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An organ boundary‐enriched gene regulatory network uncovers regulatory hierarchies underlying axillary meristem initiation
Open accessAbstract
Gene regulatory networks (GRNs) control development via cell type‐specific gene expression and interactions between transcription factors (TFs) and regulatory promoter regions. Plant organ boundaries separate lateral organs from the apical meristem and harbor axillary meristems (AMs). AMs, as stem cell niches, make the shoot a ramifying system. Although AMs have important functions in plant development, our knowledge of organ boundary and AM formation remains rudimentary. Here, we generated a cellular‐resolution genomewide gene expression map for low‐abundance Arabidopsis thaliana organ boundary cells and constructed a genomewide protein–DNA interaction map focusing on genes affecting boundary and AM formation. The resulting GRN uncovers transcriptional signatures, predicts cellular functions, and identifies promoter hub regions that are bound by many TFs. Importantly, further experimental studies determined the regulatory effects of many TFs on their targets, identifying regulators and regulatory relationships in AM initiation. This systems biology approach thus enhances our understanding of a key developmental process.
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“Recently, CUC2 was found to bind to the LAS promoter, positively regulating its expression (Tian et al., 2014; Fig. 3).”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Tian et al., 2014
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“The spl9 spl15 double mutant develops accessory meristems in its leaf axils (Tian et al., 2014; Fig. 3).”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Tian et al., 2014
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Metadata
- Authors
- Tian, C., Zhang, X., He, J., Yu, H., Wang, Y., Shi, B., Han, Y., Wang, G., Feng, X., Zhang, C., Wang, J., Qi, J., Yu, R., & Jiao, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Jiao, Yuling
- ORCID
- Venue
- Molecular Systems Biology
- Published
- 2014-10-01
- Volume
- 10
- Issue
- 10
- Pages
- 755-755
- ISSN
- 1744-4292 (ISSN-L)
- PMC
- PMC4299377
- OpenAlex
- W2148257190
- Cited by
- 133
- References
- 85
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 14 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 10
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Systems Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Agriculture of China (2011ZX08010‐002)
- National Basic Research Program of China (2012CB910902, 2014CB943500)
- National Natural Science Foundation of China (31171159, 31222033, 31300298, 31430010)
- Hundred Talents Program and the Strategic Priority Research Program of CAS
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- axillary meristem initiation, organ boundaries, gene regulatory networks, transcription factors, protein-DNA interactions, Arabidopsis thaliana, stem cell niche, regulatory hierarchy
- MeSH terms
- Models, Genetic, Promoter Regions, Genetic, Transcription Factors, Arabidopsis, Gene Expression Regulation, Plant, Meristem, Genome, Plant, Gene Expression Profiling, Arabidopsis Proteins, Gene Regulatory Networks
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