Cited by 207Genetic Associations and EpidemiologyAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

What is the genetic relationship between anxiety and depression?

Hettema, John M.·2008·American Journal of Medical Genetics Part C Seminars in Medical Genetics

Abstract

Anxiety and depression share a long, close history in psychiatric nosology and treatment. The anxiety disorders, individually and as a group, exhibit remarkably high rates of comorbidity with each other and with major depression. Analyses done in large-scale epidemiologic surveys have identified major patterns of phenomenological overlap between these conditions. Researchers have tested hypotheses of shared genetic etiologies as a potential basis of this relationship. In general, available family studies have found mixed evidence for co-aggregation of anxiety and depressive disorders, while twin studies more definitively indicate that shared genetic risk factors largely account for this comorbidity. Some of this appears to be accounted for by genetic variation in personality traits that broadly predispose to anxiety and depression. Molecular genetic studies of these conditions, though too early to draw firm conclusions, thus far provide tentative support for specific genetic loci that may generally influence susceptibility across the anxiety-depressive spectrum.

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Crossref · 10.1002/ajmg.c.30171

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Authors
Hettema, J. M.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Hettema, John M.
Venue
American Journal of Medical Genetics Part C Seminars in Medical Genetics
Publisher
Wiley
Published
2008-04-22
Volume
148C
Issue
2
Pages
140-146
ISSN
  • 1552-4868 (ISSN-L)
  • 1552-4876
OpenAlex
W1991173495
Cited by
207
References
97
Citations by year
2026: 12 · 2025: 16 · 2024: 13 · 2023: 14 · 2022: 15 · 2021: 11 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 15 · 2012: 9
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Medical Genetics Part C Seminars in Medical Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
anxiety disorders, major depressive disorder, comorbidities, shared genetic etiology, twin studies, family studies, personality traits, genetic susceptibility, genetic loci
MeSH terms
Anxiety Disorders, Major Depressive Disorder, Depressive Disorder, Family Characteristics, Female, Humans, Genetic Linkage, Male, Molecular Biology, Personality, Phenotype, Risk Factors, Twin Studies as Topic

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