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Cited by 65Substance Abuse Treatment and OutcomesChild and Adolescent Psychosocial and Emotional DevelopmentAlcohol Consumption and Health Effects

Adolescent Alcohol Use Is Positively Associated With Later Depression in a Population-Based U.K. Cohort

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Edwards, Alexis C, Heron, Jon, Dick, Danielle M, Hickman, Matt, Lewis, Glyn, Macleod, John, Kendler, Kenneth S·2014·Journal of Studies on Alcohol and Drugs
DOI 10.15288/jsad.2014.75.758PMC PMC4161696
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Abstract

OBJECTIVE: Alcohol use and internalizing problems are often positively associated during adolescence and adulthood. However, the basis of this relationship remains poorly understood, and longitudinal data collected in population-based samples could improve the development of etiological models. METHOD: Using a prospective population-based U.K. cohort, the current study examined the relationship between frequency of drinking during adolescence (ages 13-15, N = 7,100) with problems with depression and anxiety at average age 17 years 10 months (n = 4,292). Analyses were conducted separately by sex and adjusted by the inclusion of potential individual- and familial-level confounders. RESULTS: Among boys, drinking frequency was positively associated with later depression but not anxiety. This association was robust to adjustment for covariates/confounders. Among girls, drinking frequency was related to later depression and anxiety in univariable analyses. In multivariable analyses, only the association with depression remained after adjustment for covariates/confounders. RESULTS were comparable across sexes, although the effect size of drinking frequency was higher among boys. CONCLUSIONS: Higher adolescent alcohol use, even at sub-clinical levels, is associated with an increased risk of later problems with depression but may not be associated with an aggregate measure of anxiety. Future research should consider the possibility of differential relationships between multiple measures of adolescent alcohol use and distinct internalizing outcomes later in development.

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  • Adolescent alcohol exposure is associated with increased rates of major depressive disorder, particularly in females.

    “AAE is associated with increased rates of major depressive disorder [45, 46], particularly in females [47].”

    From Consequences of adolescent drug use (2023) · cites this paper as [46]

    The Multivariable analyses section reports that more frequent adolescent drinking was associated with later depression in both boys and girls. The section on outcomes across the sexes does not support a stronger association in females: adjusted effect sizes were slightly higher in boys. The paper reports later depressive episodes, rather than establishing that alcohol exposure causes major depressive disorder; page numbers were unavailable in our copy. (LLM, conf=0.90)

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  1. [27]27. Johnston, L. D., O'Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2013). Monitoring the Future National Survey Results on Drug Use, 1975-2012: Vol. 1. Secondary school students. Bethesda, MD: National Institute on Drug Abuse.
  2. [42]42. Muthén, L. K., & Muthén, B. O. (1998-2007). Mplus user's guide (5th ed.). Los Angeles, CA: Authors.

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Authors
Edwards, A. C., Heron, J., Dick, D. M., Hickman, M., Lewis, G., Macleod, J., & Kendler, K. S.
Affiliations
  • Virginia Commonwealth University (US)
  • University of Bristol (GB)
  • School of Social and Community Medicine, University of Bristol, Bristol, England
  • University College London (GB)
ORCID
Venue
Journal of Studies on Alcohol and Drugs
Publisher
Alcohol Research Documentation, Inc.
Published
2014-09
Volume
75
Issue
5
Pages
758-765
ISSN
  • 1937-1888 (ISSN-L)
  • 1938-4114
DOI
10.15288/jsad.2014.75.758
PMC
PMC4161696
OpenAlex
W2123383419
Cited by
65
References
56
Citations by year
2026: 6 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 1 · 2014: 1
FWCI
3.03
Type
journal article
Language
en
Open access
Locations
  • Journal of Studies on Alcohol and Drugs (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
  • Wellcome Trust (074268/Z/07/Z, 092731)
  • University of Bristol (092731)
  • National Institutes of Health (092731)
  • Medical Research Council (MC_PC_15018, 092731, MR/K023233/1)
  • National Institute on Alcohol Abuse and Alcoholism (K02AA018755, K01AA021399, R01AA018333)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
adolescent alcohol use, drinking frequency, depression, anxiety, internalizing problems, sex differences, developmental trajectories, etiology of depression
MeSH terms
Adolescent, Adolescent Behavior, Alcohol Drinking, Depression, Female, United Kingdom, Humans, Longitudinal Studies, Male, Population Surveillance, Risk Factors, Cohort Studies

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