, B. J., Ji, H. L., Moritz, R. L., & Simpson, R. J. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900152-mcp200 · Cited by 593 · see citing works

Biology and biogenesis of shed microvesicles

Tricarico, C. J., Clancy, J. W., & D’Souza‐Schorey, C. (2016) · Small GTPases · doi:10.1080/21541248.2016.1215283 · Cited by 588 · see citing works

Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation

Bobrie, A., Colombo, M., Krumeich, S., Raposo, G., & Théry, C. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18397 · Cited by 581 · see citing works

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Castellano, B. M., Thelen, A. M., Moldavski, O., Feltes, M., van der Welle, R. E. N., Mydock-McGrane, L., Jiang, X., van Eijkeren, R. J., Davis, O. B., Louie, S. M., et al. (2017) · Science · doi:10.1126/science.aag1417 · Cited by 562 · see citing works

Acid sphingomyelinase activity triggers microparticle release from glial cells

Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 550 · see citing works

Exosomes as intercellular signalosomes and pharmacological effectors

Record, M., Subra, C., Silvente‐Poirot, S., & Poirot, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.011 · Cited by 539 · see citing works

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

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Cellular Mechanisms Underlying the Formation of Circulating Microparticles

Morel, O., Jesel, L., Freyssinet, J., & Toti, F. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.200956 · Cited by 525 · see citing works

Induction of Autophagy Promotes Fusion of Multivesicular Bodies with Autophagic Vacuoles in K562 Cells

Fader, C. M., Sánchez‐Martínez, D., Furlán, M., & Colombo, M. I. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00677.x · Cited by 470 · see citing works

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

Möbius, W., van Donselaar, E. G., Ohno‐Iwashita, Y., Shimada, Y., Heijnen, H. F. G., Slot, J. W., & Geuze, H. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00072.x · Cited by 453 · see citing works

Mast Cell-Derived Exosomes Induce Phenotypic and Functional Maturation of Dendritic Cells and Elicit Specific Immune Responses In Vivo

Skokos, D., Goubran‐Botros, H., Demeure, C. E., Morin, J., Péronet, R., Birkenmeier, G., Boudaly, S., & Mécheri, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3037 · Cited by 444 · see citing works

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

Baixauli, F., López-Otı́n, C., & Mittelbrunn, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00403 · Cited by 443 · see citing works

Separation and Characterization of Late Endosomal Membrane Domains

Kobayashi, T., Beuchat, M.-H., Chevallier, J., Makino, A., Mayran, N., Escola, J.-M., Lebrand, C., Cosson, P., Kobayashi, T., & Gruenberg, J. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202838200 · Cited by 409 · see citing works

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

Aung, T., Chapuy, B., Vogel, D., Wenzel, D., Oppermann, M., Lahmann, M., Weinhage, T., Menck, K., Hupfeld, T., Koch, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102855108 · Cited by 373 · see citing works

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

Antonucci, F., Turola, E., Riganti, L., Caleo, M., Gabrielli, M., Perrotta, C., Novellino, L., Clementi, E., Giussani, P., Viani, P., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.489 · Cited by 328 · see citing works

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer.

Lazar, I., Clement, E., Dauvillier, S., Milhas, D., Ducoux-Petit, M., Gonidec, S. L., Moro, C., Soldan, V., Dalle, S., Balor, S., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0651 · Cited by 325 · see citing works

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Putz, U., Howitt, J. A., Doan, A., Goh, C., Low, L., Silke, J., & Tan, S. (2012) · Science Signaling · doi:10.1126/scisignal.2003084 · Cited by 312 · see citing works

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate

Nojima, H., Freeman, C. M., Schuster, R. M., Japtok, L., Kleuser, B., Edwards, M. J., Gulbins, E., & Lentsch, A. B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.030 · Cited by 308 · see citing works

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

Charoenviriyakul, C., Takahashi, Y., Morishita, M., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.009 · Cited by 280 · see citing works

Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

Strauss, K., Goebel, C., Runz, H., Möbius, W., Weiss, S., Feußner, I., Simons, M., & Schneider, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.134775 · Cited by 270 · see citing works

PIKfyve inhibition increases exosome release and induces secretory autophagy

Hessvik, N. P., Øverbye, A., Brech, A., Torgersen, M. L., Jakobsen, I. S., Sandvig, K., & Llorente, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2309-8 · Cited by 269 · see citing works

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A 2 -IIA

Duchez, A., Boudreau, L. H., Naika, G. S., Bollinger, J., Belleannée, C., Cloutier, N., Laffont, B., Mendoza-Villarroel, R. E., Lévesque, T., Rollet, E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507905112 · Cited by 244 · see citing works

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration

Esser, J., Gehrmann, U., D’Alexandri, F. L., Hidalgo-Estévez, A. M., Wheelock, C. E., Scheynius, A., Gabrielsson, S., & Rådmark, O. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.039 · Cited by 235 · see citing works

