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Cited by 163Hormonal and reproductive studiesSperm and Testicular FunctionAdipokines, Inflammation, and Metabolic Diseases

The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study

Mohr, Beth A, Bhasin, Shalender, Link, Carol L, O’Donnell, Amy B, McKinlay, John B·2006·European Journal of Endocrinology
DOI 10.1530/eje.1.02241
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Abstract

Objective: Changes in adiposity affecting total testosterone (TT) and free testosterone (FT) levels have not been examined in a population-based survey. We aimed to determine whether changes in adiposity predict follow-up levels and rates of change in TT, FT and sex hormone-binding globulin (SHBG) in men. Design: The Massachusetts Male Aging Study is a randomly sampled, population-based cohort interviewed at baseline (T1, 1987–1989; n = 1709; aged 40–70 years) and followed-up approximately 9 years later (T2, 1995–1997; n = 1156). Men were categorized as overweight (body mass index (BMI) ≥ 25 kg/m 2) or having obesity (BMI ≥ 30 kg/m 2), waist obesity (waist circumference ≥ 102 cm), or waist-to-hip ratio (WHR) obesity (WHR>0.95). For each adiposity group, we constructed four categories to represent changes between T1 and T2: overweight (or obese, etc.) at neither wave, T1 only, T2 only, or both waves. Results: After adjustment for confounding variables, men who were overweight at T2 only, or at both waves, had significantly lower mean T2 TT and SHBG levels than men in the neither group (P<0.05). Mean FT did not differ between any overweight group and the neither group. Men who were obese at both times, had the highest mean BMI, the highest fraction of severely obese men, and significantly greater rate of decline in FT than the neither group. Conclusions: In men who become overweight, the greater rate of decline in TT, but not FT, is related mostly to a lesser age-related increase in SHBG. Since weight gain is highly prevalent in older men, over-reliance on TT levels in the diagnosis of androgen deficiency could result in substantial misclassification.

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Authors
Mohr, B. A., Bhasin, S., Link, C. L., O’Donnell, A. B., & McKinlay, J. B.
Affiliations
New England Research Institutes (US)
ORCID
Bhasin, Shalender
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2006-09
Volume
155
Issue
3
Pages
443-452
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.1.02241
OpenAlex
W2104301254
Cited by
163
References
11
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 12 · 2015: 13 · 2014: 6 · 2013: 8 · 2012: 14
FWCI
8.19
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (7p01ag004673-05)
  • National Institute on Aging (AG 04673)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
adiposity, testosterone, free testosterone, sex hormone-binding globulin, older men, obesity, overweight, waist circumference, waist-to-hip ratio, body mass index, androgen deficiency, weight gain, longitudinal change
MeSH terms
Adult, Aged, Aging, Anthropometry, Body Composition, Follow-Up Studies, Humans, Life Style, Longitudinal Studies, Male, Massachusetts, Middle Aged, Motor Activity, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index, Adiposity

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