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Miranda, A. M., Lasiecka, Z. M., Xu, Y., Neufeld, J., Shahriar, S., Simoes, S., Chan, R., Oliveira, T. G., Small, S. A., & Paolo, G. D. (2018) · Nature Communications · doi:10.1038/s41467-017-02533-w · Cited by 222 · see citing works

Active endocannabinoids are secreted on extracellular membrane vesicles

Gabrielli, M., Battista, N., Riganti, L., Prada, I., Antonucci, F., Cantone, L., Matteoli, M., Maccarrone, M., & Verderio, C. (2015) · The EMBO Reports · doi:10.15252/embr.201439668 · Cited by 221 · see citing works

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties

Osteikoetxea, X., Balogh, A., Szabó-Taylor, K., Németh, A., Szabó, T. G., Pálóczi, K., Sódar, B. W., Kittel, Á., György, B., Pállinger, É., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121184 · Cited by 212 · see citing works

T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor

Zakharova, L., Svetlova, M., & Fomina, A. F. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21013 · Cited by 209 · see citing works

Targeting phospholipase D in cancer, infection and neurodegenerative disorders

Brown, H. A., Thomas, P. G., & Lindsley, C. W. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.252 · Cited by 209 · see citing works

Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

Lhermusier, T., Chap, H., & Payrastre, B. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04478.x · Cited by 194 · see citing works

Asymmetric distribution of phospholipids in the membrane of vesicles released during in vitro maturation of guinea pig reticulocytes: Evidence precluding a role for “aminophospholipid translocase”

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Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

Alonso, R., Mazzeo, C., Rodriguez, M. C., Marsh, M., Fraile‐Ramos, A., Calvo, V., Ávila‐Flores, A., Mérida, I., & Izquierdo, M. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2010.184 · Cited by 152 · see citing works

Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo

Wahlund, C. J. E., Akpinar, G. G., Hiltbrunner, S., Veerman, R. E., Näslund, T. I., & Gabrielsson, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-16609-6 · Cited by 151 · see citing works

Antigen Presentation by Exosomes Released from Peptide-Pulsed Dendritic Cells Is not Suppressed by the Presence of Active CTL

Luketic, L., Delanghe, J., Sobol, P. T., Yang, P., Frotten, E., Mossman, K. L., Gauldie, J., Bramson, J. L., & Wan, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5024 · Cited by 143 · see citing works

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

Bridges, D., Ma, J.-T., Park, S., Inoki, K., Weisman, L. S., & Saltiel, A. R. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-1034 · Cited by 142 · see citing works

Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis

Morel, O., Morel, N., Jesel, L., Freyssinet, J., & Toti, F. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-010-0239-3 · Cited by 139 · see citing works

Differences in exosome populations in human breast milk in relation to allergic sensitization and lifestyle

Paredes, P. T., Gutzeit, C., Johansson, S. M., Admyre, C., Stenius, F., Alm, J. S., Scheynius, A., & Gabrielsson, S. (2014) · Allergy · doi:10.1111/all.12357 · Cited by 135 · see citing works

Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX

Bissig, C., Lenoir, M., Velluz, M., Kufareva, I., Abagyan, R. A., Overduin, M., & Gruenberg, J. E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.003 · Cited by 126 · see citing works

The Ether Lipid Precursor Hexadecylglycerol Stimulates the Release and Changes the Composition of Exosomes Derived from PC-3 Cells

Phuyal, S., Skotland, T., Hessvik, N. P., Simolin, H., Øverbye, A., Brech, A., Parton, R. G., Ekroos, K., Sandvig, K., & Llorente, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.593962 · Cited by 126 · see citing works

Characterization of exosome subpopulations from RBL-2H3 cells using fluorescent lipids

Laulagnier, K., Vincent-Schneider, H., Hamdi, S. M., Subra, C., Lankar, D., & Record, M. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.05.010 · Cited by 114 · see citing works

Angiopoietin-2 Secretion by Endothelial Cell Exosomes

Ju, R., Zhuang, Z. W., Zhang, J., Lanahan, A. A., Kyriakides, T. R., Sessa, W. C., & Simons, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.506899 · Cited by 108 · see citing works

Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1

van der Kant, R., Zondervan, I., Janssen, L., & Neefjes, J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037325 · Cited by 101 · see citing works

Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy

Young, L. N., Cho, K., Lawrence, R., Zoncu, R., & Hurley, J. H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603650113 · Cited by 89 · see citing works

Emerging concepts on the role of exosomes in lipid metabolic diseases

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Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells

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Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

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Insights into the Effects of Mesenchymal Stem Cell-Derived Secretome in Parkinson’s Disease

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New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer’s disease

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Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation–induced systemic immunosuppression

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The Biological Function of Extracellular Vesicles during Fertilization, Early Embryo—Maternal Crosstalk and Their Involvement in Reproduction: Review and Overview

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Platelets Extracellular Vesicles as Regulators of Cancer Progression—An Updated Perspective

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Characterization and regulation of extracellular vesicles in the lumen of the ovine uterus†

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Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics

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Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses

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Adipocyte-Derived Extracellular Vesicles: State of the Art

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